Blood Clotting Cascade (Homo sapiens)

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1Prothrombinase complexThrombolysis Factor XIIIaFibrin Degradation ProductsFactor VIIIaFactor VIIaFactor IXaFibrin Monomer Factor XIIaFibrin PolymerExtrinsic PathwayTissue InjuryFactor XIaIntrinsic PathwayFibrinThrombin (II)Factor XaFactor VaFactor XIPLAUFactor XVWFFactor VFactor IXFactor XIIIbFactor XKLK1FGBSERPINF2FGGFactor VIITissue FactorFactor XIIFibrin Complement Receptor 3 SignalingFactor IIFactor VIII A1ZinctPAPlasminogenSERPINE1KLKB1FGAFactor VIIISERPINB2PlasminFactor VaFactor Xa


Coagulation is a complex process by which blood forms clots. It is an important part of hemostasis (the cessation of blood loss from a damaged vessel), wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel. Disorders of coagulation can lead to an increased risk of bleeding (hemorrhage) or clotting (thrombosis).

Source: Wikipedia

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Luchtman-Jones L, Broze GJ Jr; ''The current status of coagulation.''; Ann Med, 1995 PubMed Europe PMC


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107136view14:21, 17 September 2019MaintBotChEBI identifier normalization
106723view13:16, 17 September 2019MaintBotHMDB identifier normalization
106343view21:33, 21 August 2019KhanspersModified description
105544view06:08, 9 August 2019KhanspersModified description
95523view18:19, 19 December 2017Khanspersupdated WP ID for Fibrin Complement pathway
93044view23:57, 26 July 2017KhanspersGeneral update and addition of new pathway node
92544view20:01, 14 June 2017KhanspersQuick edit to datanode annotation or property
90044view21:55, 8 October 2016MaintBotRemoved dengue-2 interactions; moved to WP3897
84876view13:31, 29 March 2016Mkutmonfixed unconnected lines
84875view13:05, 29 March 2016Mkutmonlayout and annotation
84874view12:00, 29 March 2016Mkutmonupdated layout
71361view18:36, 17 October 2013MaintBotAutomated update of data sources
71244view19:59, 16 October 2013MaintBotAutomated update of data sources
63147view20:13, 8 May 2013MaintBotUpdating GPML version
62688view21:28, 1 May 2013MaintBotupated uniprot data source
41053view23:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
38953view00:16, 25 September 2010Khanspers
37858view19:16, 12 July 2010Khanspersadded genes
36237view17:58, 11 March 2010LslabimD2 effect
36236view17:54, 11 March 2010LslabimD2 effect
36235view17:50, 11 March 2010LslabimPeriodical save, work in progress
36234view17:40, 11 March 2010LslabimPeriodical save, work in progress
35087view12:38, 11 February 2010Thomasfixed group positions, removed incorrect line
35079view12:21, 11 February 2010Thomasremoved brace, fixed some lines
35074view12:12, 11 February 2010Thomasadded literature
35068view12:00, 11 February 2010ThomasModified description
34446view18:20, 10 December 2009MaintBotAutomatic update of empty xrefs
32022view13:23, 14 August 2009MaintBotFixed group labels
31111view15:55, 30 July 2009AndraExtended with PPPiP and Biochemical pathways
30179view20:43, 7 July 2009Khanspersremoved blank metabolite
21251view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:Blood Clotting Cascade]] moved to [[Pathway:WP272]]: Moved to stable identifier
18428view10:00, 21 August 2008ThomasReverted to version '22:24, 27 May 2008' by Thomas
18425view10:00, 21 August 2008ThomasModified categories
18423view09:59, 21 August 2008ThomasModified description
15391view22:24, 27 May 2008Khanspersconnectors
14404view20:02, 22 May 2008KhanspersAdded connectors
14402view19:58, 22 May 2008KhanspersPeriodical save, work in progress
14400view19:57, 22 May 2008KhanspersConnectors added
13043view11:11, 17 May 2008MaintBotautomated metabolite conversion
12977view10:58, 17 May 2008MaintBotSticky edges patch by Sjoerd
7926view13:46, 7 January 2008MaintBot[[Pathway:Human:Blood Clotting Cascade]] moved to [[Pathway:Homo sapiens:Blood Clotting Cascade]]: Renaming species
7588view16:02, 18 December 2007MaintBotfixed category names
7455view12:42, 4 November 2007MaintBotAdded categories to GPML
6298view22:17, 22 May 2007A.Kwagpml file for [[Human:Blood_Clotting_Cascade]]

External references


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NameTypeDatabase referenceComment
FGAGeneProductENSG00000171560 (Ensembl)
FGBGeneProductENSG00000171564 (Ensembl)
FGGGeneProductENSG00000171557 (Ensembl)
Factor IIGeneProductENSG00000180210 (Ensembl)
Factor IXGeneProductENSG00000101981 (Ensembl)
Factor IXaGeneProductENSG00000101981 (Ensembl)
Factor VGeneProductENSG00000198734 (Ensembl)
Factor VIIGeneProductENSG00000057593 (Ensembl)
Factor VIII A1GeneProductENSG00000277203 (Ensembl)
Factor VIIIGeneProductENSG00000185010 (Ensembl)
Factor VIIIaGeneProductENSG00000185010 (Ensembl)
Factor VIIaGeneProductENSG00000057593 (Ensembl)
Factor VaGeneProductENSG00000198734 (Ensembl)
Factor XGeneProductENSG00000126218 (Ensembl)
Factor XIGeneProductENSG00000088926 (Ensembl)
Factor XIIGeneProductENSG00000131187 (Ensembl)
Factor XIIIaGeneProductENSG00000143278 (Ensembl)
Factor XIIIbGeneProductENSG00000143278 (Ensembl)
Factor XIIaGeneProductENSG00000131187 (Ensembl)
Factor XIaGeneProductENSG00000088926 (Ensembl)
Factor XaGeneProductENSG00000126218 (Ensembl)
Fibrin Complement Receptor 3 SignalingPathwayWP4136 (WikiPathways)
FibrinMetaboliteCHEBI:5054 (ChEBI)
KLK1GeneProductENSG00000167748 (Ensembl)
KLKB1GeneProductENSG00000164344 (Ensembl)
PLAUGeneProductENSG00000122861 (Ensembl)
PlasminGeneProductENSG00000122194 (Ensembl)
PlasminogenGeneProductENSG00000122194 (Ensembl)
SERPINB2GeneProductENSG00000197632 (Ensembl)
SERPINE1GeneProductENSG00000106366 (Ensembl)
SERPINF2GeneProductENSG00000167711 (Ensembl)
Thrombin (II)GeneProductENSG00000180210 (Ensembl)
Tissue FactorGeneProductENSG00000117525 (Ensembl)
VWFGeneProductENSG00000110799 (Ensembl)
ZincMetaboliteHMDB0001303 (HMDB)
tPAGeneProductENSG00000104368 (Ensembl)

Annotated Interactions

No annotated interactions

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