Activation of gene expression by SREBF (SREBP) (Homo sapiens)

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10, 22, 312, 272, 8, 24, 25, 30...1-3, 15, 25...3, 17, 25, 313114293, 2525389, 34, 4252, 3, 17, 31326283, 20, 34, 35, 4219363, 25, 32413, 25, 313373318263, 25, 26, 313913, 25325, 442343721325, 31143mitochondrial outer membraneendoplasmic reticulum membranecytosolnucleoplasmNFYC RXRA NFYC NFYA PPARA:RXRACoactivator complexSREBF1-1(1-490) ALA PPARA:RXRACoactivator complexSQLEPPARA SREBP1A,2:NF-Y:SP1:GGPS1 geneTBL1X SREBP1A,1C:SCD geneSREBF1-1(1-490) SREBP1A,1C:ACACBgeneNFYC SCD geneSP1 TM7SF2ELOVL6TGS1 CARM1 CYP51A1SREBF2(1-484) MVKSREBF1-3 SP1 TM7SF2 geneSREBF1-3 SP1 SC5DL gene MED1 HMGCR gene Palm NFYC SCD gene NCOA2 HMGCS1 geneGPAM gene NCOA1 SP1PPARA NFYA SREBP1A,2:NF-Y:SP1:PMVK geneCHD9 NFYB HMGCS1NCOA6 PMVK gene FDFT1 gene SREBP1A,2:NF-Y:HMGCRgeneTBL1XR1 MED1 SREBF1-3 EPA NFYB NFYA CYP51A1 geneSREBF2(1-484) SREBF1-1(1-490) MVDNFYC MVK gene ACACASREBF1-3 SREBP1A,2 dimerSREBF1-3 SREBF1-3 SREBF1-1(1-490) ACACA gene NFYA SP1 SP1 SREBF1-1(1-490) SREBF2(1-484) SP1ACACA geneSREBF1-1(1-490) HELZ2 GGPS1ACACB gene TBL1XR1 NFYA ALA SMARCD3 FASN gene SREBP1A,2:MVD geneSCDNFYA NFYC SREBP1A,1C,2 dimerSREBF1-1(1-490) NFYA SREBF2(1-484) SC5DNFYB IDI1 geneSREBP1A,1C dimerIDI1 gene MTF1dimer:12Zn2+:HMGCRgeneSREBF2(1-484) NCOA1 NCOA6 RXRA TBL1XR1 LSS geneNCOA2 SP1 ACACBELOVL6 gene SREBF2(1-484) SREBF2(1-484) CREBBP DHCR7 geneNCOA2 SMARCD3 Peroxisome Proliferator Receptor Element (PPRE) NFYB TGS1 SREBF1-1(1-490) FDFT1 geneSREBF1-1(1-490) SREBP1A,1C,2:NF-Y:HMGCS1 geneHMGCS1 gene NFYC NFYB SREBP1A,2:NF-Y:SP1:DHCR7 geneSREBF2(1-484) HMGCR-1SREBF1-1(1-490) FASN geneAA NFYA Peroxisome Proliferator Receptor Element (PPRE) SMARCD3 NFYC NFYB NFYB IDI1RXRA HELZ2 PMVKTBL1X ALA SREBF1-1(1-490) SREBF2(1-484) SREBF1-3 GGPS1 geneLINA NFYC TM7SF2 gene SREBP1A,2:NF-Y:SP1:IDI1 geneHMGCR gene CARM1 NCOA1 TBL1X Peroxisome Proliferator Receptor Element (PPRE) SREBP1A,1C,2:NF-Y:SP1:FDFT1 geneGPAM(1-828)SQLE gene LSSNFYA CARM1 HMGCR genePalm GPAM geneSREBF2(1-484) SREBF1-1(1-490) SREBF1-1(1-490) SREBP1A,2:SQLE geneCREBBP AA MVD gene SREBF1-1(1-490) SREBF2(1-484) NFYA FDPS geneSREBF1-1(1-490) NFYC DHCR7 gene SREBF2(1-484) PPARA NFYA SREBP1A,1C:NF-Y:GPAMgeneEPA SP1 SREBF2(1-484) SREBF1-1(1-490) SREBP1A,1C:NF-Y:SP1:FASN geneSREBF2(1-484) FASNSREBP1A,2:LSS geneSREBF2(1-484) NFYA SREBP1A,1C,2:NF-Y:FDPS geneNFYB NFYA SREBP1A,1C:ACACAgeneSREBF2(1-484) FDPSNFYC NF-YSP1 NFYC NCOA6 NFYA NFYB SREBF1-3 NFYC HELZ2 SREBP1A,2:NF-Y:SC5DLgeneMTF1 NFYC LINA PPARA:RXRACoactivator complexSREBF1-1(1-490) FDFT1SREBF1-3 NFYB CREBBP NFYC NFYB DHCR7ACACB geneCHD9 SREBF1-1(1-490) NFYC SP1 FDPS gene LINA Zn2+ NF-YNFYA MVK geneMED1 NFYC AA SREBF1-1(1-490) NFYA Palm PMVK geneNFYA ELOVL6 geneCHD9 SREBF2(1-484) SREBF1-3 SREBP1A,2:NF-Y:SP1:CYP51A1 geneSREBP1A,1C,2:NF-Y:TM7SF2 geneNFYB NFYB SQLE geneNFYB SC5DL geneNFYB LSS gene SREBP1A,1C,2:ELOVL6geneCYP51A1 gene EPA TGS1 SREBF1-1(1-490) SREBF1-1(1-490) SREBF2(1-484) SREBF1-1(1-490) NFYB SREBP1A,2:NF-Y:SP1:MVK geneSREBF1-1(1-490) MVD geneSREBF1-3 NFYB GGPS1 gene SREBF1-1(1-490) SREBF1-3 333312333, 2412121633401631, 3, 13, 3233163


Description

After transiting to the nucleus SREBPs (SREBP1A/1C/2, SREBFs) bind short sequences, sterol regulatory elements (SREs), in the promoters of target genes (reviewed in Eberle et al. 2004, Weber et al. 2004). SREBPs alone are relatively weak activators of transcription, with SREBP1C being significantly weaker than SREBP1A or SREBP2. In combination with other transcription factors such as SP1 and NF-Y the SREBPs are much stronger activators. SREBP1C seems to more specifically target genes involved in fatty acid synthesis while SREBP2 seems to target genes involved in cholesterol synthesis (Pai et al. 1998). View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 2426168
Reactome-version 
Reactome version: 66
Reactome Author 
Reactome Author: May, Bruce

Quality Tags

Ontology Terms

 

Bibliography

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  9. Li J, Ding SF, Habib NA, Fermor BF, Wood CB, Gilmour RS.; ''Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues.''; PubMed Europe PMC
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  23. Chambliss KL, Slaughter CA, Schreiner R, Hoffmann GF, Gibson KM.; ''Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence.''; PubMed Europe PMC
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  28. Matsushima M, Inazawa J, Takahashi E, Suzumori K, Nakamura Y.; ''Molecular cloning and mapping of a human cDNA (SC5DL) encoding a protein homologous to fungal sterol-C5-desaturase.''; PubMed Europe PMC
  29. Villagra A, Ulloa N, Zhang X, Yuan Z, Sotomayor E, Seto E.; ''Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression.''; PubMed Europe PMC
  30. Shin ES, Lee HH, Cho SY, Park HW, Lee SJ, Lee TR.; ''Genistein downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells.''; PubMed Europe PMC
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  35. Horton JD, Goldstein JL, Brown MS.; ''SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.''; PubMed Europe PMC
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  43. Harada N, Fujimoto E, Okuyama M, Sakaue H, Nakaya Y.; ''Identification and functional characterization of human glycerol-3-phosphate acyltransferase 1 gene promoters.''; PubMed Europe PMC
  44. Magaña MM, Lin SS, Dooley KA, Osborne TF.; ''Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins.''; PubMed Europe PMC
  45. Bennett MK, Lopez JM, Sanchez HB, Osborne TF.; ''Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways.''; PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
103006view15:08, 31 January 2019Mkutmonupdated outdated Ensembl identifiers
101249view11:14, 1 November 2018ReactomeTeamreactome version 66
100788view20:41, 31 October 2018ReactomeTeamreactome version 65
100330view19:18, 31 October 2018ReactomeTeamreactome version 64
99875view16:02, 31 October 2018ReactomeTeamreactome version 63
99432view14:36, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93743view13:33, 16 August 2017ReactomeTeamreactome version 61
93257view11:18, 9 August 2017ReactomeTeamreactome version 61
87078view14:22, 18 July 2016MkutmonOntology Term : 'transcription pathway' added !
87077view14:21, 18 July 2016MkutmonOntology Term : 'sterol regulatory element-binding protein signaling pathway' added !
86336view09:15, 11 July 2016ReactomeTeamreactome version 56
83318view10:46, 18 November 2015ReactomeTeamVersion54
81757view09:58, 26 August 2015ReactomeTeamVersion53
76917view08:18, 17 July 2014ReactomeTeamFixed remaining interactions
76622view11:59, 16 July 2014ReactomeTeamFixed remaining interactions
75953view10:01, 11 June 2014ReactomeTeamRe-fixing comment source
75655view10:55, 10 June 2014ReactomeTeamReactome 48 Update
75010view13:52, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74843view10:07, 30 April 2014ReactomeTeamReactome46
74654view08:42, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AA MetaboliteCHEBI:15843 (ChEBI)
ACACA gene ProteinENSG00000278540 (Ensembl)
ACACA geneGeneProductENSG00000278540 (Ensembl)
ACACAProteinQ13085 (Uniprot-TrEMBL)
ACACB gene ProteinENSG00000076555 (Ensembl)
ACACB geneGeneProductENSG00000076555 (Ensembl)
ACACBProteinO00763 (Uniprot-TrEMBL)
ALA MetaboliteCHEBI:27432 (ChEBI)
CARM1 ProteinQ86X55 (Uniprot-TrEMBL)
CHD9 ProteinQ3L8U1 (Uniprot-TrEMBL)
CREBBP ProteinQ92793 (Uniprot-TrEMBL)
CYP51A1 gene ProteinENSG00000001630 (Ensembl)
CYP51A1 geneGeneProductENSG00000001630 (Ensembl)
CYP51A1ProteinQ16850 (Uniprot-TrEMBL)
DHCR7 gene ProteinENSG00000172893 (Ensembl)
DHCR7 geneGeneProductENSG00000172893 (Ensembl)
DHCR7ProteinQ9UBM7 (Uniprot-TrEMBL)
ELOVL6 gene ProteinENSG00000170522 (Ensembl)
ELOVL6 geneGeneProductENSG00000170522 (Ensembl)
ELOVL6ProteinQ9H5J4 (Uniprot-TrEMBL)
EPA MetaboliteCHEBI:28364 (ChEBI)
FASN gene ProteinENSG00000169710 (Ensembl)
FASN geneGeneProductENSG00000169710 (Ensembl)
FASNProteinP49327 (Uniprot-TrEMBL)
FDFT1 gene ProteinENSG00000079459 (Ensembl)
FDFT1 geneGeneProductENSG00000079459 (Ensembl)
FDFT1ProteinP37268 (Uniprot-TrEMBL)
FDPS gene ProteinENSG00000160752 (Ensembl)
FDPS geneGeneProductENSG00000160752 (Ensembl)
FDPSProteinP14324 (Uniprot-TrEMBL)
GGPS1 gene ProteinENSG00000152904 (Ensembl)
GGPS1 geneGeneProductENSG00000152904 (Ensembl)
GGPS1ProteinO95749 (Uniprot-TrEMBL)
GPAM gene ProteinENSG00000119927 (Ensembl)
GPAM geneGeneProductENSG00000119927 (Ensembl)
GPAM(1-828)ProteinQ9HCL2 (Uniprot-TrEMBL)
HELZ2 ProteinQ9BYK8 (Uniprot-TrEMBL)
HMGCR gene ProteinENSG00000113161 (Ensembl)
HMGCR geneGeneProductENSG00000113161 (Ensembl)
HMGCR-1ProteinP04035-1 (Uniprot-TrEMBL)
HMGCS1 gene ProteinENSG00000112972 (Ensembl)
HMGCS1 geneGeneProductENSG00000112972 (Ensembl)
HMGCS1ProteinQ01581 (Uniprot-TrEMBL)
IDI1 gene ProteinENSG00000067064 (Ensembl)
IDI1 geneGeneProductENSG00000067064 (Ensembl)
IDI1ProteinQ13907 (Uniprot-TrEMBL)
LINA MetaboliteCHEBI:17351 (ChEBI)
LSS gene ProteinENSG00000160285 (Ensembl)
LSS geneGeneProductENSG00000160285 (Ensembl)
LSSProteinP48449 (Uniprot-TrEMBL)
MED1 ProteinQ15648 (Uniprot-TrEMBL) MED1 is a component of each of the various Mediator complexes, that function as transcription co-activators. The MED1-containing compolexes include the DRIP, ARC, TRIP and CRSP compllexes.
MTF1

dimer:12Zn2+:HMGCR

gene
ComplexR-HSA-5660440 (Reactome)
MTF1 ProteinQ14872 (Uniprot-TrEMBL)
MVD gene ProteinENSG00000167508 (Ensembl)
MVD geneGeneProductENSG00000167508 (Ensembl)
MVDProteinP53602 (Uniprot-TrEMBL)
MVK gene ProteinENSG00000110921 (Ensembl)
MVK geneGeneProductENSG00000110921 (Ensembl)
MVKProteinQ03426 (Uniprot-TrEMBL)
NCOA1 ProteinQ15788 (Uniprot-TrEMBL)
NCOA2 ProteinQ15596 (Uniprot-TrEMBL)
NCOA6 ProteinQ14686 (Uniprot-TrEMBL)
NF-YComplexR-HSA-381204 (Reactome) NF-Y is a ubiquitous heterotrimeric transcription factor comprising subunits NF-Y A, NF-Y B, and NF-Y C. It binds the sequence CCAAT.
NFYA ProteinP23511 (Uniprot-TrEMBL)
NFYB ProteinP25208 (Uniprot-TrEMBL)
NFYC ProteinQ13952 (Uniprot-TrEMBL)
PMVK gene ProteinENSG00000163344 (Ensembl)
PMVK geneGeneProductENSG00000163344 (Ensembl)
PMVKProteinQ15126 (Uniprot-TrEMBL)
PPARA ProteinQ07869 (Uniprot-TrEMBL)
PPARA:RXRA Coactivator complexComplexR-HSA-400154 (Reactome)
Palm MetaboliteCHEBI:15756 (ChEBI)
Peroxisome Proliferator Receptor Element (PPRE) R-ALL-422139 (Reactome) Peroxisome proliferator receptor elements bind heterodimers containing a peroxisome proliferator receptor and a retinoic acid receptor. The consensus sequence is TGAMCTTTGNCCTAGWTYYG.
RXRA ProteinP19793 (Uniprot-TrEMBL)
SC5DL gene ProteinENSG00000109929 (Ensembl)
SC5DL geneGeneProductENSG00000109929 (Ensembl)
SC5DProteinO75845 (Uniprot-TrEMBL)
SCD gene ProteinENSG00000099194 (Ensembl)
SCD geneGeneProductENSG00000099194 (Ensembl)
SCDProteinO00767 (Uniprot-TrEMBL)
SMARCD3 ProteinQ6STE5 (Uniprot-TrEMBL)
SP1 ProteinP08047 (Uniprot-TrEMBL)
SP1ProteinP08047 (Uniprot-TrEMBL)
SQLE gene ProteinENSG00000104549 (Ensembl)
SQLE geneGeneProductENSG00000104549 (Ensembl)
SQLEProteinQ14534 (Uniprot-TrEMBL)
SREBF1-1(1-490) ProteinP36956-1 (Uniprot-TrEMBL)
SREBF1-3 ProteinP36956-3 (Uniprot-TrEMBL)
SREBF2(1-484) ProteinQ12772 (Uniprot-TrEMBL)
SREBP1A,1C dimerComplexR-HSA-2065537 (Reactome)
SREBP1A,1C,2 dimerComplexR-HSA-1655744 (Reactome)
SREBP1A,1C,2:ELOVL6 geneComplexR-HSA-1655762 (Reactome)
SREBP1A,1C,2:NF-Y:FDPS geneComplexR-HSA-2426134 (Reactome)
SREBP1A,1C,2:NF-Y:HMGCS1 geneComplexR-HSA-2426129 (Reactome)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 geneComplexR-HSA-2426135 (Reactome)
SREBP1A,1C,2:NF-Y:TM7SF2 geneComplexR-HSA-1655714 (Reactome)
SREBP1A,1C:ACACA geneComplexR-HSA-2426141 (Reactome)
SREBP1A,1C:ACACB geneComplexR-HSA-2426125 (Reactome)
SREBP1A,1C:NF-Y:GPAM geneComplexR-HSA-2426131 (Reactome)
SREBP1A,1C:NF-Y:SP1:FASN geneComplexR-HSA-1655738 (Reactome)
SREBP1A,1C:SCD geneComplexR-HSA-1655743 (Reactome)
SREBP1A,2 dimerComplexR-HSA-2065551 (Reactome)
SREBP1A,2:LSS geneComplexR-HSA-2426137 (Reactome)
SREBP1A,2:MVD geneComplexR-HSA-2426130 (Reactome)
SREBP1A,2:NF-Y:HMGCR geneComplexR-HSA-2426128 (Reactome)
SREBP1A,2:NF-Y:SC5DL geneComplexR-HSA-2426140 (Reactome)
SREBP1A,2:NF-Y:SP1:CYP51A1 geneComplexR-HSA-2426132 (Reactome)
SREBP1A,2:NF-Y:SP1:DHCR7 geneComplexR-HSA-2426124 (Reactome)
SREBP1A,2:NF-Y:SP1:GGPS1 geneComplexR-HSA-2426126 (Reactome)
SREBP1A,2:NF-Y:SP1:IDI1 geneComplexR-HSA-2426138 (Reactome)
SREBP1A,2:NF-Y:SP1:MVK geneComplexR-HSA-2426127 (Reactome)
SREBP1A,2:NF-Y:SP1:PMVK geneComplexR-HSA-2426139 (Reactome)
SREBP1A,2:SQLE geneComplexR-HSA-2426136 (Reactome)
TBL1X ProteinO60907 (Uniprot-TrEMBL)
TBL1XR1 ProteinQ9BZK7 (Uniprot-TrEMBL)
TGS1 ProteinQ96RS0 (Uniprot-TrEMBL)
TM7SF2 gene ProteinENSG00000149809 (Ensembl)
TM7SF2 geneGeneProductENSG00000149809 (Ensembl)
TM7SF2ProteinO76062 (Uniprot-TrEMBL)
Zn2+ MetaboliteCHEBI:29105 (ChEBI)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ACACA geneR-HSA-1655845 (Reactome)
ACACA geneR-HSA-2426160 (Reactome)
ACACAArrowR-HSA-1655845 (Reactome)
ACACB geneR-HSA-1655830 (Reactome)
ACACB geneR-HSA-2426153 (Reactome)
ACACBArrowR-HSA-1655830 (Reactome)
CYP51A1 geneR-HSA-1655847 (Reactome)
CYP51A1 geneR-HSA-2426163 (Reactome)
CYP51A1ArrowR-HSA-1655847 (Reactome)
DHCR7 geneR-HSA-1655827 (Reactome)
DHCR7 geneR-HSA-2426155 (Reactome)
DHCR7ArrowR-HSA-1655827 (Reactome)
ELOVL6 geneR-HSA-1655835 (Reactome)
ELOVL6 geneR-HSA-2426149 (Reactome)
ELOVL6ArrowR-HSA-1655835 (Reactome)
FASN geneR-HSA-1655843 (Reactome)
FASN geneR-HSA-2426148 (Reactome)
FASNArrowR-HSA-1655843 (Reactome)
FDFT1 geneR-HSA-1655850 (Reactome)
FDFT1 geneR-HSA-2426146 (Reactome)
FDFT1ArrowR-HSA-1655850 (Reactome)
FDPS geneR-HSA-1655824 (Reactome)
FDPS geneR-HSA-2426147 (Reactome)
FDPSArrowR-HSA-1655824 (Reactome)
GGPS1 geneR-HSA-1655832 (Reactome)
GGPS1 geneR-HSA-2426161 (Reactome)
GGPS1ArrowR-HSA-1655832 (Reactome)
GPAM geneR-HSA-1655837 (Reactome)
GPAM geneR-HSA-2426158 (Reactome)
GPAM(1-828)ArrowR-HSA-1655837 (Reactome)
HMGCR geneR-HSA-1655826 (Reactome)
HMGCR geneR-HSA-2426162 (Reactome)
HMGCR-1ArrowR-HSA-1655826 (Reactome)
HMGCS1 geneR-HSA-1655848 (Reactome)
HMGCS1 geneR-HSA-2426150 (Reactome)
HMGCS1ArrowR-HSA-1655848 (Reactome)
IDI1 geneR-HSA-1655823 (Reactome)
IDI1 geneR-HSA-2426152 (Reactome)
IDI1ArrowR-HSA-1655823 (Reactome)
LSS geneR-HSA-1655828 (Reactome)
LSS geneR-HSA-2426154 (Reactome)
LSSArrowR-HSA-1655828 (Reactome)
MTF1

dimer:12Zn2+:HMGCR

gene
TBarR-HSA-1655826 (Reactome)
MVD geneR-HSA-1655836 (Reactome)
MVD geneR-HSA-2426144 (Reactome)
MVDArrowR-HSA-1655836 (Reactome)
MVK geneR-HSA-1655846 (Reactome)
MVK geneR-HSA-2426157 (Reactome)
MVKArrowR-HSA-1655846 (Reactome)
NF-YR-HSA-2065966 (Reactome)
NF-YR-HSA-2426146 (Reactome)
NF-YR-HSA-2426147 (Reactome)
NF-YR-HSA-2426148 (Reactome)
NF-YR-HSA-2426150 (Reactome)
NF-YR-HSA-2426151 (Reactome)
NF-YR-HSA-2426152 (Reactome)
NF-YR-HSA-2426155 (Reactome)
NF-YR-HSA-2426156 (Reactome)
NF-YR-HSA-2426157 (Reactome)
NF-YR-HSA-2426158 (Reactome)
NF-YR-HSA-2426161 (Reactome)
NF-YR-HSA-2426162 (Reactome)
NF-YR-HSA-2426163 (Reactome)
NF-YR-HSA-2426164 (Reactome)
PMVK geneR-HSA-1655839 (Reactome)
PMVK geneR-HSA-2426156 (Reactome)
PMVKArrowR-HSA-1655839 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1655826 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1655848 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1655850 (Reactome)
R-HSA-1655823 (Reactome) The IDI1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655824 (Reactome) The FDPS gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655826 (Reactome) The HMGCR gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655827 (Reactome) The DHCR7 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655828 (Reactome) The LSS gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655830 (Reactome) The ACACB gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655832 (Reactome) The GGPS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655833 (Reactome) The TM7SF2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655835 (Reactome) The ELOVL6 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655836 (Reactome) The MVD gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655837 (Reactome) The GPAM gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655839 (Reactome) The PMVK gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655843 (Reactome) The FASN gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655844 (Reactome) The SQLE gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655845 (Reactome) The ACACA gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655846 (Reactome) The MVK gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655847 (Reactome) The CYP51A1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655848 (Reactome) The HMGCS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655849 (Reactome) The SCD gene is transcribed to yield mRNA (Li et al. 1994) and the mRNA is translated to yield protein. The SREBP1A (SREBF1A) and SREBP1C (SREBF1C) transcription factors bind the promoter of the SCD gene and activate transcription in response to low cellular cholesterol (Tabor et al. 1999, Bee et al. 2001).
R-HSA-1655850 (Reactome) The FDFT1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655852 (Reactome) The SC5D gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-2065966 (Reactome) SREBP2 (SREBF2) binds and transactivates an unusual sterol regulatory element in the promoter of the TM7SF2 gene (Schiavoni et al. 2010). NF-Y binds the promoter and is important for activation by SREBP2. SREBP1A and SREBP1C can also bind the TM7SF2 promoter (Reed et al. 2008, Rome et al. 2008).
R-HSA-2426144 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the MVD gene (Rome et al. 2008).
R-HSA-2426146 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y and SP1, bind and transactivate the promoter of the FDFT1 gene (Inoue et al. 1998, Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP2 activates FDFT1 more strongly than does SREBP1A (Pai et al. 1998).
R-HSA-2426147 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y, bind and transactivate the promoter of the FDPS gene (Ericsson et al. 1996, Pai et al. 1998, Amemiya-Kudo et al. 2002, Reed et al. 2008, Rome et al. 2008, Ishimoto et al. 2010). The binding of NF-Y synergistically enhances the binding of SREBP1 (Ericsson et al. 1996). SREBP1A activates FDPS more strongly than does SREBP2 or SREBP1C (Amemiya-Kudo et al. 2002).
R-HSA-2426148 (Reactome) SREBP1A (SREBF1A) or SREBP1C, together with NF-Y and SP1, bind and transactivate the promoter of the FASN gene (Bennett et al. 1995, Pai et al. 1998, Xiong et al. 2000, Amemiya-Kudo et al. 2002, Shin et al. 2007, Choi et al. 2008, Rome et al. 2008). NF-Y is required for response to cholesterol (Xiong et al. 2000). SREBP1A activates FASN more strongly than does SREBP1C or SREBP2 (Pai et al. 1998, Amemiya-Kudo et al. 2002).
R-HSA-2426149 (Reactome) As inferred from mouse, SREBP1A/1C/2 (SREBF1A/1C/2) binds and transactivates the promoter of the ELOVL6 gene.
R-HSA-2426150 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y, bind and transactivate the promoter of the HMGCS1 gene (Maeda et al. 1998, Pai et al. 1998, Amemiya-Kudo et al. 2002, Reed et al. 2008). SREBP1A and SREBP2 activate HMGCS1 equally (Pai et al. 1998).
R-HSA-2426151 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the SQLE gene (Reed et al. 2008). The promoter also contains a consensus binding site for NF-Y (Nagai et al. 2002).
R-HSA-2426152 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the IDI1 gene (Reed et al. 2008).
R-HSA-2426153 (Reactome) SREBP1A (SREBF1A) or SREBP1C, together with SP1, bind and transactivate promoter II of the ACACB gene in human HepG2 cells (Oh et al. 2003).
R-HSA-2426154 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the LSS gene (Pai et al. 1998, Rome et al. 2008). SREBP1A and SREBP2 activate LSS equally (Pai et al. 1998).
R-HSA-2426155 (Reactome) SREBP1A (SREBF1A) and SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the DHCR7 gene (Reed et al. 2008).
R-HSA-2426156 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the PMVK gene (Reed et al. 2008).
R-HSA-2426157 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the MVK gene (Reed et al. 2008).
R-HSA-2426158 (Reactome) SREBP1A (SREBF1A) or SREBP1C bind and transactivate promoter II of the GPAM gene (Harada et al. 2012). Promoter II is active in lipogenic tissues. As inferred from mouse, NF-Y also binds the GPAM promoter with SREBP1A/1C.
R-HSA-2426160 (Reactome) SREBP1A (SREBF1A) or SREBP1C bind two sites in the promoter of the ACACA gene (Magana et al. 1997, Rome et al. 2008). Each site is required for activation of transcription.
R-HSA-2426161 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the GGPS1 gene (Reed et al. 2008).
R-HSA-2426162 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y, bind and transactivate the promoter of the HMGCR gene (Vallett et al. 1996, Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP2 activates HMGCR slightly more than does SREBP1A (Pai et al. 1998). SREBP1A/2 binds 2 main sites and 2 auxiliary sites in the HMGCR promoter (Vallett et al. 1996).
R-HSA-2426163 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the CYP51A1 gene (Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP1A and SREBP2 activate CYP51A1 equally (Pai et al. 1998).
R-HSA-2426164 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y, bind and transactivate the promoter of the SC5DL gene (Reed et al. 2008, Rome et al. 2008).
R-HSA-6800052 (Reactome) SREBF1A (SREBP1A) and SREBF1C (SREBP1C) bind the promoter of the Stearoyl CoA Desaturase 1 (SCD1) gene and enhance transcription (Pai et al. 1998, Shimao et al. 1999, Tabor et al. 1999, Bene et al. 2001, reviewed in Horton et al. 2002).
SC5DArrowR-HSA-1655852 (Reactome)
SC5DL geneR-HSA-1655852 (Reactome)
SC5DL geneR-HSA-2426164 (Reactome)
SCD geneR-HSA-1655849 (Reactome)
SCD geneR-HSA-6800052 (Reactome)
SCDArrowR-HSA-1655849 (Reactome)
SP1R-HSA-2426146 (Reactome)
SP1R-HSA-2426148 (Reactome)
SP1R-HSA-2426152 (Reactome)
SP1R-HSA-2426153 (Reactome)
SP1R-HSA-2426155 (Reactome)
SP1R-HSA-2426156 (Reactome)
SP1R-HSA-2426157 (Reactome)
SP1R-HSA-2426161 (Reactome)
SP1R-HSA-2426163 (Reactome)
SQLE geneR-HSA-1655844 (Reactome)
SQLE geneR-HSA-2426151 (Reactome)
SQLEArrowR-HSA-1655844 (Reactome)
SREBP1A,1C dimerR-HSA-2426148 (Reactome)
SREBP1A,1C dimerR-HSA-2426153 (Reactome)
SREBP1A,1C dimerR-HSA-2426158 (Reactome)
SREBP1A,1C dimerR-HSA-2426160 (Reactome)
SREBP1A,1C dimerR-HSA-6800052 (Reactome)
SREBP1A,1C,2 dimerR-HSA-2065966 (Reactome)
SREBP1A,1C,2 dimerR-HSA-2426146 (Reactome)
SREBP1A,1C,2 dimerR-HSA-2426147 (Reactome)
SREBP1A,1C,2 dimerR-HSA-2426149 (Reactome)
SREBP1A,1C,2 dimerR-HSA-2426150 (Reactome)
SREBP1A,1C,2:ELOVL6 geneArrowR-HSA-1655835 (Reactome)
SREBP1A,1C,2:ELOVL6 geneArrowR-HSA-2426149 (Reactome)
SREBP1A,1C,2:NF-Y:FDPS geneArrowR-HSA-1655824 (Reactome)
SREBP1A,1C,2:NF-Y:FDPS geneArrowR-HSA-2426147 (Reactome)
SREBP1A,1C,2:NF-Y:HMGCS1 geneArrowR-HSA-1655848 (Reactome)
SREBP1A,1C,2:NF-Y:HMGCS1 geneArrowR-HSA-2426150 (Reactome)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 geneArrowR-HSA-1655850 (Reactome)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 geneArrowR-HSA-2426146 (Reactome)
SREBP1A,1C,2:NF-Y:TM7SF2 geneArrowR-HSA-1655833 (Reactome)
SREBP1A,1C,2:NF-Y:TM7SF2 geneArrowR-HSA-2065966 (Reactome)
SREBP1A,1C:ACACA geneArrowR-HSA-1655845 (Reactome)
SREBP1A,1C:ACACA geneArrowR-HSA-2426160 (Reactome)
SREBP1A,1C:ACACB geneArrowR-HSA-1655830 (Reactome)
SREBP1A,1C:ACACB geneArrowR-HSA-2426153 (Reactome)
SREBP1A,1C:NF-Y:GPAM geneArrowR-HSA-1655837 (Reactome)
SREBP1A,1C:NF-Y:GPAM geneArrowR-HSA-2426158 (Reactome)
SREBP1A,1C:NF-Y:SP1:FASN geneArrowR-HSA-1655843 (Reactome)
SREBP1A,1C:NF-Y:SP1:FASN geneArrowR-HSA-2426148 (Reactome)
SREBP1A,1C:SCD geneArrowR-HSA-1655849 (Reactome)
SREBP1A,1C:SCD geneArrowR-HSA-6800052 (Reactome)
SREBP1A,2 dimerR-HSA-2426144 (Reactome)
SREBP1A,2 dimerR-HSA-2426151 (Reactome)
SREBP1A,2 dimerR-HSA-2426152 (Reactome)
SREBP1A,2 dimerR-HSA-2426154 (Reactome)
SREBP1A,2 dimerR-HSA-2426155 (Reactome)
SREBP1A,2 dimerR-HSA-2426156 (Reactome)
SREBP1A,2 dimerR-HSA-2426157 (Reactome)
SREBP1A,2 dimerR-HSA-2426161 (Reactome)
SREBP1A,2 dimerR-HSA-2426162 (Reactome)
SREBP1A,2 dimerR-HSA-2426163 (Reactome)
SREBP1A,2 dimerR-HSA-2426164 (Reactome)
SREBP1A,2:LSS geneArrowR-HSA-1655828 (Reactome)
SREBP1A,2:LSS geneArrowR-HSA-2426154 (Reactome)
SREBP1A,2:MVD geneArrowR-HSA-1655836 (Reactome)
SREBP1A,2:MVD geneArrowR-HSA-2426144 (Reactome)
SREBP1A,2:NF-Y:HMGCR geneArrowR-HSA-1655826 (Reactome)
SREBP1A,2:NF-Y:HMGCR geneArrowR-HSA-2426162 (Reactome)
SREBP1A,2:NF-Y:SC5DL geneArrowR-HSA-1655852 (Reactome)
SREBP1A,2:NF-Y:SC5DL geneArrowR-HSA-2426164 (Reactome)
SREBP1A,2:NF-Y:SP1:CYP51A1 geneArrowR-HSA-1655847 (Reactome)
SREBP1A,2:NF-Y:SP1:CYP51A1 geneArrowR-HSA-2426163 (Reactome)
SREBP1A,2:NF-Y:SP1:DHCR7 geneArrowR-HSA-1655827 (Reactome)
SREBP1A,2:NF-Y:SP1:DHCR7 geneArrowR-HSA-2426155 (Reactome)
SREBP1A,2:NF-Y:SP1:GGPS1 geneArrowR-HSA-1655832 (Reactome)
SREBP1A,2:NF-Y:SP1:GGPS1 geneArrowR-HSA-2426161 (Reactome)
SREBP1A,2:NF-Y:SP1:IDI1 geneArrowR-HSA-1655823 (Reactome)
SREBP1A,2:NF-Y:SP1:IDI1 geneArrowR-HSA-2426152 (Reactome)
SREBP1A,2:NF-Y:SP1:MVK geneArrowR-HSA-1655846 (Reactome)
SREBP1A,2:NF-Y:SP1:MVK geneArrowR-HSA-2426157 (Reactome)
SREBP1A,2:NF-Y:SP1:PMVK geneArrowR-HSA-1655839 (Reactome)
SREBP1A,2:NF-Y:SP1:PMVK geneArrowR-HSA-2426156 (Reactome)
SREBP1A,2:SQLE geneArrowR-HSA-1655844 (Reactome)
SREBP1A,2:SQLE geneArrowR-HSA-2426151 (Reactome)
TM7SF2 geneR-HSA-1655833 (Reactome)
TM7SF2 geneR-HSA-2065966 (Reactome)
TM7SF2ArrowR-HSA-1655833 (Reactome)
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