RAF/MAP kinase cascade (Homo sapiens)

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14, 147, 155, 190, 206...171, 194, 21436, 40, 17612, 16, 49, 77, 90...3332, 40, 51, 74, 77...108, 110, 150, 158, 231...267, 27622, 224, 28322, 224, 2836, 77, 87, 88, 102...17, 83, 199, 29196, 104, 11268, 221, 25170, 109, 2663359, 63, 78, 88, 117...27, 51, 52, 70, 88...8, 20, 32, 101, 102, 105...24, 77, 82, 86, 192...77, 190, 217, 28235, 38, 42, 80, 114...75, 91, 97, 144, 168...174, 245, 270, 28329, 2069, 95, 133, 25024, 77, 82, 86, 192...3311, 18, 85, 92, 127...1531, 31, 37, 52, 57...70, 109, 26629, 77119, 190, 223, 22816, 70, 109, 27296, 104, 11295, 133, 25077, 13289, 161, 262153, 169, 210, 22043, 68, 73, 77, 25113, 39, 53, 111, 129...51, 70, 77, 101, 146...33, 29434, 64, 75, 91, 97...95, 133, 250plasma membraneplasma membraneplasma membranenucleoplasmplasma membraneendosome lumenGolgi lumencytosolp-S222,S226-MAP2K2 dephosphorylated"receiver" RAF/KSR1PPP2R1B ARRB2 MAP2K2 p-Y427-SHC1 p-5Y-FRS3 SPRED3 p-S445,T599,S602,S729 BRAF JAK2 WDR83 APBB1IP CNKSR2 FGA p-S338,Y341,T491,S494,S621 RAF1 p-S576 ARAF p-T,Y MAPKs V600E BRAF splicevariantsFGG p-Y349,Y350-SHC1 ITGA2B(32-1039) FGA ARRB2 HS PSMC6 p-S218,S222-MAP2K1 p-2S MAP2K homo/heterodimers p-8Y-FGFR1b p-S311,Y552 KSR1 FGF17-1 p-S311 KSR1 MAPK1 p-S218,S222-MAP2K1 Ca2+ H2ORAS GAPsGalNAc-T178-FGF23(25-251) VWF(23-763) p-S311 KSR1 YWHAB Q61R NRAS GDNF PSMD14 Neurotransmitterreceptors andpostsynaptic signaltransmissionF-actin V600E BRAF V169_M438del p-7Y-KIT FGB p-S576 ARAF UBC(457-532) p-5Y-FGFR4 RAP1B p-S214,S576 ARAF Q61K HRAS p-Y-IRS1 G12S HRAS VWF(23-763) BRAF PPP2R1A G12C KRAS IQGAP1 p-Y239,Y240,Y317-SHC1-2 p-S299,S302,T452,T455,S576 ARAF NRAS T58I KRAS Autophosphorylated FLT3 Q61L NRAS LAMTOR3 KRAS p-S,218, S222,T292 MAP2K1 KSR2 p-S299,S302,T452,T455,S576 ARAF RAP1A MAPK3 PSMD4 FGG p-S311 KSR1 UBC(153-228) PiNRAS p21RAS:GTP:activatedRAF1homo/heterodimerp-S445,S729-BRAF p-S222,S226-MAP2K2 NCAM1 p-S338,Y341,T491,S494,S621 RAF1 p-S218,S222-MAP2K1 WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complexPSMB9 Signaling by the BCell Receptor (BCR)SPTAN1 JAK3 G13D KRAS p-T202,Y204-MAPK3 HRAS KRAS NEFL DLG1 ARRB2 YWHAB ATPp-S338,Y341,T491,S494,S621 RAF1 p-S218,S222-MAP2K1 MyrG,p-Y530-SRC SPRED3 p-S365,S445,S729 BRAF p-T,Y MAPK dimers CAMK2B dephosphorylatedinactive RAFS:YWHABdimerSYNGAP1 p-S214,S576 ARAF UBC(77-152) high kinase activityBRAF mutantsFN1(32-2386) ITGA2B(32-1039) Mn2+ BRAF 599dupT MARK3 p-S311 KSR1:MARK3p-S445,T599,S602,S729 BRAF RAP1B Activated FGFR2b homodimer bound to FGF HBEGF(63-148) Mg2+ YWHAB V600E BRAF V47_D380del CAMK2D activatedRAF:scaffold:p-2SMAP2K:MAPK complexp-S222,S226-MAP2K2 F595L BRAF UBC(229-304) p-S311,Y552 KSR1 p-S311,Y552 KSR1 activatedRAF:scaffold:MAP2K:MAPK complexCSK PSMC4 YWHAB MARK3 PTPRA KSR2 PEBP1 MAP2K1 GDPV600E BRAF Mg2+ YWHAB p-S218,S222-MAP2K1 Signaling by FGFR2CAMK2G PDGFB (82-190) p-S299,S302,T452,T455,S576 ARAF CNKSR2 TLN1 p-T185,Y187-MAPK1 ATPp-S299,S302,T452,T455,S576 ARAF PiPSME2 RASA2 F595L BRAF Mn2+ SPRED dimer:NF1vemurafenib SPRED1 RAP1A E586K BRAF p-S311 KSR1 PSMB8 ARRB2 dephosphorylatedinactive RAFsQ61L NRAS PDGFA-1 LAMTOR2 Signaling by ERBB4MAP2K1 APBB1IP MyrG,p-Y530-SRC MAPK1 p-S338,Y341,T491,S494,S621 RAF1 RASA3 UBA52(1-76) V14I KRAS p-6Y,Y1112-ERBB2 E586K BRAF GRIN2B ATPp-11Y-PDGFRA PPP2CA KSR1:MARK3FN1(32-2386) NRAS PI(4,5)P2 RASA2 PP2AV600E BRAF V47_D380del PSMC1 FGF6 Mg2+ VCL ATPARRB1 MAP2Khomo/heterodimersUBC(77-152) p-S445,T599,S602,S729 BRAF LRRC7 H2OCNKSR2 F-actin KRAS YWHAB IQGAP1 MAPK3 HRAS MARK3 FGF1 p-S311 KSR1 p-T202,Y204-MAPK3 ANGPT1 RASGEF1A MyrG,p-Y530-SRC p-S311,S406 KSR1 TLN1 p-S299,S302,T452,T455,S576 ARAF p-S299,S302,T452,T455,S576 ARAF MAPK1 HRAS KRAS PPP5CHRAS p-T,Y MAPK dimers CSK PI(4,5)P2 PPP2R5B PPP2R5E UBC(153-228) MAP2K2 KRAS RASA1 Interleukin-2 familysignalingNRAS p-T,Y MAPK dimersADPp-S311KSR1:MARK3:YWHABdimerNRAS SPTBN2 PSMA6 p-S621-RAF1 p-G464E BRAF DUSP1 Q61K NRAS p-S311,Y552 KSR1 DUSP10 ADPVCL p21RAS:GTP:dephosphorylated RAF1 homo/heterodimerLAMTOR2 KRAS GTP NF1(2-2839) FGB cytosolic MAPK DUSPsp-T,Y MAPKsYWHAB p-S365,S445,S729 BRAF FGF3 p-S445,S729-BRAF Q61R NRAS mutantRAS:GTP:p-RAF:p-2SMAP2Ks:p-T,YMAPKs:scaffoldproteinsPip-6Y-PTK2 Signaling by Type 1Insulin-like GrowthFactor 1 Receptor(IGF1R)p-S299,S302,T452,T455,S576 ARAF ub-BRAP V600E BRAF V169_M438del p-S338,Y341,T491,S494,S621 RAF1 Ca2+ UBC(533-608) PPP2R5B p-Y239,Y240,Y317-SHC1-2 p-E586K BRAF V600E BRAF V47_M438del RASA4 HRAS G13R HRAS p-S445,T599,S602,S729 BRAF FGB RASGRF1 Q61K HRAS p-S299,S302,T452,T455,S576 ARAF p-T202,Y204-MAPK3 GFRA3 MARK3 p-S338,Y341,T491,S494,S621 RAF1 V14I KRAS NCAM signaling forneurite out-growthVCL p-S299,S302,T452,T455,S576 ARAF GTP H2OGTP TLN1 PSMD5 p-T,Y MAPKs p-S338,Y341,T491,S494,S621 RAF1 PEA15BRAP p-S222,S226-MAP2K2 PiMAPK1 p-8Y-FGFR1c p-T185,Y187-MAPK1 p-S621-RAF1 p21 RAS:GTPSOS1 UBC(229-304) p-T133-RASGRP3 RASAL2 ITGA2B(32-1039) PSMC2 ADPH2OUBB(1-76) p-Y194,Y195,Y272-SHC1-3 Q61K HRAS KSR2 Signaling by PDGFGTP MAPKsGTP nuclear MAPK DUSPsPhosphorylated p-6Y-ERBB2 heterodimers RASAL1 p-G464E BRAF RAP1B p-6Y-FRS2 PAQR3PSMA1 PSMA5 Signaling by Insulinreceptorp-S445,S729-BRAF PSMD1 GRIN1 GTP DUSP8 ATPG12D NRAS DAB2IP PSMD9 p-S311 KSR1 NRAS CNKSR1 Activated FGFR2c homodimer bound to FGF PI(4,5)P2 CSK GTP KRAS MARK3 UBB(153-228) KL-1 p-7Y,Y1112-ERBB2 TLN1 ADPARRB2 KSR1 SPRED2 SPTBN5 MARK3 EGF KSR2 Ca2+ ADPp-V600K BRAF MyrG,p-Y530-SRC G13R HRAS BRAF 599dupT p-Y-JAK1 p-L597V BRAF L597V BRAF ATPDUSP5 KRAS PPP2R5C G13R HRAS H2OYWHAB IL17RD ITGA2B(32-1039) p-S338,Y341,T491,S494,S621 RAF1 DUSP9 UbGRB2-1 G12S HRAS p-S445,T599,S602,S729 BRAFRANBP9 CNKSR1 Mg2+ GFRA4 GTP YWHAB p-S445,T599,S602,S729 BRAF p-S311,Y552 KSR1 RASGRF2 G13D NRAS p-Y-IRS2 KSR2 V600E BRAF V47_M438del p-S311 KSR1 p-Y364,Y418,Y536-IL2RB p-S445,T599,S602,S729 BRAF PSMB5 p-5Y-RET RASAL1 PSMF1 UBB(77-152) p21RAS:GTP:'activator'RAF:YWHAB dimerYWHAB p-S311,Y552 KSR1 p-S621-RAF1 p-S338,Y341,T491,S494,S621 RAF1 PSMD7 RAP1A CNKSR2 RAP1A PPP2R5D DUSP7 CUL3 FLT3LG GDP RAP1B YWHAB BRAPp21 RAS:GTP:ub-BRAPMAPK3 FN1(32-2386) PSMB3 LAMTOR2 p-S445,T599,S602,S729 BRAF UBB(153-228) NRTN VWF(23-763) GTP UBC(609-684) kinase dead BRAF mutants F-actin G12D KRAS V14I KRAS LAMTOR3 p-S311,Y552 KSR1 p-S299,S302,T452,T455,S576 ARAF PSMB6 p-Y1172,Y1226-ERBB4 JM-A CYT-2 isoform p-T202,Y204-MAPK3 Signaling by SCF-KITPSMB4 FN1(32-2386) p-S445,S729-BRAF p-S338,Y341,T491,S494,S621 RAF1 Q61K NRAS G12V KRAS IL17RD:p-2SMAP2Ks:MAPKsp21RAS:GTP:activatedRAF1homo/heterodimer:PEBP1Ca2+ RASGRF2 p-S218,S222-MAP2K1 p-S445,T599,S602,S729 BRAF Q61K HRAS H2OUBC(457-532) PSMC3 PEA15 High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 p-T202,Y204-MAPK3 p-S445,S729-BRAF MARK3 SPRED2 F-actin MyrG,p-Y530-SRC IL2RG Signaling by FGFR4Q61L HRAS KBTBD7 HRAS FGG p21 RAS:GTP:BRAPKL-2 Fc epsilon receptor(FCERI) signalingp-T,Y MAPK monomersand dimersCAMK2A SPRED dimer:ub-NF1Cell surfaceinteractions at thevascular wallBRAF inhibitors:highkinase activityBRAF mutantsCNKSR2 RAS:GTP:inactivep-RAF:p-2SMAP2Ks:p-T,YMAPKs:scaffoldproteinsACTN2 VWF(23-763) YWHAB MAPK1 G12V HRAS G13D KRAS p-S259,S621-RAF1 V600K BRAF ARRB1 ITGB3 RAP1A G13D NRAS FGA ITGB3 p-T184-RASGRP1 PP2AKRAS HRAS CSK p-S338,Y341,T491,S494,S621 RAF1G12V HRAS KLB p-S338,Y341,T491,S494,S621 RAF1 KRAS FGA p-T,Y MAPK monomersand dimersCALM1 MAPK3 p21 RAS:GTP:RAS GAPsRASGRP4 HRAS CSK BRAP APBB1IP YWHAB G13D NRAS p-S338,Y341,T491,S494,S621 RAF1 p-S222,S226-MAP2K2 p-S621-RAF1 p-S222,S226-MAP2K2 NRAS YWHAB GFRA2 FGF10 p21RAS:GTP:p-S621RAF1homo/heterodimerFGA Signaling by EGFRFGF20 p-S445,S729-BRAF CSK G469A BRAF RAP1B MARK3 G12S NRAS FGF23(25-251) p-T202,Y204-MAPK3 p-S365,S445,S729 BRAF GTP V600E BRAF V169_M438del p-S218,S222-MAP2K1 NRAS Mn2+ RASAL2 Q61L HRAS FGF18 MAPK3 HRAS p-S311,Y552 KSR1 V600E BRAF splicevariant dimerVWF(23-763) PAQR3 p-T185,Y187-MAPK1 G12C KRAS Q61R NRAS G13D KRAS p-2S,T MAP2K1:p-2SMAPK2K2 heterodimerG12V KRAS DUSP16 FGA dabrafenib mesylate PDGFB(82-241) kinase dead BRAF mutants HRAS p-S299,S302,T452,T455,S576 ARAF V600E BRAF NRAS MARK3 PSMD8 PSMB7 Mn2+ IL17RDp-S445,T599,S602,S729 BRAF p-S445,T599,S602,S729 BRAF p-S311,Y552 KSR1 V600E BRAF V169_M438del p-S311,S406KSR1:MARK3CNKSR1 CNKSR2 YWHAB WDR83:LAMTOR2:LAMTOR3ADPp-Y419-SRC UBC(1-76) ADPSPRED1 SPRED2 p-T185,Y187-MAPK1 PPP2R1A KRAS PEBP1SYNGAP1 RAP1B G12C KRAS UBC(609-684) CSK p-S445,S729-BRAF p-S218,S222-MAP2K1 GRIN1:GRIN2A,C,D di-heteromers,GRIN1:GRIN2 tri-heteromers p-6Y-EGFR p-S445,T599,S602,S729 BRAF DAB2IP G12C KRAS DLG2 HGF(495-728) VCL BRAP:KSR1:MARK3p-ERBB4cyt1 homodimers NRAS FGF8-1 KSR2 hyperphosphorylatedBRAFRAP1A TLN1 MyrG,p-Y530-SRC APBB1IP p-T,Y MAPKs p-S445,S729-BRAF Signaling by FGFR1FGF9 KRAS HGF(32-494) RAP1B DLG4 Ca2+ APBB1IP D153V KRAS MAP2K2 mutantRAS:inactiveBRAF:p-S338,T491,S494,S729 RAF1WDR83 PiPSMA3 p-S445,S729-BRAF D153V KRAS YWHAB ARRB1 p-S299,S302,T452,T455,S576 ARAF PLX-4720 Ca2+ MAPK3 p-S311,Y552 KSR1 p-2S MAP2Khomo/heterodimersp-T,Y MAPK dimers GTP RASA4 IL17RD FGB PI(4,5)P2 p-S338,Y341,T491,S494,S621 RAF1 PI(4,5)P2 V600E BRAF V169_D380del VCL p-S222,S226-MAP2K2 MARK3 NRAS p-S311,Y552 KSR1 Mg2+ SPRED2 Q61H KRAS MARK3 G12D NRAS FGF4 inactive RAFsp-S445,T599,S602,S729 BRAF PSMC5 ITGA2B(32-1039) p-S338,Y341,T491,S494,S621 RAF1 p-S311,Y552 KSR1 IQGAP1 PSMB10 FN1(32-2386) p-T202,Y204-MAPK3 APBB1IP T58I KRAS G12V HRAS p-S338,Y341,T491,S494,S621 RAF1 PSME1 V600E BRAF V47_D380del GTP FGF19 KRAS p-S311 KSR1 GTPYWHAB KRAS CNKSR1 p21RAS:GTP:homo/heterodimerized RAF complexNF1(2-2839) p-S445,S729-BRAF PPP2R1B ATPRPS27A(1-76) PSMA8 BRAF YWHAB HRAS PiQ61L HRAS PLX-4720 CNKSR1 p-S218,S222-MAP2K1 PPP2R5A RAF/MAPK scaffoldsG12D KRAS G12V KRAS G12S NRAS SPTB ITGB3 p-S338,Y341,T491,S494,S621 RAF1 Signaling by ERBB2p-S445,T599,S602,S729 BRAF p-S576 ARAF G12D KRAS G13D KRAS p-2S MAP2K1:p-2SMAPK2K2 heterodimerMARK3 PAQR3:inactive RAFsITGB3 PPP2CB PSMB2 Mn2+ PDGFA-2 SPTBN1 p-S576 ARAF Q61R HRAS p-F595L BRAF SPTBN4 MyrG,p-Y530-SRC ARRB2 Mn2+ ARTN p-S338,Y341,T491,S494,S621 RAF1 GTP p-Y317-SHC1-2 p-Y-SHC2 p-S338,Y341,T491,S494,S621 RAF1 FGF22 highkinaseactivityBRAFmutants:scaffold:p-2S MAP2K:p-T,Y MAPK complexIL2 NRAS V600E BRAF HRAS Ca2+ MAPK monomers anddimersp-S214,S576 ARAF p-E586K BRAF Q61K NRAS Q61H KRAS SPRED dimerRAP1B NF1(2-2839)p-S299,S302,T452,T455,S576 ARAF MARK3 NF1(2-2839) activated RAFhomo/heterodimerFGF16 RAS GEFsp-S222,S226-MAP2K2 activatedRAF:scaffold:p-2SMAP2K:p-2T MAPKcomplexHRAS Phosphorylated ERBB2:ERBB4cyt1 heterodimers p-S218,S222-MAP2K1 p-S222,S226-MAP2K2 DAP12 interactionsG13D NRAS p-S299,S302,T452,T455,S576 ARAF T58I KRAS Mn2+ p-S621-RAF1 MAPK1 p-S311,Y552 KSR1 FGG p-S445,T599,S602,S729 BRAF IQGAP1 RASAL3 CNKSR2 p-S445,S729-BRAF p-S445,T599,S602,S729 BRAF p-S338,Y341,T491,S494,S621 RAF1 PSME4 WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complexG12V HRAS G469A BRAF G464E BRAF L597V BRAF p-S445,T599,S602,S729 BRAF p-6Y-FGFR3b Phosphorylated p-Y877-ERBB2 heterodimers PSMA2 KRAS p-S311,Y552 KSR1 ARRB1 G12D NRAS ITGB3 FN1(32-2386) RASA1 PSMD6 Q61H KRAS PI(4,5)P2 p-S445,T599,S602,S729 BRAF Interleukin-3,Interleukin-5 andGM-CSF signalingp-T202,Y204-MAPK3 CNKSR2 RAP1A MAP3K11p-S299,S302,T452,T455,S576 ARAF Mn2+ 'activator'RAF:YWHAB dimerG12V KRAS ITGB3 p-S445,T599,S602,S729 BRAF DUSP8 FGB Q61L NRAS ARRB2 p-S338,Y341,T491,S494,S621 RAF1 FGB p-S311 KSR1 SPRED1 GTP SPTA1 Mg2+ ADPNRAS ITGB3 KSR1 FGG IQGAP1 ARRB1 p-S445,S729-BRAF PSPN GTP YWHAB p-S311,Y552 KSR1 UBC(1-76) p-S311 KSR1 NRAS BRAF 599dupT GTP FN1(32-2386) p-12Y-PDGFRB PSMB11 HRAS IQGAP1 HRAS ATPVWF(23-763) 26S proteasomep-S311 KSR1 p-S445,T599,S602,S729 BRAF PPP2R5E p-S299,S302,T452,T455,S576 ARAF Signaling by FGFR3G12S HRAS PSMD11 RBX1 p-S445,T599,S602,S729 BRAF p-S445,T599,S602,S729 BRAF IQGAP1 V600E BRAF V169_D380del DUSP2 BRAF inhibitorsF-actin MARK3 KBTBD7:CUL3:RBX1V600E BRAF V47_D380del p-S338,Y341,T491,S494,S621 RAF1 p-S222,S226-MAP2K2 PSMA4 SHFM1 PPP2R5D MARK3 p-5Y,S1119-TEK FGB RASGRP1 V600E BRAF V47_M438del p-S338,Y341,T491,S494,S621 RAF1 G12D NRAS Q61K NRAS FGA Phosphorylated ERBB2:ERBB4cyt2 heterodimers p-Y-SHC3 IL17RD:p-2SMAP2Ks:p-T,Y MAPKsT58I KRAS Gly D153V KRAS NRAS p-T185,Y187-MAPK1 RAF activatingkinasesPHBUBC(381-456) CNKSR1 VCL p-S311,Y552 KSR1 p-S338,Y341,T491,S494,S621 RAF1 p-S299,S302,T452,T455,S576 ARAF PSMD12 KRAS Neuregulins p-S299,S302,T452,T455,S576 ARAF G12S NRAS p-S218,S222-MAP2K1 FGF2(10-155) EGF-like ligands HRAS p-S338,Y341,T491,S494,S621 RAF1 YWHAB IQGAP1 NRAS p-T,Y MAPK monomersand dimers:PEA15ub-NF1(2-2839) p-S299,S302,T452,T455,S576 ARAF p-S445,S729-BRAF UBA52(1-76) V600E BRAF V47_D380del Mg2+ RASA3 p-S311,Y552 KSR1 V14I KRAS G469A BRAF PI(4,5)P2 Signaling by NTRK1(TRKA)p-S311,S406KSR1:MARK3:YWHABdimerKSR2 APBB1IP Q61R HRAS PPP2CB KITLG-1(26-190) ITGA2B(32-1039) LAMTOR3 HRAS DUSP16 PSMD13 FGG G12S NRAS ITGA2B(32-1039) MAPK1 MAPK3 YWHAB dimerp-S338,Y341,T491,S494,S621 RAF1 PI(4,5)P2 KRAS p-V600K BRAF G12D KRAS p-S338,Y341,T491,S494,S621 RAF1 SPRED3 Q61R NRAS DUSP10 V600E BRAF V169_D380del Ca2+ GTP p-L597V BRAF p-S338,Y341,T491,S494,S621 RAF1 PPP2CA p-T202,Y204-MAPK3 RAS:GTP:moderatekinase activityp-RAF:p-2SMAP2Ks:p-T,YMAPKs:scaffoldproteinsV600E BRAF V47_M438del PPP2R5A p-S445,S729-BRAF CNKSR1 FN1(32-2386) p-S338,Y341,T491,S494,S621 RAF1 GTP V600E BRAF V169_D380del PLX-4720 CNKSR1 UbUBC(533-608) p-S299,S302,T452,T455,S576 ARAF p-T185,Y187-MAPK1 p-5Y-LAT-2 p-F595L BRAF Mg2+ DLG3 V600E BRAF V47_M438del FGG VWF(23-763) SPRED3 DUSP4 MAPK monomers anddimersPLX-4720 UBC(381-456) p21RAS:GTP:activatedRAFhomo/heterodimersL-Glu RAS:GTP:moderatekinase activityBRAFmutants:p-RAF:YWHABITGA2B(32-1039) p-S445,S729-BRAF F-actin p-Y-SHC1 p-S259,S621-RAF1 RAPGEF2 GTP PSMD10 ARRB1 FGG CSK SPRED1 PSMD3 VCL UBB(77-152) MAP2K1 PPP2R5C p-Y1234,Y1235,Y1349,Y1356-MET WDR83 p-S311 KSR1 Q61R HRAS Q61L NRAS p-S299,S302,T452,T455,S576 ARAF p-T185,Y187-MAPK1 ARRB1 p-S222,S226-MAP2K2 inactive RAFs:YWHABdimerUBC(305-380) dabrafenib mesylate YWHAB UBB(1-76) NRAS GTP ITGB3 p-S445,T599,S602,S729 BRAF p-6Y-FGFR3c RPS27A(1-76) FGA YWHAB SPRED1 TLN1 FGF5-1 F-actin p-Y420-FYN p-S338,Y341,T491,S494,S621 RAF1 VCL p21RAS:GTP:activatedRAFhomo/heterodimercomplexesYWHAB p-Y341,T491,S494,S621 RAF1 p21 RAS:GDPARRB1 KRAS MARK3 Ca2+ VWF(23-763) p-S259,S621-RAF1 p-T185,Y187-MAPK1 D153V KRAS UBC(305-380) DAG hyperphosphorylatedRAF1GTP DUSP6 TLN1 MARK3 NRAS GTP vemurafenib Q61H KRAS p-S311,S406 KSR1 MAPKs G13R HRAS SPRED2 p-Y349,Y350,Y427-SHC1 PSMB1 HRAS SPRED3 V600E BRAF V169_D380del FGB MyrG,p-Y530-SRC Q61R HRAS TLN1 PSMA7 RASmutants:GTP:p-RAFhomo/heterodimerp-T185,Y187-MAPK1 RASAL3 GTP ARRB2 APBB1IP V600K BRAF F-actin GFRA1 V600E BRAF V169_M438del PSMD2 G464E BRAF MARK3 IL2RA G12S HRAS p-S445,T599,S602,S729 BRAF RAP1A PSME3 KSR2 p-S222,S226-MAP2K2 Q61L HRAS 138, 28721, 79, 98138, 287281181181138, 28776, 113, 124, 182, 183, 189...281138, 287181138297212138, 2872511814181138, 287181116138, 2873, 5, 7, 26, 28...1814, 286271290138, 287138, 287181138, 287181131, 175, 233, 242138, 287138, 287181138, 28720555, 65, 19654, 208, 232, 277, 295137181138, 287138, 287138, 287138, 28719, 66, 128, 136, 207...181138, 287138, 2871812, 10, 45, 48, 58...84, 14271, 15223, 81, 123, 198181138, 287181251109192138, 28776, 113, 124, 182, 183, 189...138, 28776, 113, 124, 182, 183, 189...18115, 103156, 186, 188, 226, 268...18118125, 60, 162, 200, 249...205281138, 287138, 287138, 287181138, 28750, 62, 159, 284, 299...18115, 10376, 113, 124, 182, 183, 189...181138, 287138, 287