Signaling by NOTCH1 (Homo sapiens)
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2-4, 7, 12...
103
13, 17, 27, 49, 56...
112
33, 34, 63, 112
108
2, 115
7, 69, 73
47, 97
23, 40, 109
19, 53, 86, 98, 106...
108
13, 17, 27, 49, 56...
91
47
58
31, 32, 89
28, 66
9, 29
12
47
25
51
112
53
20, 36, 39, 42, 107
33, 34, 63, 112
14, 18, 24
4, 92
47, 70, 97, 117
26, 74, 90
103
65, 91
25
15, 22, 104
58
3, 35, 45, 84, 94
13, 17, 27, 49, 56...
18, 67
19, 86, 98, 106, 118
12
76
38, 66
Signal sending cell
cytosol
cytosol
Signal receiving cell
nucleoplasm
TLE1
UBA52(1-76)
UBB(1-76)
MAML
TLE1
UBC(77-152)
UBC(305-380)
NOTCH1 I1718T Transmembrane Fragment
NOTCH1
HD
domain
mutant
fragments/Ub-DLL/JAG:NOTCH1 HD domain mutant fragments
DTX1
UBB(153-228)
NEXT1 PEST domain
mutants
UBC(457-532)
DTX2
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
UBC(609-684)
UBC(1-76)
UBC(533-608)
NEURL
UBC(305-380)
UBB(77-152)
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
HDAC8
MAML3
UBB(1-76)
UBB(153-228)
HES1 gene
UBC(153-228)
CREBBP
JAG2
UBC(609-684)
UBB(153-228)
NOTCH1 L1678P Transmembrane Fragment
DLL/JAG:NOTCH1
NCOR2
UBC(533-608)
NOTCH1 HD+PEST Domain Mutants
UBA52(1-76)
HDAC9
JAG1
NOTCH1(1665-2555)
RPS27A(1-76)
UBC(609-684)
KAT2A
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
UBC(153-228)
UBC(1-76)
NOTCH1 L1574Q Extracellular Fragment
HEY1 gene
TLE2
UBC(305-380)
UBB(1-76)
HES1
ADAM10
HEY
JAG2
UBB(77-152)
FBXW7gamma
NOTCH1 L1600P Extracellular Fragment
DTX4
NOTCH1
UBC(609-684)
p-NICD1:FBXW7:SKP1:CUL1:RBX1
UBB(153-228)
JAG1
UBC(229-304)
NICD1
NICD1:HIF1A
CREBBP
HDAC3
RPS27A(1-76)
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
DLL4
ADAM10/17:Zn2+
JAG1
UBC(153-228)
UBC(1-76)
FRINGE-modified NOTCH1 Extracellular Fragment (NECD1)
JAG1
NOTCH1 A1701P Transmembrane Fragment
CDK8
UBB(1-76)
NOTCH1(1665-2555)
HEYL
NOTCH1(1665-1720)
NEXT1 P2474Afs*4
PSEN2(298-448)
UBC(229-304)
MAML1
NOTCH1
UBC(77-152)
UBA52(1-76)
UBB(1-76)
RPS27A(1-76)
KAT2B
UBC(229-304)
MAMLD1
Ub-DLL/JAG:NOTCH1 HD
domain mutants
DLL1
MIB1
DLL4
NOTCH1 I1616T Extracellular Fragment
UBC(381-456)
Ub-DTX:ITCH
UBC(77-152)
UBC(77-152)
NOTCH1 L1596H Extracellular Fragment
NOTCH1 V1676D S2 cleavage fragment
HEY2
DTX2
RPS27A(1-76)
UBB(153-228)
NOTCH1 I1718T Transmembrane Fragment
MAML3
JAG1
UBC(457-532)
UBB(77-152)
DLK1
UBA52(1-76)
NOTCH1 L1600P Extracellular Fragment
UBA52(1-76)
UBC(77-152)
TBL1X
DLL1
NICD1:NBEA
UBC(305-380)
DLL1
p-NICD1
FRINGE-modified NOTCH1 Extracellular Fragment (NECD1)
UBC(77-152)
NOTCH1 L1596H Extracellular Fragment
NOTCH1 L1600P Extracellular Fragment
JAG1
DLL4
DTX4
DTX2
KAT2A
DLL4
DTX1
NOTCH1(1665-2555)
NICD1:RBPJ:SNW1
Ub
NOTCH1(1665-2555)
SNW1
UBC(533-608)
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
UBB(153-228)
UBB(77-152)
UBC(77-152)
UBC(305-380)
PSENEN
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
DLL1
ADP
JAG2
DTX2
UBC(609-684)
TLE3-3
RPS27A(1-76)
UBC(533-608)
UBC(305-380)
NEXT1 P2514Rfs*4
NOTCH1
t(7;9)(NOTCH1:M1580_K2555) fragment
UBB(77-152)
FRINGE-modified NOTCH1 Extracellular Fragment (NECD1)
DLL1
UBC(153-228)
UBA52(1-76)
NEXT1 Q2440*
UBC(153-228)
NOTCH1(1721-1753)
UBC(77-152)
UBC(153-228)
NOTCH1(1665-2555)
UBC(381-456)
RPS27A(1-76)
MAML2
UBB(1-76)
HDAC1
MYC gene
DTX1
UBC(305-380)
RPS27A(1-76)
HDAC7
UBC(457-532)
NOTCH1(1665-2555)
NOTCH1(1665-2555)
JAG2
HDAC4
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
JAG2
UBC(153-228)
DLL4
DLL4
NOTCH1 Q2440* Transmembrane Fragment
DTX4
MAML3
SNW1
UBB(153-228)
UBC(457-532)
UBC(381-456)
HDAC5
UBC(533-608)
CREBBP
MAML1
NOTCH1:DLK1
RBPJ
EP300
DTX1
Zn2+
NICD1
NBEA
RBPJ:NCOR
corepressor complex
NOTCH1
HD+PEST
Domain
Mutant
Fragments/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutant Fragments
KAT2A
UBB(77-152)
UBC(229-304)
HDAC2
PSEN1(299-467)
NICD1
ITCH
UBB(1-76)
JAG1
RPS27A(1-76)
UBA52(1-76)
NOTCH1 V1676D Transmembrane Fragment
UBA52(1-76)
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
UBC(609-684)
UBB(153-228)
NCOR2
HDAC11
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
UBC(77-152)
DLL1:NOTCH1
p-NICD1
NOTCH1 L1678P Transmembrane Fragment
UBC(229-304)
HDAC8
UBB(1-76)
UBB(77-152)
NICD1:DTX
NOTCH1 L1600P Extracellular Fragment
DTX4
UBA52(1-76)
FBXW7gamma
RBPJ:SNW1
UBC(229-304)
NOTCH1 I1718T Transmembrane Fragment
NOTCH1 P2514Rfs*4 Transmembrane Fragment
TLE3-3
NOTCH1(1665-2555)
UBC(1-76)
NOTCH1:DTX
SKP1
HDAC10
NOTCH1(1665-2555)
CREBBP
DTX2
NOTCH1 F1592S Extracellular Fragment
NOTCH1 L1574Q Extracellular Fragment
DLL4
UBC(77-152)
Signaling by
TGF-beta Receptor
Complex
KAT2B
NOTCH1 V1676D Transmembrane Fragment
NOTCH1 Q2440* Transmembrane Fragment
DNER:NOTCH1:DTX
KAT2B
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
UBB(77-152)
DLK1
ARRB2
UBC(153-228)
HDAC6
NOTCH1 L1574Q Extracellular Fragment
DNER
MYC gene
TLE
UBC(305-380)
UBC(229-304)
MAML3
MIB2
UBA52(1-76)
DLL1
UBC(381-456)
NOTCH1 Q2395* Transmembrane Fragment
SKP1
NEURL1B
UBC(305-380)
NOTCH1(1665-1720)
NOTCH1 L1596H Extracellular Fragment
DTX1
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
NOTCH1 I1616N Extracellular Fragment
ARRB1
PSEN1(1-298)
UBB(77-152)
NCOR1
UBA52(1-76)
NICD1
UBC(77-152)
JAG2
UBB(1-76)
UBC(609-684)
NOTCH1(1665-1720)
ADAM17
FBXW7alpha
UBC(381-456)
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
UBC(609-684)
CNTN1
MAML2
gamma-secretase
complex
HEY1 gene
HDAC1
NOTCH1 V1676D Transmembrane Fragment
MAMLD1
UBC(77-152)
NOTCH1 L1574Q Extracellular Fragment
UBC(609-684)
UBB(77-152)
UBB(1-76)
NOTCH1 HD domain mutants
NCSTN
TLE4
JAG1
JAG2
NUMB
MAML1
MAMLD1
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
UBC(533-608)
RBX1
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
MAML2
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
NBEA
HDAC6
JAG1
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
UBC(305-380)
JAG1:NOTCH1
EP300
UBB(1-76)
Ubiquitin ligase
RPS27A(1-76)
UBC(229-304)
KAT2B
DTX1
NOTCH1 R1598P Extracellular Fragment
HEY2 gene
UBC(381-456)
UBC(229-304)
NOTCH1(1665-2555)
UBC(381-456)
UBC(1-76)
ITCH
EP300
UBB(153-228)
NICD1
RPS27A(1-76)
RPS27A(1-76)
NOTCH1
UBB(1-76)
KAT2A
MYC
UBA52(1-76)
NOTCH1 Q2440* Transmembrane Fragment
DTX2
NOTCH1 L1678P Transmembrane Fragment
HES5 gene
NOTCH1 P2514Rfs*4 Transmembrane Fragment
NOTCH1:DTX
UBC(1-76)
HDAC11
NOTCH1 I1680N S2 cleavage fragment
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
JAG2
UBC(153-228)
HDAC9
UBC(533-608)
RPS27A(1-76)
PCAF
NICD1
NOTCH1 I1616T Extracellular Fragment
UBC(381-456)
Ub
KAT2B
UBC(457-532)
CDK8:CCNC
UBC(229-304)
NBEA
UBC(533-608)
NOTCH1 V1576E Extracellular Fragment
UBC(229-304)
NOTCH1
t(7;9)(NOTCH1:M1580_K2555)
ARRB1
DTX4
DLL4
HDAC4
UBC(457-532)
RPS27A(1-76)
SNW1
ITCH
PSEN2(1-297)
NOTCH1 L1600P Extracellular Fragment
DLL/JAG:NOTCH1 HD
domain mutants
NOTCH1 L1574P Extracellular Fragment
NICD1
DTX1
UBB(1-76)
UBC(533-608)
UBC(609-684)
MAMLD1
UBB(77-152)
NOTCH1 Coactivator
Complex:HEY Genes
MAML2
UBC(153-228)
HEY2 gene
UBC(381-456)
JAG1
JAG2
NEXT1 Q2395*
EP300
UBC(457-532)
NOTCH1 I1616T Extracellular Fragment
CREBBP
UBC(381-456)
NOTCH1 F1592S Extracellular Fragment
JAG1
UBC(381-456)
ARRB2
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
NOTCH1 F1592S Extracellular Fragment
UBC(229-304)
ATP
NOTCH1 L1593P Extracellular Fragment
DLL1
MAML1
UBC(533-608)
DLL4:NOTCH1
NOTCH1 I1718T S2 cleavage fragment
SNW1
ARRB1
UBB(153-228)
NOTCH1 I1680N Transmembrane Fragment
NOTCH1 L1574P Extracellular Fragment
DLL1
HEYL Gene
FRINGE-modified NOTCH1 Extracellular Fragment (NECD1)
NOTCH1 L1593P Extracellular Fragment
UBB(153-228)
UBC(609-684)
HES1:TLE
UBB(153-228)
ITCH
UBC(457-532)
UBC(77-152)
MAML3
CREBBP
MAML1
UBC(305-380)
DLL4
Ub
DTX4
UBC(381-456)
UBC(1-76)
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
UBC(1-76)
JAG2:NOTCH1
NOTCH1 Coactivator
Complex:HES5 Gene
NOTCH1 L1600P Extracellular Fragment
NOTCH1(1665-2555)
DLL4
DTX1
KAT2B
DTX2
NOTCH1 V1576E Extracellular Fragment
UBC(609-684)
UBB(153-228)
RBPJ
UBB(1-76)
RBPJ
UBC(533-608)
NOTCH1 L1574P Extracellular Fragment
UBC(457-532)
UBC(305-380)
HES1 gene
NOTCH1:DTX:ARRB
EP300
NOTCH1 L1600P Extracellular Fragment
HEY1
DLL4
UBB(153-228)
NOTCH1 A1701P S2 cleavage fragment
Ub-NOTCH1:DTX:ARRB
DTX:ITCH
HDAC7
UBC(1-76)
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment
JAG1
UBC(229-304)
HES1
UBC(305-380)
NOTCH1 V1576E Extracellular Fragment
DLL4
MAML2
NOTCH1 R1598P Extracellular Fragment
NOTCH1(1665-2555)
NICD1
KAT2A
SNW1
TBL1XR1
CCNC
Ub-DLL/JAG:NOTCH1
HD+PEST Domain
Mutants
MAML3
UBC(77-152)
SNW1
JAG2
UBB(77-152)
NOTCH1(1665-2555)
NOTCH1(1665-2555)
NOTCH1 L1574P Extracellular Fragment
NOTCH1 Q2395* Transmembrane Fragment
NOTCH1 L1574P Extracellular Fragment
DTX2
Ub
UBC(381-456)
DTX4
NCOR:HDAC:TBL1
NOTCH1 I1616N Extracellular Fragment
DLL4
UBC(1-76)
UBB(77-152)
NOTCH1 P2474Afs*4 Transmembrane Fragment
NOTCH1 P2474Afs*4 Transmembrane Fragment
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
ARRB2
NOTCH1 R1598P Extracellular Fragment
NOTCH1(1665-2555)
UBC(153-228)
NCOR1
UBC(457-532)
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
NOTCH1 L1593P Extracellular Fragment
RPS27A(1-76)
UBC(1-76)
KAT2B
NOTCH1 L1574P Extracellular Fragment
UBC(77-152)
JAG2
MAMLD1
NOTCH1(1665-2555)
NOTCH1 I1680N Transmembrane Fragment
MAML2
UBC(229-304)
JAG2
NOTCH1(1665-2555)
NOTCH1 I1680N Transmembrane Fragment
APH1B
UBB(153-228)
UBC(609-684)
DTX4
Pre-NOTCH Expression
and Processing
UBC(457-532)
NOTCH1 R1598P Extracellular Fragment
APH1A
NOTCH1(1665-2555)
UBC(533-608)
NICD1
UBC(533-608)
NOTCH1 L1574P Extracellular Fragment
UBC(381-456)
NOTCH1 HD+PEST Domain Mutant Fragments
NOTCH1 A1701P Transmembrane Fragment
UBB(1-76)
RBPJ
JAG2
JAG1
SNW1
Mitotic G1 phase and
G1/S transition
NOTCH1 I1616N Extracellular Fragment
UBC(305-380)
HEYL Gene
JAG1
UBC(77-152)
UBC(609-684)
UBB(153-228)
UBA52(1-76)
NOTCH1 Coactivator
Complex:HES1 Gene
UBB(77-152)
UBC(1-76)
NOTCH1 A1701P Transmembrane Fragment
CDK8
UBC(229-304)
NOTCH1 V1576E Extracellular Fragment
HEY Genes
CNTN1:NOTCH1:DTX
DLL1
EP300
UBC(153-228)
NOTCH1
HD
domain
mutants/Ub-DLL/JAG:NOTCH1 HD domain mutants
NOTCH1
CREBBP
UBB(153-228)
UBA52(1-76)
JAG2
CUL1
NOTCH1:NUMB:ITCH
NUMB
DTX1
NICD1
MAMLD1
HDAC3
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
UBC(153-228)
NOTCH1 Coactivator
Complex
NOTCH1 L1596H Extracellular Fragment
NOTCH1(1665-2555)
Ub-DLL/JAG:NOTCH1
fragment
MAMLD1
UBC(609-684)
UBC(1-76)
UBC(533-608)
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
UBA52(1-76)
RPS27A(1-76)
UBC(1-76)
Ub-NOTCH1:NUMB:ITCH
DLL1
UBC(381-456)
DLL4
DLL/JAG:NOTCH1
HD+PEST Domain
Mutants
RBPJ
UBC(153-228)
MAML1
DLL4
NOTCH1(1665-2555)
UBC(533-608)
HES5
JAG2
NOTCH1 F1592S Extracellular Fragment
MIB/NEURL
UBC(229-304)
DTX
NOTCH1 L1600P Extracellular Fragment
HDAC2
NOTCH1(1665-2555)
EP300
NOTCH1 L1678P S2 cleavage fragment
NOTCH1(1665-2555)
UBB(77-152)
NOTCH1 L1574P Extracellular Fragment
UBB(1-76)
RBPJ
NOTCH1:DLL/JAG
UBB(77-152)
NOTCH1 P2514Rfs*4 Transmembrane Fragment
UBC(457-532)
RBPJ
NOTCH1 I1616T Extracellular Fragment
DTX2
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment
UBC(609-684)
NOTCH1 Q2395* Transmembrane Fragment
KAT2A
UBC(533-608)
UBC(457-532)
UBC(1-76)
NUMB
ARRB
Ub-DLL/JAG:NOTCH1
HDAC5
DLL1
DNER
Ub
NICD1
UBC(153-228)
JAG1
RPS27A(1-76)
DTX1
NOTCH1 Coactivator
Complex:MYC Gene
DLL1
UBC(153-228)
HIF1A
RPS27A(1-76)
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
MAML3
NOTCH1 P2474Afs*4 Transmembrane Fragment
HDAC10
DTX4
UBB(1-76)
DLL1
UBC(1-76)
RBX1
NEXT1
TBL1X
UBC(457-532)
NOTCH1/Fringe-modified NOTCH1
NOTCH1(1665-1720)
KAT2A
ITCH
CUL1
CNTN1
UBC(609-684)
UBC(381-456)
UBC(457-532)
DLL/JAG
HIF1A
MAML2
UBC(381-456)
RBPJ
DLL1
FBXW7alpha
RBPJ
UBA52(1-76)
SNW1
UBC(1-76)
NOTCH1 HD domain mutant fragments
NOTCH1(1665-2555)
CCNC
UBB(77-152)
MAML1
NOTCH1(1665-2555)
UBC(457-532)
TLE4
TLE2
TBL1XR1
FBXW7:SKP1:CUL1:RBX1
NOTCH1 Coactivator
Complex:CDK8:CCNC
NOTCH1(1665-2555)
UBC(153-228)
NOTCH1
HD+PEST
Domain
Mutants/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutants
HES5 gene
UBC(457-532)
UBC(305-380)
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
UBA52(1-76)
SNW1
DLL1
DTX4
p-NICD1
NOTCH1 I1616N Extracellular Fragment
FRINGE-modified NOTCH1 Extracellular Fragment (NECD1)
ITCH
UBC(305-380)
Ub-p-NICD1
UBC(533-608)
NOTCH1 L1593P Extracellular Fragment
UBC(305-380)
UBC(229-304)
NICD1
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664)
UBC(77-152)
DTX2
1, 5, 8, 21, 37...
11
11
51
6, 10, 16, 30, 41...
11
108
11
11
11
11
47, 97
12
43
47
11
51
95
11
51
11
11
34, 105
11