Signaling by NOTCH1 (Homo sapiens)

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2-4, 7, 12...10313, 17, 27, 49, 56...11233, 34, 63, 1121082, 1157, 69, 7347, 9723, 40, 10919, 53, 86, 98, 106...10813, 17, 27, 49, 56...91475831, 32, 8928, 669, 29124725511125320, 36, 39, 42, 10733, 34, 63, 11214, 18, 244, 9247, 70, 97, 11726, 74, 9010365, 912515, 22, 104583, 35, 45, 84, 9413, 17, 27, 49, 56...18, 6719, 86, 98, 106, 118127638, 66Signal sending cellcytosolcytosolSignal receiving cellnucleoplasmTLE1 UBA52(1-76) UBB(1-76) MAMLTLE1 UBC(77-152) UBC(305-380) NOTCH1 I1718T Transmembrane Fragment NOTCH1HDdomainmutantfragments/Ub-DLL/JAG:NOTCH1 HD domain mutant fragmentsDTX1 UBB(153-228) NEXT1 PEST domainmutantsUBC(457-532) DTX2 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(609-684) UBC(1-76) UBC(533-608) NEURL UBC(305-380) UBB(77-152) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) HDAC8 MAML3 UBB(1-76) UBB(153-228) HES1 geneUBC(153-228) CREBBP JAG2 UBC(609-684) UBB(153-228) NOTCH1 L1678P Transmembrane Fragment DLL/JAG:NOTCH1NCOR2 UBC(533-608) NOTCH1 HD+PEST Domain Mutants UBA52(1-76) HDAC9 JAG1 NOTCH1(1665-2555) RPS27A(1-76) UBC(609-684) KAT2A 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(153-228) UBC(1-76) NOTCH1 L1574Q Extracellular Fragment HEY1 gene TLE2 UBC(305-380) UBB(1-76) HES1ADAM10 HEYJAG2 UBB(77-152) FBXW7gamma NOTCH1 L1600P Extracellular Fragment DTX4 NOTCH1UBC(609-684) p-NICD1:FBXW7:SKP1:CUL1:RBX1UBB(153-228) JAG1 UBC(229-304) NICD1 NICD1:HIF1ACREBBPHDAC3 RPS27A(1-76) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) DLL4 ADAM10/17:Zn2+JAG1 UBC(153-228) UBC(1-76) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) JAG1 NOTCH1 A1701P Transmembrane Fragment CDK8 UBB(1-76) NOTCH1(1665-2555) HEYL NOTCH1(1665-1720) NEXT1 P2474Afs*4 PSEN2(298-448) UBC(229-304) MAML1 NOTCH1UBC(77-152) UBA52(1-76) UBB(1-76) RPS27A(1-76) KAT2B UBC(229-304) MAMLD1 Ub-DLL/JAG:NOTCH1 HDdomain mutantsDLL1 MIB1 DLL4 NOTCH1 I1616T Extracellular Fragment UBC(381-456) Ub-DTX:ITCHUBC(77-152) UBC(77-152) NOTCH1 L1596H Extracellular Fragment NOTCH1 V1676D S2 cleavage fragment HEY2 DTX2 RPS27A(1-76) UBB(153-228) NOTCH1 I1718T Transmembrane Fragment MAML3 JAG1 UBC(457-532) UBB(77-152) DLK1UBA52(1-76) NOTCH1 L1600P Extracellular Fragment UBA52(1-76) UBC(77-152) TBL1X DLL1 NICD1:NBEAUBC(305-380) DLL1 p-NICD1 FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) UBC(77-152) NOTCH1 L1596H Extracellular Fragment NOTCH1 L1600P Extracellular Fragment JAG1 DLL4DTX4 DTX2 KAT2A DLL4 DTX1 NOTCH1(1665-2555) NICD1:RBPJ:SNW1UbNOTCH1(1665-2555) SNW1 UBC(533-608) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBB(153-228) UBB(77-152) UBC(77-152) UBC(305-380) PSENEN 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) DLL1ADPJAG2 DTX2 UBC(609-684) TLE3-3 RPS27A(1-76) UBC(533-608) UBC(305-380) NEXT1 P2514Rfs*4 NOTCH1t(7;9)(NOTCH1:M1580_K2555) fragmentUBB(77-152) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) DLL1 UBC(153-228) UBA52(1-76) NEXT1 Q2440* UBC(153-228) NOTCH1(1721-1753)UBC(77-152) UBC(153-228) NOTCH1(1665-2555) UBC(381-456) RPS27A(1-76) MAML2 UBB(1-76) HDAC1 MYC geneDTX1 UBC(305-380) RPS27A(1-76) HDAC7 UBC(457-532) NOTCH1(1665-2555) NOTCH1(1665-2555) JAG2 HDAC4 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) JAG2 UBC(153-228) DLL4 DLL4 NOTCH1 Q2440* Transmembrane Fragment DTX4 MAML3 SNW1 UBB(153-228) UBC(457-532) UBC(381-456) HDAC5 UBC(533-608) CREBBP MAML1 NOTCH1:DLK1RBPJ EP300 DTX1 Zn2+ NICD1 NBEARBPJ:NCORcorepressor complexNOTCH1HD+PESTDomainMutantFragments/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutant FragmentsKAT2A UBB(77-152) UBC(229-304) HDAC2 PSEN1(299-467) NICD1ITCHUBB(1-76) JAG1 RPS27A(1-76) UBA52(1-76) NOTCH1 V1676D Transmembrane Fragment UBA52(1-76) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(609-684) UBB(153-228) NCOR2 HDAC11 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(77-152) DLL1:NOTCH1p-NICD1NOTCH1 L1678P Transmembrane Fragment UBC(229-304) HDAC8 UBB(1-76) UBB(77-152) NICD1:DTXNOTCH1 L1600P Extracellular Fragment DTX4 UBA52(1-76) FBXW7gamma RBPJ:SNW1UBC(229-304) NOTCH1 I1718T Transmembrane Fragment NOTCH1 P2514Rfs*4 Transmembrane Fragment TLE3-3 NOTCH1(1665-2555) UBC(1-76) NOTCH1:DTXSKP1 HDAC10 NOTCH1(1665-2555) CREBBP DTX2 NOTCH1 F1592S Extracellular Fragment NOTCH1 L1574Q Extracellular Fragment DLL4 UBC(77-152) Signaling byTGF-beta ReceptorComplexKAT2B NOTCH1 V1676D Transmembrane Fragment NOTCH1 Q2440* Transmembrane Fragment DNER:NOTCH1:DTXKAT2B 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBB(77-152) DLK1 ARRB2 UBC(153-228) HDAC6 NOTCH1 L1574Q Extracellular Fragment DNERMYC gene TLEUBC(305-380) UBC(229-304) MAML3 MIB2 UBA52(1-76) DLL1 UBC(381-456) NOTCH1 Q2395* Transmembrane Fragment SKP1 NEURL1B UBC(305-380) NOTCH1(1665-1720) NOTCH1 L1596H Extracellular Fragment DTX1 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NOTCH1 I1616N Extracellular Fragment ARRB1 PSEN1(1-298) UBB(77-152) NCOR1 UBA52(1-76) NICD1UBC(77-152) JAG2 UBB(1-76) UBC(609-684) NOTCH1(1665-1720) ADAM17 FBXW7alpha UBC(381-456) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(609-684) CNTN1MAML2 gamma-secretasecomplexHEY1 gene HDAC1 NOTCH1 V1676D Transmembrane Fragment MAMLD1 UBC(77-152) NOTCH1 L1574Q Extracellular Fragment UBC(609-684) UBB(77-152) UBB(1-76) NOTCH1 HD domain mutants NCSTN TLE4 JAG1 JAG2 NUMB MAML1 MAMLD1 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(533-608) RBX1 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) MAML2 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NBEA HDAC6 JAG1 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(305-380) JAG1:NOTCH1EP300 UBB(1-76) Ubiquitin ligaseRPS27A(1-76) UBC(229-304) KAT2B DTX1 NOTCH1 R1598P Extracellular Fragment HEY2 gene UBC(381-456) UBC(229-304) NOTCH1(1665-2555) UBC(381-456) UBC(1-76) ITCHEP300 UBB(153-228) NICD1 RPS27A(1-76) RPS27A(1-76) NOTCH1UBB(1-76) KAT2A MYCUBA52(1-76) NOTCH1 Q2440* Transmembrane Fragment DTX2 NOTCH1 L1678P Transmembrane Fragment HES5 geneNOTCH1 P2514Rfs*4 Transmembrane Fragment NOTCH1:DTXUBC(1-76) HDAC11 NOTCH1 I1680N S2 cleavage fragment 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) JAG2UBC(153-228) HDAC9 UBC(533-608) RPS27A(1-76) PCAFNICD1 NOTCH1 I1616T Extracellular Fragment UBC(381-456) UbKAT2B UBC(457-532) CDK8:CCNCUBC(229-304) NBEAUBC(533-608) NOTCH1 V1576E Extracellular Fragment UBC(229-304) NOTCH1t(7;9)(NOTCH1:M1580_K2555)ARRB1 DTX4 DLL4 HDAC4 UBC(457-532) RPS27A(1-76) SNW1 ITCH PSEN2(1-297) NOTCH1 L1600P Extracellular Fragment DLL/JAG:NOTCH1 HDdomain mutantsNOTCH1 L1574P Extracellular Fragment NICD1 DTX1 UBB(1-76) UBC(533-608) UBC(609-684) MAMLD1 UBB(77-152) NOTCH1 CoactivatorComplex:HEY GenesMAML2 UBC(153-228) HEY2 gene UBC(381-456) JAG1 JAG2 NEXT1 Q2395* EP300 UBC(457-532) NOTCH1 I1616T Extracellular Fragment CREBBP UBC(381-456) NOTCH1 F1592S Extracellular Fragment JAG1 UBC(381-456) ARRB2 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NOTCH1 F1592S Extracellular Fragment UBC(229-304) ATPNOTCH1 L1593P Extracellular Fragment DLL1 MAML1 UBC(533-608) DLL4:NOTCH1NOTCH1 I1718T S2 cleavage fragment SNW1 ARRB1 UBB(153-228) NOTCH1 I1680N Transmembrane Fragment NOTCH1 L1574P Extracellular Fragment DLL1 HEYL Gene FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) NOTCH1 L1593P Extracellular Fragment UBB(153-228) UBC(609-684) HES1:TLEUBB(153-228) ITCH UBC(457-532) UBC(77-152) MAML3 CREBBP MAML1 UBC(305-380) DLL4 UbDTX4 UBC(381-456) UBC(1-76) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(1-76) JAG2:NOTCH1NOTCH1 CoactivatorComplex:HES5 GeneNOTCH1 L1600P Extracellular Fragment NOTCH1(1665-2555) DLL4 DTX1 KAT2B DTX2 NOTCH1 V1576E Extracellular Fragment UBC(609-684) UBB(153-228) RBPJ UBB(1-76) RBPJ UBC(533-608) NOTCH1 L1574P Extracellular Fragment UBC(457-532) UBC(305-380) HES1 gene NOTCH1:DTX:ARRBEP300 NOTCH1 L1600P Extracellular Fragment HEY1 DLL4 UBB(153-228) NOTCH1 A1701P S2 cleavage fragment Ub-NOTCH1:DTX:ARRBDTX:ITCHHDAC7 UBC(1-76) NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment JAG1UBC(229-304) HES1 UBC(305-380) NOTCH1 V1576E Extracellular Fragment DLL4 MAML2 NOTCH1 R1598P Extracellular Fragment NOTCH1(1665-2555) NICD1 KAT2A SNW1 TBL1XR1 CCNC Ub-DLL/JAG:NOTCH1HD+PEST DomainMutantsMAML3 UBC(77-152) SNW1 JAG2 UBB(77-152) NOTCH1(1665-2555) NOTCH1(1665-2555) NOTCH1 L1574P Extracellular Fragment NOTCH1 Q2395* Transmembrane Fragment NOTCH1 L1574P Extracellular Fragment DTX2 UbUBC(381-456) DTX4 NCOR:HDAC:TBL1NOTCH1 I1616N Extracellular Fragment DLL4 UBC(1-76) UBB(77-152) NOTCH1 P2474Afs*4 Transmembrane Fragment NOTCH1 P2474Afs*4 Transmembrane Fragment 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) ARRB2 NOTCH1 R1598P Extracellular Fragment NOTCH1(1665-2555) UBC(153-228) NCOR1 UBC(457-532) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NOTCH1 L1593P Extracellular Fragment RPS27A(1-76) UBC(1-76) KAT2B NOTCH1 L1574P Extracellular Fragment UBC(77-152) JAG2 MAMLD1 NOTCH1(1665-2555) NOTCH1 I1680N Transmembrane Fragment MAML2 UBC(229-304) JAG2 NOTCH1(1665-2555) NOTCH1 I1680N Transmembrane Fragment APH1B UBB(153-228) UBC(609-684) DTX4 Pre-NOTCH Expressionand ProcessingUBC(457-532) NOTCH1 R1598P Extracellular Fragment APH1A NOTCH1(1665-2555) UBC(533-608) NICD1 UBC(533-608) NOTCH1 L1574P Extracellular Fragment UBC(381-456) NOTCH1 HD+PEST Domain Mutant Fragments NOTCH1 A1701P Transmembrane Fragment UBB(1-76) RBPJ JAG2 JAG1 SNW1 Mitotic G1 phase andG1/S transitionNOTCH1 I1616N Extracellular Fragment UBC(305-380) HEYL Gene JAG1 UBC(77-152) UBC(609-684) UBB(153-228) UBA52(1-76) NOTCH1 CoactivatorComplex:HES1 GeneUBB(77-152) UBC(1-76) NOTCH1 A1701P Transmembrane Fragment CDK8 UBC(229-304) NOTCH1 V1576E Extracellular Fragment HEY GenesCNTN1:NOTCH1:DTXDLL1 EP300UBC(153-228) NOTCH1HDdomainmutants/Ub-DLL/JAG:NOTCH1 HD domain mutantsNOTCH1CREBBP UBB(153-228) UBA52(1-76) JAG2 CUL1 NOTCH1:NUMB:ITCHNUMBDTX1 NICD1 MAMLD1 HDAC3 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(153-228) NOTCH1 CoactivatorComplexNOTCH1 L1596H Extracellular Fragment NOTCH1(1665-2555) Ub-DLL/JAG:NOTCH1fragmentMAMLD1 UBC(609-684) UBC(1-76) UBC(533-608) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBA52(1-76) RPS27A(1-76) UBC(1-76) Ub-NOTCH1:NUMB:ITCHDLL1 UBC(381-456) DLL4 DLL/JAG:NOTCH1HD+PEST DomainMutantsRBPJ UBC(153-228) MAML1 DLL4 NOTCH1(1665-2555) UBC(533-608) HES5JAG2 NOTCH1 F1592S Extracellular Fragment MIB/NEURLUBC(229-304) DTXNOTCH1 L1600P Extracellular Fragment HDAC2 NOTCH1(1665-2555) EP300 NOTCH1 L1678P S2 cleavage fragment NOTCH1(1665-2555) UBB(77-152) NOTCH1 L1574P Extracellular Fragment UBB(1-76) RBPJ NOTCH1:DLL/JAGUBB(77-152) NOTCH1 P2514Rfs*4 Transmembrane Fragment UBC(457-532) RBPJ NOTCH1 I1616T Extracellular Fragment DTX2 NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment UBC(609-684) NOTCH1 Q2395* Transmembrane Fragment KAT2A UBC(533-608) UBC(457-532) UBC(1-76) NUMB ARRBUb-DLL/JAG:NOTCH1HDAC5 DLL1 DNER UbNICD1 UBC(153-228) JAG1 RPS27A(1-76) DTX1 NOTCH1 CoactivatorComplex:MYC GeneDLL1 UBC(153-228) HIF1ARPS27A(1-76) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) MAML3 NOTCH1 P2474Afs*4 Transmembrane Fragment HDAC10 DTX4 UBB(1-76) DLL1 UBC(1-76) RBX1 NEXT1TBL1X UBC(457-532) NOTCH1/Fringe-modified NOTCH1NOTCH1(1665-1720) KAT2A ITCH CUL1 CNTN1 UBC(609-684) UBC(381-456) UBC(457-532) DLL/JAGHIF1A MAML2 UBC(381-456) RBPJ DLL1 FBXW7alpha RBPJ UBA52(1-76) SNW1 UBC(1-76) NOTCH1 HD domain mutant fragments NOTCH1(1665-2555) CCNC UBB(77-152) MAML1 NOTCH1(1665-2555) UBC(457-532) TLE4 TLE2 TBL1XR1 FBXW7:SKP1:CUL1:RBX1NOTCH1 CoactivatorComplex:CDK8:CCNCNOTCH1(1665-2555) UBC(153-228) NOTCH1HD+PESTDomainMutants/Ub-DLL/JAG:NOTCH1 HD+PEST Domain MutantsHES5 gene UBC(457-532) UBC(305-380) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBA52(1-76) SNW1 DLL1 DTX4 p-NICD1 NOTCH1 I1616N Extracellular Fragment FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) ITCH UBC(305-380) Ub-p-NICD1UBC(533-608) NOTCH1 L1593P Extracellular Fragment UBC(305-380) UBC(229-304) NICD1 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(77-152) DTX2 1, 5, 8, 21, 37...1111516, 10, 16, 30, 41...111081111111147, 971243471151951151111134, 10511