Inositol phosphate metabolism (Homo sapiens)

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14, 15, 37, 39, 757, 454734, 474151, 7445, 675951, 74327, 4553, 592, 492234, 47194, 22, 747, 40, 45, 7252, 5824, 33, 41, 43, 44, 4813, 17, 22, 28, 35...7, 45, 721527, 16, 18, 40, 718, 31, 34, 4745, 7245, 67, 724, 22, 744, 18, 5724, 33, 41, 43, 44, 4830, 681534, 18, 5745, 67, 7227, 35, 5620, 644734, 4724, 33, 41, 43, 44, 4820, 6434, 4728, 35, 60, 625145, 6773, 745245, 67, 722217, 7319222245, 67, 7245, 7212, 21, 25, 29, 42...4524, 33, 41, 43, 44, 485, 6, 11, 38, 46...10, 27, 35, 5634, 474, 18, 5717, 73, 741673, 747, 45197, 16, 18, 4034, 47, 7422, 749, 26endoplasmic reticulum lumencytosolendoplasmic reticulum lumennucleoplasmNUDT3 PLCdeghOCRL PiATPITPKA IPMKMg2+ H2OMg2+ PLCE1 Mn2+ I3PINPP4B PiPiNUDT10 ATPI1PIP6K1/3I(1,3,4,6)P4INPP1 PLCG1 ADPH2ONUDT11 INPP1:Mg2+IPPKCa2+ (PP)2-IP4IPMKOCRL H2OPP-IP4PL(C)D4:3xCa2+1-PP-IP5 IPPKH2O3,5-(PP)2-IP4 I(1,3,4,5,6)P5MTMR7NUDT4:Mg2+/Mn2+ITPK1:Mg2+H2OIMPA2 H2OPLCB3 NUDT4 H2O5-PP-IP4H2OINPP4A/BNUDT10 PiH2OPPIP5K1 I(3,4,6)P3ATPI(1,4,5)P3Ca2+ I(1,3,4,6)P45-PPP-IP5IP6K1/3ATPPiNUDT11 MINPP1PLCD1 PiADPITPKC I(1,3,4,5,6)P5PLCbz1-PP-IP5 I(1,3,4,5)P4PiFe2+ PLCD3 IMPA1/2H2OIP6K1 (PP)2-IP4PLCB2 INPP5D Ca2+ NUDT3 ITPK1 INPP5A 1,5-(PP)2-IP4 1,5-(PP)2-IP4Glc6PI(1,3)P23-PP-IP4 IP6H2OATPMg2+ IP6PLCH2 ATPMn2+ ATPPiI(1,4)P2IP6K1 5-PP-IP4IP6K2 IP6K1 INPP5J Mg2+ MTMR91,5-(PP)2-IP3PLCG2 Mg2+ IMPA1 IP6K1/3NUDT(1)3-PP-IP5 IMPA2 INPP5(4)ATPIns3-PP-IP5 Ca2+ INPP4A Mg2+ Mn2+ ISYNA1 IP6K3 IMPA1 PiITPK1 PLCH1 NUDT11 NUDT3 DAGIP6K2 NUDT4 ADPH2OATPI(1,4,5,6)P4H2OPiMg2+ H2OIP6K1 INPP5J Mg2+ ATPOCRL INPP5B(321-993) PiADPATPINPP4A/BIP6K1/2DAG and IP3signaling5-PP-IP4 ADPITPKA/B/CI(1,3,4)P3NUDT3 PiPI(4,5)P25-PPP-IP55-PP-IP5H2OSYNJ1 1,5-(PP)2-IP3PiI(1,4,5,6)P4GlycosaminoglycanmetabolismCALM1 ATPADPInositolpolyphosphate5-phosphatasePLCB4 IP6K3 ADP1-PP-IP5H2OINPP5A/BMg2+ NUDT4 I(1,3,4,5,6)P5INPP5(3)/ITPK1ATPADPNUDT(1)I(1,4,5)P3I(3,4)P2ATPITPK1 ITPKB ATPNAD+ I(1,3,4,5)P4IP6K1/21,5-(PP)2-IP4H2OPLCB1 I(3,4,5,6)P4IPMKMTMR9 ATPI(1,4,5)P3IP6K2 1-PP-IP4 IP6K1/3PiPLCZ1 ATPNUDT(1)IP6K1 PPIP5K1/2Mg2+ NUDT11 1/3-PP-IP5H2OMTMR7 MIOX:2xFe2+ADPNUDT10 ADPMTMR7:MTMR9PI(4,5)P2ITPK1:Mg2+ADPINPP4B PTEN Mg2+ 3,5-(PP)2-IP4 ATPIP6K1 PiPiMINPP1Mg2+ I4PADPINPP4A Mg2+ Pi1,5-(PP)2-IP4 INPP5B(321-993) 5-PP-IP5IP6ADPINPPL1 SYNJ1 I(1,3,4,5)P4PiINPP1 ADPGlcAATPH2OI(1,2,4,5,6)P5ADPIMPA1/21-PP-IP5PLD4(1-762) ITPK1:Mg2+NUDT4 H2OMn2+ O2PPIP5K2 ITPK1 ITPK1:Mg2+NUDT4 ISYNA1:NAD+IP6K1 PTEN:Mg2+MIOX Mg2+ DAGITPK1 PiH2OH2O1/3-PP-IP5PLCD4 Mn2+ NUDT(1)ADPADPIP6K3 IP6K3 INPP1:Mg2+Mg2+ IP6K1/2ADPH+ADPH2OH2OADP1-PP-IP4ADPNUDT10 Pi3, 236119


Inositol phosphates (IPs) are molecules involves in signalling processes in eukaryotes. myo-Inositol consists of a six-carbon cyclic alcohol with an axial 2-hydroxy and five equatorial hydroxyls. Mono-, di-, and triphosphorylation of the inositol ring generates a wide variety of stereochemically distinct signalling entities. Inositol 1,4,5-trisphosphate (I(1,4,5)P3), is formed when the phosphoinositide phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is hydrolysed by a phospholipase C isozyme. An array of inositol trisphosphate (IP3) and tetrakisphosphate (IP4) molecules are synthesised by the action of various kinases and phosphatases in the cytosol. These species then transport between the cytosol and the nucleus where they are acted on by inositol polyphosphate multikinase (IPMK), inositol-pentakisphosphate 2-kinase (IPPK), inositol hexakisphosphate kinase 1 (IP6K1) and 2 (IP6K2), to produce IP5, IP6, IP7, and IP8 molecules. Some of these nuclear produced IPs transport back to the cytosol where they are converted to an even wider variety of IPs, by kinases and phosphatases, including the di- and triphospho inositol phosphates aka pyrophosphates (Irvine & Schell 2001, Bunney & Katan 2010, Alcazar-Romain & Wente 2008, York 2006, Monserrate and York 2010). View original pathway at:Reactome.


Pathway is converted from Reactome ID: 1483249
Reactome version: 66
Reactome Author 
Reactome Author: Williams, MG

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