Pre-NOTCH Expression and Processing (Homo sapiens)

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1, 10, 11, 13, 17...51, 1075, 14, 19, 13211, 46, 51, 125, 13311620, 51, 12651, 1297730, 436565241081813, 475, 14, 19, 13220, 25, 62, 63, 78...516, 20, 26, 28, 32...20, 94, 119108nucleoplasmGolgi lumenendoplasmic reticulum lumencytosolHIST2H2BE EIF2C3 H2AFJ 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) UDPTNRC6B PRKCIRBPJ NOTCH3 mRNA AGO2 TNRC6C NOTCH4 mRNA CREBBP AcK10-H3F3A MAMLD1 Ack10-HIST2H3A Glc,Gal-GlcNAc-Fuc-Pre-NOTCH2 HIST1H2BH NOTCH2(1582-2471) EIF2C1 SIRT6 CMPGlc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCHE2F1 miR-449A NOTCH4 gene FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) NOTCHmiR-150 Pre-NOTCHTNRC6A TNRC6A EIF2C1 NOTCH1 mRNA:miR-449RISCTNRC6A H2AFX RFNG ST3GAL3/4/6SIRT6 Signaling by NOTCH4NOTCH3 coactivatorcomplexHIST1H2BL NOTCH2 mRNAGlc,GlcNAc-Fuc-Pre-NOTCH3 Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 HIST2H2BE TNRC6B HIST1H2BC POFUT1miR-200B EIF2C4 EIF2C4 CCND1 SNW1 MIR34A gene EIF2C1 HIST1H2BH FRINGE-modifiedNOTCHMOV10 NOTCH1 mRNA HIST3H2BB NOTCH4(1337-2003) NOTCH1(1665-2555) H3F3A EIF2C3 miR-34B ATP2A2 HIST1H2BC MOV10 TNRC6A RBPJ TFDP2 Glc,GlcNAc-Fuc-Pre-NOTCHGDPNOTCHMOV10 AGO2 12xFucT-6xFucS-NOTCH4(24-2003) B4GALT1 homodimerMIR34B gene HIST1H2AJ HIST1H2BN NOTCH1 gene 17xFucT-2xFucS-NOTCH1(19-2555) HIST1H4 TFDP2 EIF2C4 NOTCH3(1572-2321) NOTCH1 mRNA AGO2 MAML3 p-S68-ELF3 MAML3 LFNG POGLUT1EIF2C4 miR-181C Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH3 Glc,Fuc-Pre-NOTCHHIST1H2BA E2F3 TNRC6C HIST2H2AC TNRC6A EIF2C4 EIF2C3 NOTCH4 gene HIST1H2BL NOTCH4(1337-2003) NOTCH1 mRNANOTCH2 mRNA KAT2A HIST1H2BO MIR34 genesEIF2C1 CCND1:CREBBP:NOTCH1GeneCMP-Neu5AcEIF2C1 Pre-NOTCH3 miR-34C 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) ATPTNRC6B TNRC6B 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) TP53 TetramerTNRC6C TP53 EIF2C1 TNRC6C TNRC6C EIF2C1 Pre-NOTCH2HIST1H2BD HIST1H2BB 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) miR-449B H2AFX miR-34A MOV10 12xFucT-11xGlcS-6xFucS-NOTCH4(24-1336) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) FURINmiR-449 RISCGlc,Gal-GlcNAc-Fuc-Pre-NOTCH4 MAML2 HIST1H2BD NOTCH2(1582-2471) H2AFB1 H2AFX HIST1H2AD JUNMIR34A gene EIF2C4 EIF2C3 AGO2 HIST1H2AJ MAML2 Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH4 HIST1H2BJ TFDP1 EIF2C3 NOTCH1 gene AGO2 AGO2 HIST1H2BB AGO2 18xFucT-FucS-NOTCH2(26-2471) NOTCH1 CoactivatorComplexEIF2C4 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) MOV10 MFNG MAMLD1 E2F1 MOV10 CREBBP miR-449B NOTCH4 mRNAmiR-34C HIST2H2AA3 miR-449C HIST2H2AC FRINGE-modified NOTCH4 Extracellular fragment (NECD4) MOV10 TNRC6B NICD1 TNRC6B 19xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) ADPH2AFZ NICD3 H2AFZ MOV10 HIST1H2BC 10xFucT-4xFucS-NOTCH3(40-2321) SIRT6NOTCH4 gene EIF2C3 HIST1H2BN RAB6AFRINGE-modified NOTCH3 Extracellular Fragment (NECD3) Glc,GlcNAc-Fuc-Pre-NOTCH2 HIST2H2AA3 TNRC6A ST3GAL6 H2AFJ miR-200B/C RISCHIST1H3A UDP-GlcNOTCH3(1572-2321) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH1 NOTCH1 mRNA UDPTNRC6B FRINGE-modified NOTCH2 extracellular fragment (NECD2) Nucleosome (H3K9ac)TNRC6C MOV10 NOTCH1 gene p-S68-ELF3Pre-NOTCH2 NOTCH1 mRNA,NOTCH4mRNAMAML2 RUNX1H2AFV AcK10-H3F3A SIRT6:Nucleosome:NOTCH1,NOTCH4 geneNOTCH3 gene TNRC6B TNRC6C Fringe familyNOTCH1 gene HIST1H2AD Ack10-HIST2H3A H2BFS miR-206 SNW1 TNRC6B HIST1H2AC HIST1H2BA NOTCH4(1337-2003) NOTCH2 genePre-NOTCH3miR-150 Ack10-HIST1H3A TNRC6C HIST1H2BJ EIF2C1 NOTCH1(1665-2555) Signaling by NOTCH2TNRC6C HIST1H2BO FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) NOTCH1mRNA:miR-200B/CRISC18xFucT-16xGlcS-FucS-NOTCH2(26-1581) NOTCH4(1337-2003) 12xFucT-8xGlcS-6xFucS-NOTCH4(24-1336) HIST1H2BB HIST1H2AJ TNRC6B B4GALT1 AGO2 NOTCH3 geneNOTCH4 mRNA:miR-181CRISCNOTCH3 gene NOTCH1(1665-2555) Pre-NOTCH1 ATP2A1-3H2BFS NOTCH1 mRNA:miR-34RISCmiR-302A RISCH2AFJ TNRC6C miR-34B Fringe-modifiedNOTCHMAML1 miR-206 TNRC6A NOTCH1 coactivatorcomplex:NOTCH3 geneMOV10 HIST1H2AB HIST1H2AB ST3GAL4 H2AFV E2F1/3:DP1/2:NOTCH1GeneHIST2H3A HIST1H2BJ Pre-NOTCH4NOTCH2(1582-2471) ATP2A3 FRINGE-modified NOTCH2 Extracellular Fragment (NECD2) TNRC6A HIST3H2BB HIST1H2BM UDP-Gal14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) NOTCH1 mRNA Glc,GlcNAc-Fuc-Pre-NOTCH4 NOTCH3 mRNA AGO2 GDP-FucNOTCH3 mRNA:miR-150RISCmiR-34C MAML1 RUNX1:NOTCH4 geneHIST1H4 EIF2C3 TNRC6A TNRC6B ST3GAL3 FRINGE-modified NOTCH4 Extracellular Fragment (NECD4) MOV10 HIST1H2AB UDP-GlcNAcHIST3H2BB miR-200C HIST1H2BD TP53 EP300 NOTCH1(1665-2555) Signaling by NOTCH1EIF2C4 NOTCH2 mRNA:miR-34RISCHIST1H2BL H2AFB1 TNRC6C Fuc-Pre-NOTCHGlc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH2 NOTCH3 mRNA:miR-206RISCHIST1H2AC HIST1H2BK EIF2C4 Glc,Gal-GlcNAc-Fuc-Pre-NOTCHHIST1H2BM miR-302A p-S68-ELF3:NOTCH3geneHIST1H2BM ELF3miR-181C RISCPre-NOTCH4 EIF2C1 CREBBP HIST2H2AA3 EP300 HIST1H2AC NOTCH3(1572-2321) AGO2 TNRC6A KAT2A MAMLD1 NOTCH4 geneHIST1H2BK miR-34A HIST1H2AD MOV10 NOTCH4 gene AGO2 MOV10 TMED2EIF2C3 TNRC6A 12xFucT-8xGlcS-6xFucS-NOTCH4(24-2003) miR-206 RISCEIF2C1 TNRC6B miR-200C HIST1H2BA EIF2C4 SEL1LMOV10 NOTCH2(1582-2471) miR-150 RISCTNRC6C miR-449C TNRC6B AGO2 TNRC6C E2F3 H2AFZ 12xFucT-8xGlcS-6xFucS-NOTCH4(24-2003) EIF2C3 Pre-NOTCH1EIF2C3 KAT2B EIF2C1 NOTCH1 gene EIF2C3 EIF2C4 2'-O-acetyl-ADP-riboseATP2A1 MIR34C gene HIST1H4 H2BFS miR-200B MIR34B gene 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) HIST1H2BH EIF2C3 EIF2C1 EIF2C4 H2AFV miR-181C NICD1 TNRC6A MAML3 CCND1:CREBBPRBPJ Glc,GlcNAc-Fuc-Pre-NOTCH1 NOTCH3 mRNAAGO2 NOTCH3(1572-2321) EIF2C1 EIF2C1 CCND1 Signaling by NOTCH3NOTCH4 mRNA TNRC6A EIF2C4 TNRC6A TNRC6C miR-302A HIST1H2BO miR-34B miR-34A TP53 Tetramer:MIR34genesHIST1H2BN miR-34 RISCEIF2C1 AGO2 Ack10-HIST1H3A AGO2 NOTCH1 geneE2F1/3:DP1/2KAT2B EIF2C3 EIF2C4 NOTCH4 mRNA EIF2C3 TNRC6B EIF2C4 TNRC6A miR-449A TNRC6B NAD+SIRT6:Nucleosome(H3K9ac):NOTCH1,NOTCH4 geneRUNX1 HIST2H2AC NOTCH1 gene,NOTCH4gene17xFucT-14xGlcS-2xFucS-NOTCH1(19-1664) HIST2H2BE MOV10 MAML1 HIST1H2BK H2AFB1 FRINGE-modified NOTCH3 Extracellular fragment (NECD3) Glc,Fuc-Pre-NOTCHCREBBP EIF2C3 NOTCH4 mRNA:miR-302ARISCTFDP1 Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) MIR34C gene UDPTNRC6C 3, 4, 8, 12, 15...65491161081162439, 41, 53, 60, 76...772, 7, 9, 16, 21...5, 14, 19, 13286