Signaling by NOTCH1 (Homo sapiens)

From WikiPathways

Jump to: navigation, search
1, 3, 5, 6, 10...12, 243, 38, 47, 7313, 35, 79, 102, 1033829, 78, 116803926451, 54, 1075, 14, 31, 71, 818038944416, 11832, 49, 64, 66, 67, 77...455918, 7530, 96, 11710, 596, 23, 27, 34, 4832, 49, 64, 66, 67, 77...2, 8883, 84399928, 52, 701185932, 49, 64, 66, 67, 77...2619, 69, 9230, 4310, 15, 33, 59912, 95995, 9, 14, 31, 71...3, 38, 47, 7350, 101, 104Signal receiving cellSignal sending cellcytosolcytosolnucleoplasmp-NICD1 UBB(153-228) NCOR1 UBC(229-304) NOTCH1 L1574P Extracellular Fragment DLL1 FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) DTX2 NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment DLL4 NOTCH1(1665-2555) NOTCH1(1665-2555) ATPDTX4 DLL1 NOTCH1 I1616N Extracellular Fragment UBB(153-228) HDAC9 HIF1AKAT2B UBC(457-532) SNW1 UBC(381-456) UBC(381-456) UBB(153-228) CNTN1UBC(77-152) UBC(1-76) APH1B NOTCH1 I1718T Transmembrane Fragment DTX1 NICD1 NCOR2 UBC(381-456) RBPJ NOTCH1 P2474Afs*4 Transmembrane Fragment JAG2:NOTCH1NOTCH1 Q2440* Transmembrane Fragment UBC(381-456) JAG1 FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) UBB(1-76) ITCH NOTCH1 L1600P Extracellular Fragment DLL/JAG:NOTCH1CDK8:CCNCUBC(533-608) UBC(305-380) DTX2 UBB(1-76) UBC(533-608) ARRB1 UBC(533-608) RPS27A(1-76) DTX1 ARRBDLL1 ADAM17 MAMLJAG1 NCOR1 NOTCH1 L1596H Extracellular Fragment DLL1 NEXT1 Q2395* NOTCH1UBA52(1-76) NOTCH1 P2514Rfs*4 Transmembrane Fragment TBL1XR1 DLL4 DLL/JAG:NOTCH1 HDdomain mutantsUBB(77-152) NOTCH1 L1574P Extracellular Fragment UBC(229-304) NOTCH1 I1616T Extracellular Fragment RPS27A(1-76) NOTCH1 A1701P Transmembrane Fragment NOTCH1(1665-2555) UBB(1-76) DLL1 UBB(1-76) NOTCH1(1665-2555) DLL1 UBB(1-76) NOTCH1(1665-2555) JAG1 UBC(457-532) UBC(457-532) TBL1XR1 NOTCH1(1665-2555) UBC(1-76) MAML3 NOTCH1(1665-2555) DTXNOTCH1 R1598P Extracellular Fragment NOTCH1:DLK119xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) Ub-DLL/JAG:NOTCH1HD+PEST DomainMutantsNOTCH1DLL4 DLL/JAG:NOTCH1HD+PEST DomainMutantsNOTCH1 V1676D Transmembrane Fragment UBB(1-76) UBB(1-76) DTX1 UBC(153-228) NCOR2 UBB(1-76) UBC(609-684) NOTCH1(1665-2555) NOTCH1 P2474Afs*4 Transmembrane Fragment NUMB HDAC1 DTX4 TBL1X UBC(229-304) NOTCH1 L1574Q Extracellular Fragment UBC(77-152) HIF1A UBB(153-228) NEXT1 P2514Rfs*4 UBC(1-76) NOTCH1 L1678P Transmembrane Fragment FBXW7gamma DTX2 UBB(1-76) HES1:TLEMAMLD1 NOTCH1 L1596H Extracellular Fragment UBC(381-456) DTX4 DTX2 NOTCH1 L1574Q Extracellular Fragment MYC geneHES5NOTCH1 HD+PEST Domain Mutant Fragments 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) CUL1 UBC(609-684) NOTCH1 R1598P Extracellular Fragment NICD1 NOTCH1 CoactivatorComplex:CDK8:CCNCJAG2 NOTCH1 I1680N Transmembrane Fragment NEXT1 PEST domainmutantsMAML2 NOTCH1 F1592S Extracellular Fragment CCNC HDAC5 KAT2B UBC(381-456) DTX2 NICD1:DTXTLE2 HDAC8 Ub-NOTCH1:DTX:ARRBUBC(381-456) NOTCH1 Q2395* Transmembrane Fragment DTX1 HES5 gene NOTCH1(1665-2555) NOTCH1 HD domain mutants NOTCH1 I1616T Extracellular Fragment NOTCH1 L1596H Extracellular Fragment UBC(77-152) UBC(381-456) NOTCH1(1665-2555) UBA52(1-76) UBC(457-532) NOTCH1 I1616N Extracellular Fragment KAT2A SNW1 RPS27A(1-76) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(1-76) UBC(457-532) DLL4 RPS27A(1-76) ITCHRBPJ MAMLD1 SKP1 MAMLD1 UBC(457-532) UBC(229-304) UBC(229-304) DLL4 MAML1 TLE3-3 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) MAML1 JAG2 HDAC5 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NOTCH1 R1598P Extracellular Fragment SNW1 NOTCH1(1665-2555) RPS27A(1-76) UBC(153-228) HDAC9 UBC(305-380) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) RPS27A(1-76) PSEN1(299-467) KAT2A UBC(229-304) UBB(77-152) NOTCH1 A1701P Transmembrane Fragment UBC(533-608) JAG1 ITCHUBB(77-152) UBC(609-684) ARRB1 UBC(381-456) UBC(1-76) TLE2 Pre-NOTCH Expressionand ProcessingTLE3-3 NOTCH1(1721-1753)DTX1 NOTCH1UBC(609-684) UBB(77-152) UBA52(1-76) UBC(609-684) NOTCH1 L1574P Extracellular Fragment NOTCH1 Q2440* Transmembrane Fragment UBB(77-152) NCOR:HDAC:TBL1UBC(305-380) NOTCH1 I1718T S2 cleavage fragment MAML1 UBB(77-152) DTX2 KAT2A DLL4 UBC(229-304) DLL1 UBC(533-608) HEY1 UBC(77-152) DLL1 DTX4 HEY2 NOTCH1 L1600P Extracellular Fragment RPS27A(1-76) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) HDAC6 UBB(153-228) UBC(153-228) PSEN1(1-298) UBC(609-684) UBC(229-304) UBB(77-152) UBB(153-228) KAT2B KAT2A TLE4 UBC(229-304) JAG1 gamma-secretasecomplexUBA52(1-76) UBC(77-152) CDK8 NOTCH1(1665-2555) UBC(533-608) HDAC2 ITCH HEY1 gene UBC(609-684) HDAC10 UBB(153-228) TLE1 UBB(1-76) NOTCH1 I1616T Extracellular Fragment ARRB2 RPS27A(1-76) UBB(77-152) UBC(77-152) ITCH NOTCH1UBB(77-152) CREBBP MIB2 SNW1 UBB(1-76) HES5 geneUbNICD1:RBPJ:SNW1ARRB1 UBC(153-228) NOTCH1(1665-2555) UBC(229-304) MAML2 JAG1 JAG2 UBB(153-228) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) MAML3 MAML1 DLL1NOTCH1 L1593P Extracellular Fragment DLL1 MIB/NEURLUBC(153-228) HEY1 gene UBA52(1-76) FBXW7alpha UBC(381-456) NUMB NOTCH1:DLL/JAGUBC(609-684) MAMLD1 UBB(77-152) JAG1 JAG2 HDAC8 Ub-NOTCH1:NUMB:ITCHKAT2A UBC(457-532) DTX:ITCHNOTCH1(1665-2555) NOTCH1HDdomainmutants/Ub-DLL/JAG:NOTCH1 HD domain mutantsUBC(609-684) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) Ub-DLL/JAG:NOTCH1fragmentUBC(457-532) CNTN1:NOTCH1:DTXJAG1 UBC(305-380) CUL1 NOTCH1 P2514Rfs*4 Transmembrane Fragment NOTCH1 CoactivatorComplexUBC(1-76) RBPJ UBC(305-380) CREBBP UBC(457-532) Ub-p-NICD1NOTCH1:DTX:ARRBTLE4 CREBBP UBC(1-76) Mitotic G1-G1/SphasesJAG1 Ub-DTX:ITCHHDAC1 NOTCH1 P2514Rfs*4 Transmembrane Fragment NOTCH1 V1576E Extracellular Fragment UBC(305-380) DLL1 UBB(77-152) DLL4 DLL4 JAG1 JAG2 UBC(1-76) UBC(457-532) NOTCH1 L1600P Extracellular Fragment ITCH JAG1 NOTCH1:DTXPSEN2(1-297) MAML1 CREBBP FBXW7:SKP1:CUL1:RBX1UBC(1-76) UbDLL4 NOTCH1(1665-2555) UBC(153-228) NOTCH1HD+PESTDomainMutantFragments/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutant FragmentsRPS27A(1-76) JAG1:NOTCH1MAML2 MAMLD1 NEURL NOTCH1 L1678P Transmembrane Fragment NOTCH1 CoactivatorComplex:HEY GenesFRINGE-modified NOTCH1 Extracellular Fragment (NECD1) HES1 UBB(1-76) HDAC3 MAML1 NOTCH1 I1680N Transmembrane Fragment NOTCH1 CoactivatorComplex:MYC Gene19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(153-228) UBC(153-228) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NICD1 MAML2 UBC(77-152) NOTCH1 L1574Q Extracellular Fragment MAMLD1 EP300ADAM10/17:Zn2+Ub-DLL/JAG:NOTCH1UBC(153-228) UBB(153-228) UBC(1-76) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NOTCH1HDdomainmutantfragments/Ub-DLL/JAG:NOTCH1 HD domain mutant fragmentsNOTCH1(1665-2555) EP300 HDAC6 NCSTN UBC(609-684) MAML3 NOTCH1 F1592S Extracellular Fragment UBC(153-228) RBPJ NOTCH1(1665-2555) HDAC3 DTX1 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NOTCH1t(7;9)(NOTCH1:M1580_K2555)MAML1 SNW1 UBC(305-380) NOTCH1:DTXUBB(1-76) UBC(77-152) UBA52(1-76) RBX1 UBC(609-684) ADAM10 EP300 UBC(457-532) DTX4 NOTCH1 I1718T Transmembrane Fragment NICD1 UBC(305-380) MAML2 UBA52(1-76) FBXW7gamma JAG2 ARRB2 UBB(77-152) MAML2 JAG2 UBC(1-76) KAT2B RPS27A(1-76) NOTCH1(1665-2555) JAG1 TBL1X DNER:NOTCH1:DTXJAG2 NOTCH1 L1600P Extracellular Fragment DLL4:NOTCH1Ubiquitin ligaseUBB(77-152) UBB(77-152) HEY2 gene p-NICD1:FBXW7:SKP1:CUL1:RBX1NOTCH1 R1598P Extracellular Fragment UBC(229-304) PSENEN MAMLD1 UBC(153-228) NOTCH1:NUMB:ITCHUBC(457-532) NOTCH1 F1592S Extracellular Fragment DTX4 NOTCH1 L1574P Extracellular Fragment MIB1 NOTCH1(1665-1720) DNER 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) KAT2A UBB(153-228) UBC(153-228) NOTCH1 L1600P Extracellular Fragment CNTN1 DLL4 DLL4 MYCNICD1 RPS27A(1-76) UBC(533-608) NOTCH1 V1576E Extracellular Fragment 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NOTCH1 L1600P Extracellular Fragment NOTCH1(1665-2555) UBC(457-532) UBC(381-456) RPS27A(1-76) NOTCH1(1665-1720) UBB(1-76) CREBBP DTX1 JAG1 TLEUBB(1-76) UBC(381-456) UBC(381-456) JAG2 Signaling byTGF-beta ReceptorComplexHEYHES1 geneUBC(305-380) NOTCH1(1665-2555) DTX1 HES1 gene NOTCH1 L1678P S2 cleavage fragment HDAC2 CREBBPHDAC7 UBC(153-228) UBC(381-456) NOTCH1 L1593P Extracellular Fragment UbUBC(609-684) UBC(533-608) RBPJ APH1A CREBBP UBA52(1-76) NOTCH1t(7;9)(NOTCH1:M1580_K2555) fragmentNOTCH1 I1680N S2 cleavage fragment NUMBSNW1 UBB(153-228) UBC(533-608) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(609-684) UBC(77-152) NOTCH1 CoactivatorComplex:HES5 GeneUBC(229-304) NOTCH1 A1701P Transmembrane Fragment RBPJ:NCORcorepressor complexUBC(381-456) NOTCH1(1665-2555) Zn2+ DTX4 NOTCH1 L1574P Extracellular Fragment p-NICD1NOTCH1 CoactivatorComplex:HES1 GeneJAG2 UBC(229-304) DTX1 NOTCH1(1665-2555) UBC(305-380) JAG1NICD1 UBC(305-380) NOTCH1 I1680N Transmembrane Fragment HEYL Gene KAT2B FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) KAT2B UBC(533-608) UBB(153-228) DLK1UBC(609-684) MYC gene KAT2B UBC(1-76) UBA52(1-76) NOTCH1 Q2440* Transmembrane Fragment NOTCH1 V1676D S2 cleavage fragment RPS27A(1-76) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NEXT1 P2474Afs*4 HEY2 gene 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) HDAC11 NOTCH1(1665-1720) UBB(1-76) RBPJ NOTCH1/Fringe-modified NOTCH1UBA52(1-76) NOTCH1 I1718T Transmembrane Fragment JAG2UBC(533-608) UBC(229-304) NOTCH1 Q2395* Transmembrane Fragment UBC(305-380) DLK1 UBB(153-228) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NOTCH1 A1701P S2 cleavage fragment UBC(533-608) JAG1 UBC(305-380) NOTCH1UBC(1-76) KAT2A HES1JAG2 UBC(533-608) UBA52(1-76) NOTCH1 L1593P Extracellular Fragment UBC(457-532) UBC(153-228) UBC(381-456) RBPJ HEYL UBC(305-380) UBC(533-608) HEYL Gene NOTCH1(1665-2555) NOTCH1 L1574P Extracellular Fragment NEURL1B UBB(153-228) UBC(153-228) UBC(229-304) NEXT1 Q2440* JAG2 EP300 NICD1UBA52(1-76) UBC(457-532) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) HEY GenesNOTCH1HD+PESTDomainMutants/Ub-DLL/JAG:NOTCH1 HD+PEST Domain MutantsFBXW7alpha EP300 NOTCH1 L1600P Extracellular Fragment UBC(153-228) UBB(77-152) NOTCH1 L1574P Extracellular Fragment NICD1:HIF1ANOTCH1 L1574P Extracellular Fragment UBC(77-152) NOTCH1 Q2395* Transmembrane Fragment ARRB2 UBC(77-152) NOTCH1 L1593P Extracellular Fragment UBC(1-76) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) MAML2 UBC(609-684) NOTCH1 V1576E Extracellular Fragment RBPJ HDAC11 DTX1 UBC(381-456) UBA52(1-76) UBA52(1-76) UBC(77-152) UBC(229-304) DLL1:NOTCH1CCNC NOTCH1 L1600P Extracellular Fragment NOTCH1 V1576E Extracellular Fragment UBB(153-228) NOTCH1 V1676D Transmembrane Fragment UBC(305-380) PCAFJAG2 NOTCH1/Fringe-modified NOTCH1DLL1 UBC(153-228) NICD1 NOTCH1 L1574Q Extracellular Fragment DLL419xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(77-152) UBA52(1-76) HDAC4 UBC(77-152) TLE1 NOTCH1 L1678P Transmembrane Fragment DLL4 NOTCH1 I1616N Extracellular Fragment UBC(457-532) SNW1 DNERSKP1 HDAC7 HDAC4 MAML3 RPS27A(1-76) DLL4 NOTCH1(1665-1720) DTX2 UBA52(1-76) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(77-152) DLL/JAGUBC(1-76) DTX4 NOTCH1 V1676D Transmembrane Fragment NOTCH1(1665-2555) UBC(305-380) NOTCH1(1665-2555) NOTCH1 HD domain mutant fragments NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment HDAC10 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) RBX1 RPS27A(1-76) NOTCH1 F1592S Extracellular Fragment MAML3 UBC(457-532) NOTCH1 P2474Afs*4 Transmembrane Fragment NICD1Ub-DLL/JAG:NOTCH1 HDdomain mutantsRPS27A(1-76) UBC(1-76) RPS27A(1-76) DTX2 NICD1 MAML3 NOTCH1(1665-2555) UBB(77-152) UBB(77-152) UBB(1-76) UBC(229-304) NOTCH1 I1616N Extracellular Fragment UBC(77-152) UBC(77-152) UbUbNEXT1SNW1 p-NICD1 JAG2 UBB(153-228) DLL1 DLL1 NOTCH1 I1616T Extracellular Fragment EP300 DTX2 EP300 UBB(153-228) DTX2 DTX4 UBC(609-684) RBPJ UBC(305-380) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(533-608) UBC(533-608) NICD1 PSEN2(298-448) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) DTX4 NOTCH1(1665-2555) ADPNOTCH1 HD+PEST Domain Mutants SNW1 RBPJ:SNW1NOTCH1 L1596H Extracellular Fragment UBC(609-684) CDK8 UBA52(1-76) DLL1 DLL4 UBC(533-608) MAML3 UBC(1-76) 80442121442110, 5959214421217, 11, 17, 22, 37...4, 8, 20, 25, 41...21212121362121973, 11599