Monoamine GPCRs (Rattus norvegicus)

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AdrenergicReceptorsGi/Go PathwayGq/G11 PathwayDopamineReceptorsGs PathwayGs PathwaySerotoninReceptorsMuscarinicAcetylcholine ReceptorsHistamineReceptorsChrm3Chrm2Drd2Adrb3Chrm5Htr6SerotoninHTR1EHtr1bHtr7Adra1bChrm4Adrb2EpinephrineAdra2bChrm1Adra2cAdrb1Htr1dAdra1dADRA2AHtr2bAdra1aMuscarineDrd4Drd3Drd1aHtr1aHtr4DopamineHrh1NorepinephrineDrd5Acetylcholine HTR5BHtr2cHtr1fHrh2HistamineHtr5aHtr2a


G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: Wikipedia

Monoamine GPCRs are Rhodopsin-like GPCRs that bind to monoamine neurotransmitters. Monoamine neurotransmitters


This pathway was inferred from Homo sapiens pathway WP58(r20799) with a 83% conversion rate.

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106973view13:43, 17 September 2019MaintBotHMDB identifier normalization
98238view12:40, 14 August 2018EgonwReplace a PubChem SID with a PubChem CID.
96090view19:08, 15 February 2018KhanspersModified description
74145view11:00, 1 April 2014EgonwReplaced InChIs and an InChIKey with more traditional identifiers.
69439view19:04, 8 July 2013MaintBotUpdated to 2013 gpml schema
67489view11:08, 26 June 2013DdiglesOntology Term : 'G protein mediated signaling pathway' added !
53515view12:23, 8 November 2012EgonwRDF tidy
48267view21:58, 17 May 2012MaintBotAutomatic update of PubChem xrefs
41763view02:41, 2 March 2011MaintBotRemoved redundant pathway information and comments
34131view19:30, 9 December 2009MaintBotAutomatic update of empty xrefs
32381view16:56, 15 August 2009MaintBotFixed text labels
32024view13:24, 14 August 2009MaintBotFixed group labels
31419view20:57, 13 August 2009MaintBotFixed text labels
31018view01:07, 30 July 2009MaintBotConverted from Homo sapiens
21259view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Monoamine GPCRs]] moved to [[Pathway:WP276]]: Moved to stable identifier
8270view13:46, 7 January 2008MaintBot[[Pathway:Rat:Monoamine GPCRs]] moved to [[Pathway:Rattus norvegicus:Monoamine GPCRs]]: Renaming species
7755view16:15, 18 December 2007MaintBotfixed category names
7433view12:42, 4 November 2007MaintBotAdded categories to GPML
19517view22:20, 22 May 2007J.S.Fonggpml file for [[Rat:Monoamine_GPCRs]]
6577view22:20, 22 May 2007Nsalomonisgpml file for [[Rat:Monoamine_GPCRs]]

External references


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NameTypeDatabase referenceComment
ADRA2AGeneProduct25083 (Entrez Gene)
Acetylcholine MetaboliteHMDB0000895 (HMDB)
Adra1aGeneProduct29412 (Entrez Gene)
Adra1bGeneProduct24173 (Entrez Gene)
Adra1dGeneProduct29413 (Entrez Gene)
Adra2bGeneProduct24174 (Entrez Gene)
Adra2cGeneProduct24175 (Entrez Gene)
Adrb1GeneProduct24925 (Entrez Gene)
Adrb2GeneProduct24176 (Entrez Gene)
Adrb3GeneProduct25645 (Entrez Gene)
Chrm1GeneProduct25229 (Entrez Gene)
Chrm2GeneProduct81645 (Entrez Gene)
Chrm3GeneProduct24260 (Entrez Gene)
Chrm4GeneProduct25111 (Entrez Gene)
Chrm5GeneProduct53949 (Entrez Gene)
DopamineMetaboliteCHEBI:18243 (ChEBI)
Drd1aGeneProduct24316 (Entrez Gene)
Drd2GeneProduct24318 (Entrez Gene)
Drd3GeneProduct29238 (Entrez Gene)
Drd4GeneProduct25432 (Entrez Gene)
Drd5GeneProduct25195 (Entrez Gene)
EpinephrineMetaboliteHMDB0000068 (HMDB)
HTR5BGeneProduct79247 (Entrez Gene)
HistamineMetaboliteCHEBI:18295 (ChEBI)
Hrh1GeneProduct24448 (Entrez Gene)
Hrh2GeneProduct25461 (Entrez Gene)
Htr1aGeneProduct24473 (Entrez Gene)
Htr1bGeneProduct25075 (Entrez Gene)
Htr1dGeneProduct25323 (Entrez Gene)
Htr1fGeneProduct60448 (Entrez Gene)
Htr2aGeneProduct29595 (Entrez Gene)
Htr2bGeneProduct29581 (Entrez Gene)
Htr2cGeneProduct25187 (Entrez Gene)
Htr4GeneProduct25324 (Entrez Gene)
Htr5aGeneProduct25689 (Entrez Gene)
Htr6GeneProduct64354 (Entrez Gene)
Htr7GeneProduct65032 (Entrez Gene)
MuscarineMetabolite9308 (PubChem-compound)
NorepinephrineMetaboliteHMDB0000216 (HMDB)
SerotoninMetaboliteCHEBI:28790 (ChEBI)

Annotated Interactions

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