Glycosaminoglycan metabolism (Homo sapiens)

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85, 11825, 1451, 52, 65, 14250, 9227, 46, 73, 74, 78...18, 141, 151324112512928, 42, 149717, 77, 106, 107, 13611, 1025753, 60, 138135, 53, 60, 116, 126...63, 982, 23, 1157, 77, 106, 107, 13669, 76, 11920, 39, 10311, 10210513113, 117, 14722, 6744, 112, 12240, 47, 8449, 120131, 52, 65, 1421324, 45, 61, 66, 68...70, 1006, 8110521, 38, 48, 1301378, 14, 2943, 51, 58, 111, 13421, 38, 48, 1301433, 59, 64, 75, 13320, 39, 1031106, 8125, 14596137252, 65, 128, 148, 1529, 5620, 39, 1031333, 70, 86, 10019, 93, 124, 13582, 97, 13212555, 797, 77, 106, 107, 13640, 47, 845, 53, 60, 116, 126...137, 15453, 60, 1382, 23, 11514320, 39, 10330, 13935, 57, 14422, 674, 16, 9115, 80, 1214034, 362689, 10414379, 12311431, 101, 108, 1091210, 17, 37, 15311, 10218, 141, 15194, 13162, 9579, 123Golgi lumenGolgi lumenlysosomal lumencytosolUDP-GlcNAc OGN Gal-Xyl-GPC2 aldehydo-L-iduronicacidCHST15GlcA-Gal-Gal-Xyl-GPC2 VCAN Heparan-GPC5 CMPHS(5)-GPC5 Heparan-PGsGal-Gal-Xyl-GPC2 KS(2)-OMD HS(6)-SDC1 (HA)50UDP-GlcNAcchondroitin(2)-BCAN Gal-Xyl-NCAN (HA)50GPC2 B3GNT7 CHST13 aldehydo-L-iduronicacidGlcAC6S-BCAN GlcA-Gal-Gal-Xyl-BGN GalNAcPRELP UDP-GlcAp-CHP1 HS(4)-AGRN Heparan(1)-GPC1 GPC2 HS(6)-SDC1 C4S-PG KS(2)-LUM XylS-SDC3 C4S-CSPG4 HS(6)-SDC4 HS(3)-GPC3 GUSB tetramerHEXA Gal-GlcNAc(S)-Gal-GlcNAc(S)-GalD4S-PGs Heparan(3)-GPC3 Keratan(1)-KERA Gal-Xyl-SDC2 GlcA-Gal-Gal-Xyl-VCAN IDS dimerHS/HPIN-PGsGlcA-Gal-Gal-Xyl-proteinsHS(4)-GPC5 STAB2(1136-2551) CHPF H2Odermatan-core proteins UDP-GalNAcHeparan(2)-GPC2 LUM CHST6 Heparan(3)-HSPG2 Heparan(1)-PGsHeparan(3)-GPC1 ChEBI:63515 chain bHEXBHS2ST1CSE-BCAN HS(3)-SDC2 ST3GAL1 B4GALT3 N-glycan PRELP Heparan(1)-SDC2 CHST14 substratesBCAN Gal-GlcNAc(S)-GalKSPG(2)Keratan(4)-ACAN B4GALT4 UDPGlcA-Gal-Gal-Xyl-DCN dermatan-core proteins HS(2)-SDC4 Heparan(4)-SDC1 chondroitin(1)-VCAN CSE-BGN HS(4)-SDC2 KS(1)-KERA HS3ST1 ChEBI:63517 chainUDPHS(6)-GPC3 Gal-Gal-Xyl-SDC1 APSL-AspHeparan(1)-SDC1 GlcNAcHA:HAR:HYAL2CSE-CSPG5 UDPPAPSGlcA-Gal-Gal-Xyl-SDC2 XylS-CSPG4 UDPHeparan(1)-GPC2 HS(1)-GPC3 BGN HARsXylS-DCN ABCC5Gal-Gal-Xyl-SDC4 Gal-glycan KERA HS core proteinsKS(2)-OGN SLC9A1 Heparan-GPC6 H2OHS(6)-HSPG2 H2OB4GALT2 PAPSHS(6)-GPC5 Ac-CoAGlcA-Gal-Gal-Xyl-CSPG5 CSPGsLYVE1 C6S chain CHST14 productsHS/HPIN-PGs B4GAT1 Heparan(1)-GPC4 GalGlcA-Gal-Gal-Xyl-SDC3 HPSE(158-543) bHEXBKS(2)-OGN UDPKeratan(3)-PGPAPSC6S-PGs Heparan(3)-SDC4 HS(4)-GPC2 chondroitin(1)-BGN HA polymerHS(1)-HSPG2 HS(3)-PGs GlcA-Gal-Gal-Xyl-CSPG5 CHST11 KS(2)-FMOD BCAN H2OHS(5)-GPC6 Keratan(3)-LUM Heparan(2)-PGsHS(3)-AGRN H2OGlcNAcPAPHeparan-GPC4 GlcA-Gal-Gal-Xyl-GPC4 C6S-VCAN Gal-Xyl-DCN Heparan(3)-AGRN SDC3 Gal-Xyl-AGRN XYLT1 ST3GAL2 SDC3 HAS1,2,3Heparan(3)-SDC3 D2,4(S)2-PGPAPHS(1)-PGs KS(2)-LUM Heparan-GPC1 HEXAMn2+ SO4(2-)HEXAHS(1)-SDC2 HS(6)-GPC4 HAS1 Ca2+ HS(5)-SDC4 H2OKS(1)-FMOD NCAN KS(2)-KERA PAPSHS(2)-AGRN HS(6)-GPC2 C4S-BCAN CS/DS core proteinsGal-Gal-Xyl-NCAN H2OHS(2)-GPC6 SO4(2-)Keratan(4)-PRELP KS(2)-OMD C6S-NCAN Heparan-SDC2 B4GALT1-6 homodimersCa2+ H2OD2,4(S)2-CSPG5 H2OGlcA-Gal-Gal-Xyl-GPC4 SDC4 HYAL1 CSGALNACT1 Ca2+ KSPG(1)D4S-PGs SLC26A1,2HEXB(122-311) HEXB(315-556) HS(6)-SDC2 D2,4(S)2-VCAN KS(2)-FMOD Heparan(2)-HSPG2 Heparan sulfatechain(7)GPC3(25-?) GlcA-Gal-Gal-Xyl-NCAN STAB2(1136-2551) AGRN(30-2045) N-glycan KERA ST3GAL1-4,6GlcA-Gal-Gal-Xyl-SDC3 ST3GAL4 KS(2)-ACAN UDPHS3ST6 H+SDC1 Heparan-GPC3 HEXB(315-556) D4S-BCAN Heparan(2)-GPC5 HS(6)-GPC2 Heparan-AGRN CSPG5 Heparan sulfatechain(6)C6S-PGHeparan(1)-HSPG2 Keratan(2)-PRELP Gal-Xyl-CSPG5 HS3ST3A1 Gal-glycan-proteinSO4(2-)HS(3)-GPC5 CHST2,5,6B3GNT3 HS(4)-PGsGal-Gal-Xyl-GPC1 B3GAT3:Mn2+ dimerHeparan(2)-SDC1 B3GAT3 Gal-glycan FMOD chondroitin(1)-DCN ATPIDUAGPC1 XylS-GPC1 Keratan(3)-ACAN D2,4,4(S)3-PGs CHEBI:63868 chainHS3STsulfotransferasesCHST7 KS(2)-KERA NCAN Heparan(4)-GPC6 Heparan sulfatechain(2)HS(2)-SDC1 HS(6)-GPC1 DSE,DSEL substratesIDUAGPC1 D4S-DCN HS3ST3B1 UDP-GlcNAc PAPSUDP-GalHS(6)-GPC1 ChEBI:63519 chainHeparan(2)-GPC1 KS core proteinsUDP-Glc CHPF,CHSY3D4S-CSPG4 CH3COO-HS(2)-HSPG2 KS(2)-PRELP KS(2)-OMD HS(3)-PGs HS(3)-GPC2 NAGLU(59-743)ChEBI:63516 chainADPKeratan(3)-KERA C6S chain H2OCSPGsHS/HPIN-PGsCSE-PG KS(1)-OGN UMPHeparan(1)-GPC6 GlcA-Gal-Gal-Xyl-GPC6 GPC5(25-?) Keratan(2)-FMOD CSE-DCN BGN B3GALT6Gal-Gal-Xyl-HSPG2 SO4(2-)HS(5)-PGs HS(6)-GPC6 Gal-Gal-Xyl-GPC5 XylS-SDC4 Gal-Gal-Xyl-AGRN GlcA-Gal-Gal-Xyl-GPC3 UDPC4S/C6S chainsUDP-GlcAGPC6 GPC3(25-?) HMMR GlcA-Gal-Gal-Xyl-DCN B3GNT2 SO4(2-)GUSB CHST14Gal-Gal-Xyl-DCN NDST2 D2,4(S)2-PGs PAPSS2 HS(4)-GPC4 SLC35B3 GLCEHS(1)-SDC4 DSE,DSEL productsEXT1:EXT2Heparan(2)-SDC2 Heparan(4)-SDC4 NDST1 Keratan(4)-PGHeparan(1)-SDC3 Gal-Xyl-proteinsHS(6)-GPC6 Heparan(3)-GPC5 chondroitin(3)-CSPG5 HS(4)-SDC4 C4S-BGN Gal-Xyl-GPC3 Keratan(1)-PGHS(4)-GPC1 HS(4)-SDC3 C4S-DCN PAPSchondroitin(1)-coreproteinsGlcA-Gal-Gal-Xyl-BCAN CHSY3 C6S-CSPG5 Heparan(3)-GPC6 KS(2)-KERA D4S-PGs Keratan(2)-ACAN SGSHCHST9-2 Keratan(1)-LUM HS(6)-HSPG2 HS(3)-PGsHeparan(2)-GPC4 HAS3 HS3ST5 HEXA D2,4(S)2-PG HEXB(315-556) Asparagine N-linkedglycosylationHS(6)-SDC3 SDC2 GlcA-Gal-Gal-Xyl-SDC1 UDP-GlcNAcHeparan-HSPG2 GlcA-Gal-Gal-Xyl-CSproteinsHeparan(1)-GPC3 HS(3)-HSPG2 C6S-BGN Heparan sulfatechain(5)B4GALT6 SDC1 OxA-GNSNDST3 Gal-Xyl-CSPG4 HS/HPIN-PGsOxA-ARSB D2,4(S)2-CSPG4 chondroitin(2)-VCAN Heparan sulfatechainGal-Gal-Xyl-CSPG4 UDP-GlcNAc, UDP-GlcSDC4 Keratan(4)-OMD HPSE2(1-592)UDPCSPG5 HS(5)-GPC4 HS(6)-GPC1 Chondroitin chain UDP-GalIDS(456-550) Gal-Gal-Xyl-CSPG5 B4GALT7HPSE(36-109) Keratan(2)-LUM KS(2)-OGN OMD HEXAGal-glycan ACAN PAPGal-Gal-Xyl-SDC2 HYAL2 KS(2)-ACAN Heparan(2)-SDC3 UDP-GlcAHS6ST2 H2OGAG core proteinsEXT2 Heparan-GPC2 KS(2)-PRELP HS(5)-GPC1 KS(2)-PRELP HYAL1-like proteinsUDP-GalHSPG2(22-4391) GlcNAcGlcA-Gal-Gal-Xyl-CSPG4 H2OHEXB(315-556) Keratan(3)-FMOD Gal-Xyl-BGN Heparan chain(2)HSPGschondroitin(2)-CSPG4 C4S-CSPG5 D2,4(S)2-PG N-glycan ACAN GPC6 ST3GAL6 Chondroitin chainH2OCHSY3 SGSHHS(6)-SDC4 PAPSS1,2SDC2 HS(4)-PGs Gal-Xyl-SDC4 C6S-PG DSPGsCHST2 HS(4)-PGs HS(2)-GPC4 beta-xylosidaseChEBI:63515 chainHS(5)-PGs chondroitin(1)-BCAN KS(1)-PRELP PPiFMOD XylS-BCAN UDP-GalNAcUDP-GalAGRN(30-2045) CSPGsCMP-Neu5AcHeparan(4)-GPC1 HS(6)-SDC2 UDP-GlcNAcUDPD4S-PGs XylS-GPC2 CHPF2 B3GNT4 Heparan(3)-SDC1 Gal-Xyl-GPC6 N-glycan LUM CSE-VCAN IdoA-GalNAc(4S)-GlcA-Gal-Gal-XylGlcA-Gal-Gal-Xyl-BCAN D2,4(S)2-PGs p-CHP1 Gal-Xyl-BCAN C4S chain KS(1)-OMD D4S-PGsH2OGlcACSE-PGD2,4,4(S)3-PGs B3GAT2 Gal-Xyl-GPC5 GlcNAcCHPF HS(1)-SDC1 HS(2)-SDC2 UDP-GalAc-CoAD4S-VCAN HS(1)-GPC4 HYAL1-like proteinsSDC1 NDSTsCHST12 XYLT2 HAHSPGsHeparan(1)-AGRN HS(2)-PGsHeparan(4)-AGRN D2,4,4(S)3-BCAN CHST3,7H2OHS(1)-GPC2 D2,4,4(S)3-DCN HS(6)-AGRN GlcA-Gal-Gal-Xyl-AGRN CHST3 HS3ST2 B4GALT5 HS(6)-AGRN Heparan chain(1)HS(2)-GPC3 XylS-VCAN DSEL Heparan sulfatechain(4)Gal-Xyl-VCAN HS(5)-PGsCSGALNACTMn2+ C4S-NCAN HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+Heparan(4)-HSPG2 PAPHYAL1 XylS-NCAN HYAL2 Gal-Gal-Xyl-GPC6 N-glycan FMOD Gal-Xyl-SDC3 Keratan(4)-OGN D2,4,4(S)3-VCAN SDC3 CoA-SHHeparan(4)-GPC4 Gal-Xyl-HSPG2 Gal-glycan PRELP Heparan(3)-PGsC6S-CSPG4 C4S-PGGALNS oligomerD2,4,4(S)3-PGs chondroitin(3)-coreproteinsGLB1 GlcA-Gal-Gal-Xyl-HSPG2 KSPG(2)HS(5)-SDC3 XylS-GPC6 UDPUDPHS(3)-GPC4 Keratan(1)-OGN H2OD2,4,4(S)3-BGN linker chain(2)N-glycan OMD D2,4,4(S)3-PGs(HA)2Heparan(2)-SDC4 keratansulfate1,4-beta-D-galactosidaseC4S-PG KERA KS(1)-LUM HS(3)-GPC6 H2OHS6ST3 GlcA-Gal-Gal-Xyl-GPC2 GlcA-Gal-Gal-Xyl-GPC1 chondroitin(1)-CSPG5 chondroitin(3)-BCAN BGALGPC5(25-?) HS/HPIN-PGs GPC3(25-?) GlcA-Gal-Gal-Xyl-BGN chondroitin(3)-BGN UDPGPC5(25-?) Heparan-SDC1 PAPDSE CHST1C4S-VCAN HS(6)-GPC4 HS(4)-GPC3 GlcNAc-GlcA-GlcNAcHS6ST1 SO4(2-)XylS-HSPG2(22-4391) HS(5)-SDC2 Ca2+ Heparan(2)-GPC3 Gal-Gal-Xyl-GPC4 XylS-SDC2 xylosyl-coreproteinsCSE-PG GPC6 GlcA-Gal-Gal-Xyl-SDC1 HSPG2(22-4391) CSPG4 SLC35B2 Keratan(3)-OGN Heparan(4)-SDC2 HEXB(315-556) UDP-GlcAST3GAL3 DSPGsKeratan(1)-FMOD Heparan(4)-GPC2 Heparan(2)-AGRN chondroitin(3)-NCAN HS(6)-GPC6 GalHeparan(4)-PGsB3GAT3 GlcA-Gal-Gal-Xyl-VCAN PAPHS(6)-GPC2 PAPSACAN Keratan(2)-PGHS(1)-SDC3 D2,4,4(S)3-NCAN HS3ST4 GPC4 HEXB(122-311) Heparan-SDC3 VCAN Heparan(4)-SDC3 Gal-Gal-Xyl-proteinsbHEXBchondroitin(1)-CSPG4 H2OKeratan(4)-FMOD Heparan(4)-GPC3 CSE-PGs HS(5)-AGRN CSGALNACT2 HS3STsKeratan(2)-OGN HS(5)-HSPG2 KS(2)-FMOD HS core proteinsXYLT1, XYLT2XylS-CSPG5 HPSE dimerDSPGsLYVE1 USTUDPGPC1 D4S-CSPG5 PAPPAPH2OGlcA-b1,3-GlcNAcHYAL2HS(4)-HSPG2 Gal(S)-GlcNAc(S)-Gal-GlcNAc(S)-GalHEXB(122-311) BGALSDC4 PAPHEXB(122-311) PAPSS1 GlcA-b1,3-GlcNAcC4S-PGs Heparan(1)-SDC4 HS3ST1GlcNAc-Gal-GlcNAc(S)-GalGlcA-β1,3-GlcNAcDSE,DSELHS(1)-AGRN HS(3)-GPC1 GlcA-Gal-Gal-Xyl-GPC6 SLC26A1 D2,4(S)2-NCAN GlcA-Gal-Gal-Xyl-HSPG2 H+chondroitin(3)-core proteins GLB1L GLB1 HEXA CD44 HS(6)-GPC5 PAPH2OD2,4,4(S)3-PGs B4GALT1 SO4(2-)Gal-Xyl-GPC4 D4S-NCAN CS/HS precursorHS(2)-PGs HS(2)-GPC5 H2OHMMR HSPG2(22-4391) Keratan(2)-OMD IDS(34-455) D4S-BGN ARSB:Ca2+C6S-DCN CHSY1D2,4(S)2-BGN GlcA-Gal-Gal-Xyl-AGRN HS(6)-SDC3 Gal-Xyl-SDC1 Gal-Gal-Xyl-VCAN GPC4 Keratan(4)-LUM B3GNT1,2,3,4,7GlcA-Gal-Gal-Xyl-GPC3 HS(6)-AGRN Keratan(1)-ACAN PAPSGal-Gal-Xyl-SDC3 uridine5'-monophosphateGal-Gal-Xyl-BGN Heparan(1)-GPC5 CD44 CEMIPChondroitin chainsHA HS(5)-GPC3 D4S-PGs HA GlcNAc(S)-Gal-GlcNAc(S)-GalHS(3)-SDC1 Gal-Gal-Xyl-GPC3 CHST9,11,12,13CoA-SHDCN XylS-GPC4 PAPSKeratan(1)-OMD XylS-GPC3(25-?) CHPF,CHPF2,CHSY3GalNAcH2OGlcA-Gal-Gal-Xyl-GPC5 CSE-CSPG4 GlcA-Gal-Gal-Xyl-SDC4 Heparan(4)-GPC5 CSPG4 Gal-glycan OGN SLC9A1 GPC4 NAGLU(59-743)HYAL3 Heparan sulfatechain(1)UDP-XylHAS2 HMMR HYAL3 GlcA-Gal-Gal-Xyl-SDC4 KSPG(2)chondroitin(2)-coreproteinsGlcA-Gal-Gal-Xyl-NCAN HS(6)-GPC3 HS(3)-SDC4 chondroitin(3)-DCN C4S chain STAB2(1136-2551) HS(2)-PGs chondroitin(2)-DCN UDPNDST4 chondroitin(1)-NCAN Gal-glycan LUM D-xyloseHS(1)-GPC1 N-glycan-proteinGal-Xyl-GPC1 HGSNAT oligomerchondroitin(2)-BGN HEXB(315-556) GlcA-Gal-Gal-Xyl-HSproteinsGal-glycan OMD XylS-GPC5(25-?) SLC26A2 Keratan(3)-PRELP HS(4)-GPC6 XylS-SDC1 PAPSKS(1)-ACAN AGRN(30-2045) HS(1)-GPC6 B3GAT1 HS(2)-SDC3 HS(6)-SDC1 H2OC6S-PG C4S-PG DCN HS(2)-GPC2 CHST5 HS(6)-GPC5 H2OGlcA-Gal-Gal-Xyl-SDC2 HS(5)-SDC1 Gal-Gal-Xyl-BCAN H2OGPC2 KS(2)-LUM Keratan(2)-KERA ATPHS(6)-SDC4 HS(6)-HSPG2 HS(6)-GPC4 HS(2)-GPC1 EXT1 HS(1)-GPC5 SO4(2-)chondroitin(3)-CSPG4 SLC35B2,3GlcAKeratan(1)-PRELP D2,4(S)2-BCAN GLB1L Heparan(3)-SDC2 HS(3)-SDC3 Keratan(4)-KERA HEXB(122-311) N-glycan OGN XylS-BGN chondroitin(2)-CSPG5 D2,4,4(S)3-CSPG4 B3GAT dimerschondroitin(2)-NCAN Heparan(2)-GPC6 HS(6)-GPC3 CD44 Heparan(3)-GPC2 SDC2 CSE-NCAN LYVE1 HS3ST5 HS(6)-SDC3 Heparan(3)-GPC4 UDP-GlcNAc, UDP-GlcKeratan(3)-OMD GlcA-Gal-Gal-Xyl-CSPG4 UDPGlcA-Gal-Gal-Xyl-GPC5 SLC35D2Heparan-SDC4 GlcA-Gal-Gal-Xyl-GPC1 SLC9A1:p-CHP:Ca2+UDP-Glc D2,4,4(S)3-CSPG5 XylS-AGRN(30-2045) HEXB(122-311) Heparan sulfatechain(3)HS(5)-GPC2 D2,4(S)2-DCN HS(6)-SDC2 HS6STschondroitin(3)-VCAN HS(1)-PGsHS(1)-PGs PAPSHS(4)-SDC1 KS(2)-ACAN 54, 88, 90, 150