PI Metabolism (Homo sapiens)

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9-11, 15, 38...31701920, 32, 47, 58, 72...1, 33, 68, 74, 107...63, 96, 123, 127, 14737, 95, 9852, 126, 16150, 73, 17263, 111, 123, 12716, 115, 12134, 89, 12553, 11081, 87, 125130199762, 70, 87123, 14748, 139, 14926, 18, 21, 2444, 82, 140, 14640226, 99, 100, 165, 168...6, 18, 21, 24, 29...5, 7348, 139, 14962, 70, 81, 87, 8917, 40, 45, 57, 9123, 124, 131, 13314, 102, 108, 119, 1633, 39, 103, 134, 1537, 22, 28-30, 46...26, 9985, 15435, 105, 1423114312945, 84, 91, 148, 151123, 1478, 83, 106, 111, 155...6, 18, 2183, 111, 1551454012223, 111, 124, 131, 13314488, 13110914326, 99, 100, 165, 168...63, 111, 123, 12727, 131, 133, 16414513261, 83, 111, 112, 1556, 8, 56, 61, 64...14, 40, 45, 57, 91...78, 101, 1581308, 61, 83, 106, 111...50, 73, 172123, 14725, 51, 8610636, 66, 68, 74, 107...193, 39, 103, 15326, 995954, 6915842, 55, 94, 118127, 15223, 111, 124, 131, 1333125, 8978, 101, 15848, 139, 1496, 8, 56, 64, 111...109130109, 1221304, 75, 92Golgi lumenearly endosome lumenlate endosome lumencytosolcytoplasmic vesicle membraneendoplasmic reticulum lumennucleoplasmMTMR2 PIP5K1B VAC14 PIP4K2 dimersARF1MTMR2:SBF1ADPPI RAB5A EPH-Ephrin signalingMTMR10OCRL PiINPP4B H2OMTMR8:MTMR9p-Y281,292-RUFY1:PI3PH2OPIK3R6 Mn2+ p-Y281,292-RUFY1 PLEKHA3,8INPP5D PI4K2A PI(3,4)P2PiPI(3,4)P2PI4PGPChoPIK3R5 MTMR7Mg2+ PI(4,5)P2PIK3R1 MTMR12 PiADPRAB4A:GTPPiATPPTPN13:PLEKHA1,2PI(4,5)P2 PIK3C2A:Ca2+/Mg2+PIK3C(1)PiSYNJ1 ADPINPP5E PCPI(4,5)P2INPP5K MTMR4 ATPMTM1 ADPPI:PITPNBADPPIK3CA PI3P INPP4A MTMR10 MTMR9 ARF1/3:GTPATPPITPNB RAB5A:GTPPI(4,5)P2 PI3PPIP4K2A MTMR9 PI(4,5)P2 PiPIKFYVE:VAC14:FIG4PIK3R2 PIP4K2B PLEKHA3 PiPIK3R4 H2OPI4KA/2BFIG4 PIMTMR2SYNJ1 Mg2+ ADPPIK3CA PC:PITPNBGTP SYNJ2 PiMTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2GDPD5PIKFYVE:VAC14:FIG4ADPPiH2OTMEM55BTCR signalingMn2+ PI(3,5)P2 ADPPiMTMR2 PIK3C2G GTP PI3P MTMR6 PIK3C3 RUFY1MTM1 p-Y281,292-RUFY1:p-Y281,292-RUFY1:RAB4A:GTP:RAB5:GTP:RAB14:GTPLysoPtdChoPI4K2A/2BPIP4K2A INPP4A/BPIP5K1A MTMR7 PI TNFAIP8L2 PI4K2B PiSYNJ2 MTMR6PTPN13 MTMR6 PC:PITPNBOCRL PI5PPIP5K1A/BPI5PPIK3C3 INPP4A/BFIG4 PI4KBPLEKHA4,(5,6)p-Y281,292-RUFY1 ADPPIMg2+ MTMR4 H2OARF3 Ca2+ ATPMTMR7 PI3P PIK3C2A MTMR8 PIKFYVE PLEKHA5 MTMR2 PLEKHA5 PI4PPLEKHA2 MTM1 PI3PSACM1LATPMTMR6:MTMR9,MTMR8:MTMR9MTMR2 PIK3R3 PLEKHA6 PIK3C2A Regulation of TP53Activity throughAcetylationMTMR12Ca2+ MTMR6:MTMR9MTMR7 PLEKHA4 PI4K2B PiPIP5K1B TNFAIP8L3 H2OMTMR3 MTMR8PIK3CG H2OPI(3,5)P2MTM1:MTMR12ATPSYNJs,OCRLPIP5K1A-CPIK3(2)PIK3C2B PI3PMTMR1 PI(4,5)P2,PI(3,4)P2,PI(3,4,5)P3GDPD1ARF1 PIK3CB InsMTMR9ATPMn2+ MTM1ADPPI3PPiVAC14 PI4KB PIK3C2A/3Mg2+ ATPATPVAC14 PIP4K2B ARF1 FIG4 PI3PH2OATPPI(3,4)P2 MTMR12 PI(4,5)P2,PI(3,4,5)P3PiSBF1 GroPInsPiPTENRAB14:GTPPiSYNJ1 SBF1PI4KA/2A/2BPI(3,4,5)P3 LCFA(-)MTMR2 Ca2+ PIP5K1C PLEKHA2 PIP5K1A PTPN13 PNPLA7PLEKHA1 PLEKHA8 PLEKHA4 PI(3,5)P2PIK3R5 SYNJ2 PI5PADPMTMR2:SBF2 TetramerPI(3,4)P2PI(4,5)P2PIP4K2B PI5P MTMR2:MTMR10RAB14 PIK3CG ADPMTM1 SYNJ2 SBF2 homodimerPiMTM1,MTMR2,MTMR4,MTMR7PI4K2B PIKFYVE PIK3R2 GTP PIP5K1B PIP4K2 dimersMTM1,MTMR2,MTMR4PIK3R1 INPP5(1) MTMR6 PI4K2A PITPNB PIK3CD PCH2OPI3PGTP TNFAIP8 proteinsADPMn2+ RAB5A H2OADPPiMTMR9 PIMTM1,MTMR2,MTMR4,MTMR7PITPNB PI(3,4,5)P3TNFAIP8 PLEKHA8 PIP4K2C H2OSACM1LPiSACM1Lp-Y281,292-RUFY1MTMR2 PiRAB4A PI5PPIKFYVE PIK3R3 PI4KA SYNJ/INPP5(1)PTPN13:PLEKHA1,2:PIP2PI4P H2OATPPI5P, PI3P,PI(3,5)P2ADPINPP4A ADPPC PIP5K1A ATPPIK3C3 PIPI(3,4)P2 PLEKHA4,(5,6):PI3PMg2+ PIK3C2A/3PIK3C2A/3GDPD3PITPNB TNFAIP8L1 ATPPLEKHA1 RAB14 PLEKHA6 ATPPI4PRAB4A ADPH2OMTM1 PIP4K2C MTMR7:MTMR9PIP5K1C PIK3R4 INPP5(2)Ca2+ OCRL/INPP5EPIP4K2/5K1ChoPGTP G3PPIADPMTMR2 PIP5K1A ADPSYNJs,OCRLARF1 H2OATPMTMR14 ARF1/3:GTP:PI4KBPIP5K1C PIP5K1B PI(3,5)P2Ca2+ PIP5K1A-CPI(3,4,5)P3 ARF3 PIP3 activates AKTsignalingPIK3R6 GDE1PI4K2A/2BH2OENPP6Ca2+ ATPMTMR2 PIK3CD MAGTMEM55BPI5PMTMR9 PI(3,5)P2PI4K2A INPP5J H2OPI(3,5)P2PIP4K2A ADPARF1:PLEKHA3,8:PI4PPIK3R4 MTMR2:MTMR12PIKFYVE:VAC14:FIG4PIK3C2A H2OINPPL1 MTMR4 H2OPI(3,4,5)P3 PIP5K1A BMXMTMR8 PIK3C2A TPTE PI4PPIK3C2A SBF2 ADPPNPLA6H2OPIGTP ATPPIK3C2G OCRL TPTE2 H2OPIK3C2A Mg2+ H2OMTMR2 homodimerPIK3CB lysophosphatidylcholineSBF2 PI3Pp-Y281,292-RUFY1PLEKHA3 PIK3C2A/GPIP5K1A/BPIP5K1B INPP4B ATPPiINPP5FChoPI4K2B PI(4,5)P2,PI(3,4,5)P3PI4KA PC SYNJ1 PI:PITPNBADPTPTE2-like proteinsATP65, 150, 162591589513015810610913012, 13, 79, 80, 116...13012248, 139, 14913267, 120108108121