RAF/MAP kinase cascade (Homo sapiens)

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11, 52, 55, 65, 80...323, 32871, 118, 38518, 21, 227, 292, 302...15, 90, 100, 121, 140...4, 69, 73, 82, 88...14, 28, 34, 35, 48...98, 107, 136, 228, 234...10, 143, 15110, 85, 98, 107, 136...109, 170, 198, 27135, 48, 124, 32527, 31, 44, 111, 215...11, 49, 328, 362137, 170, 32439, 54, 106, 273, 328...85, 95, 107, 108, 117...163, 209, 327231, 269, 320, 322, 32880, 231, 269104, 148, 203, 30157, 72, 144, 25719, 77, 78, 83, 129...23, 29, 68, 101, 102, 202...194, 248, 352194, 248, 352103, 348, 362, 3842, 10, 115, 157, 199...173, 32716, 26, 91, 97, 105...173, 307, 327, 339104, 148, 20336, 70, 98, 123, 168...137, 170, 32499, 32859, 167, 368, 3881, 21, 24, 33, 75...132, 138, 254, 388284, 32371, 118, 38541, 134, 164, 22039, 54, 106, 273, 328...51, 152, 172, 327, 343...113, 294, 315, 3451, 74, 84, 107, 115...165, 18841, 164194, 248, 270, 352124, 252, 3256, 13, 60, 130, 170...388104, 148, 203184, 246, 367124, 252, 3256, 60, 130, 170, 175...30, 56, 58, 76, 126...253, 330, 37284, 94, 96, 114, 124...plasma membranecytosolplasma membraneplasma membraneGolgi lumenplasma membraneendosome lumennucleoplasmp-S299,S302,T452,T455,S576 ARAF PPP2R5A S-Farn-Me-2xPalmS HRAS S-Farn-Me-PalmS KRAS4A CNKSR1 MAP2K2 YWHAB p-S299,S302,T452,T455,S576 ARAF p-S338,Y341,T491,S494,S621 RAF1 p-S218,S222-MAP2K1 MAP2K1 P124L p-T185,Y187-MAPK1 SPRED1 p-Y-JAK1 ub-BRAP NCAM signaling forneurite out-growthS-Farn-Me PalmS NRAS RASAL1 FN1(32-2386) EREG(60-108) MARK3 ITGB3 DUSP7 ITGB3 p-S222,S226-MAP2K2 KSR2 PSME3 PPP2R1B EGF-like ligands BRAF V600E V47_M438del p-T185,Y187-MAPK1 S-Farn-Me-PalmS KRAS4A p21RAS:GTP:p-S621RAF1homo/heterodimerS-Farn-Me-PalmS KRAS4A DAB2IP GDP single mechanismMAPK inhibitorsPSMB3 PSME2 PIK3CA RASAL2 GFRA2 S-Farn-Me PalmS NRAS RASAL3 YWHAB MAP2K2 S-Farn-Me-PalmS KRAS4A UBC(533-608) CNKSR1 ITGA2B(32-1039) p-S311,Y552 KSR1 p-S218,S222-MAP2K1 Ca2+ Mn2+ DUSP8 LAMTOR3 PTPN3 p-T133-RASGRP3 IL2 p-S222,S226-MAP2K2 Mn2+ p-T,Y MAPK monomersand dimers:PEA15ATPGTP p-S445,S729-BRAF p-Y239,Y240,Y317-SHC1-2 BRAF V600E V47_D380del UBC(153-228) p-S218,S222-MAP2K1 VWF(23-763) BRAF V600E V47_D380del RAP1A SYNGAP1 LAMTOR3 MyrG,p-Y530-SRC S-Farn-Me PalmS NRAS KSR1 DUSP1 MAP2K2 P128Q MAP2K1 K57N Signaling by PDGFp-S311,Y552 KSR1 YWHAB p-S218,S222-MAP2K1 SPRED1 RASAL2 SPRED3 Mg2+ Signaling by NTRK1(TRKA)High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 p-S445,T599,S602,S729 BRAF ARRB2 GFRA1 p-S222,S226-MAP2K2 H2OFGF1 S-Farn-Me-PalmS KRAS4A MAP2K1 F53V PPP2R5D p-S299,S302,T452,T455,S576 ARAF H2OS-Farn-Me-PalmS KRAS4A CAMK2G UBC(77-152) RAP1A V600E BRAF V169_D380del YWHAB UBC(229-304) S-Farn-Me PalmS NRAS Pip-S338,Y341,T491,S494,S621 RAF1 p-S311,Y552 KSR1 HGF(495-728) PTPN7 p-5Y,S1119-TEK PSMA3 SPRED2 SPRED dimer:NF1p-T185,Y187-MAPK1 activatedRAF:scaffold:p-2SMAP2K:p-2T MAPKcomplexMAP2K1 P124Q UBA52(1-76) UBC(381-456) S-Farn-Me KRAS4B PSMF1 LAMTOR3 RASA2 KL-2 PI(4,5)P2 p-S311 KSR1 PiMAP2K1 F53L MARK3 p21RAS:GTP:dephosphorylated RAF1 homo/heterodimerp-S311 KSR1:MARK3SPRED1 FGA p-S311 KSR1 p-S576 ARAF S-Farn-Me-2xPalmS HRAS S-Farn-Me-2xPalmS HRAS Ca2+ VCL S-Farn-Me PalmS NRAS PAQR3 DLG3 MARK3 p21 RAS:GTP:ub-BRAPH2OSignaling by FGFR4p-S311 KSR1 p-8Y-FGFR1c DUSP8 p-S222,S226-MAP2K2 PSMD4 p-2S MAP2K homo/heterodimers VCL PTPN7:p-T-MAPKdimersUbMAP2K1 F53S MAP2K2 L46F BRAP:KSR1:MARK3p-S338,Y341,T491,S494,S621 RAF1 YWHAB RANBP9 CNKSR2 YWHAB TGFA(24-98) UBC(381-456) MAP2K2 Y134C PSMA6 S-Farn-Me-2xPalmS HRAS S-Farn-Me-PalmS KRAS4A Interleukin-2 familysignalingp-S311 KSR1 MARK3 S-Farn-Me KRAS4B SOS1 p-S445,T599,S602,S729 BRAF MAP2K1 F53C F-actin S-Farn-Me-PalmS KRAS4A BRAF K601N F-actin PSMD11 p-S259,S621-RAF1 p-S299,S302,T452,T455,S576 ARAF p-S445,T599,S602,S729 BRAF p-S311 KSR1 MyrG-p-Y419-SRC p-S365,S445,S729 BRAF YWHAB BRAF G469A p-S445,T599,S602,S729 BRAF GTP p-S338,Y341,T491,S494,S621 RAF1 EGF MAP2K2 V35M MAP2K1 G128V p-S311,Y552 KSR1 PPP2R5E p-T287-CAMK2G p-S338,Y341,T491,S494,S621 RAF1 APBB1IP PSMB5 FGB PDGFB (82-190) p-T183,Y185-MAPK12 RPS27A(1-76) IL17RD p-S621-RAF1 PSMC4 p-Y317-SHC1-2 GDNF PSMD10 p-S459 PTPN3 PiPI(4,5)P2 PPP2R1A MARK3 S-Farn-Me-2xPalmS HRAS ITGA2B(32-1039) MAP2K2 F57C FGF10 PEA15p-S445,S729-BRAF ARRB1 p21RAS:GTP:activatedRAF1homo/heterodimer:PEBP1PAQR3BRAF Q257R Mn2+ Autophosphorylated FLT3 MAP2K1 K57T Pip-Y1172,Y1226-ERBB4 JM-A CYT-2 isoform RAP1A PIK3CA high kinase activityBRAF mutantsp-S299,S302,T452,T455,S576 ARAF p-T,Y MAPK monomersand dimersp-11Y-PDGFRA KSR1 p-S621-RAF1 p-S445,S729-BRAF BRAF inhibitors:highkinase activityBRAF mutantsp-S445,S729-BRAF p-6Y-FGFR3b IQGAP1 KSR2 PSMD6 p-S222,S226-MAP2K2 S-Farn-Me KRAS4B p-S214,S576 ARAF FN1(32-2386) PTPRA PSMD8 p-S445,S729-BRAF Mg2+ ATPp-Y349,Y350-SHC1 p-S311 KSR1 PPP2R5B p-S445,S729-BRAF MAPKsp-S299,S302,T452,T455,S576 ARAF FGF8-1 p-S311,Y552 KSR1 FGB KLB ATPRAP1B p-S445,S729-BRAF p-S311KSR1:MARK3:YWHABdimerMAPK3 ATPDLG4 VCL BRAF L485F activated RAFhomo/heterodimerFGB BRAP CNKSR2 CNKSR2 GalNAc-T178-FGF23(25-251) CSK Signaling by Type 1Insulin-like GrowthFactor 1 Receptor(IGF1R)FGF19 APBB1IP p-S214,S576 ARAF p-Y364,Y418,Y536-IL2RB NF1(2-2839) WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complexMAP2K1 S-Farn-Me-2xPalmS HRAS p-S222,S226-MAP2K2 hyperphosphorylatedBRAFp-S338,Y341,T491,S494,S621 RAF1 V600E BRAF splicevariantsp-S445,S729-BRAF SPRED1 FGG p-S311,Y552 KSR1 UBB(153-228) S-Farn-Me-2xPalmS HRAS p-12Y-PDGFRB MARK3 p-S311,Y552 KSR1 PTPN7 RGL1 PEBP1DUSP2 F-actin S-Farn-Me-PalmS KRAS4A p-T,Y MAPK monomersand dimersp-S445,T599,S602,S729 BRAF p-S311,Y552 KSR1 RASGRP1 RGL1 BRAF V600E MAPK3 GTP NEFL S-Farn-Me KRAS4B GTP H2Op-S299,S302,T452,T455,S576 ARAF p-Y194,Y195,Y272-SHC1-3 p-S299,S302,T452,T455,S576 ARAF FGA ARRB1 MAPK1 FGF23(25-251) p-S445,T599,S602,S729 BRAF DUSP10 p-S299,S302,T452,T455,S576 ARAF MyrG,p-Y530-SRC PPP2CB S-Farn-Me PalmS NRAS SPRED3 PIK3R2 p-S222,S226-MAP2K2 S-Farn-Me-2xPalmS HRAS Activated FGFR2c homodimer bound to FGF Activated FGFR2b homodimer bound to FGF PSMA1 SPTBN1 PSMD7 nuclear MAPK DUSPsLAMTOR2 IL17RDUBC(305-380) RAP1B p-S445,T599,S602,S729 BRAF p-S338,Y341,T491,S494,S621 RAF1FGA UBB(1-76) p-S445,S729-BRAF GTP SPRED dimer:ub-NF1PDGFA-2 p-ERBB4cyt1 homodimers p-S576 ARAF UBC(457-532) L-Glu BRAF V600E V47_M438del S-Farn-Me KRAS4B ub-NF1(2-2839) p-S338,Y341,T491,S494,S621 RAF1 Ca2+ MAPK3 SPRED2 CNKSR1 SPRED3 GTP p-T,Y MAPKs S-Farn-Me KRAS4B MyrG,p-Y530-SRC p-S311 KSR1 MAPK3 p-S299,S302,T452,T455,S576 ARAF p-T,Y MAPKs S-GCCMRAS:GTP:SHOC2:PP1MAP2K1 V60E MAP2K1 Q56P JAK2 p-S338,Y341,T491,S494,S621 RAF1 S-Farn-Me-PalmS KRAS4A p-S445,T599,S602,S729 BRAF FGF17-1 S-Farn-Me-2xPalmS HRAS p-S299,S302,T452,T455,S576 ARAF S-Farn-Me-PalmS KRAS4A PSMD5 S-Farn-Me PalmS NRAS PAQR3:inactive RAFsMg2+ UbFGA FGA p-T202,Y204-MAPK3 p-T,Y MAPK dimersBRAF V600E V169_M438del S-Farn-Me-2xPalmS HRAS p-S311,Y552 KSR1 PDGFA-1 p-5Y-RET S-Farn-Me-2xPalmS HRAS dual mechanism MAPKinhibitorsp21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitorsYWHAB p-T202,Y204-MAPK3 RAS GEFsp-S445,T599,S602,S729 BRAF SPRED2 YWHAB KBTBD7:CUL3:RBX1p-S445,S729-BRAF p-S338,Y341,T491,S494,S621 RAF1 p-S338,Y341,T491,S494,S621 RAF1 MAP2K1 C121S FGG p-S445,T599,S602,S729 BRAF p-S338,Y341,T491,S494,S621 RAF1 S-Farn-Me PalmS NRAS TLN1 activatedRAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitorsARRB2 S-Farn-Me-PalmS KRAS4A GTP p-S311 KSR1 IQGAP1 MAP2K2 N126D PiADPp-S311,S406 KSR1 PSMC6 p-S311,Y552 KSR1 BRAF inhibitorsS-Farn-Me KRAS4B MAP2K1 E203K IL17RD AREG(101-187) p-S299,S302,T452,T455,S576 ARAF Signaling by Insulinreceptorp-S299,S302,T452,T455,S576 ARAF RASGEF1A PSMA4 ADPSPTBN5 Autophosphorylated p-Y877-ERBB2 heterodimers KBTBD7 p-S338,Y341,T491,S494,S621 RAF1 Signaling by ERBB4RASGRP4 PSMA5 MAP2K1 E44_E57del p-S218,S222-MAP2K1 p-S299,S302,T452,T455,S576 ARAF YWHAB GTP RASA2 FGF20 p-S445,T599,S602,S729 BRAF DUSP10 p-S311,Y552 KSR1 p-S222,S226-MAP2K2 S-Farn-Me PalmS NRAS p-S311,Y552 KSR1 ATPp-S299,S302,T452,T455,S576 ARAF RAP1B CSK PPP2R5D ADPS-Farn-Me KRAS4B PIK3R1 p-S299,S302,T452,T455,S576 ARAF F-actin p-Y420-FYN PEA15 H2OPSMD1 MAPK3 ARRB2 ITGB3 S-Farn-Me KRAS4B PPP2CA VWF(23-763) IL2RA S-Farn-Me-PalmS KRAS4A cytosolic MAPK DUSPsUBC(609-684) Fc epsilon receptor(FCERI) signalingTLN1 UBB(77-152) LRRC7 S-Farn-Me PalmS NRAS p-S576 ARAF ARRB1 FGG TLN1 S-Farn-Me KRAS4B dual mechanismMAP2K1/2 inhibitorsIQGAP1 S-Farn-Me PalmS NRAS RAF dimer inhibitorsPPP2R5A PSMB2 TLN1 FGF6 FGB RAP1A CSK RGL3 PSPN WDR83 S-Farn-Me-2xPalmS HRAS PPP2R5B MARK3 p-S338,Y341,T491,S494,S621 RAF1 S-Farn-Me PalmS NRAS p-S259,S621-RAF1 p-S338,Y341,T491,S494,S621 RAF1 p-S445,S729-BRAF KSR2 S-Farn-Me KRAS4B IQGAP1 CNKSR2 p-S445,T599,S602,S729 BRAF PiPSMD2 p-S311,Y552 KSR1 GTP Gly p-T,Y MAPKsATPPI(4,5)P2 RASGRF1 PDGFB(82-241) S-GGC MRAS SPRED2 MARK3 activatedRAF:scaffold:MAP2K:MAPK complexCUL3 p-S338,Y341,T491,S494,S621 RAF1 HGF(32-494) RAF activatingkinasesGDPSignaling by FGFR2p-S365,S445,S729 BRAF GRIN2B DUSP9 Mg2+ p-S621-RAF1 PIK3R1 BRAF K601E p-S338,Y341,T491,S494,S621 RAF1 WDR83 PIK3R2 FGF5-1 YWHAB PPP2R5C p-S299,S302,T452,T455,S576 ARAF H2OCNKSR1 PPP2CB CSK S-Farn-Me-2xPalmS HRAS ARTN GTPS-Farn-Me KRAS4B p-T,Y MAPK dimers 26S proteasomeUBB(77-152) APBB1IP SHFM1 activatedRAF:scaffold:p-2SMAP2K:p-2TMAPK:singlemechanism MAPKinhibitorsCSK p-S445,T599,S602,S729 BRAFSPRED1 p-Y-SHC2 S-Farn-Me-PalmS KRAS4A ADPYWHAB dimerPTPN3p-T,Y MAPK dimers FGF3 PSMD3 ATPMAP2K1 p-5Y-LAT-2 p-S445,S729-BRAF Ca2+ APBB1IP FGF22 PPP1CC Ca2+ PPP2R1B GTP PSMC2 ITGA2B(32-1039) CAMK2D PSMC3 'activator'RAF:YWHAB dimerPhosphorylated ERBB2:ERBB4cyt1 heterodimers VCL GTP p-S365,S445,S729 BRAF p-S445,T599,S602,S729 BRAF p-S338,Y341,T491,S494,S621 RAF1 BRAP p-T,Y MAPKs p21 RAS:GTP:PI3Kp-T185,Y187-MAPK1 p-S311,Y552 KSR1 GTP p-S311,Y552 KSR1 H2ODLG1 KL-1 PiGRIN2D p-7Y,Y1112-ERBB2 NF1(2-2839) BRAF V600E V169_M438del DUSP4 p-S311 KSR1 S-Farn-Me-PalmS KRAS4A MARK3 p-S445,S729-BRAF ATPhyperphosphorylatedRAF1SPTBN2 S-Farn-Me PalmS NRAS MAP2K1 and MAP2K2mutantsRASA4 RASAL3 p21 RAS:GTPPTPN3:p-T183,Y185-MAPK12p-S621-RAF1 S-Farn-Me-2xPalmS HRAS PP2Ap-S299,S302,T452,T455,S576 ARAF PEBP1 BRAPMAPK3 MAP2K1 Y130C p-S445,T599,S602,S729 BRAF PPP2R1A FGG p21 RAS:GTP:RAS GAPsp-7Y-KIT p-S338,Y341,T491,S494,S621 RAF1 Mg2+ p-S311,Y552 KSR1 p-S445,T599,S602,S729 BRAF SPTAN1 V600E BRAF V169_D380del p-S311,S406KSR1:MARK3S-Farn-Me KRAS4B FGF2(10-155) MAPK monomers anddimersGTP activatedRAF:scaffold:p-2SMAP2K:MAPK:dualmechanism MAPKinhibitorsWDR83 p-2S MAP2K1:p-2SMAPK2K2 heterodimerp-T202-MAPK3 RPS27A(1-76) p-S576 ARAF MAP2K2 p-T287-CAMK2D PSMB8 MARK3 PSMA8 RASA4 MAPK1 PSMB11 PPP2R5E ITGA2B(32-1039) ITGB3 UBC(533-608) p-S,218, S222,T292 MAP2K1 DUSP16 MAPKs p-S299,S302,T452,T455,S576 ARAF p-S445,S729-BRAF BRAF 599dupT S-Farn-Me KRAS4B S-Farn-Me-PalmS KRAS4A p21 RAS:GTP:BRAPNRTN MAPK1 FGF18 p-2S,T MAP2K1:p-2SMAPK2K2 heterodimerp-S299,S302,T452,T455,S576 ARAF PHBRAF/MAPK scaffoldsV600E BRAF splicevariant dimerSHOC2 p-S299,S302,T452,T455,S576 ARAF FGF4 HBEGF(63-148) S-Farn-Me KRAS4B p-S445,S729-BRAF JAK3 DLG2 p-S338,Y341,T491,S494,S621 RAF1 GRB2-1 CALM1 dephosphorylatedinactive RAFsS-Farn-Me-2xPalmSHRAS:GTPH2OS-Farn-Me PalmS NRAS S-Farn-Me PalmS NRAS FGF9 PI3KPPP2R5C RBX1 YWHAB MAP2K1 D67N activatedRAF:scaffold:p-2S MAP2K:MAPK:singlemechanism MAP2KinhibitorsYWHAB FN1(32-2386) S-Farn-Me-2xPalmS HRAS GTP Pip-S311,Y552 KSR1 DAB2IP IL17RD:p-2SMAP2Ks:MAPKsp-S311 KSR1 UBB(1-76) SYNGAP1 PSMB4 ANGPT1 ACTN2 p-Y-IRS1 BTC(32-111) YWHAB PSMD13 p-S338,Y341,T491,S494,S621 RAF1 p-S621-RAF1 p-S445,T599,S602,S729 BRAF p-8Y-FGFR1b MAPK1 RAS processingp-5Y-FRS3 p21RAS:GTP:activatedRAFhomo/heterodimersNeuregulins RALGDS YWHAB SPRED3 p-S621-RAF1 p-S576 ARAF PSMA2 SPTA1 p-T,Y MAPK dimers PI(4,5)P2 p-Y349,Y350,Y427-SHC1 FN1(32-2386) p-S311,S406KSR1:MARK3:YWHABdimerp-T202,Y204-MAPK3 MARK3 NF1(2-2839)p-6Y-FRS2 UBC(305-380) RAL GDS proteinsNF1(2-2839) MARK3 PPP2CA Signaling by FGFR1IQGAP1 DUSP5 MAP2K1 F53Y MAPK3 MAP2K1 G128D PSMB6 Signaling by ERBB2p-S311,Y552 KSR1 RASGRF2 RASGRF2 MAP2K1 FN1(32-2386) S-Farn-Me-2xPalmS HRAS GFRA4 RALGDS MAPK1 KSR2 S-Farn-Me-PalmS KRAS4A YWHAB SPRED2 ARRB1 Signaling by EGFRSPTBN4 Mn2+ UBA52(1-76) MAPK3 GTP p-S222,S226-MAP2K2 UBC(1-76) PSMD12 MARK3 DAG GTP SPTB p-S218,S222-MAP2K1 CALM1 RGL3 MAPK1 p-T286-CAMK2A MAPK monomers anddimersPSMB7 p-5Y-FGFR4 KITLG-1(26-190) p-S338,Y341,T491,S494,S621 RAF1 p-S338,Y341,T491,S494,S621 RAF1 APBB1IP MAP2K1 P124S p-T185-MAPK1 GTP p-T185,Y187-MAPK1 inactive RAFs:YWHABdimerRASAL1 RASA3 p-S214,S576 ARAF single mechanismMAP2K1/2 inhibitorsGTP p-S445,T599,S602,S729 BRAF p-T202,Y204-MAPK3 BRAF V600E V169_M438del CAMK2A UBC(1-76) p-T287-CAMK2B p-T184-RASGRP1 p-S311,Y552 KSR1 V600E BRAF V169_D380del PSMB10 p-6Y-FGFR3c GRIN1 PSME4 S-Farn-Me KRAS4B D-Ser p-Y239,Y240,Y317-SHC1-2 ITGA2B(32-1039) dephosphorylatedinactive RAFS:YWHABdimerp-S445,S729-BRAF FGB H2OLAMTOR2 PPP1CB RGL2 UBC(229-304) ARRB2 p-S338,Y341,T491,S494,S621 RAF1 Signaling by FGFR3MyrG,p-Y530-SRC S-Farn-Me PalmS NRAS p-T202,Y204-MAPK3 PSMC1 p-S445,T599,S602,S729 BRAF YWHAB Ca2+ UBC(77-152) CNKSR2 VCL S-Farn-Me KRAS4B BRAF V600E V47_M438del MAPK1 ADPS-Farn-Me KRAS4B IL2RG BRAF V600E V47_D380del p-T202,Y204-MAPK3 ITGB3 MyrG,p-Y530-SRC p-S338,Y341,T491,S494,S621 RAF1 UBB(153-228) RAP1B p-S299,S302,T452,T455,S576 ARAF EPGN(23-154) RAP1B Signaling by the BCell Receptor (BCR)Other interleukinsignalingp21RAS:GTP:activatedRAFhomo/heterodimercomplexesp21RAS:GTP:homo/heterodimerized RAF complexFGG p-S445,T599,S602,S729 BRAF p-S311,Y552 KSR1 Phosphorylated ERBB2:ERBB4cyt2 heterodimers DUSP16 UBC(457-532) Neurotransmitterreceptors andpostsynaptic signaltransmissionPSMC5 MAP2Khomo/heterodimersMn2+ S-Farn-Me PalmS NRAS PIK3CB GTP RASA1 p-Y341,T491,S494,S621 RAF1 YWHAB ATPGTP PTPN7p-Y1234,Y1235,Y1349,Y1356-MET p-6Y-PTK2 S-Farn-Me PalmS NRAS MARK3 ARRB2 ADPKSR1:MARK3Ca2+ MAP2K1 D67Y UBC(153-228) p-S338,Y341,T491,S494,S621 RAF1 MAP2K2 C125S S-Farn-Me-2xPalmS HRAS p-S311,S406 KSR1 VWF(23-763) KSR2 p-T185,Y187-MAPK1 RAS GAPsWDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complexPPP5CARRB1 p21RAS:GTP:'activator'RAF:YWHAB dimerSPRED3 VWF(23-763) TLN1 S-Farn-Me-PalmS KRAS4A p-S445,T599,S602,S729 BRAF RASA1 S-Farn-Me-2xPalmS HRAS VWF(23-763) p-6Y-ERBB2 heterodimers PSMB9 RAP1A PSMD9 RAPGEF2 YWHAB PSMB1 p-T183,Y185-MAPK12 BRAF G534R activatedRAF:scaffold:p-2SMAP2K:MAPK complexS-Farn-Me-2xPalmS HRAS GTP HS WDR83:LAMTOR2:LAMTOR3PI(4,5)P2 p-S218,S222-MAP2K1 S-Farn-Me-2xPalmS HRAS p-6Y-EGFR MAPK1 FLT3LG Signaling by SCF-KITCAMK2B S-Farn-Me_2xPalmSHRAS:GTP:RAL GDSproteinsp-Y-SHC1 MARK3 inactive RAFsS-Farn-Me KRAS4B ADPBRAF K499E CNKSR1 ADPMAPK12p21RAS:GTP:activatedRAF1homo/heterodimerp-S445,T599,S602,S729 BRAF p-T183,Y185-MAPK12p-Y427-SHC1 p-Y-IRS2 dephosphorylated"receiver" RAF/KSR1Interleukin-3,Interleukin-5 andGM-CSF signalingp-6Y,Y1112-ERBB2 SPRED dimerCell surfaceinteractions at thevascular wallS-Farn-Me-2xPalmS HRAS p-S445,T599,S602,S729 BRAF PTPN7:p-T,Y-MAPKdimersp-S445,T599,S602,S729 BRAF p-S259,S621-RAF1 p-S218,S222-MAP2K1 PSME1 BRAF S467A PSMA7 DUSP6 ADPPIK3CB PP2ARASA3 NCAM1 p-2S MAP2Khomo/heterodimersIL17RD:p-2SMAP2Ks:p-T,Y MAPKsGTP PSMD14 DAP12 interactionsp-Y-SHC3 RGL2 p-S299,S302,T452,T455,S576 ARAF ATPp-S445,T599,S602,S729 BRAF p-S445,S729-BRAF F-actin p-S299,S302,T452,T455,S576 ARAF GFRA3 FGF16 PiMAP3K11p-S338,Y341,T491,S494,S621 RAF1 S-Farn-Me-PalmS KRAS4A ADPLAMTOR2 p21 RAS:GDPp-S459PTPN3:p-T183,Y185-MAPK12UBC(609-684) S-Farn-Me PalmS NRAS MARK3 67, 25126474, 1013, 5, 9, 22, 25...29101272, 30844101, 1254426410120262, 127, 258, 287, 319321, 335242149, 150, 169, 221, 225...106444626931830012, 211, 3642384412426444149, 150, 169, 221, 225...2646844101, 28110110181, 180, 370, 3812372812818, 38, 45, 47, 176...101, 125444444101, 12510174, 156101, 32186, 120, 2822087, 17, 43, 50, 53...266, 38337119, 205, 233, 3162694440, 161, 1974446, 268259149, 150, 169, 221, 225...160, 178, 195, 196, 279...37820, 89, 185, 213, 256...26474, 15644264149, 150, 169, 221, 225...79, 158, 236, 274, 309...135, 189, 29844