Mitotic Metaphase and Anaphase (Homo sapiens)

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4, 12, 1631, 11, 1818, 13, 183, 10312, 1581252, 6, 8, 13, 17endoplasmic reticulum membranecytosolCLIP1 CENPF CENPP NUP107 PDS5B PSMA7 Sister Centromere PPP2CB STAG1 VRK2-2 ANAPC4 KNTC1 ESPL1 UBC(229-304) TMPO-1 MAD1L1 TAOK1 AHCTF1 STAG2 CENPH WAPAL NUDC ANAPC15 KIF2B CDC16 DYNC1I2 SGOL1 UBC(457-532) CDC23 2xAcK-SMC3 ANKLE2:VRK1/VRK2ANAPC4 CDC23 NUP37 CENPE CDCA8 CDC20:pAPC/C:K11polyUb-PTTG1CENPL UBE2C APITD1 PDS5B NDC80 PPP2CA WAPAL RAD21(173-450) p-S454-RAD21(451-631)CLASP2 UBC(153-228) NUP85 PPP2CA APITD1 NUF2 SMC1A RAD21 ANKLE2SHFM1 CENPN CLIP1 CLASP2 KIF2C ZWINT NDEL1 PPP2R5A MAD2L1 VRK1/VRK2PPP2R2A MAD2L1 STAG1 CENPQ CDC20:p-APC/C:PTTG1CLIP1 Mitotic PrometaphaseANAPC16 ESPL1(1536-2120) Microtubule protofilament MIS12 2xAcK-SMC3 BANF1 INCENP PSMB8 PDS5A EMD DYNC1LI1 SKA1 ZWILCH p-S21,S75,T159-CDCA5 SPDL1 CLASP2 CENPO INCENP PDS5A UBA52(1-76) CENPF CDCA8 PLK1 SMC1A SMC1A DYNLL2 Cohesin ComplexRAD21(173-450) CENPA CDC26 B9D2 CENPK NDEL1 UBB(77-152) DYNC1I1 SMC3 HDAC8-1 RAD21(173-450)SKA2 SPC24 LMNA-1 CDC23 Lamin filaments EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:ChromatinBIRC5 RANBP2 ANAPC5 ZWILCH CENPQ PPP1CC EMD ANAPC5 CENPM PPP2R5D Sister Centromere FBXO5ANAPC2 p-S21,S75,T159-CDCA5p-T210-PLK1UBC(533-608) SGOL1 UbSPC25 PSMC6 ATPPPP2R5C ZW10 MAPRE1 VRK1 CENPH PTTG1CENPA NUP160 NUP37 CDC20 RCC2 CLASP1 RAD21(1-172) PSMA4 MAD2L1 ERCC6L CDC16 ANAPC15 ERCC6L UBE2D1 VRK1 ESPL1ANAPC11 LEMD2 ANAPC2 LMNB1 PPP2R5E PSMD4 CDC20 DYNC1LI1 PSMC2 p-S454-RAD21 UBE2E1 RPS27 NUP85 2xAcK-SMC3 BIRC5 PPP2R5E NUP133 CENPI ANKLE2 K11polyUb-PTTG1 DYNLL2 SEH1L-1 SGOL1 VRK2-2 PDS5B PSMC4 KIF2A PSME3 ANAPC11 DYNC1I1 SKA1 CENPF CENPC1 ESPL1(1507-1535) PPP2CB ANAPC7 p-S454-RAD21(451-631) UBE2E1 SEC13 DYNC1H1 PPP2R5C MAD1L1 CleavedCohesin:PDS5:WAPALUBE2D1 KIF2C p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:MicrotubulesUBC(1-76) CENPL NUP43 NUP43 CDC20 PLK1 PPP2R1A SPDL1 DYNC1LI2 RANGAP1 KNTC1 PPP2CA PSME2 CENPM NUP98-5 AURKB B9D2 SGOL2 ITGB3BP Microtubule protofilament PPP2R5D CENPP MLF1IP PPP2R5B ANAPC15 PSMA5 p-T2,T3,S4-BANF1CENPI PSME1 BUB1B SEC13 PAFAH1B1 CleavedCohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:MicrotubulesITGB3BP PSMD5 p-T2,T3,S4-BANF1 XPO1 CENPT PSMD6 ANAPC4 CASC5 B9D2 DYNLL1 CDC26 Sister Centromere CDC20 PDS5A DYNLL1 CENPK MAPRE1 PiNUP107 PSMA8 WAPAL PSMB11 PP2A(Aalpha:B55alpha:Calpha)PAFAH1B1 SPDL1 26S proteasomePSMD10 KIF2C NDE1 CENPA Ac-CoAUBE2D1 XPO1 PPP2R1B MIS12 DYNLL1 INCENP CENPH ESPL1(1-1506) UBC(381-456) ANAPC7 PPP2R5E MIS12 PSME4 ITGB3BP CENPT PDS5A PSMF1 CLASP1 PSMC1 SPC24 NDEL1 NUP107 CENPC1 NDE1 RAD21(1-172)RANGAP1 PSMB1 CENPT PPP2R5A DYNC1I2 EMD/ TMPO/ LEMD3/LEMD2DYNC1H1 LEMD3 PPP1CC PPP2CB CDC27 KIF2B PSMB2 ANAPC10 p-S454-RAD21(451-631) SMC1A SEH1L-1 TAOK1 ZWILCH BUB1B RCC2 CASC5 SKA2 PSMD7 ZWINT PPP2R1A Sister Chromosomal Arm ZW10 CENPE PMF1 p-S21,S75,T159-CDCA5 SGOL2 PMF1 PSMA6 SPC25 ZWINT STAG2 CENPE TMPO-1 RANGAP1 CoA-SHZW10 RPS27 MAPRE1 PTTG1 KNTC1 CENPQ CENPP ANAPC16 PDS5B PSMA2 PSMB4 CASC5 Microtubule protofilament KIF2B BUB3 DYNLL2 PSMB6 RANBP2 STAG1 PSMD13 KIF18A BUB1B CENPM SGOL2 UBE2E1 AHCTF1 PPP2R5B PPP2R5D Sister Centromere KIF18A PPP2R1A PPP2R1A NUP133 PAFAH1B1 BIRC5 STAG1 NUP160 CDC20 PPP2R5C CLASP1 SisterCentromere:Kinetochore:MicrotubulesKIF2A NDE1 AHCTF1 ANAPC7 PPP2R1B PSMB5 PSMD9 DYNC1I2 Sister Chromosomal Arm LMNA-2 PPP2R5A XPO1 ANAPC2 MLF1IP ANAPC11 DSN1 ANAPC1 DYNC1LI2 SPC25 BUB1 PPP2R5B PPP2R1B STAG2 CKAP5 CENPC1 CENPI PMF1 PTTG1 UBC(305-380) RANBP2 SPC24 CDC16 SEC13 CDC20 Sister Centromere RPS27 NUP160 NUP133 AURKB AURKB PSMB3 ERCC6L UBE2C NDC80 DYNC1LI2 CDC20:p-APC/CNUDC PSMB9 LEMD3 KIF18A CENPO ChromatinPSMD14 SEH1L-1 NUP98-5 PPP1CC CDC27 KIF2A BUB1 CENPN PSMB7 PSMD3 ANAPC5 RAD21RPS27A(1-76) PSMD11 PSMB10 p-FBXO5DYNC1I1 MLF1IP NUP98-5 PSMD1 ADPTAOK1 UBC(77-152) PSMC5 APITD1 DYNC1H1 ANAPC10 CDCA8 NSL1 CENPL CKAP5 PTTG1:ESPL1DSN1 NSL1 MAD1L1 UBB(1-76) RCC2 UBC(609-684) BANF1 SKA2 NSL1 CENPO NUP85 BUB3 PLK1 H2OUBB(153-228) CDC27 PSMA3 CENPN PSMD8 NUF2 STAG2 PSMD12 DYNC1LI1 PPP2CA BUB1 ANAPC1 PSMA1 HDAC8LEMD2 SKA1 ESPL1 AutocleavedNDC80 PSMD2 WAPALBANF1CENPK CKAP5 NUDC Lamin dimersPSMC3 CDC26 ANAPC10 BUB3 NUP43 DSN1 NUP37 RAD21(1-172) ANAPC16 ANAPC1 UBE2C PDS5NUF2 779, 147912


Description

Metaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ensure that later, when the chromosomes are separated, each new nucleus that is formed receives one copy of each chromosome. This pathway has not yet been annotated in Reactome.

The metaphase to anaphase transition during mitosis is triggered by the destruction of mitotic cyclins.

In anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement along the spindle microtubules and through the physical interaction of polar microtubules. View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 2555396
Reactome-version 
Reactome version: 66

Quality Tags

Ontology Terms

 

Bibliography

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  1. Deardorff MA, Bando M, Nakato R, Watrin E, Itoh T, Minamino M, Saitoh K, Komata M, Katou Y, Clark D, Cole KE, De Baere E, Decroos C, Di Donato N, Ernst S, Francey LJ, Gyftodimou Y, Hirashima K, Hullings M, Ishikawa Y, Jaulin C, Kaur M, Kiyono T, Lombardi PM, Magnaghi-Jaulin L, Mortier GR, Nozaki N, Petersen MB, Seimiya H, Siu VM, Suzuki Y, Takagaki K, Wilde JJ, Willems PJ, Prigent C, Gillessen-Kaesbach G, Christianson DW, Kaiser FJ, Jackson LG, Hirota T, Krantz ID, Shirahige K.; ''HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.''; PubMed Europe PMC
  2. Jallepalli PV, Waizenegger IC, Bunz F, Langer S, Speicher MR, Peters JM, Kinzler KW, Vogelstein B, Lengauer C.; ''Securin is required for chromosomal stability in human cells.''; PubMed Europe PMC
  3. Hagting A, Den Elzen N, Vodermaier HC, Waizenegger IC, Peters JM, Pines J.; ''Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.''; PubMed Europe PMC
  4. Haraguchi T, Koujin T, Segura-Totten M, Lee KK, Matsuoka Y, Yoneda Y, Wilson KL, Hiraoka Y.; ''BAF is required for emerin assembly into the reforming nuclear envelope.''; PubMed Europe PMC
  5. Moshe Y, Boulaire J, Pagano M, Hershko A.; ''Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome.''; PubMed Europe PMC
  6. Zou H, McGarry TJ, Bernal T, Kirschner MW.; ''Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis.''; PubMed Europe PMC
  7. Plafker SM, Plafker KS, Weissman AM, Macara IG.; ''Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import.''; PubMed Europe PMC
  8. Waizenegger I, Giménez-Abián JF, Wernic D, Peters JM.; ''Regulation of human separase by securin binding and autocleavage.''; PubMed Europe PMC
  9. Wei SJ, Williams JG, Dang H, Darden TA, Betz BL, Humble MM, Chang FM, Trempus CS, Johnson K, Cannon RE, Tennant RW.; ''Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation.''; PubMed Europe PMC
  10. Jin L, Williamson A, Banerjee S, Philipp I, Rape M.; ''Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.''; PubMed Europe PMC
  11. Hauf S, Roitinger E, Koch B, Dittrich CM, Mechtler K, Peters JM.; ''Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2.''; PubMed Europe PMC
  12. Asencio C, Davidson IF, Santarella-Mellwig R, Ly-Hartig TB, Mall M, Wallenfang MR, Mattaj IW, Gorjánácz M.; ''Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis.''; PubMed Europe PMC
  13. Waizenegger IC, Hauf S, Meinke A, Peters JM.; ''Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase.''; PubMed Europe PMC
  14. Voges D, Zwickl P, Baumeister W.; ''The 26S proteasome: a molecular machine designed for controlled proteolysis.''; PubMed Europe PMC
  15. Schmitz MH, Held M, Janssens V, Hutchins JR, Hudecz O, Ivanova E, Goris J, Trinkle-Mulcahy L, Lamond AI, Poser I, Hyman AA, Mechtler K, Peters JM, Gerlich DW.; ''Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells.''; PubMed Europe PMC
  16. Haraguchi T, Kojidani T, Koujin T, Shimi T, Osakada H, Mori C, Yamamoto A, Hiraoka Y.; ''Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly.''; PubMed Europe PMC
  17. Zhang X, Horwitz GA, Prezant TR, Valentini A, Nakashima M, Bronstein MD, Melmed S.; ''Structure, expression, and function of human pituitary tumor-transforming gene (PTTG).''; PubMed Europe PMC
  18. Hauf S, Waizenegger IC, Peters JM.; ''Cohesin cleavage by separase required for anaphase and cytokinesis in human cells.''; PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
101402view11:29, 1 November 2018ReactomeTeamreactome version 66
100940view21:04, 31 October 2018ReactomeTeamreactome version 65
100477view19:39, 31 October 2018ReactomeTeamreactome version 64
100022view16:22, 31 October 2018ReactomeTeamreactome version 63
99575view14:55, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99197view12:43, 31 October 2018ReactomeTeamreactome version 62
93842view13:40, 16 August 2017ReactomeTeamreactome version 61
93398view11:22, 9 August 2017ReactomeTeamreactome version 61
87983view13:21, 25 July 2016RyanmillerOntology Term : 'cell cycle pathway, mitotic' added !
87969view13:16, 25 July 2016RyanmillerOntology Term : 'regulatory pathway' added !
86483view09:19, 11 July 2016ReactomeTeamreactome version 56
83171view10:15, 18 November 2015ReactomeTeamVersion54
81540view13:04, 21 August 2015ReactomeTeamVersion53
77009view08:30, 17 July 2014ReactomeTeamFixed remaining interactions
76714view12:08, 16 July 2014ReactomeTeamFixed remaining interactions
76040view10:10, 11 June 2014ReactomeTeamRe-fixing comment source
75749view11:24, 10 June 2014ReactomeTeamReactome 48 Update
75099view14:05, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74746view08:49, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
26S proteasomeComplexR-HSA-68819 (Reactome)
2xAcK-SMC3 ProteinQ9UQE7 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:16761 (ChEBI)
AHCTF1 ProteinQ8WYP5 (Uniprot-TrEMBL)
ANAPC1 ProteinQ9H1A4 (Uniprot-TrEMBL)
ANAPC10 ProteinQ9UM13 (Uniprot-TrEMBL)
ANAPC11 ProteinQ9NYG5 (Uniprot-TrEMBL)
ANAPC15 ProteinP60006 (Uniprot-TrEMBL)
ANAPC16 ProteinQ96DE5 (Uniprot-TrEMBL)
ANAPC2 ProteinQ9UJX6 (Uniprot-TrEMBL)
ANAPC4 ProteinQ9UJX5 (Uniprot-TrEMBL)
ANAPC5 ProteinQ9UJX4 (Uniprot-TrEMBL)
ANAPC7 ProteinQ9UJX3 (Uniprot-TrEMBL)
ANKLE2 ProteinQ86XL3 (Uniprot-TrEMBL)
ANKLE2:VRK1/VRK2ComplexR-HSA-2995385 (Reactome)
ANKLE2ProteinQ86XL3 (Uniprot-TrEMBL)
APITD1 ProteinQ8N2Z9 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
AURKB ProteinQ96GD4 (Uniprot-TrEMBL)
Ac-CoAMetaboliteCHEBI:15351 (ChEBI)
B9D2 ProteinQ9BPU9 (Uniprot-TrEMBL)
BANF1 ProteinO75531 (Uniprot-TrEMBL)
BANF1ComplexR-HSA-2995377 (Reactome)
BIRC5 ProteinO15392 (Uniprot-TrEMBL)
BUB1 ProteinO43683 (Uniprot-TrEMBL)
BUB1B ProteinO60566 (Uniprot-TrEMBL)
BUB3 ProteinO43684 (Uniprot-TrEMBL)
CASC5 ProteinQ8NG31 (Uniprot-TrEMBL)
CDC16 ProteinQ13042 (Uniprot-TrEMBL)
CDC20 ProteinQ12834 (Uniprot-TrEMBL)
CDC20:p-APC/C:PTTG1ComplexR-HSA-174212 (Reactome)
CDC20:p-APC/CComplexR-HSA-174081 (Reactome)
CDC20:pAPC/C:K11polyUb-PTTG1ComplexR-HSA-3095944 (Reactome)
CDC23 ProteinQ9UJX2 (Uniprot-TrEMBL)
CDC26 ProteinQ8NHZ8 (Uniprot-TrEMBL)
CDC27 ProteinP30260 (Uniprot-TrEMBL)
CDCA8 ProteinQ53HL2 (Uniprot-TrEMBL)
CENPA ProteinP49450 (Uniprot-TrEMBL)
CENPC1 ProteinQ03188 (Uniprot-TrEMBL)
CENPE ProteinQ02224 (Uniprot-TrEMBL)
CENPF ProteinP49454 (Uniprot-TrEMBL)
CENPH ProteinQ9H3R5 (Uniprot-TrEMBL)
CENPI ProteinQ92674 (Uniprot-TrEMBL)
CENPK ProteinQ9BS16 (Uniprot-TrEMBL)
CENPL ProteinQ8N0S6 (Uniprot-TrEMBL)
CENPM ProteinQ9NSP4 (Uniprot-TrEMBL)
CENPN ProteinQ96H22 (Uniprot-TrEMBL)
CENPO ProteinQ9BU64 (Uniprot-TrEMBL)
CENPP ProteinQ6IPU0 (Uniprot-TrEMBL)
CENPQ ProteinQ7L2Z9 (Uniprot-TrEMBL)
CENPT ProteinQ96BT3 (Uniprot-TrEMBL)
CKAP5 ProteinQ14008 (Uniprot-TrEMBL)
CLASP1 ProteinQ7Z460 (Uniprot-TrEMBL)
CLASP2 ProteinO75122 (Uniprot-TrEMBL)
CLIP1 ProteinP30622 (Uniprot-TrEMBL)
ChromatinComplexR-ALL-2537690 (Reactome)
Cleaved Cohesin:PDS5:WAPALComplexR-HSA-2467805 (Reactome)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:MicrotubulesComplexR-HSA-2467806 (Reactome)
CoA-SHMetaboliteCHEBI:15346 (ChEBI)
Cohesin ComplexComplexR-HSA-2545214 (Reactome)
DSN1 ProteinQ9H410 (Uniprot-TrEMBL)
DYNC1H1 ProteinQ14204 (Uniprot-TrEMBL)
DYNC1I1 ProteinO14576 (Uniprot-TrEMBL)
DYNC1I2 ProteinQ13409 (Uniprot-TrEMBL)
DYNC1LI1 ProteinQ9Y6G9 (Uniprot-TrEMBL)
DYNC1LI2 ProteinO43237 (Uniprot-TrEMBL)
DYNLL1 ProteinP63167 (Uniprot-TrEMBL)
DYNLL2 ProteinQ96FJ2 (Uniprot-TrEMBL)
EMD ProteinP50402 (Uniprot-TrEMBL)
EMD/ TMPO/ LEMD3/ LEMD2ComplexR-HSA-2993892 (Reactome)
EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:ChromatinComplexR-HSA-2993900 (Reactome)
ERCC6L ProteinQ2NKX8 (Uniprot-TrEMBL)
ESPL1 AutocleavedComplexR-HSA-2467770 (Reactome)
ESPL1 ProteinQ14674 (Uniprot-TrEMBL)
ESPL1(1-1506) ProteinQ14674 (Uniprot-TrEMBL)
ESPL1(1507-1535) ProteinQ14674 (Uniprot-TrEMBL)
ESPL1(1536-2120) ProteinQ14674 (Uniprot-TrEMBL)
ESPL1ProteinQ14674 (Uniprot-TrEMBL)
FBXO5ProteinQ9UKT4 (Uniprot-TrEMBL)
H2OMetaboliteCHEBI:15377 (ChEBI)
HDAC8-1 ProteinQ9BY41-1 (Uniprot-TrEMBL)
HDAC8ComplexR-HSA-2545205 (Reactome)
INCENP ProteinQ9NQS7 (Uniprot-TrEMBL)
ITGB3BP ProteinQ13352 (Uniprot-TrEMBL)
K11polyUb-PTTG1 ProteinO95997 (Uniprot-TrEMBL)
KIF18A ProteinQ8NI77 (Uniprot-TrEMBL)
KIF2A ProteinO00139 (Uniprot-TrEMBL)
KIF2B ProteinQ8N4N8 (Uniprot-TrEMBL)
KIF2C ProteinQ99661 (Uniprot-TrEMBL)
KNTC1 ProteinP50748 (Uniprot-TrEMBL)
LEMD2 ProteinQ8NC56 (Uniprot-TrEMBL)
LEMD3 ProteinQ9Y2U8 (Uniprot-TrEMBL)
LMNA-1 ProteinP02545-1 (Uniprot-TrEMBL)
LMNA-2 ProteinP02545-2 (Uniprot-TrEMBL)
LMNB1 ProteinP20700 (Uniprot-TrEMBL)
Lamin dimersComplexR-HSA-2995373 (Reactome)
Lamin filaments R-HSA-5228493 (Reactome)
MAD1L1 ProteinQ9Y6D9 (Uniprot-TrEMBL)
MAD2L1 ProteinQ13257 (Uniprot-TrEMBL)
MAPRE1 ProteinQ15691 (Uniprot-TrEMBL)
MIS12 ProteinQ9H081 (Uniprot-TrEMBL)
MLF1IP ProteinQ71F23 (Uniprot-TrEMBL)
Microtubule protofilament R-HSA-8982424 (Reactome)
Mitotic PrometaphasePathwayR-HSA-68877 (Reactome) The dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and the chromosomes begin to move to the metaphase plate.
NDC80 ProteinO14777 (Uniprot-TrEMBL)
NDE1 ProteinQ9NXR1 (Uniprot-TrEMBL)
NDEL1 ProteinQ9GZM8 (Uniprot-TrEMBL)
NSL1 ProteinQ96IY1 (Uniprot-TrEMBL)
NUDC ProteinQ9Y266 (Uniprot-TrEMBL)
NUF2 ProteinQ9BZD4 (Uniprot-TrEMBL)
NUP107 ProteinP57740 (Uniprot-TrEMBL)
NUP133 ProteinQ8WUM0 (Uniprot-TrEMBL)
NUP160 ProteinQ12769 (Uniprot-TrEMBL)
NUP37 ProteinQ8NFH4 (Uniprot-TrEMBL)
NUP43 ProteinQ8NFH3 (Uniprot-TrEMBL)
NUP85 ProteinQ9BW27 (Uniprot-TrEMBL)
NUP98-5 ProteinP52948-5 (Uniprot-TrEMBL)
PAFAH1B1 ProteinP43034 (Uniprot-TrEMBL)
PDS5A ProteinQ29RF7 (Uniprot-TrEMBL)
PDS5B ProteinQ9NTI5 (Uniprot-TrEMBL)
PDS5ComplexR-HSA-2484796 (Reactome)
PLK1 ProteinP53350 (Uniprot-TrEMBL)
PMF1 ProteinQ6P1K2 (Uniprot-TrEMBL)
PP2A (Aalpha:B55alpha:Calpha)ComplexR-HSA-377182 (Reactome)
PPP1CC ProteinP36873 (Uniprot-TrEMBL)
PPP2CA ProteinP67775 (Uniprot-TrEMBL)
PPP2CB ProteinP62714 (Uniprot-TrEMBL)
PPP2R1A ProteinP30153 (Uniprot-TrEMBL)
PPP2R1B ProteinP30154 (Uniprot-TrEMBL)
PPP2R2A ProteinP63151 (Uniprot-TrEMBL)
PPP2R5A ProteinQ15172 (Uniprot-TrEMBL)
PPP2R5B ProteinQ15173 (Uniprot-TrEMBL)
PPP2R5C ProteinQ13362 (Uniprot-TrEMBL)
PPP2R5D ProteinQ14738 (Uniprot-TrEMBL)
PPP2R5E ProteinQ16537 (Uniprot-TrEMBL)
PSMA1 ProteinP25786 (Uniprot-TrEMBL)
PSMA2 ProteinP25787 (Uniprot-TrEMBL)
PSMA3 ProteinP25788 (Uniprot-TrEMBL)
PSMA4 ProteinP25789 (Uniprot-TrEMBL)
PSMA5 ProteinP28066 (Uniprot-TrEMBL)
PSMA6 ProteinP60900 (Uniprot-TrEMBL)
PSMA7 ProteinO14818 (Uniprot-TrEMBL)
PSMA8 ProteinQ8TAA3 (Uniprot-TrEMBL)
PSMB1 ProteinP20618 (Uniprot-TrEMBL)
PSMB10 ProteinP40306 (Uniprot-TrEMBL)
PSMB11 ProteinA5LHX3 (Uniprot-TrEMBL)
PSMB2 ProteinP49721 (Uniprot-TrEMBL)
PSMB3 ProteinP49720 (Uniprot-TrEMBL)
PSMB4 ProteinP28070 (Uniprot-TrEMBL)
PSMB5 ProteinP28074 (Uniprot-TrEMBL)
PSMB6 ProteinP28072 (Uniprot-TrEMBL)
PSMB7 ProteinQ99436 (Uniprot-TrEMBL)
PSMB8 ProteinP28062 (Uniprot-TrEMBL)
PSMB9 ProteinP28065 (Uniprot-TrEMBL)
PSMC1 ProteinP62191 (Uniprot-TrEMBL)
PSMC2 ProteinP35998 (Uniprot-TrEMBL)
PSMC3 ProteinP17980 (Uniprot-TrEMBL)
PSMC4 ProteinP43686 (Uniprot-TrEMBL)
PSMC5 ProteinP62195 (Uniprot-TrEMBL)
PSMC6 ProteinP62333 (Uniprot-TrEMBL)
PSMD1 ProteinQ99460 (Uniprot-TrEMBL)
PSMD10 ProteinO75832 (Uniprot-TrEMBL)
PSMD11 ProteinO00231 (Uniprot-TrEMBL)
PSMD12 ProteinO00232 (Uniprot-TrEMBL)
PSMD13 ProteinQ9UNM6 (Uniprot-TrEMBL)
PSMD14 ProteinO00487 (Uniprot-TrEMBL)
PSMD2 ProteinQ13200 (Uniprot-TrEMBL)
PSMD3 ProteinO43242 (Uniprot-TrEMBL)
PSMD4 ProteinP55036 (Uniprot-TrEMBL)
PSMD5 ProteinQ16401 (Uniprot-TrEMBL)
PSMD6 ProteinQ15008 (Uniprot-TrEMBL)
PSMD7 ProteinP51665 (Uniprot-TrEMBL)
PSMD8 ProteinP48556 (Uniprot-TrEMBL)
PSMD9 ProteinO00233 (Uniprot-TrEMBL)
PSME1 ProteinQ06323 (Uniprot-TrEMBL)
PSME2 ProteinQ9UL46 (Uniprot-TrEMBL)
PSME3 ProteinP61289 (Uniprot-TrEMBL)
PSME4 ProteinQ14997 (Uniprot-TrEMBL)
PSMF1 ProteinQ92530 (Uniprot-TrEMBL)
PTTG1 ProteinO95997 (Uniprot-TrEMBL)
PTTG1:ESPL1ComplexR-HSA-2467796 (Reactome)
PTTG1ProteinO95997 (Uniprot-TrEMBL)
PiMetaboliteCHEBI:18367 (ChEBI)
RAD21 ProteinO60216 (Uniprot-TrEMBL)
RAD21(1-172) ProteinO60216 (Uniprot-TrEMBL)
RAD21(1-172)ProteinO60216 (Uniprot-TrEMBL)
RAD21(173-450) ProteinO60216 (Uniprot-TrEMBL)
RAD21(173-450)ProteinO60216 (Uniprot-TrEMBL)
RAD21ProteinO60216 (Uniprot-TrEMBL)
RANBP2 ProteinP49792 (Uniprot-TrEMBL)
RANGAP1 ProteinP46060 (Uniprot-TrEMBL)
RCC2 ProteinQ9P258 (Uniprot-TrEMBL)
RPS27 ProteinP42677 (Uniprot-TrEMBL)
RPS27A(1-76) ProteinP62979 (Uniprot-TrEMBL)
SEC13 ProteinP55735 (Uniprot-TrEMBL)
SEH1L-1 ProteinQ96EE3-1 (Uniprot-TrEMBL)
SGOL1 ProteinQ5FBB7 (Uniprot-TrEMBL)
SGOL2 ProteinQ562F6 (Uniprot-TrEMBL)
SHFM1 ProteinP60896 (Uniprot-TrEMBL)
SKA1 ProteinQ96BD8 (Uniprot-TrEMBL)
SKA2 ProteinQ8WVK7 (Uniprot-TrEMBL)
SMC1A ProteinQ14683 (Uniprot-TrEMBL)
SMC3 ProteinQ9UQE7 (Uniprot-TrEMBL)
SPC24 ProteinQ8NBT2 (Uniprot-TrEMBL)
SPC25 ProteinQ9HBM1 (Uniprot-TrEMBL)
SPDL1 ProteinQ96EA4 (Uniprot-TrEMBL)
STAG1 ProteinQ8WVM7 (Uniprot-TrEMBL)
STAG2 ProteinQ8N3U4 (Uniprot-TrEMBL)
Sister Centromere:Kinetochore:MicrotubulesComplexR-HSA-2484902 (Reactome)
Sister Centromere R-ALL-1638792 (Reactome)
Sister Chromosomal Arm R-ALL-1638790 (Reactome)
TAOK1 ProteinQ7L7X3 (Uniprot-TrEMBL)
TMPO-1 ProteinP42167-1 (Uniprot-TrEMBL)
UBA52(1-76) ProteinP62987 (Uniprot-TrEMBL)
UBB(1-76) ProteinP0CG47 (Uniprot-TrEMBL)
UBB(153-228) ProteinP0CG47 (Uniprot-TrEMBL)
UBB(77-152) ProteinP0CG47 (Uniprot-TrEMBL)
UBC(1-76) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(153-228) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(229-304) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(305-380) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(381-456) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(457-532) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(533-608) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(609-684) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(77-152) ProteinP0CG48 (Uniprot-TrEMBL)
UBE2C ProteinO00762 (Uniprot-TrEMBL)
UBE2D1 ProteinP51668 (Uniprot-TrEMBL)
UBE2E1 ProteinP51965 (Uniprot-TrEMBL)
UbComplexR-HSA-113595 (Reactome)
VRK1 ProteinQ99986 (Uniprot-TrEMBL)
VRK1/VRK2ComplexR-HSA-2995386 (Reactome)
VRK2-2 ProteinQ86Y07-2 (Uniprot-TrEMBL)
WAPAL ProteinQ7Z5K2 (Uniprot-TrEMBL)
WAPALProteinQ7Z5K2 (Uniprot-TrEMBL)
XPO1 ProteinO14980 (Uniprot-TrEMBL)
ZW10 ProteinO43264 (Uniprot-TrEMBL)
ZWILCH ProteinQ9H900 (Uniprot-TrEMBL)
ZWINT ProteinO95229 (Uniprot-TrEMBL)
p-FBXO5ProteinQ9UKT4 (Uniprot-TrEMBL)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:MicrotubulesComplexR-HSA-2500242 (Reactome)
p-S21,S75,T159-CDCA5 ProteinQ96FF9 (Uniprot-TrEMBL)
p-S21,S75,T159-CDCA5ProteinQ96FF9 (Uniprot-TrEMBL)
p-S454-RAD21 ProteinO60216 (Uniprot-TrEMBL)
p-S454-RAD21(451-631) ProteinO60216 (Uniprot-TrEMBL)
p-S454-RAD21(451-631)ProteinO60216 (Uniprot-TrEMBL)
p-T2,T3,S4-BANF1 ProteinO75531 (Uniprot-TrEMBL)
p-T2,T3,S4-BANF1ComplexR-HSA-2995380 (Reactome)
p-T210-PLK1ProteinP53350 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
26S proteasomemim-catalysisR-HSA-174202 (Reactome)
ADPArrowR-HSA-163010 (Reactome)
ANKLE2:VRK1/VRK2ArrowR-HSA-2995389 (Reactome)
ANKLE2ArrowR-HSA-2995388 (Reactome)
ANKLE2R-HSA-2995389 (Reactome)
ATPR-HSA-163010 (Reactome)
Ac-CoAArrowR-HSA-2545203 (Reactome)
BANF1ArrowR-HSA-2995388 (Reactome)
BANF1R-HSA-2995376 (Reactome)
CDC20:p-APC/C:PTTG1ArrowR-HSA-174121 (Reactome)
CDC20:p-APC/C:PTTG1R-HSA-174144 (Reactome)
CDC20:p-APC/CArrowR-HSA-174202 (Reactome)
CDC20:p-APC/CR-HSA-174121 (Reactome)
CDC20:p-APC/Cmim-catalysisR-HSA-174144 (Reactome)
CDC20:pAPC/C:K11polyUb-PTTG1ArrowR-HSA-174144 (Reactome)
CDC20:pAPC/C:K11polyUb-PTTG1R-HSA-174202 (Reactome)
ChromatinR-HSA-2995376 (Reactome)
Cleaved Cohesin:PDS5:WAPALArrowR-HSA-2467811 (Reactome)
Cleaved Cohesin:PDS5:WAPALR-HSA-2545203 (Reactome)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:MicrotubulesArrowR-HSA-2467809 (Reactome)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:MicrotubulesR-HSA-2467811 (Reactome)
CoA-SHR-HSA-2545203 (Reactome)
Cohesin ComplexArrowR-HSA-2545203 (Reactome)
EMD/ TMPO/ LEMD3/ LEMD2R-HSA-2995376 (Reactome)
EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:ChromatinArrowR-HSA-2995376 (Reactome)
ESPL1 AutocleavedArrowR-HSA-2467775 (Reactome)
ESPL1 Autocleavedmim-catalysisR-HSA-2467809 (Reactome)
ESPL1R-HSA-2467775 (Reactome)
ESPL1R-HSA-2467798 (Reactome)
ESPL1mim-catalysisR-HSA-2467775 (Reactome)
FBXO5R-HSA-163010 (Reactome)
H2O