Glycerophospholipid biosynthesis (Homo sapiens)

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37, 44, 85, 149, 178...54, 16057, 18710145, 69, 129, 19225, 94, 1892, 18815962, 87, 100, 185, 19923, 24, 64, 157, 20341, 83, 101, 115, 1524, 32206, 20825, 107, 18941, 83, 101, 115, 15239, 1361058, 7210127, 57, 63, 77, 109...1015210, 74, 15683, 101, 1527, 38, 48, 83, 101...6, 26, 19820, 53, 66, 88, 95...18656101, 105101175, 20050, 97, 15361, 195, 20720, 53, 66, 88, 95...6, 26, 41, 83, 101...1, 16646, 47, 143, 190101, 105103, 106, 123, 162, 176...27, 57, 63, 77, 109...83, 101, 15213, 10440, 110, 16543, 73, 89, 106, 113106, 176, 20062, 100, 185, 19935, 43, 73, 106, 113...4, 3252115, 20830, 68, 82103, 106, 123, 162, 176...175, 200169, 173566, 7, 26, 28, 41...20, 53, 66, 88, 95...14, 122, 20416355, 196, 20233, 10813330, 68, 82127, 155128, 147, 15810530, 68, 821013, 78, 99, 14660, 168, 17912243, 73, 89, 106, 11332, 85, 90, 117, 171...57, 187105150142, 19451, 80, 120, 16135, 43, 73, 106, 113...61, 19152, 67, 19722, 36, 49, 140, 18120675, 132, 2069, 29, 11110170, 205122, 2045, 1455683, 15215583, 101, 15213520, 53, 66, 88, 95...132101, 1165020, 53, 66, 88, 95...38, 42, 1051018133, 7112534, 91, 121, 15962, 100, 185, 19915, 79, 11431, 183148, 164, 18452, 67, 19712583, 101, 1522, 1810117, 141, 146, 151, 18013750, 97, 1532119, 25, 43, 65, 92...16, 59, 131, 17410183, 15211, 13812, 93, 98, 14420, 53, 66, 88, 95...75, 206106, 176, 20041, 101, 116102, 11930, 68, 8284, 11858, 76late endosome lumenmitochondrial intermembrane spaceperoxisomal matrixendoplasmic reticulum lumencytosolmitochondrial matrixGolgi lumenmitochondrial matrixmitochondrial intermembrane spacePLD1/2PLA2G4CCDS1:Mg2+H2OLIPH, ICasein kinase IILCFA(-)PLA2(2)Ca2+ Mn2+ PTDSS2GlycerolGPChoPCTP PC:PITPNBPLA2G12A LPCAT1 PLA2G4A LysoPtdCho2-MAGMIGA2 LPCAT3 PETAMg2+ PLD2 2-acyl LPEPLA2G4B ACHE PLA2G4B PLA2G4D PLA2G4D ETACa2+ LPCAT2 H2OHADHA LPCATPC Ca2+ PLA2G4B PLA2(11)Mn2+ PLA2G4D PLA2G3 H2OPLA2(15)H2OCoA-SHAGPAT3 PLA2G2A PLA2(7)CDS1 EPT1 RCOOHALPI:2Ca2+:Mg2+dimerH2OPLA2G4CAGPAT5 PLD1 1-acyl LPCPTPMT1GPChoCa2+ PI4PDDHD2 L-SerPC PEMTSTARD10 ACP6Na+acyl groupMIGA1 AGPAT6 PC:PITPNBDGAT1 PLA2G10 acyl-CoA1-acyl LPSPTDSS1CPNE6 PCYT1B acyl-CoAPLA2G2D AGK:Mg2+H2OPITPNB MFSD2APLA2G5 PLA2G4F LIPI CoA-SHPLA2G2D CoA-SHH2OPAG3PAWAT2fatty aldehydeacyl-CoACa2+ LPCAT3 ETASTARD10PL CHKA PNPLA8 PLA2G4D LPCAT1 LPCAT3 1-acyl LPAPLA2G4B PLA2G2A PLA2G2A LPCAT3 PLBD1 Ca2+ PLA2(1)1-MMGHRASLSNH3Mg2+ CDIPT:Mg2+/Mn2+AGPAT1 LPGAT1 ALPI CHK/ETNKETNK2 H2OH2OGPCHO, GPETAMPLA2G4A LPCAT1 acetateMYS-LPAH2OCTPCoA-SHCDIPT LCFA(-)H2OMAGCHKA TMEM86BMLCLPITPNB Mn2+ Ca2+ PI4PPC OSBPL5,8,10OSBPL5 PLA2G2E GPAM/GPAT2PLA2(8)AdoMetPIPSNAD+FADPLA2G4F Mg2+ PLA2(12)H2OGPD1/GPD1L homodimerLCFA(-)CPNEs:PLHRASLS5 MBOAT1 PLA2(8)PLA2G10 PC H2OCoA-SHLCFA(-)cytidine5'-monophosphateMn2+ H+PLA2G4F Mg2+ STARD10 MBOAT2 PPiPLA2G6PLA2G4F PGS1AcChoPLA2G4A LCFA(-)GPAM(1-828) PLA2G2D acyl-CoAPLA2G4E 1-acyl LPELPGAT1 Zn2+ PETADGAT2L6,L7PPITPNM2 LCFA(-)LCFA(-)PLA2G1B Ca2+ CholinesteraseH2OPLA2G4E L-SerH2OPLA2G2F AlcoholPLA2G4E PLA2G4B PLA2(16)PLA2G16 PILPC (22:6)PLA2G4E H2OPAcytidine5'-monophosphateCDP-DAGCa2+ CH3CHOPECHATPLA2G4CMBOAT2 CoA-SHCa2+ PC BMPPLA2G2A DHAPPA DLCLLCFA(-)PLA2G4E CDP-DAGMAG,DAGPIPNPLA2/3ETNK1 CEPT1/EPT11-acyl LPIG3PLPCAT4 Ca2+ PA1-acyl LPCPLA2G2F PLA2G4D ADPphosphate monoesterDGAT2L7P PSPLA2G2A PLA2(14)PLA2G4A STARD10:PCDHAPMAG Ca2+GlycerolPLA2G4D PLA2G2F LPCAT1 LPCAT2 MLCLPLA2G4A PLA2G2A G3PLCFA(-)PLA2G2A PHOSPHO1 1-acyl LPEChoLCFA(-)fatty acidGO3PPLA2G4A H2OTAZAGPAT4 acyl-CoAPLA2G6 PLA2G4F H2OCoA-SHPLA2(6)Ca2+ ETNPPL PLA2G4F PI PLA2G2A:Ca2+AGPAT5LPINLCLAT1 PLA2G4A PLA2G12A LCLAT1PLD1-4/6PLA2G4A acyl-CoAacyl-CoAPi1-acyl LPGPLA2G2D LPCAT4 Ca2+ STARD7:PCCLH2OcardiolipinLPCAT3 AGK 2-acyl LPACoA-SHLCFA(-)PPiPLA2G2E FADH2PLA2(16)H2OGlycerolSTARD7:PCChoPLA2G6 PLA2(5)1-acyl LPSCoA-SHH2Ocytidine5'-monophosphatePGPH2OAGPAT6LPC(14:0)PLA2G15CEPT1 CSNK2B MBOAT1 PMETAM DAGPITPNM1,2,3Mg2+ STARD7 GPETAM PLA2G4A PLA2G4F PLA2G4F PLA2(3)Ca2+ MBOAT7cytidine5'-monophosphatePCCPNE3 CPNE1 HRASLS2 LPIN2 Ca2+ LPCAT1PLA2G2E CDP-ChoLPEATPiBCHE PLD3 PLA2(1)PISD:PyruvoylDDHD1 PNPLA2 LPSATHADH octamerPISD(1-377) SLC44A1 CPNE1 PIPChoPLA2G4B PLA2G4D MIGA complexesPMCHO PLA2G2F ATPChoSLC44A3 MGLL dimerMBOAT2 LPCAT4 lysoPCPGLPA,PAPLA2G5 LCFA(-)PLA2G1B PLA2G3 CTPPITPNM3 LPA H2OADPH2OPLA2G10 ADPH2ORARRES3 PCYT1 dimerPG2-acyl LPCacyl-CoAp-S284-STARD102-acyl LPGDLCLPMCHO, PMETAMPLA2G5 Ca2+ HRASLS acyl-CoAChoNAPEPLA2G4D PLA2G4CH2OPALPEATPLD4 PGMBOAT1 PLA2G4F PLA2R1(21-?)PLA2(9)Ca2+ PECoA-SHMGLL Ca2+ HADHB PLA2G4D PLBD1 PCPLB1PGacyl-CoAPLA2G2F LPCAT1 cardiolipinPLD2 LPIN1 Mg2+ CoA-SH1-acyl LPAH2ODDHD1,2H2OLPCAT1 PC CEPT1:Mg2+/Mn2+InsCHPT1 AGPATCa2+ PLA2(4)CEPT1 PPiH2OTAGMBOAT71-acyl LPGGPETAPI:PITPNBPLA2GLPGATPLA2G4B LPCAT4 CDP-ETAPiPLA2G12A LCFA(-)H2OCoA-SHPLA2G4B PLA2G4A:Ca2+PCYT2 dimerPLA2G2A:Ca2+acyl-CoA2-acyl LPSPITPNM1 PLA2G4A GPD2PLA2G16 SLC44A5 AGPAT2 PEPLA2G4D PGNADHPLA2(15)PLBD1 H2ODGAT2 PCTP:PCH2OGPAEAPNPLA3 LPCATPLA2G12A PSPEPPiPLA2G2A Na+LPIN3 LCFA(-)H2OPEGPCHO PIH2OPLA2G4F LPCAT4 ABHD4PLA2G5 ETAAcyl-CoAPLA2G16 CoA-SHLPSATPSPLA2G4D Mg2+ H2OAc-CoASTARD7DGAT2L6 G3PABHD3CSNK2A2 CHKB LPCAT4 PITPNB PLA1APiCa2+ PCTPCoA-SHPLA2G4A PCPLD6 CPNE6 acyl-CoALPCAT4 ChoCDS22-acyl LPSPLA2G16 LCFA(-)GPCPD1AcChoPLBD1 GPD1L ChoPGDAG PLA2(13)PLD1 MBOAT2 H2OCTL1-5CoA-SHPLA2(1)PLA2G2F 1-acyl LPIPLA2G4C 1-acyl LPEPLA2G4E GPAT2 GNPATAGPAT9 LIPH PHOSPHO1:Mg2+1-acyl LPGLCFA(-)STARD7 PLA2(10)GlycerolPNPLA8 LCFA(-)CRLS1PI:PITPNBMg2+ PLA2G2A PLA2G2A PLBD1 PLA2G4A Ca2+ LCFA(-)SLC44A2 Ca2+ LPGATPCYT2 PCH2OLCFA(-)LPC (22:6)PI PLA2G4D Ca2+ 1-acyl LPCETNPPL tetramerPC CoA-SHLCFA(-)PLA2G4B CTPCHPT1:Mg2+/Mn2+STARD10:LPCAT1:PCPLA2G4E PLA2G1B PLA2G4F ADPATPCHKB acyl-CoAacyl-CoAMBOAT1 LPCAT4 PLA2G4D PCYT1A CSNK2A1 PLA2G4CPLA2G2E PITPNB CPNE7 acyl-CoAOSBPL8 acyl-CoACO2cytidine5'-monophosphateDAGCa2+ PLD6 dimer2-acyl LPIPLA2G4D AdoHcyPLA2G1B LPCAT3 ATPPLA2G4C GPD1 PCPiLCFA(-)PLPyruvoyl PLD6 PLA2G4D ATPLPCAT4 PCDGAT1/2DAGCRLS11-acyl LPAOSBPL10 PLA2G16 2-acyl LPGPLA2G2A:Ca2+PLA2G2F PLA2G4A PISD(378-409) PGCPNE7 SLC44A4 PLA2G4B PLA2G10 H2OCHK dimerCPNEsCPNE3 1AGPCcytidine5'-monophosphate15586, 155