Meiotic synapsis (Homo sapiens)

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2, 91, 84, 6513, 71, 10nucleoplasmnuclear envelopeHIST1H2BL STAG2 HIST1H2BJ TERF2IP HIST1H2BO HIST1H2BN HIST1H2AC H2BFS POT1 ACD ligated C-strand Okazaki fragment HIST2H2AA3 SYCP2 SYNE2STAG1 SMC3 HIST1H2BH HIST3H3 REC8 HSPA2 SMC1A HIST1H2BH STAG3 HIST2H2BE HIST1H2BA STAG1 Axial-LateralElement ofSynaptonemalComplexSMC1B RAD21 HIST3H2BB TERF1 STAG1 HIST1H2BD TERF2 REC8 HIST1H2BH SMC3 HIST1H2BM SynaptonemalComplex:BRCA1BRCA1SYCP2 STAG1 TERF1 HIST1H2BA HIST2H2AC HIST1H2AD TERF2IP Telomere AttachmentPlateH2AFX STAG2 SMC1A STAG2 HIST2H2BE SMC1B HIST3H3 SMC3 HIST1H2BB HIST1H4 H2AFX HIST1H2BK DNA TEX12 SUN2HIST1H2BN STAG1 HIST1H2BC REC8 SMC3 STAG3 UBE2I SMC3 H2AFB1 H2BFS STAG1 SMC1A SMC1A HIST1H2BO H2BFS HIST1H4 HIST1H4 HIST3H3 Meiotic CohesincomplexHIST1H2BO H2AFJ LMNB1(2-586) SYCP3 HIST1H2BJ HIST3H2BB SUN2 HIST1H2AJ RAD21 POT1 HIST1H2BL STAG3 H2BFS TEX12HIST1H2BH HIST1H2BK DNA HIST1H2BB H2AFZ HIST1H2BN STAG3 H2BFS RAD21 HIST1H2BD Unsynapsed chromatinFKBP6H2AFV LMNB1(2-586)HIST1H2BJ TINF2 SYNE2 HIST1H2BA HIST2H2BE HIST1H2AC SYCP3 REC8 SUN1DNA H2BFS HIST1H2BN SynaptonemalComplex:BRCA1:ATRSYNE1RAD21 HIST1H2BN HIST1H2BD DIDO1-1HIST1H2BJ HIST1H2BC ATRHIST1H2BM STAG2 HIST1H2BK SMC1B SYCP3 HIST1H2BD HIST1H2BJ ATR HIST1H2BB SYCP2 HIST1H2BL SYCE2SMC1B Unsynapsed chromatinwith gamma-H2A.xDIDO1-1 HIST1H2BH HIST2H2BE HIST1H2BA HIST1H2BB HIST1H2BO HIST1H2BC SYCP3 HIST1H2BC HIST3H3 SMC1B H2AFZ HIST2H2BE SYCE3RAD21 SYCP2 HIST1H2BM TERF2 HIST3H3 HIST1H2BH HIST1H2BM HIST1H2BK H2AFV UBE2IHIST1H2BL HIST3H2BB REC8 HIST1H2BK HIST1H2BO TINF2 LMNA-2REC8 SYCP3HIST1H4 SYCP3 STAG3 HIST1H2BD SMC3 SYCP3 RAD21 SMC3 SMC1A RAD21 HIST2H2BE SMC1B STAG2 STAG1 SYNE1 HIST3H2BB HIST2H2AA3 DNA H2AFX HIST1H2BC STAG2 STAG3 HIST2H2AC REC8 STAG2 H2AFX H2AFX SMC1B SYCE1 SYCP2G-strand Chromosome end with two additional single strand repeats and a subterminal loop - Telomeric LMNA-2 HIST1H2BM HIST1H2BK SMC1A HIST1H2BD SYCP1SYCP2 HIST1H2AD H2AFB1 STAG1 SYCP1 STAG2 SMC1A HIST1H2AJ STAG3 HIST3H2BB ADPHIST1H2BA HIST1H2AB Extended AndProcessed TelomereEnd and AssociatedDNA Binding andPackaging ProteinComplex Folded IntoHigher OrderStructureSUN1 REC8 HIST1H2BA ACD HSPA2HIST1H2BO SYCE3 ATPFKBP6 SYCE1HIST1H2BC HIST3H2BB p-S140-H2AFX SMC1B HIST1H4 HIST1H2BJ Synaptonemal ComplexHIST1H2BB HIST1H4 HIST1H2BB H2AFJ HIST3H3 HIST1H2BM SYCE2 SMC1A HIST1H2BL ligated C-strand Okazaki fragment HIST1H2BL STAG3 SMC3 HIST1H2AB BRCA1 SYCP2 SYCP3 HIST1H2BN G-strand Chromosome end with two additional single strand repeats and a subterminal loop - Telomeric RAD21 SYCP2 BRCA1 11


Description

Meiotic synapsis is the stable physical pairing of homologous chromosomes that begins in leptonema of prophase I and lasts until anaphase of prophase I. First, short segments of axial elements form along chromosomes. Telomeres then cluster at a region of the inner nuclear membrane and axial elements extend and fuse along the length of the chromosomes. Subsequent to the initiation of recombination transverse filaments of SYCP1 link axial/lateral elements to a central element containing SYCE1 and SYCE2, thus forming the synaptonemal complex (reviewed in Yang and Wang 2009).
Unsynapsed regions are silenced during pachynema by recruitment of BRCA1 and ATR, which phosphorylates histone H2AX (reviewed in Inagaki et al. 2010). View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 1221632
Reactome-version 
Reactome version: 66
Reactome Author 
Reactome Author: May, Bruce

Quality Tags

Ontology Terms

 

Bibliography

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  1. Garcia-Cruz R, Roig I, Robles P, Scherthan H, Garcia Caldés M.; ''ATR, BRCA1 and gammaH2AX localize to unsynapsed chromosomes at the pachytene stage in human oocytes.''; PubMed Europe PMC
  2. Inagaki A, Schoenmakers S, Baarends WM.; ''DNA double strand break repair, chromosome synapsis and transcriptional silencing in meiosis.''; PubMed Europe PMC
  3. Tarsounas M, Pearlman RE, Gasser PJ, Park MS, Moens PB.; ''Protein-protein interactions in the synaptonemal complex.''; PubMed Europe PMC
  4. Prieto I, Tease C, Pezzi N, Buesa JM, Ortega S, Kremer L, Martínez A, Martínez-A C, Hultén MA, Barbero JL.; ''Cohesin component dynamics during meiotic prophase I in mammalian oocytes.''; PubMed Europe PMC
  5. Scherthan H, Weich S, Schwegler H, Heyting C, Härle M, Cremer T.; ''Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing.''; PubMed Europe PMC
  6. Garcia-Cruz R, Brieño MA, Roig I, Grossmann M, Velilla E, Pujol A, Cabero L, Pessarrodona A, Barbero JL, Garcia Caldés M.; ''Dynamics of cohesin proteins REC8, STAG3, SMC1 beta and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes.''; PubMed Europe PMC
  7. Roig I, Liebe B, Egozcue J, Cabero L, Garcia M, Scherthan H.; ''Female-specific features of recombinational double-stranded DNA repair in relation to synapsis and telomere dynamics in human oocytes.''; PubMed Europe PMC
  8. Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T, Livingston DM.; ''Association of BRCA1 with Rad51 in mitotic and meiotic cells.''; PubMed Europe PMC
  9. Yang F, Wang PJ.; ''The Mammalian synaptonemal complex: a scaffold and beyond.''; PubMed Europe PMC
  10. Ward IM, Chen J.; ''Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.''; PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
101286view11:17, 1 November 2018ReactomeTeamreactome version 66
100823view20:48, 31 October 2018ReactomeTeamreactome version 65
100364view19:23, 31 October 2018ReactomeTeamreactome version 64
99910view16:06, 31 October 2018ReactomeTeamreactome version 63
99466view14:39, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99121view12:40, 31 October 2018ReactomeTeamreactome version 62
93808view13:37, 16 August 2017ReactomeTeamreactome version 61
93350view11:21, 9 August 2017ReactomeTeamreactome version 61
87987view13:23, 25 July 2016RyanmillerOntology Term : 'cell cycle pathway, meiotic' added !
87882view12:20, 25 July 2016RyanmillerOntology Term : 'regulatory pathway' added !
86434view09:18, 11 July 2016ReactomeTeamreactome version 56
83156view10:11, 18 November 2015ReactomeTeamVersion54
81763view10:09, 26 August 2015ReactomeTeamVersion53
76957view08:23, 17 July 2014ReactomeTeamFixed remaining interactions
76662view12:03, 16 July 2014ReactomeTeamFixed remaining interactions
75991view10:05, 11 June 2014ReactomeTeamRe-fixing comment source
75694view11:03, 10 June 2014ReactomeTeamReactome 48 Update
75050view13:56, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74694view08:46, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACD ProteinQ96AP0 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:16761 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
ATR ProteinQ13535 (Uniprot-TrEMBL)
ATRProteinQ13535 (Uniprot-TrEMBL)
Axial-Lateral

Element of Synaptonemal

Complex
ComplexR-HSA-912338 (Reactome)
BRCA1 ProteinP38398 (Uniprot-TrEMBL)
BRCA1ProteinP38398 (Uniprot-TrEMBL)
DIDO1-1 ProteinQ9BTC0-1 (Uniprot-TrEMBL)
DIDO1-1ProteinQ9BTC0-1 (Uniprot-TrEMBL)
DNA R-ALL-29428 (Reactome)
Extended And

Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order

Structure
ComplexR-HSA-182751 (Reactome)
FKBP6 ProteinO75344 (Uniprot-TrEMBL)
FKBP6ProteinO75344 (Uniprot-TrEMBL)
G-strand Chromosome end with two additional single strand repeats and a subterminal loop - Telomeric R-HSA-182791 (Reactome)
H2AFB1 ProteinP0C5Y9 (Uniprot-TrEMBL)
H2AFJ ProteinQ9BTM1 (Uniprot-TrEMBL)
H2AFV ProteinQ71UI9 (Uniprot-TrEMBL)
H2AFX ProteinP16104 (Uniprot-TrEMBL)
H2AFZ ProteinP0C0S5 (Uniprot-TrEMBL)
H2BFS ProteinP57053 (Uniprot-TrEMBL)
HIST1H2AB ProteinP04908 (Uniprot-TrEMBL)
HIST1H2AC ProteinQ93077 (Uniprot-TrEMBL)
HIST1H2AD ProteinP20671 (Uniprot-TrEMBL)
HIST1H2AJ ProteinQ99878 (Uniprot-TrEMBL)
HIST1H2BA ProteinQ96A08 (Uniprot-TrEMBL)
HIST1H2BB ProteinP33778 (Uniprot-TrEMBL)
HIST1H2BC ProteinP62807 (Uniprot-TrEMBL)
HIST1H2BD ProteinP58876 (Uniprot-TrEMBL)
HIST1H2BH ProteinQ93079 (Uniprot-TrEMBL)
HIST1H2BJ ProteinP06899 (Uniprot-TrEMBL)
HIST1H2BK ProteinO60814 (Uniprot-TrEMBL)
HIST1H2BL ProteinQ99880 (Uniprot-TrEMBL)
HIST1H2BM ProteinQ99879 (Uniprot-TrEMBL)
HIST1H2BN ProteinQ99877 (Uniprot-TrEMBL)
HIST1H2BO ProteinP23527 (Uniprot-TrEMBL)
HIST1H4 ProteinP62805 (Uniprot-TrEMBL)
HIST2H2AA3 ProteinQ6FI13 (Uniprot-TrEMBL)
HIST2H2AC ProteinQ16777 (Uniprot-TrEMBL)
HIST2H2BE ProteinQ16778 (Uniprot-TrEMBL)
HIST3H2BB ProteinQ8N257 (Uniprot-TrEMBL)
HIST3H3 ProteinQ16695 (Uniprot-TrEMBL)
HSPA2 ProteinP54652 (Uniprot-TrEMBL)
HSPA2ProteinP54652 (Uniprot-TrEMBL)
LMNA-2 ProteinP02545-2 (Uniprot-TrEMBL)
LMNA-2ProteinP02545-2 (Uniprot-TrEMBL)
LMNB1(2-586) ProteinP20700 (Uniprot-TrEMBL)
LMNB1(2-586)ProteinP20700 (Uniprot-TrEMBL)
Meiotic Cohesin complexComplexR-HSA-912384 (Reactome)
POT1 ProteinQ9NUX5 (Uniprot-TrEMBL)
RAD21 ProteinO60216 (Uniprot-TrEMBL)
REC8 ProteinO95072 (Uniprot-TrEMBL)
SMC1A ProteinQ14683 (Uniprot-TrEMBL)
SMC1B ProteinQ8NDV3 (Uniprot-TrEMBL)
SMC3 ProteinQ9UQE7 (Uniprot-TrEMBL)
STAG1 ProteinQ8WVM7 (Uniprot-TrEMBL)
STAG2 ProteinQ8N3U4 (Uniprot-TrEMBL)
STAG3 ProteinQ9UJ98 (Uniprot-TrEMBL)
SUN1 ProteinO94901 (Uniprot-TrEMBL)
SUN1ProteinO94901 (Uniprot-TrEMBL)
SUN2 ProteinQ9UH99 (Uniprot-TrEMBL)
SUN2ProteinQ9UH99 (Uniprot-TrEMBL)
SYCE1 ProteinQ8N0S2 (Uniprot-TrEMBL)
SYCE1ProteinQ8N0S2 (Uniprot-TrEMBL)
SYCE2 ProteinQ6PIF2 (Uniprot-TrEMBL)
SYCE2ProteinQ6PIF2 (Uniprot-TrEMBL)
SYCE3 ProteinA1L190 (Uniprot-TrEMBL)
SYCE3ProteinA1L190 (Uniprot-TrEMBL)
SYCP1 ProteinQ15431 (Uniprot-TrEMBL)
SYCP1ProteinQ15431 (Uniprot-TrEMBL)
SYCP2 ProteinQ9BX26 (Uniprot-TrEMBL)
SYCP2ProteinQ9BX26 (Uniprot-TrEMBL)
SYCP3 ProteinQ8IZU3 (Uniprot-TrEMBL)
SYCP3ProteinQ8IZU3 (Uniprot-TrEMBL)
SYNE1 ProteinQ8NF91 (Uniprot-TrEMBL)
SYNE1ProteinQ8NF91 (Uniprot-TrEMBL)
SYNE2 ProteinQ8WXH0 (Uniprot-TrEMBL)
SYNE2ProteinQ8WXH0 (Uniprot-TrEMBL)
Synaptonemal Complex:BRCA1:ATRComplexR-HSA-912463 (Reactome)
Synaptonemal Complex:BRCA1ComplexR-HSA-912476 (Reactome) BRCA1 localizes to axial elements of the synaptonemal complex in unsynapsed regions of chromosomes. The localization requires SYCP1 of the synaptonemal complex.
Synaptonemal ComplexComplexR-HSA-912422 (Reactome)
TERF1 ProteinP54274 (Uniprot-TrEMBL)
TERF2 ProteinQ15554 (Uniprot-TrEMBL)
TERF2IP ProteinQ9NYB0 (Uniprot-TrEMBL)
TEX12 ProteinQ9BXU0 (Uniprot-TrEMBL)
TEX12ProteinQ9BXU0 (Uniprot-TrEMBL)
TINF2 ProteinQ9BSI4 (Uniprot-TrEMBL)
Telomere Attachment PlateComplexR-HSA-912372 (Reactome)
UBE2I ProteinP63279 (Uniprot-TrEMBL)
UBE2IProteinP63279 (Uniprot-TrEMBL)
Unsynapsed chromatin with gamma-H2A.xComplexR-HSA-975781 (Reactome)
Unsynapsed chromatinComplexR-HSA-975778 (Reactome)
ligated C-strand Okazaki fragment R-ALL-176395 (Reactome)
p-S140-H2AFX ProteinP16104 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ADPArrowR-HSA-912470 (Reactome)
ATPR-HSA-912470 (Reactome)
ATRR-HSA-912450 (Reactome)
Axial-Lateral

Element of Synaptonemal

Complex
ArrowR-HSA-912389 (Reactome)
Axial-Lateral

Element of Synaptonemal

Complex
R-HSA-912408 (Reactome)
Axial-Lateral

Element of Synaptonemal

Complex
R-HSA-912505 (Reactome)
BRCA1R-HSA-912467 (Reactome)
DIDO1-1R-HSA-912505 (Reactome)
Extended And

Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order

Structure
R-HSA-912408 (Reactome)
FKBP6R-HSA-912505 (Reactome)
HSPA2R-HSA-912505 (Reactome)
LMNA-2R-HSA-912408 (Reactome)
LMNB1(2-586)R-HSA-912408 (Reactome)
Meiotic Cohesin complexR-HSA-912389 (Reactome)
R-HSA-912389 (Reactome) Axial elements begin assembling as short linear segments along the long axis of the chromosome in leptotene phase. Eventually the short segments will fuse to form the complete axial element along the entire length of the chromosome. After synapsis the axial elements are also known as lateral elements of the synaptonemal complex. Within axial elements the sister chromatids are bound together by meiotic cohesin (Prieto et al. 2004, Garcia-Cruz et al. 2010). The bound chromatids are anchored to a complex containing SYCP2 and SYCP3 via a direct or indirect interaction with cohesin (Garcia-Cruz et al. 2010).
R-HSA-912408 (Reactome) As sections of the axial elements form, the telomeres migrate to one site on the inner nuclear membrane to form the telomere bouquet (Scherthan et al. 1996). A current model shows the synaptonemal complex interacting with SUN1 and SUN2, which span the inner membrane and bind Nesprin-1 and Nesprin-2, which span the outer membrane and bind cytoplasmic actin. Lamin-B1 and Lamin-C2 are located adjacent to the attachment plate on the inner membrane.
R-HSA-912450 (Reactome) Unsynapsed regions of chromosomes accumulate BRCA1, the kinase ATR, and the phosphorylated histone gammaH2AX. In mouse the recruitment of ATR depends on BRCA1.
R-HSA-912467 (Reactome) Unsynapsed regions of chromosomes are silenced during pachytene phase by a process called Meiotic Silencing of Unsynapsed Chromatin (MSUC) and, in the case of the X and Y chromosomes, Meiotic Sex Chromosome Inactivation (MSCI). Unsynapsed meiotic chromatin recruits BRCA1 (Scully et al. 1997, Garcia-Cruz et al. 2009). In mouse, the recruitment requires SYCP3 of axial elements of the synaptonemal complex, which may remain exposed in unsynapsed regions.
R-HSA-912470 (Reactome) The ATR kinase phosphorylates histone H2A.X at serine 139 (Ward and Chen 2001, Garcia-Cruz et al. 2009).
R-HSA-912505 (Reactome) Initiation of recombination precedes and is required for synapsis (Roig et al. 2004). The synaptonemal complex forms when transverse filaments of SYCP1 link axial/lateral elements of sister chromatids to a central element comprising SYCE1, SYCE2, and other proteins (Tarsounas et al. 1997). The order of assembly is unknown.
SUN1R-HSA-912408 (Reactome)
SUN2R-HSA-912408 (Reactome)
SYCE1R-HSA-912505 (Reactome)
SYCE2R-HSA-912505 (Reactome)
SYCE3R-HSA-912505 (Reactome)
SYCP1R-HSA-912505 (Reactome)
SYCP2R-HSA-912389 (Reactome)
SYCP3R-HSA-912389 (Reactome)
SYNE1R-HSA-912408 (Reactome)
SYNE2R-HSA-912408 (Reactome)
Synaptonemal Complex:BRCA1:ATRArrowR-HSA-912450 (Reactome)
Synaptonemal Complex:BRCA1:ATRmim-catalysisR-HSA-912470 (Reactome)
Synaptonemal Complex:BRCA1ArrowR-HSA-912467 (Reactome)
Synaptonemal Complex:BRCA1R-HSA-912450 (Reactome)
Synaptonemal ComplexArrowR-HSA-912505 (Reactome)
TEX12R-HSA-912505 (Reactome)
Telomere Attachment PlateArrowR-HSA-912408 (Reactome)
UBE2IR-HSA-912505 (Reactome)
Unsynapsed chromatin with gamma-H2A.xArrowR-HSA-912470 (Reactome)
Unsynapsed chromatinR-HSA-912467 (Reactome)
Unsynapsed chromatinR-HSA-912470 (Reactome)
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