S Phase (Homo sapiens)

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9, 104, 29, 35, 4123, 343025, 27131817, 38172, 405, 25, 391327825, 27, 28, 3215, 212, 11, 16, 26, 3738242725, 3912313, 11, 14, 22, 26...5, 19, 25, 33cytosolnucleoplasmPSMD1 UBC(609-684) WAPAL UBB(1-76) PSMB9 PSMD10 UBC(1-76) CDKN1B UBC(457-532) p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1))p-T286-CCND1CAKp-Y15-CDK2 PSMD6 CCND1 CCNA:p-Y15-CDK2PSMC1 E2F4 ATPCDCA5 CUL1:SKP1:SKP2:CKS1BRPS27A(1-76) Sister Chromosomal Arm p-T305,S472-AKT3 UBC(229-304) STAG2 PSMA7 CDKN1B:(CDK4:CCND1,(CDK2:CCNE1))PSMD3 PSMC5 UBC(153-228) PSMC6 p-T160-CDK2 Cohesin:PDS5:WAPAL:Chromosomal ArmCDKN1B p-T309,S474-AKT2 p-S130-CDKN1A p-T160-CDK2 WAPAL p-S28-LIN52 p-T308,S473-AKT1 UBB(77-152) CDK2 RAD21 Sister Chromosomal Arm p-S795-RB1 p-Y342-PTK6 CDKN1B CCNE1 Sister Centromere CDKN1B CCNA1 p-Y342-PTK6PSMB11 CCNA1 phospho(T286)-CyclinD1:Cdk4RPS27A(1-76) WAPAL CCNE2 UBC(457-532) CUL1:SKP1:SKP2UBA52(1-76) CCNA2 PDS5A CDCA5CCNE2 CDK2 PSMB1 CCNA2 CCNA1 STAG1 p-T187-CDKN1B UBC(609-684) MitoticTelophase/CytokinesisSister ChromosomalArmRAD21 2xAcK-SMC3 CCNA2 ATPUBC(305-380) PSMA5 p-S130-CDKN1A SKP2 RAD21 PSME2 CCNA1 CCNA2 CoA-SHPDS5B PSMA3 UBC(609-684) UBC(1-76) SMC3 PSMD13 CDK2 MAX SHFM1 UBB(153-228) CDK4 CDKN1APSME1 PSMB8 PSMC4 CDC25A PSMB3 CUL1 PSMD10 UBC(229-304) CDC25A gene p-T286-CCND1 PSMB6 CCNH UBA52(1-76) CCNE1 UBC(381-456) UBC(77-152) MYC PSMB7 SKP1 UBC(457-532) RAD21 STAG1 PSMA3 Sister Chromosomal Arm p-T157-CDKN1B SKP2 PSMA1 SKP1 CDK2 CCNE2 UBC(533-608) UBC(381-456) CDCA5 TFDP1 ADPCCNA2 PSMD6 Ac-Cohesin:PDS5:WAPAL:CentromereUBC(305-380) multi-ubiquitinatedphospho-(T286)Cyclin D1PSMA7 PSMD4 CDK2FZR1 CCNA:CDK2PSMA2 CDKN1B UBC(381-456) SHFM1 PiPSME4 UBC(1-76) SMC1A PSMD3 PSMC4 RBBP4 CDKN1BUbPDS5A ADPPSMB8 PSMD2 PDS5B LIN9 RAD21 CCNA2 CUL1 ESCO2 CyclinE/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitinCDC25A geneCDKN1Ahyperphosphorylated RB1 LIN54 PSMB4 UbPSMA1 PDS5B TFDP2 phospho(T286)-CyclinD1:Cdk4PSMB7 p-T286-CCND1 PSME3 STAG2 Ubiquitin ligasePSMC3 UBC(305-380) CABLES1CCNA2 UBB(77-152) PSMB5 WAPAL CCNE1 Synthesis of DNACDK4 p-T160-CDK2 CDKN1A,CDKN1BCDC25B CyclinA:Cdk2:phospho-p27/p21 complexPSMC3 TFDP1 RPS27A(1-76) PSMD14 CCNA2 ATPp-S130-CDKN1A CCNA:p-T160-CDK2,CCNE:p-T160-CDK2CCNA1 PSMD8 UBC(229-304) UBC(533-608) CDKN1A,CDKN1BMYC:MAX:CDC25A genePSMD2 26S proteasomePSMB5 2xAcK-SMC3 p-Y88-CDKN1B CCNA2 PSMA4 PSMD13 STAG1 CCND1 STAG2 PSMB6 CCNA:p-T160-CDK2ADPSisterCentromeres:Ac-Cohesin:PDS5:CDCA5:WAPALp-T160-CDK2 PSMD4 ATPPSMD12 PSMC2 Sister Centromere CCNE1 CCNE1 CDK4 p-T,p-S-AKTCCNA2 CDK2 PSMB4 CCNA2 SMC1A ATPUBB(153-228) MNAT1 PSMD7 CCNA:CDK2SMC1A PSME3 PSMD5 ESCOPDS5A ADPPSMC6 p-T286-CCND1 UBC(533-608) UBC(609-684) CDC25ALIN37 CCNACyclinE/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1BSKP1 RPS27A(1-76) UBC(457-532) ESCO1 p-T145-CDKN1A CUL1 SisterChromosomalArms:Ac-Cohesin:PDS5:CDCA5:WAPALCCNE2 SMC1A CDKN1A ADPPSMA8 UBC(77-152) CDC25A gene SKP2 PDS5B PSMD11 CDKN1A PSMB2 CDKN1BUBC(533-608) CCNA1 PSMC1 SKP2 FZR1,p-S795-RB1PSMB9 CDKN1B Sister CentromereCCNA1 CDK2 PDS5A 2xAcK-SMC3 E2F1 PSMB3 p-T286-CCND1PSMD1 p-T187-CDKN1B PSMD11 PDS5B UBC(305-380) UBB(77-152) ADPPSME2 CCNE2 UBC(381-456) p-FZR1,p-RB1CCNA1 CDK7 CDKN1A CCNE1 RBL2 Mitotic PrometaphaseCDK4 p-S130-CDKN1A TFDP2 CCND1 UBB(1-76) p-T-CDKN1A/BPSMD9 CKS1B SKP1 PSMB10 Cohesin:PDS5:WAPAL:CentromereUBA52(1-76) DREAM complex:CDC25AgenePSMC2 UBB(77-152) PSMD8 WAPAL ADPCyclinE/A:p-T160-CDK2:CDKN1A,CDKN1BUBB(153-228) CCNA1 PDS5A CCNA1 PSMB10 CCND1 PSMF1 PSME1 RAD21 Ac-Cohesin:PDS5:WAPAL:Chromosomal Armp-FZR1 CKS1B CyclinA:Cdk2:p21/p27complexPSMD9 CDK2 CDK4 CDK4 UBB(153-228) PDS5B p-T187-CDKN1B WAPAL CCND1:CDK4PSMF1 PSMA6 SMC1A UBB(1-76) Sister Centromere p-T160-CDK2 ATPPSMC5 CCNE1 E2F1:TFDP1,TFDP2:CDC25A geneUBC(1-76) UBC(153-228) ADPATPUBC(153-228) H2OCCNA1 UBA52(1-76) E2F5 p-T187-CDKN1B STAG2 CCNE1 PSMD12 PSMB1 STAG1 PSMA2 STAG2 CDKN1A CCNA2 Cdc25 A/BUBC(153-228) STAG1 PSMA5 PSMD14 PSMA4 2xAcK-SMC3 SMC3 STAG1 26S proteasomeCUL1 PSMD7 UBC(77-152) CDC25A gene UBC(229-304) GSK3BCyclinE/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1BUBB(1-76) PDS5A PSMD5 p-Y88-CDKN1B:(CDK4:CCND1,(CDK2:CCNE1))p-T160-CDK2 Ac-CoAPSMB2 STAG2 CKS1BWEE1SMC1A UBC(77-152) CCNA1 PSMA6 ATPCKS1B 416, 1536386, 1529, 35153842015


Description

DNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continues, the E type cyclins shared by the G1 and S phases, are destroyed and the levels of the mitotic cyclins rise. View original pathway at Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 69242
Reactome-version 
Reactome version: 75

Quality Tags

Ontology Terms

 

Bibliography

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  6. Voges D, Zwickl P, Baumeister W.; ''The 26S proteasome: a molecular machine designed for controlled proteolysis.''; PubMed Europe PMC Scholia
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  8. Aprelikova O, Xiong Y, Liu ET.; ''Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase.''; PubMed Europe PMC Scholia
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  10. Wu CL, Kirley SD, Xiao H, Chuang Y, Chung DC, Zukerberg LR.; ''Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers.''; PubMed Europe PMC Scholia
  11. Zhang J, Shi X, Li Y, Kim BJ, Jia J, Huang Z, Yang T, Fu X, Jung SY, Wang Y, Zhang P, Kim ST, Pan X, Qin J.; ''Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast.''; PubMed Europe PMC Scholia
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  13. Orend G, Hunter T, Ruoslahti E.; ''Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells.''; PubMed Europe PMC Scholia
  14. Van Den Berg DJ, Francke U.; ''Roberts syndrome: a review of 100 cases and a new rating system for severity.''; PubMed Europe PMC Scholia
  15. Wei SJ, Williams JG, Dang H, Darden TA, Betz BL, Humble MM, Chang FM, Trempus CS, Johnson K, Cannon RE, Tennant RW.; ''Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation.''; PubMed Europe PMC Scholia
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  20. Bembenek J, Yu H.; ''Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a.''; PubMed Europe PMC Scholia
  21. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ.; ''The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.''; PubMed Europe PMC Scholia
  22. Gordillo M, Vega H, Trainer AH, Hou F, Sakai N, Luque R, Kayserili H, Basaran S, Skovby F, Hennekam RC, Uzielli ML, Schnur RE, Manouvrier S, Chang S, Blair E, Hurst JA, Forzano F, Meins M, Simola KO, Raas-Rothschild A, Schultz RA, McDaniel LD, Ozono K, Inui K, Zou H, Jabs EW.; ''The molecular mechanism underlying Roberts syndrome involves loss of ESCO2 acetyltransferase activity.''; PubMed Europe PMC Scholia
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  24. Pagano M, Pepperkok R, Verde F, Ansorge W, Draetta G.; ''Cyclin A is required at two points in the human cell cycle.''; PubMed Europe PMC Scholia
  25. Tsvetkov LM, Yeh KH, Lee SJ, Sun H, Zhang H.; ''p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27.''; PubMed Europe PMC Scholia
  26. Whelan G, Kreidl E, Kreidl E, Wutz G, Egner A, Peters JM, Eichele G.; ''Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin.''; PubMed Europe PMC Scholia
  27. Ganoth D, Bornstein G, Ko TK, Larsen B, Tyers M, Pagano M, Hershko A.; ''The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27.''; PubMed Europe PMC Scholia
  28. Zhu XH, Nguyen H, Halicka HD, Traganos F, Koff A.; ''Noncatalytic requirement for cyclin A-cdk2 in p27 turnover.''; PubMed Europe PMC Scholia
  29. DeGregori J, Kowalik T, Nevins JR.; ''Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes.''; PubMed Europe PMC Scholia
  30. Jackman M, Kubota Y, den Elzen N, Hagting A, Pines J.; ''Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm.''; PubMed Europe PMC Scholia
  31. Guo Y, Yang K, Harwalkar J, Nye JM, Mason DR, Garrett MD, Hitomi M, Stacey DW.; ''Phosphorylation of cyclin D1 at Thr 286 during S phase leads to its proteasomal degradation and allows efficient DNA synthesis.''; PubMed Europe PMC Scholia
  32. Hao B, Zheng N, Schulman BA, Wu G, Miller JJ, Pagano M, Pavletich NP.; ''Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.''; PubMed Europe PMC Scholia
  33. Mitra J, Enders GH, Azizkhan-Clifford J, Lengel KL.; ''Dual regulation of the anaphase promoting complex in human cells by cyclin A-Cdk2 and cyclin A-Cdk1 complexes.''; PubMed Europe PMC Scholia
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  35. Vigo E, Müller H, Prosperini E, Hateboer G, Cartwright P, Moroni MC, Helin K.; ''CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase.''; PubMed Europe PMC Scholia
  36. Sarshad AA, Corcoran M, Al-Muzzaini B, Borgonovo-Brandter L, Von Euler A, Lamont D, Visa N, Percipalle P.; ''Glycogen synthase kinase (GSK) 3β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells.''; PubMed Europe PMC Scholia
  37. Hou F, Zou H.; ''Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion.''; PubMed Europe PMC Scholia
  38. Patel P, Asbach B, Shteyn E, Gomez C, Coltoff A, Bhuyan S, Tyner AL, Wagner R, Blain SW.; ''Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4.''; PubMed Europe PMC Scholia
  39. Carrano AC, Eytan E, Hershko A, Pagano M.; ''SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27.''; PubMed Europe PMC Scholia
  40. Rankin S, Ayad NG, Kirschner MW.; ''Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates.''; PubMed Europe PMC Scholia
  41. Galaktionov K, Chen X, Beach D.; ''Cdc25 cell-cycle phosphatase as a target of c-myc.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
115059view17:00, 25 January 2021ReactomeTeamReactome version 75
113503view11:58, 2 November 2020ReactomeTeamReactome version 74
112703view16:10, 9 October 2020ReactomeTeamReactome version 73
101618view11:48, 1 November 2018ReactomeTeamreactome version 66
101154view21:34, 31 October 2018ReactomeTeamreactome version 65
100681view20:07, 31 October 2018ReactomeTeamreactome version 64
100231view16:52, 31 October 2018ReactomeTeamreactome version 63
99783view15:18, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99337view12:47, 31 October 2018ReactomeTeamreactome version 62
93537view11:26, 9 August 2017ReactomeTeamreactome version 61
86636view09:22, 11 July 2016ReactomeTeamreactome version 56
83395view11:07, 18 November 2015ReactomeTeamVersion54
81589view13:07, 21 August 2015ReactomeTeamVersion53
77049view08:35, 17 July 2014ReactomeTeamFixed remaining interactions
76754view12:11, 16 July 2014ReactomeTeamFixed remaining interactions
76079view10:14, 11 June 2014ReactomeTeamRe-fixing comment source
75789view11:32, 10 June 2014ReactomeTeamReactome 48 Update
75139view14:08, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74786view08:52, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
26S proteasomeComplexR-HSA-177750 (Reactome)
26S proteasomeComplexR-HSA-68819 (Reactome)
2xAcK-SMC3 ProteinQ9UQE7 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:456216 (ChEBI)
ATPMetaboliteCHEBI:30616 (ChEBI)
Ac-CoAMetaboliteCHEBI:15351 (ChEBI)
Ac-Cohesin:PDS5:WAPAL:CentromereComplexR-HSA-2473149 (Reactome)
Ac-Cohesin:PDS5:WAPAL:Chromosomal ArmComplexR-HSA-2473153 (Reactome)
CABLES1ProteinQ8TDN4 (Uniprot-TrEMBL)
CAKComplexR-HSA-69221 (Reactome)
CCNA1 ProteinP78396 (Uniprot-TrEMBL)
CCNA2 ProteinP20248 (Uniprot-TrEMBL)
CCNA:CDK2ComplexR-HSA-141608 (Reactome)
CCNA:CDK2ComplexR-HSA-187501 (Reactome)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2ComplexR-HSA-8848491 (Reactome)
CCNA:p-T160-CDK2ComplexR-HSA-187952 (Reactome)
CCNA:p-Y15-CDK2ComplexR-HSA-187907 (Reactome)
CCNAComplexR-HSA-170089 (Reactome)
CCND1 ProteinP24385 (Uniprot-TrEMBL)
CCND1:CDK4ComplexR-HSA-113844 (Reactome)
CCNE1 ProteinP24864 (Uniprot-TrEMBL)
CCNE2 ProteinO96020 (Uniprot-TrEMBL)
CCNH ProteinP51946 (Uniprot-TrEMBL)
CDC25A ProteinP30304 (Uniprot-TrEMBL)
CDC25A gene ProteinENSG00000164045 (Ensembl)
CDC25A geneGeneProductENSG00000164045 (Ensembl)
CDC25AProteinP30304 (Uniprot-TrEMBL)
CDC25B ProteinP30305 (Uniprot-TrEMBL)
CDCA5 ProteinQ96FF9 (Uniprot-TrEMBL)
CDCA5ProteinQ96FF9 (Uniprot-TrEMBL)
CDK2 ProteinP24941 (Uniprot-TrEMBL)
CDK2ProteinP24941 (Uniprot-TrEMBL)
CDK4 ProteinP11802 (Uniprot-TrEMBL)
CDK7 ProteinP50613 (Uniprot-TrEMBL)
CDKN1A ProteinP38936 (Uniprot-TrEMBL)
CDKN1A,CDKN1BComplexR-HSA-182504 (Reactome)
CDKN1A,CDKN1BComplexR-HSA-182558 (Reactome)
CDKN1AProteinP38936 (Uniprot-TrEMBL)
CDKN1B ProteinP46527 (Uniprot-TrEMBL)
CDKN1B:(CDK4:CCND1,(CDK2:CCNE1))ComplexR-HSA-8848419 (Reactome)
CDKN1BProteinP46527 (Uniprot-TrEMBL)
CKS1B ProteinP61024 (Uniprot-TrEMBL)
CKS1BProteinP61024 (Uniprot-TrEMBL)
CUL1 ProteinQ13616 (Uniprot-TrEMBL)
CUL1:SKP1:SKP2:CKS1BComplexR-HSA-187547 (Reactome)
CUL1:SKP1:SKP2ComplexR-HSA-187541 (Reactome)
Cdc25 A/BComplexR-HSA-187904 (Reactome)
CoA-SHMetaboliteCHEBI:15346 (ChEBI)
Cohesin:PDS5:WAPAL:CentromereComplexR-HSA-2545177 (Reactome)
Cohesin:PDS5:WAPAL:Chromosomal ArmComplexR-HSA-2545179 (Reactome)
Cyclin

A:Cdk2:p21/p27

complex
ComplexR-HSA-187926 (Reactome)
Cyclin A:Cdk2:phospho-p27/p21 complexComplexR-HSA-187912 (Reactome)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitinComplexR-HSA-187568 (Reactome)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1BComplexR-HSA-187565 (Reactome)
Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1BComplexR-HSA-187516 (Reactome)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1BComplexR-HSA-187522 (Reactome)
DREAM complex:CDC25A geneComplexR-HSA-8964470 (Reactome)
E2F1 ProteinQ01094 (Uniprot-TrEMBL)
E2F1:TFDP1,TFDP2:CDC25A geneComplexR-HSA-8961960 (Reactome)
E2F4 ProteinQ16254 (Uniprot-TrEMBL)
E2F5 ProteinQ15329 (Uniprot-TrEMBL)
ESCO1 ProteinQ5FWF5 (Uniprot-TrEMBL)
ESCO2 ProteinQ56NI9 (Uniprot-TrEMBL)
ESCOComplexR-HSA-2468046 (Reactome)
FZR1 ProteinQ9UM11 (Uniprot-TrEMBL)
FZR1,p-S795-RB1ComplexR-HSA-187963 (Reactome)
GSK3BProteinP49841 (Uniprot-TrEMBL)
H2OMetaboliteCHEBI:15377 (ChEBI)
LIN37 ProteinQ96GY3 (Uniprot-TrEMBL)
LIN54 ProteinQ6MZP7 (Uniprot-TrEMBL)
LIN9 ProteinQ5TKA1 (Uniprot-TrEMBL)
MAX ProteinP61244 (Uniprot-TrEMBL)
MNAT1 ProteinP51948 (Uniprot-TrEMBL)
MYC ProteinP01106 (Uniprot-TrEMBL)
MYC:MAX:CDC25A geneComplexR-HSA-8932399 (Reactome)
Mitotic Telophase/CytokinesisPathwayR-HSA-68884 (Reactome) In this final phase of mitosis, new membranes are formed around two sets of chromatids and two daughter cells are formed. The chromosomes and the spindle fibers disperse, and the fiber ring around the center of the cell, composed of actin, contracts, pinching the cell into two daughter cells.
Mitotic PrometaphasePathwayR-HSA-68877 (Reactome) The dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and the chromosomes begin to move to the metaphase plate.
PDS5A ProteinQ29RF7 (Uniprot-TrEMBL)
PDS5B ProteinQ9NTI5 (Uniprot-TrEMBL)
PSMA1 ProteinP25786 (Uniprot-TrEMBL)
PSMA2 ProteinP25787 (Uniprot-TrEMBL)
PSMA3 ProteinP25788 (Uniprot-TrEMBL)
PSMA4 ProteinP25789 (Uniprot-TrEMBL)
PSMA5 ProteinP28066 (Uniprot-TrEMBL)
PSMA6 ProteinP60900 (Uniprot-TrEMBL)
PSMA7 ProteinO14818 (Uniprot-TrEMBL)
PSMA8 ProteinQ8TAA3 (Uniprot-TrEMBL)
PSMB1 ProteinP20618 (Uniprot-TrEMBL)
PSMB10 ProteinP40306 (Uniprot-TrEMBL)
PSMB11 ProteinA5LHX3 (Uniprot-TrEMBL)
PSMB2 ProteinP49721 (Uniprot-TrEMBL)
PSMB3 ProteinP49720 (Uniprot-TrEMBL)
PSMB4 ProteinP28070 (Uniprot-TrEMBL)
PSMB5 ProteinP28074 (Uniprot-TrEMBL)
PSMB6 ProteinP28072 (Uniprot-TrEMBL)
PSMB7 ProteinQ99436 (Uniprot-TrEMBL)
PSMB8 ProteinP28062 (Uniprot-TrEMBL)
PSMB9 ProteinP28065 (Uniprot-TrEMBL)
PSMC1 ProteinP62191 (Uniprot-TrEMBL)
PSMC2 ProteinP35998 (Uniprot-TrEMBL)
PSMC3 ProteinP17980 (Uniprot-TrEMBL)
PSMC4 ProteinP43686 (Uniprot-TrEMBL)
PSMC5 ProteinP62195 (Uniprot-TrEMBL)
PSMC6 ProteinP62333 (Uniprot-TrEMBL)
PSMD1 ProteinQ99460 (Uniprot-TrEMBL)
PSMD10 ProteinO75832 (Uniprot-TrEMBL)
PSMD11 ProteinO00231 (Uniprot-TrEMBL)
PSMD12 ProteinO00232 (Uniprot-TrEMBL)
PSMD13 ProteinQ9UNM6 (Uniprot-TrEMBL)
PSMD14 ProteinO00487 (Uniprot-TrEMBL)
PSMD2 ProteinQ13200 (Uniprot-TrEMBL)
PSMD3 ProteinO43242 (Uniprot-TrEMBL)
PSMD4 ProteinP55036 (Uniprot-TrEMBL)
PSMD5 ProteinQ16401 (Uniprot-TrEMBL)
PSMD6 ProteinQ15008 (Uniprot-TrEMBL)
PSMD7 ProteinP51665 (Uniprot-TrEMBL)
PSMD8 ProteinP48556 (Uniprot-TrEMBL)
PSMD9 ProteinO00233 (Uniprot-TrEMBL)
PSME1 ProteinQ06323 (Uniprot-TrEMBL)
PSME2 ProteinQ9UL46 (Uniprot-TrEMBL)
PSME3 ProteinP61289 (Uniprot-TrEMBL)
PSME4 ProteinQ14997 (Uniprot-TrEMBL)
PSMF1 ProteinQ92530 (Uniprot-TrEMBL)
PiMetaboliteCHEBI:43474 (ChEBI)
RAD21 ProteinO60216 (Uniprot-TrEMBL)
RBBP4 ProteinQ09028 (Uniprot-TrEMBL)
RBL2 ProteinQ08999 (Uniprot-TrEMBL)
RPS27A(1-76) ProteinP62979 (Uniprot-TrEMBL)
SHFM1 ProteinP60896 (Uniprot-TrEMBL)
SKP1 ProteinP63208 (Uniprot-TrEMBL)
SKP2 ProteinQ13309 (Uniprot-TrEMBL)
SMC1A ProteinQ14683 (Uniprot-TrEMBL)
SMC3 ProteinQ9UQE7 (Uniprot-TrEMBL)
STAG1 ProteinQ8WVM7 (Uniprot-TrEMBL)
STAG2 ProteinQ8N3U4 (Uniprot-TrEMBL)
Sister Centromeres:Ac-Cohesin:PDS5:CDCA5:WAPALComplexR-HSA-1638799 (Reactome)
Sister

Chromosomal

Arms:Ac-Cohesin:PDS5:CDCA5:WAPAL
ComplexR-HSA-1638802 (Reactome)
Sister Centromere R-ALL-1638792 (Reactome)
Sister CentromereR-ALL-1638792 (Reactome)
Sister Chromosomal ArmR-ALL-1638790 (Reactome)
Sister Chromosomal Arm R-ALL-1638790 (Reactome)
Synthesis of DNAPathwayR-HSA-69239 (Reactome) The actual synthesis of DNA occurs in the S phase of the cell cycle. This includes the initiation of DNA replication, when the first nucleotide of the new strand is laid down during the synthesis of the primer. The DNA replication preinitiation events begin in late M or early G1 phase.
TFDP1 ProteinQ14186 (Uniprot-TrEMBL)
TFDP2 ProteinQ14188 (Uniprot-TrEMBL)
UBA52(1-76) ProteinP62987 (Uniprot-TrEMBL)
UBB(1-76) ProteinP0CG47 (Uniprot-TrEMBL)
UBB(153-228) ProteinP0CG47 (Uniprot-TrEMBL)
UBB(77-152) ProteinP0CG47 (Uniprot-TrEMBL)
UBC(1-76) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(153-228) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(229-304) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(305-380) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(381-456) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(457-532) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(533-608) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(609-684) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(77-152) ProteinP0CG48 (Uniprot-TrEMBL)
UbComplexR-HSA-113595 (Reactome)
UbComplexR-HSA-68524 (Reactome)
Ubiquitin ligaseR-HSA-69593 (Reactome)
WAPAL ProteinQ7Z5K2 (Uniprot-TrEMBL)
WEE1ProteinP30291 (Uniprot-TrEMBL)
hyperphosphorylated RB1 ProteinP06400 (Uniprot-TrEMBL) The pRB C-terminus contains a cluster of seven candidate in vivo cdk phosphorylation sites (residues 795, 807, 811, 821, and 826) and is phosphorylated in vitro by cyclin A, cyclin E, and cyclin D-associated kinases.
multi-ubiquitinated

phospho-(T286)

Cyclin D1
ComplexR-HSA-177997 (Reactome)
p-FZR1 ProteinQ9UM11 (Uniprot-TrEMBL)
p-FZR1,p-RB1ComplexR-HSA-187920 (Reactome)
p-S130-CDKN1A ProteinP38936 (Uniprot-TrEMBL)
p-S28-LIN52 ProteinQ52LA3 (Uniprot-TrEMBL)
p-S795-RB1 ProteinP06400 (Uniprot-TrEMBL)
p-T,p-S-AKTComplexR-HSA-202074 (Reactome)
p-T-CDKN1A/BComplexR-HSA-198605 (Reactome)
p-T145-CDKN1A ProteinP38936 (Uniprot-TrEMBL)
p-T157-CDKN1B ProteinP46527 (Uniprot-TrEMBL)
p-T160-CDK2 ProteinP24941 (Uniprot-TrEMBL)
p-T187-CDKN1B ProteinP46527 (Uniprot-TrEMBL)
p-T286-CCND1 ProteinP24385 (Uniprot-TrEMBL)
p-T286-CCND1ProteinP24385 (Uniprot-TrEMBL)
p-T305,S472-AKT3 ProteinQ9Y243 (Uniprot-TrEMBL)
p-T308,S473-AKT1 ProteinP31749 (Uniprot-TrEMBL)
p-T309,S474-AKT2 ProteinP31751 (Uniprot-TrEMBL)
p-Y15-CDK2 ProteinP24941 (Uniprot-TrEMBL)
p-Y342-PTK6 ProteinQ13882 (Uniprot-TrEMBL)
p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1))ComplexR-HSA-8848415 (Reactome)
p-Y342-PTK6ProteinQ13882 (Uniprot-TrEMBL)
p-Y88-CDKN1B ProteinP46527 (Uniprot-TrEMBL)
p-Y88-CDKN1B:(CDK4:CCND1,(CDK2:CCNE1))ComplexR-HSA-8848441 (Reactome)
phospho(T286)-Cyclin D1:Cdk4ComplexR-HSA-75812 (Reactome)
phospho(T286)-Cyclin D1:Cdk4ComplexR-HSA-75814 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
26S proteasomemim-catalysisR-HSA-187574 (Reactome)
26S proteasomemim-catalysisR-HSA-75825 (Reactome)
ADPArrowR-HSA-174164 (Reactome)
ADPArrowR-HSA-187520 (Reactome)
ADPArrowR-HSA-187916 (Reactome)
ADPArrowR-HSA-187948 (Reactome)
ADPArrowR-HSA-187949 (Reactome)
ADPArrowR-HSA-198613 (Reactome)
ADPArrowR-HSA-75820 (Reactome)
ADPArrowR-HSA-8848436 (Reactome)
ATPR-HSA-174164 (Reactome)
ATPR-HSA-187520 (Reactome)
ATPR-HSA-187916 (Reactome)
ATPR-HSA-187948 (Reactome)
ATPR-HSA-187949 (Reactome)
ATPR-HSA-198613 (Reactome)
ATPR-HSA-75820 (Reactome)
ATPR-HSA-8848436 (Reactome)
Ac-CoAR-HSA-2468039 (Reactome)
Ac-CoAR-HSA-2473152 (Reactome)
Ac-Cohesin:PDS5:WAPAL:CentromereArrowR-HSA-2473152 (Reactome)
Ac-Cohesin:PDS5:WAPAL:CentromereR-HSA-2473151 (Reactome)
Ac-Cohesin:PDS5:WAPAL:Chromosomal ArmArrowR-HSA-2468039 (Reactome)
Ac-Cohesin:PDS5:WAPAL:Chromosomal ArmR-HSA-2468041 (Reactome)
CABLES1ArrowR-HSA-174164 (Reactome)
CAKmim-catalysisR-HSA-187949 (Reactome)
CCNA:CDK2ArrowR-HSA-174054 (Reactome)
CCNA:CDK2ArrowR-HSA-174110 (Reactome)
CCNA:CDK2ArrowR-HSA-174273 (Reactome)
CCNA:CDK2R-HSA-174164 (Reactome)
CCNA:CDK2R-HSA-174273 (Reactome)
CCNA:CDK2R-HSA-187934 (Reactome)
CCNA:CDK2R-HSA-187949 (Reactome)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2ArrowR-HSA-187574 (Reactome)
CCNA:p-T160-CDK2ArrowR-HSA-187949 (Reactome)
CCNA:p-T160-CDK2mim-catalysisR-HSA-187948 (Reactome)
CCNA:p-Y15-CDK2ArrowR-HSA-174164 (Reactome)
CCNA:p-Y15-CDK2R-HSA-174110 (Reactome)
CCNAR-HSA-174054 (Reactome)
CCND1:CDK4R-HSA-75820 (Reactome)
CDC25A geneR-HSA-188345 (Reactome)
CDC25AArrowR-HSA-188345 (Reactome)
CDCA5R-HSA-2468041 (Reactome)
CDCA5R-HSA-2473151 (Reactome)
CDK2R-HSA-174054 (Reactome)
CDKN1A,CDKN1BR-HSA-187934 (Reactome)
CDKN1A,CDKN1BR-HSA-198613 (Reactome)
CDKN1A,CDKN1Bmim-catalysisR-HSA-187934 (Reactome)
CDKN1AArrowR-HSA-187828 (Reactome)
CDKN1AR-HSA-187828 (Reactome)
CDKN1B:(CDK4:CCND1,(CDK2:CCNE1))R-HSA-8848414 (Reactome)
CDKN1BArrowR-HSA-187506 (Reactome)
CDKN1BR-HSA-187506 (Reactome)
CKS1BR-HSA-187545 (Reactome)
CUL1:SKP1:SKP2:CKS1BArrowR-HSA-187545 (Reactome)
CUL1:SKP1:SKP2:CKS1BArrowR-HSA-187574 (Reactome)
CUL1:SKP1:SKP2:CKS1BR-HSA-187552 (Reactome)