Matrix Metalloproteinases (Rattus norvegicus)

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1StromelysinsCollagenasesBased on Vu & Werb (2000)Matrix metalloproteinases: effectors ofMembrane-type MMPsMatrilysinOtherGenes Dev 14:2123-2133Potential Inducers of TranscriptionInhibitorsMetalloelastaseGelatinasesEnamelysindevelopment and normal physiology.Mmp16Mmp1aMmp8Mmp9Timp3Mmp28Mmp14Timp2MMP24Tcf20Mmp12Mmp7Mmp3Mmp13Timp4Mmp19Mmp23Mmp2Mmp17Mmp15Mmp20Mmp27Mmp21Mmp25BsgTnfTimp1Mmp11Mmp10


Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily.

Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense.

Source: Wikipedia


This pathway was inferred from Homo sapiens pathway WP129(r20953) with a 87% conversion rate.

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Ontology Terms



  1. Vu TH, Werb Z; ''Matrix metalloproteinases: effectors of development and normal physiology.''; Genes Dev, 2000 PubMed Europe PMC Scholia


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69444view19:05, 8 July 2013MaintBotUpdated to 2013 gpml schema
67452view11:03, 26 June 2013DdiglesOntology Term : 'cell-extracellular matrix signaling pathway' added !
58971view18:45, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41770view02:41, 2 March 2011MaintBotRemoved redundant pathway information and comments
35330view08:32, 12 February 2010ThomasModified description
35328view08:31, 12 February 2010Thomasmoved reference from comments to bibliography
34765view00:41, 14 January 2010KhanspersUpdated xrefs
34138view19:32, 9 December 2009MaintBotAutomatic update of empty xrefs
32382view16:56, 15 August 2009MaintBotFixed text labels
32025view13:24, 14 August 2009MaintBotFixed group labels
31420view20:57, 13 August 2009MaintBotFixed text labels
31001view01:00, 30 July 2009MaintBotConverted from Homo sapiens
21265view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Matrix Metalloproteinases]] moved to [[Pathway:WP278]]: Moved to stable identifier
8258view13:46, 7 January 2008MaintBot[[Pathway:Rat:Matrix Metalloproteinases]] moved to [[Pathway:Rattus norvegicus:Matrix Metalloproteinases]]: Renaming species
7749view16:15, 18 December 2007MaintBotfixed category names
7430view12:42, 4 November 2007MaintBotAdded categories to GPML
19510view22:20, 22 May 2007M.Ramirezgpml file for [[Rat:Matrix_Metalloproteinases]]
6575view22:20, 22 May 2007Kdahlquistgpml file for [[Rat:Matrix_Metalloproteinases]]

External references


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NameTypeDatabase referenceComment
BsgGeneProduct25246 (Entrez Gene)
MMP24GeneProduct83513 (Entrez Gene)
Mmp10GeneProduct117061 (Entrez Gene)
Mmp11GeneProduct25481 (Entrez Gene)
Mmp12GeneProduct117033 (Entrez Gene)
Mmp13GeneProduct171052 (Entrez Gene)
Mmp14GeneProduct81707 (Entrez Gene)
Mmp15GeneProduct291848 (Entrez Gene)
Mmp16GeneProduct65205 (Entrez Gene)
Mmp17GeneProduct288626 (Entrez Gene)
Mmp19GeneProduct304608 (Entrez Gene)
Mmp1aGeneProduct300339 (Entrez Gene)
Mmp20GeneProduct300341 (Entrez Gene)
Mmp21GeneProduct293573 (Entrez Gene)
Mmp23GeneProduct94339 (Entrez Gene)
Mmp25GeneProductENSRNOG00000029621 (Ensembl)
Mmp27GeneProduct300340 (Entrez Gene)
Mmp2GeneProduct81686 (Entrez Gene)
Mmp28GeneProduct303384 (Entrez Gene)
Mmp3GeneProduct171045 (Entrez Gene)
Mmp7GeneProduct25335 (Entrez Gene)
Mmp8GeneProduct63849 (Entrez Gene)
Mmp9GeneProduct81687 (Entrez Gene)
Tcf20GeneProduct366964 (Entrez Gene)
Timp1GeneProduct116510 (Entrez Gene)
Timp2GeneProduct29543 (Entrez Gene)
Timp3GeneProduct25358 (Entrez Gene)
Timp4GeneProduct680130 (Entrez Gene)
TnfGeneProduct24835 (Entrez Gene)

Annotated Interactions

No annotated interactions
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