Signaling by ERBB2 (Homo sapiens)

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5376985111911, 126761, 30, 35, 44, 689, 40129334, 32, 95, 1034276331, 3511757619811911, 69, 12617108, 1158822, 26, 31, 32, 37...8829, 56, 90761087862, 11729, 36, 56, 121119767632, 61, 103994, 12, 12021, 34, 43, 66, 80...987657cytosolplasma membraneplasma membranePIK3R1 UBC(153-228) p-10Y-ERBB3-1 GRB2-1 UBC(1-76) ATPERBB3:RNF41RPS27A(1-76) UBC(305-380) SOS1 p-T,p-S-AKTEGFR p-6Y-EGFR ATPRPS27A(1-76) p-10Y-ERBB3-1 ERBB2:ERBB2IP:HSP90:CDC37p-S139,3Y-SHC1-1 GTP p-Y,Y877-ERBB2 NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3KPhosphorylated p-Y877-ERBB2 heterodimers ERBB2 UBC(533-608) Heterodimers ofp-ERBB2dephosphorylated atY1248NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 UBC(229-304) UBC(305-380) UBC(1-76) Phosphorylated ERBB2:ERBB4cyt1 heterodimers RNF41UBC(381-456) p-6Y,Y1112-ERBB2 ADPEGF UBC(381-456) PTPN12p-Y342-PTK6DIAPH1 UBA52(1-76) HSP90AA1 PhosphorylatedERBB2:ERBB3heterodimersGTP p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimersUb-RNF41:p-USP8p-6Y,Y1112-ERBB2 ERBB3-1 UBB(77-152) UBC(609-684) ERBB3-1 UBC(229-304) UBC(533-608) PIK3CA p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform UBC(381-456) p-6Y-EGFR NRG2 NRG2 p-Y1046,Y1178,Y1232-ERBB4 JM-B CYT-1 isoform RPS27A(1-76) NRG1 p-6Y-ERBB2 KRAS UBC(457-532) UBC(457-532) NRG1/2Phosphorylated p-6Y-ERBB2 heterodimers UBB(153-228) UBC(609-684) NRG2 UBC(77-152) Ligand-ActivatedEGFR/ERBB3/ERBB4UBA52(1-76) ADPUBC(77-152) PIK3CA NRG2 RHO GTPases ActivateForminsUBB(1-76) UBC(1-76) UBB(153-228) p-Y-ERBB2 UBB(77-152) PIK3CA:PIK3R1NRG1/2:p-10Y-ERBB3:p-ERBB2:GRB7MEMO1 Ub-ERBB3UBB(1-76) UBC(381-456) EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3KPIK3R1 UBC(153-228) RPS27A(1-76) NRG2 GRB2-1:SOS1UBC(457-532) UBC(457-532) ATPp-7Y,Y1112-ERBB2 p-Y419/420/426-N-myristoyl-SRC/FYN/YES1p-T308,S473-AKT1 GAB1 p-10Y-ERBB3-1 UBB(1-76) NRG1 PhosphorylatedERBB2:EGFRheterodimersPhosphorylated p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers GDP CDC37p-7Y,Y1112-ERBB2 UBB(153-228) PTPN12 ERBB2IP Phosphorylated p-6Y-ERBB2 heterodimers UBC(229-304) UBC(609-684) UBC(1-76) p-Y,Y877-ERBB2 NRG2 UBC(457-532) Phosphorylated p-6Y-ERBB2 heterodimers NRG1 p-10Y-ERBB3-1 DAG and IP3signalingNRGs/EGFLs:ERBB4:ERBB2 NRG1 ERBB2 UBC(533-608) active p-T507,S645,S664-PRKCD ERBB2IP UBC(77-152) p-Y1046,Y1178,Y1232-ERBB4 JM-B CYT-1 isoform p-T309,S474-AKT2 UBC(77-152) H2Op-6Y-ERBB2 Phosphorylatedp-Y877-ERBB2heterodimersUBC(457-532) UBB(77-152) ActivatedPRKCA(PRKCD,PRKCE)Phosphorylated p-Y877-ERBB2 heterodimers NRG2 STUB1EGF:p-EGFR:p-ERBB2:GRB2:GAB1Ubp-7Y,Y1112-ERBB2 MATKUBC(457-532) KRAS UBC(1-76) UBB(153-228) EGF ADPUBB(77-152) ADPp-6Y-EGFR NRG2 Ub-ERBB2:ERBB2IP:HSP90:CDC37UBC(153-228) EGF p-S139,3Y-SHC1-1 ADPUBC(305-380) UbERBB3-1 ATPEGF ERBB2 UBB(153-228) UBC(381-456) SHC1 p-6Y,Y1112-ERBB2 p-7Y-ERBB2 HRAS UBB(77-152) Phosphorylated ERBB2:ERBB4cyt1 heterodimers GRB7 NRG1/2:ERBB3p21 RAS:GDPUBC(153-228) Phosphorylated p-Y877-ERBB2 heterodimers UBC(1-76) ERBB3-1 NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 NRG1 UBC(229-304) UBC(229-304) Phosphorylated p-6Y-ERBB2 heterodimers UBC(1-76) ERBB3-1 UBA52(1-76) UBC(533-608) RNF41 Phosphorylated p-Y877-ERBB2 heterodimers RPS27A(1-76) UBC(381-456) RNF41 Phosphorylated p-6Y-ERBB2 heterodimers UBC(153-228) UBB(77-152) GAB1 Phosphorylatedp-6Y-ERBB2heterodimersUBC(305-380) Signaling by PTK6SHC1p-10Y-ERBB3-1 MyrG-p-Y426-YES1 NRG2 GRB2-1 NRG2 PI(4,5)P2UBC(229-304) EGF-like ligands EGF ERBB4 JM-B CYT-1 isoform Neuregulins p-Y239,Y240,Y317-SHC1-2 ADPp-7Y,Y1112-ERBB2 UBC(457-532) UBC(153-228) p-10Y-ERBB3-1 UBA52(1-76) MEMO1HSP90AA1 p-S139,3Y-SHC1-1,p-S29,3Y-SHC1-2:PTPN12ERBB3-1DAGs p-7Y,Y1112-ERBB2 MyrG-p-Y419-SRC UBC(609-684) ERBB4 JM-A CYT-2 isoform NRAS CUL5p-6Y,Y1112-ERBB2 MyrG-p-Y420-FYN UBB(1-76) UBA52(1-76) UBC(229-304) p-6Y-EGFR p-Y349,Y350,Y427-SHC1-1 NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 UBB(1-76) UbH2OCDC37 NRG1 p-ERBB2heterodimers:MEMO1:RHOA:GTP:DIAPH1UBC(609-684) UBC(533-608) UBC(533-608) UBC(1-76) p-10Y-ERBB3-1 PhosphorylatedERBB2:EGFRheterodimers:PTPN18UBC(609-684) UBC(77-152) ERBB4 JM-A CYT-1 isoform HSP90AA1 Phosphorylated p-6Y-ERBB2 heterodimers p-Y-ERBB2 UBB(77-152) PIP3 activates AKTsignalingDAG PTK6EGF:p-EGFR:p-ERBB2:PLCG1pT497,T638,S657-PRKCA UBC(609-684) Phosphorylated p-Y877-ERBB2 heterodimers EGF HSP90AA1 UBC(305-380) RNF41 Phosphorylated ERBB2:ERBB4cyt2 heterodimers UBC(1-76) SOS1 UBC(609-684) RPS27A(1-76) p-Y-ERBB2 UbUBC(153-228) p-7Y,Y1112-ERBB2 PTPN18 CDC37 GRB2-1 ADPUSP8EGF UBC(609-684) UBC(1-76) GRB2-1 UBC(381-456) NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2NRG2 p-Y,Y877-ERBB2 p-ERBB2heterodimers:PTK6UBB(77-152) UBC(229-304) UBC(1-76) PiPIK3CA UBC(609-684) ATPSOS1 Neuregulins PIK3R1 RPS27A(1-76) p-T945-USP8p-Y-ERBB2 EGFR UBB(1-76) GDPUBA52(1-76) UBC(229-304) GAB1 p-T945-USP8 p-7Y-ERBB2 EGF:p-EGFR:p-ERBB2:GRB2:SOS1UBC(305-380) ERBB2IPEGF UBB(77-152) ADPUBC(381-456) UBB(153-228) PLCG1p-3Y-SHC1-1,p-3Y-SHC1-2NRG1 UBC(77-152) Phosphorylated p-6Y-ERBB2 heterodimers UBB(1-76) UBC(533-608) RHOA PS UBC(381-456) p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform p-T305,S472-AKT3 UBC(229-304) PTPN18 UBC(305-380) ATPRHOA:GTP:DIAPH1SOS1 NRG1 PIK3R1 p-4Y-PLCG1Neuregulins UBC(533-608) UBB(153-228) UBC(533-608) PhosphorylatedERBB2:ERBB4cyt1heterodimersADPGRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimersUb-RNF41UBC(533-608) UBC(153-228) DIAPH1 p-S29,3Y-SHC1-2 GRB2-1 PhosphorylatedERBB2:ERBB4heterodimersUBB(1-76) UBB(153-228) p-Y-ERBB2 MEMO1 p-Y,Y877-ERBB2 EGF UBB(77-152) p-S29,3Y-SHC1-2 p-6Y,Y1112-ERBB2 UBB(153-228) UBA52(1-76) UBC(305-380) EGF UBC(77-152) PI(3,4,5)P3CDC37 UBC(305-380) RPS27A(1-76) UBA52(1-76) p-6Y-EGFR ERBB3-1 PTK6 UBA52(1-76) GRB2-1 PhosphorylatedERBB2(dephosphorylated at Y1196,Y1112 and Y1248):EGFR heterodimers:PTPN18Phosphorylated p-Y877-ERBB2 heterodimers p-Y1023,Y1139,Y1221,Y1222-ERBB2 UBB(1-76) GTP NRGs/EGFLs:ERBB4:p-Y877-ERBB2 UBC(381-456) GTPp-7Y,Y1112-ERBB2 p-T566,T710,S729-PRKCE UBC(77-152) PiNRG1/2:p-ERBB3:p-ERBB2:PI3KUBC(305-380) p-6Y-EGFR p-ERBB2heterodimers:MEMO1UBC(457-532) Phosphorylated p-Y877-ERBB2 heterodimers UBC(153-228) UBC(229-304) ERBB2 p-Y349,Y350-SHC1 EGFR p-6Y-EGFR EGF-like ligands NRAS Phosphorylated ERBB2:ERBB4cyt2 heterodimers p21 RAS:GTPUBB(153-228) PTPN18Phosphorylated p-Y877-ERBB2 heterodimers UbRHOA HRAS Ca2+ RNF41 SHC1:PhosphorylatedERBB2 heterodimersUBC(457-532) UBC(457-532) UBC(305-380) RAF/MAP kinasecascadep-Y877-ERBB2 Phosphorylated p-6Y-ERBB2 heterodimers UBC(381-456) ERBB2 heterodimersPhosphorylated p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers EGF EGF-like ligands p-6Y-EGFR NRG1 NRG1 UBA52(1-76) UBC(153-228) NRG1 p-Y-ERBB2 UBC(533-608) GRB2-1 p-6Y,Y1112-ERBB2 UBB(1-76) UBC(77-152) p-6Y-EGFR CDC37 UBC(77-152) p-Y877-ERBB2heterodimersp-Y349,Y350-SHC1 Ub-ERBB2:ERBB2IP:Ub-HSP90:CDC37RPS27A(1-76) RPS27A(1-76) UBB(1-76) NRG2 p-6Y,Y1112-ERBB2 ATPNRG1 UBC(77-152) MATK p-ERBB2 heterodimersPLCG1 UBB(77-152) p-ERBB2heterodimers:MATKRPS27A(1-76) UBA52(1-76) UBB(153-228) UBC(609-684) GRB7ERBB2IP p-Y,Y877-ERBB2 EGF p-Y,Y877-ERBB2 HSP90UBC(153-228) GRB2:GAB1PIK3CA ATPp-S139,3Y-SHC1-1,p-S29,3Y-SHC1-2ADPATPATP335, 7129, 56, 1218947, 77, 912, 6, 8, 16, 19...104, 1181083, 7, 10, 13-15, 18...10839, 45, 55, 64, 85...24