Mitotic Telophase/Cytokinesis (Homo sapiens)

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5, 61, 731, 2, 48nucleoplasmcytosolADPSMC1A Cohesin:PDS5:WAPALNIPBL Sister Chromosomal Arm p-S904,S905-KIF23PDS5NIPBL:MAU2KIF23PDS5B p-S274,S326-NUDCSTAG2 SMC3 SMC3 ADPp-S528-KIF20APDS5B MAU2 STAG1 STAG1 WAPAL RAD21 WAPAL SMC3 RAD21 MAU2 Cohesin:PDS5:WAPAL:NIPBL:MAU2:ChromatinPDS5A STAG2 ADPPDS5B STAG2 ATPPDS5A STAG1 ATPNIPBL Cohesin ComplexChromatinSister Centromere Sister Chromosomal Arm KIF20Ap-T210-PLK1NUDCWAPALSister Centromere S PhaseSMC1A PDS5A SMC1A ATPRAD21


In this final phase of mitosis, new membranes are formed around two sets of chromatids and two daughter cells are formed. The chromosomes and the spindle fibers disperse, and the fiber ring around the center of the cell, composed of actin, contracts, pinching the cell into two daughter cells. View original pathway at:Reactome.


Pathway is converted from Reactome ID: 68884
Reactome version: 66

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  1. Kueng S, Hegemann B, Peters BH, Lipp JJ, Schleiffer A, Mechtler K, Peters JM.; ''Wapl controls the dynamic association of cohesin with chromatin.''; PubMed Europe PMC
  2. Gandhi R, Gillespie PJ, Hirano T.; ''Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase.''; PubMed Europe PMC
  3. Liu X, Zhou T, Kuriyama R, Erikson RL.; ''Molecular interactions of Polo-like-kinase 1 with the mitotic kinesin-like protein CHO1/MKLP-1.''; PubMed Europe PMC
  4. Shintomi K, Hirano T.; ''Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1.''; PubMed Europe PMC
  5. Aumais JP, Williams SN, Luo W, Nishino M, Caldwell KA, Caldwell GA, Lin SH, Yu-Lee LY.; ''Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis.''; PubMed Europe PMC
  6. Zhou T, Aumais JP, Liu X, Yu-Lee LY, Erikson RL.; ''A role for Plk1 phosphorylation of NudC in cytokinesis.''; PubMed Europe PMC
  7. Watrin E, Schleiffer A, Tanaka K, Eisenhaber F, Nasmyth K, Peters JM.; ''Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression.''; PubMed Europe PMC
  8. Neef R, Preisinger C, Sutcliffe J, Kopajtich R, Nigg EA, Mayer TU, Barr FA.; ''Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis.''; PubMed Europe PMC


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101213view11:10, 1 November 2018ReactomeTeamreactome version 66
100751view20:36, 31 October 2018ReactomeTeamreactome version 65
100295view19:13, 31 October 2018ReactomeTeamreactome version 64
99841view15:56, 31 October 2018ReactomeTeamreactome version 63
99398view14:34, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99091view12:39, 31 October 2018ReactomeTeamreactome version 62
93890view13:43, 16 August 2017ReactomeTeamreactome version 61
93460view11:24, 9 August 2017ReactomeTeamreactome version 61
87994view13:25, 25 July 2016RyanmillerOntology Term : 'cell cycle pathway, mitotic' added !
87991view13:24, 25 July 2016RyanmillerOntology Term : 'regulatory pathway' added !
86555view09:20, 11 July 2016ReactomeTeamreactome version 56
83384view11:04, 18 November 2015ReactomeTeamVersion54
81564view13:06, 21 August 2015ReactomeTeamVersion53
77030view08:32, 17 July 2014ReactomeTeamFixed remaining interactions
76735view12:09, 16 July 2014ReactomeTeamFixed remaining interactions
76059view10:12, 11 June 2014ReactomeTeamRe-fixing comment source
75769view11:27, 10 June 2014ReactomeTeamReactome 48 Update
75119view14:07, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74766view08:51, 30 April 2014ReactomeTeamNew pathway

External references


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NameTypeDatabase referenceComment
ADPMetaboliteCHEBI:16761 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
ChromatinComplexR-ALL-2537690 (Reactome)
Cohesin ComplexComplexR-HSA-1641505 (Reactome)
Cohesin:PDS5:WAPAL:NIPBL:MAU2:ChromatinComplexR-HSA-2537688 (Reactome)
Cohesin:PDS5:WAPALComplexR-HSA-2468042 (Reactome)
KIF20AProteinO95235 (Uniprot-TrEMBL)
KIF23ProteinQ02241 (Uniprot-TrEMBL)
MAU2 ProteinQ9Y6X3 (Uniprot-TrEMBL)
NIPBL ProteinQ6KC79 (Uniprot-TrEMBL)
NIPBL:MAU2ComplexR-HSA-2470930 (Reactome)
NUDCProteinQ9Y266 (Uniprot-TrEMBL)
PDS5A ProteinQ29RF7 (Uniprot-TrEMBL)
PDS5B ProteinQ9NTI5 (Uniprot-TrEMBL)
PDS5ComplexR-HSA-2468044 (Reactome)
RAD21 ProteinO60216 (Uniprot-TrEMBL)
S PhasePathwayR-HSA-69242 (Reactome) DNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continues, the E type cyclins shared by the G1 and S phases, are destroyed and the levels of the mitotic cyclins rise.
SMC1A ProteinQ14683 (Uniprot-TrEMBL)
SMC3 ProteinQ9UQE7 (Uniprot-TrEMBL)
STAG1 ProteinQ8WVM7 (Uniprot-TrEMBL)
STAG2 ProteinQ8N3U4 (Uniprot-TrEMBL)
Sister Centromere R-ALL-1638792 (Reactome)
Sister Chromosomal Arm R-ALL-1638790 (Reactome)
WAPAL ProteinQ7Z5K2 (Uniprot-TrEMBL)
WAPALProteinQ7Z5K2 (Uniprot-TrEMBL)
p-S274,S326-NUDCProteinQ9Y266 (Uniprot-TrEMBL)
p-S528-KIF20AProteinO95235 (Uniprot-TrEMBL)
p-S904,S905-KIF23ProteinQ02241 (Uniprot-TrEMBL)
p-T210-PLK1ProteinP53350 (Uniprot-TrEMBL)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
ADPArrowR-HSA-156673 (Reactome)
ADPArrowR-HSA-156682 (Reactome)
ADPArrowR-HSA-156723 (Reactome)
ATPR-HSA-156673 (Reactome)
ATPR-HSA-156682 (Reactome)
ATPR-HSA-156723 (Reactome)
ChromatinR-HSA-2470935 (Reactome)
Cohesin ComplexR-HSA-2468040 (Reactome)
Cohesin:PDS5:WAPAL:NIPBL:MAU2:ChromatinArrowR-HSA-2470935 (Reactome)
Cohesin:PDS5:WAPALArrowR-HSA-2468040 (Reactome)
Cohesin:PDS5:WAPALR-HSA-2470935 (Reactome)
KIF20AR-HSA-156723 (Reactome)
KIF23R-HSA-156673 (Reactome)
NIPBL:MAU2R-HSA-2470935 (Reactome)
NUDCR-HSA-156682 (Reactome)
PDS5R-HSA-2468040 (Reactome)
R-HSA-156673 (Reactome) The polo-like kinase PLK1 phosphorylates KIF23 (also known as MKLP1 i.e. mitotic kinesin-like protein 1) on serine residues S904 and S905.
R-HSA-156682 (Reactome) The polo-like kinase PLK1 phosphorylates NUDC on serine residues S274 and S326.
R-HSA-156723 (Reactome) The polo-like kinase PLK1 phosphorylates KIF20A (also known as MKLP2 i.e. mitotic kinesin-like protein 2) on serine residue S528.
R-HSA-2468040 (Reactome) WAPAL (WAPL) and PDS5 proteins (PDS5A and/or PDS5B) are associated with cohesin throughout most of the cell cycle (Kueng et al. 2006, Gandhi et al. 2006). FGF motifs present in the N-terminal region of WAPAL participate in WAPAL binding to PDS5 and cohesin subunits RAD21, STAG1 (SA1) and STAG2 (SA2) (Shintomi and Hirano 2009).
R-HSA-2470935 (Reactome) Cohesin, in complex with WAPAL and PDS5 (PDS5A or PDS5B) binds decondensed chromatin in telophase (Kueng et al. 2006). This binding is facilitated by the NIPBL:MAU2 complex, also known as the 'cohesin loading complex'. NIPBL:MAU2 complex is associated with chromatin from telophase until prophase (Watrin et al. 2006) but seems to form a transient rather than stable complex with cohesin.
WAPALR-HSA-2468040 (Reactome)
p-S274,S326-NUDCArrowR-HSA-156682 (Reactome)
p-S528-KIF20AArrowR-HSA-156723 (Reactome)
p-S904,S905-KIF23ArrowR-HSA-156673 (Reactome)
p-T210-PLK1mim-catalysisR-HSA-156673 (Reactome)
p-T210-PLK1mim-catalysisR-HSA-156682 (Reactome)
p-T210-PLK1mim-catalysisR-HSA-156723 (Reactome)
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