Tryptophan metabolism (Rattus norvegicus)

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C01144IsophenoxazineBenzoate degradation via hydroxylationXanthurenic3-Hydroxy-L-kynurenine4,6-Dihydroxyquinoline2,3-DihydroxyindoleN-MethyltryptamineGlycolysis / GluconeogenesisIndolelactate5-Hydroxykynurenamine6-Hydroxykynurenate3-Methyldioxyindole4,8-DihydroxyquinolineCinnavalininateAnthranilateAnthranilateOxaloacetate5-Hydroxyindoleacetaldehyde4-(2-Aminophenyl)-2,4-dioxobutanoateC005272-Formaminobenzoylacetate5-(3'-Carboxy-3'-oxopropyl) -4,6-dihydroxypicolinate5-(2'-Carboxyethyl)-4,6-dihydroxypicolinateIndole-3-acetate7,8-Dihydro-7,8-dihydroxykynurenate2-Formylaminobenzaldehyde4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate(Z)-5-Oxohex-2-enedioate3-HydroxykynurenamineC008773-(2-Aminoethyl)-1H-indol-5-olN-Methylserotonin5-Hydroxy-N-formylkynurenine5-Hydroxy-L-tryptophanQuinolinateFormyl-5-hydroxykynurenamine5-(2'-Formylethyl)-4,6-dihydroxypicolinate2-AminomuconateL-Tryptophanyl-tRNAMelatonin5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolin3-Methoxyanthranilate3-MethylindolepyruvateGlucobrassicinC003323-Indoleglycolaldehyde2-AminomuconatePhenylAla, Tyr and Trp biosynthesis2-Amino-3-carboxymuconate5-Hydroxyindolepyruvate4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate2-OxoglutarateIndole-3-acetaldoxime3-HydroxyanthranilateNicotinate and nicotinamide metabolismKynurenate5-Hydroxyindoleacetate6-HydroxyindolelactateIndole-3-ethanol8-MethoxykynurenateIndole-3-acetaldehyde2-OxoadipateN-Acetylindoxyl5-MethoxyindoleacetateBenzoate degradation via hydroxylationIndolepyruvateFormylanthranilate7,8-Dihydroxykynurenate5-HydroxyindoleacetylglycineFormyl-N-acetyl-5-methoxykynurenamineIdo1Tdo2N-AcetylisatinCyp2f41.13.12.3Prmt1Aldh3a21.13.11.232.1.1.49Aldh3a2KynuRnf25Acat1TryptamineDdc2-Aminophenol1.1.1.190AadatL-TryptophanCYPC12Cyp2d2N-AcetylserotoninFormylkynurenine1.1.1.1913.2.1.1473-IndoleacetonitrileTph13.5.1.93.5.1.4L-KynurenineMaobAldh1a2KynuAox1Prmt11.14.16.3ALDH1A4Dhcr24MaobOgdh2.6.1.271.5.1.-GcdhCyp2a1Aadat4.1.99.1AsmtAbp1Mdm2Cyp1a1Cyp1a24.1.1.43Maob1.7.3.21.1.1.110Aldh21.13.11.17Aldh1a13.5.1.491.14.13.9Ido1Asmt3.5.5.16-HydroxymelatoninEchs1Hadh1.14.99.2Ido1IndoleDdcPrmt1Inmt1.13.11.105-Hydroxykynurenine3.5.99.55-MethoxytryptamineCyp2c801.3.1.181.13.11.-Mdm21.2.1.322.1.1.47Aldh1a1Indole-3-acetamideAldh9a1Cyp4f11.2.3.7KynuCyp19a1Cyp7b1HaaoDd5Cyp2b15Aldh2Cyp2j4Ube3aMdm2Aldh1a24.2.1.84Wars4.1.1.-1.13.99.3Acetyl-CoA2.6.1.27AFMIDUbe3aMaobCyp2a2Aldh9a1CatCyp1b1CYP3A41.4.3.2Rnf25Hsd17b10GcdhDdc2.6.1.27AanatCYP2A13Acmsd1.2.1.-1.10.3.41.14.16.-Cyp2e1Aldh1a4


Description

This pathway describes the metabolism of tryptophan, an essential amino acid. This pathway was originally converted from rat to human, using ortholog information. Original pathway was created by Sebastien Burel.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP465(r30270) with a 58% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
104907view19:17, 24 June 2019KhanspersModified description
104906view19:15, 24 June 2019Khanspersremoved genmapp comments
104823view12:58, 19 June 2019FehrhartModified description
74148view11:32, 1 April 2014EgonwReplaced an InChI with a more traditional identifier.
72159view12:14, 25 October 2013EgonwAdded a missing metabolite ID.
71802view20:34, 17 October 2013MaintBotAutomated update of data sources
69433view19:04, 8 July 2013MaintBotUpdated to 2013 gpml schema
67725view11:55, 26 June 2013DdiglesOntology Term : 'tryptophan metabolic pathway' added !
60278view22:09, 15 March 2013EgonwMore ChEBI / PubChem-compound identifiers.
60255view08:44, 15 March 2013EgonwMore ChEBI identifiers.
60235view22:09, 14 March 2013EgonwAdded ChEBI ids for three metabolites.
60234view22:04, 14 March 2013EgonwConverted many labels into Metabolite DataNode's.
53504view10:06, 8 November 2012Egonw
47755view04:47, 6 April 2012Khanspersupdated xrefs
41758view02:41, 2 March 2011MaintBotRemoved redundant pathway information and comments
34128view19:29, 9 December 2009MaintBotAutomatic update of empty xrefs
32379view16:54, 15 August 2009MaintBotFixed text labels
32020view13:23, 14 August 2009MaintBotFixed group labels
31416view20:56, 13 August 2009MaintBotFixed text labels
30955view00:44, 30 July 2009MaintBotConverted from Homo sapiens
21247view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Tryptophane Metabolism KEGG]] moved to [[Pathway:WP270]]: Moved to stable identifier
8468view13:46, 7 January 2008MaintBot[[Pathway:Rat:Tryptophane Metabolism KEGG]] moved to [[Pathway:Rattus norvegicus:Tryptophane Metabolism KEGG]]: Renaming species
7850view16:23, 18 December 2007MaintBotfixed category names
7409view12:42, 4 November 2007MaintBotAdded categories to GPML
6606view22:20, 22 May 2007L.M.Ferrantegpml file for [[Rat:Tryptophane_Metabolism_KEGG]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(Z)-5-Oxohex-2-enedioateMetabolite(Z)-5-Oxohex-2-enedioate
1.1.1.110GeneProduct
1.1.1.190GeneProduct
1.1.1.191GeneProduct
1.10.3.4GeneProduct
1.13.11.-GeneProduct
1.13.11.10GeneProduct
1.13.11.17GeneProduct
1.13.11.23GeneProduct
1.13.12.3GeneProduct
1.13.99.3GeneProduct
1.14.13.9GeneProduct
1.14.16.-GeneProduct
1.14.16.3GeneProduct
1.14.99.2GeneProduct
1.2.1.-GeneProduct
1.2.1.32GeneProduct
1.2.3.7GeneProduct
1.3.1.18GeneProduct
1.4.3.2GeneProduct
1.5.1.-GeneProduct
1.7.3.2GeneProduct
2,3-DihydroxyindoleMetabolite
2-Amino-3-carboxymuconateMetabolite2-Amino-3-carboxymuconate
2-AminomuconateMetabolite2-Aminomuconate
2-AminophenolMetaboliteCHEBI:18112 (ChEBI) 2-Aminophenol
2-Formamino benzoylacetateMetabolite2-Formaminobenzoylacetate
2-FormylaminobenzaldehydeMetabolite
2-OxoadipateMetabolite2-Oxoadipate
2-OxoglutarateMetabolite2-Oxoglutarate
2.1.1.47GeneProduct
2.1.1.49GeneProduct
2.6.1.27GeneProduct
3-(2-Aminoethyl) -1H-indol-5-olMetabolite3-(2-Aminoethyl)-1H-indol-5-ol
3-Hydroxy- L-kynurenineMetabolite3-Hydroxy-L-kynurenine
3-HydroxyanthranilateMetabolite3-Hydroxyanthranilate
3-HydroxykynurenamineMetabolite3-Hydroxykynurenamine
3-IndoleacetonitrileMetabolite3-Indoleacetonitrile
3-IndoleglycolaldehydeMetabolite
3-MethoxyanthranilateMetabolite3-Methoxyanthranilate
3-MethyldioxyindoleMetabolite
3-MethylindolepyruvateMetabolite3-Methylindolepyruvate
3.2.1.147GeneProduct
3.5.1.4GeneProduct
3.5.1.49GeneProduct
3.5.1.9GeneProduct
3.5.5.1GeneProduct
3.5.99.5GeneProduct
4,6-DihydroxyquinolineMetaboliteCHEBI:28799 (ChEBI) 4,6-Dihydroxyquinoline
4,8-DihydroxyquinolineMetabolite4,8-Dihydroxyquinoline
4-(2-Amino-3-hydroxyphenyl) -2,4-dioxobutanoateMetabolite4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
4-(2-Amino-5-hydroxyphenyl) -2,4-dioxobutanoateMetabolite389617 (Chemspider) 4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
4-(2-Aminophenyl)-2,4-dioxobutanoateMetabolite4-(2-Aminophenyl)-2,4-dioxobutanoate
4.1.1.-GeneProduct
4.1.1.43GeneProduct
4.1.99.1GeneProduct
4.2.1.84GeneProduct
5-(2'-Carboxyethyl)-4,6-dihydroxypicolinateMetabolite5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate
5-(2'-Formylethyl)-4,6-dihydroxypicolinateMetabolite5-(2'-Formylethyl)-4,6-dihydroxypicolinate
5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinMetabolite5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate
5-(3'-Carboxy-3'-oxopropyl) -4,6-dihydroxypicolinateMetabolite5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
5-Hydroxy -L-tryptophanMetabolite5-Hydroxy-L-tryptophan
5-Hydroxy-N-formylkynurenineMetabolite5-Hydroxy-N-formylkynurenine
5-HydroxyindoleacetaldehydeMetabolite5-Hydroxyindoleacetaldehyde
5-HydroxyindoleacetateMetabolite5-Hydroxyindoleacetate
5-HydroxyindoleacetylglycineMetabolite
5-HydroxyindolepyruvateMetabolite
5-HydroxykynurenamineMetaboliteCHEBI:28715 (ChEBI) 5-Hydroxykynurenamine
5-HydroxykynurenineMetaboliteCHEBI:2076 (ChEBI)
5-MethoxyindoleacetateMetabolite5-Methoxyindoleacetate
5-MethoxytryptamineMetabolite
6-HydroxyindolelactateMetabolite6-Hydroxyindolelactate
6-HydroxykynurenateMetabolite440752 (PubChem-compound) 6-Hydroxykynurenate
6-HydroxymelatoninMetabolite
7,8-Dihydro-7,8-dihydroxykynurenateMetabolite7,8-Dihydro-7,8-dihydroxykynurenate
7,8-DihydroxykynurenateMetabolite7,8-Dihydroxykynurenate
8-MethoxykynurenateMetabolite8-Methoxykynurenate
AFMIDGeneProduct688283 (Entrez Gene)
ALDH1A4GeneProduct
AadatGeneProduct29416 (Entrez Gene)
AanatGeneProduct25120 (Entrez Gene)
Abp1GeneProduct65029 (Entrez Gene)
Acat1GeneProduct25014 (Entrez Gene)
Acetyl-CoAMetaboliteCHEBI:15351 (ChEBI) Acetyl-CoA
AcmsdGeneProduct171385 (Entrez Gene)
Aldh1a1GeneProduct24188 (Entrez Gene)
Aldh1a2GeneProduct116676 (Entrez Gene)
Aldh1a4GeneProduct
Aldh2GeneProduct29539 (Entrez Gene)
Aldh3a2GeneProduct65183 (Entrez Gene)
Aldh9a1GeneProduct64040 (Entrez Gene)
AnthranilateMetaboliteAnthranilate
Aox1GeneProduct54349 (Entrez Gene)
AsmtGeneProduct246281 (Entrez Gene)
C00332MetaboliteCHEBI:15345 (ChEBI) Acetoacetyl-CoA
C00527MetaboliteGlutaryl-CoA
C00877MetaboliteCHEBI:15473 (ChEBI) Crotonoyl-CoA
C01144MetaboliteCHEBI:15453 (ChEBI) (S)-3-Hydroxybutanoyl-CoA
CYP2A13GeneProduct
CYP3A4GeneProduct
CYPC12GeneProduct
CatGeneProduct24248 (Entrez Gene)
CinnavalininateMetaboliteCinnavalininate
Cyp19a1GeneProduct25147 (Entrez Gene)
Cyp1a1GeneProduct24296 (Entrez Gene)
Cyp1a2GeneProduct24297 (Entrez Gene)
Cyp1b1GeneProduct25426 (Entrez Gene)
Cyp2a1GeneProduct24894 (Entrez Gene)
Cyp2a2GeneProduct24895 (Entrez Gene)
Cyp2b15GeneProduct685222 (Entrez Gene)
Cyp2c80GeneProduct292330 (Entrez Gene)
Cyp2d2GeneProduct25053 (Entrez Gene)
Cyp2e1GeneProduct25086 (Entrez Gene)
Cyp2f4GeneProduct54246 (Entrez Gene)
Cyp2j4GeneProduct65210 (Entrez Gene)
Cyp4f1GeneProduct56266 (Entrez Gene)
Cyp7b1GeneProduct25429 (Entrez Gene)
Dd5GeneProduct117060 (Entrez Gene)
DdcGeneProduct24311 (Entrez Gene)
Dhcr24GeneProduct298298 (Entrez Gene) predicted
Echs1GeneProduct140547 (Entrez Gene)
Formyl-5-hydroxykynurenamineMetabolite
Formyl-N-acetyl-5- methoxykynurenamineMetaboliteFormyl-N-acetyl-5-methoxykynurenamine
FormylanthranilateMetaboliteFormylanthranilate
FormylkynurenineMetaboliteCHEBI:18377 (ChEBI) Formylkynurenine
GcdhGeneProduct364975 (Entrez Gene) predicted
GlucobrassicinMetaboliteGlucobrassicin
HaaoGeneProduct56823 (Entrez Gene)
HadhGeneProduct113965 (Entrez Gene)
Hsd17b10GeneProduct63864 (Entrez Gene)
Ido1GeneProduct66029 (Entrez Gene)
Indole-3-acetaldehydeMetaboliteIndole-3-acetaldehyde
Indole-3-acetaldoximeMetaboliteIndole-3-acetaldoxime
Indole-3-acetamideMetaboliteCHEBI:16031 (ChEBI) Indole-3-acetamide
Indole-3-acetateMetaboliteIndole-3-acetate
Indole-3-ethanolMetabolite
IndoleMetaboliteCHEBI:35581 (ChEBI)
IndolelactateMetaboliteCHEBI:17282 (ChEBI) Indolelactate
IndolepyruvateMetabolite803 (PubChem-compound) Indolepyruvate
InmtGeneProduct368066 (Entrez Gene)
IsophenoxazineMetaboliteIsophenoxazine
KynuGeneProduct116682 (Entrez Gene)
KynurenateMetaboliteCHEBI:58454 (ChEBI) 4-Hydroxy-2-quinolinecarboxylic
L-KynurenineMetaboliteCHEBI:16946 (ChEBI) L-Kynurenine
L-TryptophanMetaboliteCHEBI:16828 (ChEBI)
L-Tryptophanyl-tRNAMetabolite
MaobGeneProduct25750 (Entrez Gene)
Mdm2GeneProduct314856 (Entrez Gene)
MelatoninMetaboliteCHEBI:16796 (ChEBI)
N-AcetylindoxylMetaboliteCHEBI:15363 (ChEBI) N-Acetylindoxyl
N-AcetylisatinMetaboliteCHEBI:16050 (ChEBI) N-Acetylisatin
N-AcetylserotoninMetaboliteN-Acetylserotonin
N-MethylserotoninMetaboliteN-Methylserotonin
N-MethyltryptamineMetaboliteN-Methyltryptamine
OgdhGeneProduct360975 (Entrez Gene)
OxaloacetateMetaboliteOxaloacetate
Prmt1GeneProduct60421 (Entrez Gene)
QuinolinateMetaboliteCHEBI:29959 (ChEBI)
Rnf25GeneProduct301515 (Entrez Gene)
Tdo2GeneProduct64206 (Entrez Gene)
Tph1GeneProduct24848 (Entrez Gene)
TryptamineMetaboliteCHEBI:16765 (ChEBI)
Ube3aGeneProduct361585 (Entrez Gene)
WarsGeneProduct314442 (Entrez Gene)
XanthurenicMetaboliteXanthurenic

Annotated Interactions

No annotated interactions
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