Potassium Channels (Homo sapiens)

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3, 4, 9, 11, 15...5, 1026, 252617291312, 19, 23, 277141620116282226218cytosolK+Kv8 subunits of voltage gated potassium channels Kv2 subunits of voltage gated potassium channels KCNK9 HCN1 Kv7 subunits of voltage gated potassium channels GNB5 KCNK7 KCNJ8 K+GNG13 GNG10 GNGT2 TWIK channelsKCNAB2 ATPGNG4 KCNJ2 KCNJ6 GNG12 KCNJ11 GNB5 K+K+GABBR2 K+KCNJ16 GNG11 KCNK17 KCNJ10 GNB1 KCNJ11 KCNJ10 KCNK2 GNGT2 KCNF1 KCNAB3 GNG11 GNB3 KCNK10 KCNJ4 GNG7 GNG2 Kv11 subunits of voltage gated potassium channels KCNJ tetramerK+GABA KCNN1 G-protein beta-gammacomplexGABBR1 GNG11 THIK1 homodimersKCNAB1 KCNK1 KCNJ4 GNB4 GNG2 K+GNGT1 KCNJ2 KCNN3 GABA B receptorG-proteinbeta-gamma complexGNG8 HCN2 GNG10 GNG8 GNGT2 K+GNG12 GNG4 KCNJ4 GNB1 K+KCNMB1 KCNJ10 cAMPGNG3 GNG10 GNB1 KCNK3 Kv3 subunits of voltage gated potassium channels GABA cAMP Kv9 subunits of voltage gated potassium channels KCNN2 KCNK18 ABCC8 GNG7 GNGT1 KCNJ9 ATP sensitive K+channels (SUR1)GNB4 GABBR1 KCNJ5 KCNMB4 KCNJ16 KCNJ8 Kv6 subunits of voltage gated potassium channels K+HCN3 GNG12 KCNJ15 KCNK13 KCNJ14 HCN channelsKCND1,2,3 GNG5 GNG2 KCNK4 KCNJ12 K+GNB3 Kv12 subunit of voltage gated potassium channels TASKGNB5 GNG13 KCNJ15 Small conductanceCa2+ activatedpotassium channelK+Kv1 subunits of voltage gated potassium channels HCN3 GNG3 GNG5 KCNJ3 KCNMB3 Kv10 subunits of voltage gated potassium channels HCN2 GNG4 KCNJ5 GABBR1:GABBR2:GABAGABBR1 GNB2 HCN4 HCN1 KCNJ1 GABA B receptorG-proteinbeta-gamma and Kir3channel complexATP sensitive K+channels-inwardlyrectifying (SUR2)HCN4 K+KCNJ9 K+BK channelGNG5 Potassium transportchannels (Kir 1.1and Kir 4.1/5.1)GNB2 GNG7 KCNJ16 Kir heterotetramersK+KCNJ12 GNG8 KCNK6 GNG3 K+HCN channel bound tocAMPGNG13 KCNJ2 KCNJ3 GABA TRESK homodimerABCC9 GNB2 GABBR2 TALK 1and 2KCNK16 KCNMA1 GABBR2 Octamer of Voltagegated K+ channelsKCNJ12 KCNMB2 GNB4 GNB3 GNGT1 KCNN4KCNJ6 TREK homodimers


Potassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation of action potentials in cardiac muscle and help release of insulin form pancreatic beta cells.
Broadly K+ channels are classified into voltage gated K+ channels, Hyperpolarization activated cyclic nucleotide gated K+ channels (HCN), Tandem pore domain K+ channels, Ca2+ activated K+ channels and inwardly rectifying K+ channels. View original pathway at Reactome.


Pathway is converted from Reactome ID: 1296071
Reactome version: 75
Reactome Author 
Reactome Author: Mahajan, SS

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  1. Meuth SG, Kanyshkov T, Melzer N, Bittner S, Kieseier BC, Budde T, Wiendl H.; ''Altered neuronal expression of TASK1 and TASK3 potassium channels in rodent and human autoimmune CNS inflammation.''; PubMed Europe PMC Scholia
  2. Fowler CE, Aryal P, Suen KF, Slesinger PA.; ''Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins.''; PubMed Europe PMC Scholia
  3. Kim J, Hoffman DA.; ''Potassium channels: newly found players in synaptic plasticity.''; PubMed Europe PMC Scholia
  4. Norris AJ, Foeger NC, Nerbonne JM.; ''Neuronal voltage-gated K+ (Kv) channels function in macromolecular complexes.''; PubMed Europe PMC Scholia
  5. Hill MA, Yang Y, Ella SR, Davis MJ, Braun AP.; ''Large conductance, Ca2+-activated K+ channels (BKCa) and arteriolar myogenic signaling.''; PubMed Europe PMC Scholia
  6. Alesutan I, Föller M, Sopjani M, Dërmaku-Sopjani M, Zelenak C, Fröhlich H, Velic A, Fraser S, Kemp BE, Seebohm G, Völkl H, Lang F.; ''Inhibition of the heterotetrameric K+ channel KCNQ1/KCNE1 by the AMP-activated protein kinase.''; PubMed Europe PMC Scholia
  7. Han J, Kang D, Kim D.; ''Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1.''; PubMed Europe PMC Scholia
  8. Cramer NP, Best TK, Stoffel M, Siarey RJ, Galdzicki Z.; ''GABAB-GIRK2-mediated signaling in Down syndrome.''; PubMed Europe PMC Scholia
  9. MacKinnon R.; ''New insights into the structure and function of potassium channels.''; PubMed Europe PMC Scholia
  10. Ohya S, Fujimori T, Kimura T, Yamamura H, Imaizumi Y.; ''Novel spliced variants of large-conductance Ca(2+)-activated K(+)-channel β2-subunit in human and rodent pancreas.''; PubMed Europe PMC Scholia
  11. Biel M, Wahl-Schott C, Michalakis S, Zong X.; ''Hyperpolarization-activated cation channels: from genes to function.''; PubMed Europe PMC Scholia
  12. Kréneisz O, Benoit JP, Bayliss DA, Mulkey DK.; ''AMP-activated protein kinase inhibits TREK channels.''; PubMed Europe PMC Scholia
  13. Theilig F, Goranova I, Hirsch JR, Wieske M, Unsal S, Bachmann S, Veh RW, Derst C.; ''Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.''; PubMed Europe PMC Scholia
  14. Fallen K, Banerjee S, Sheehan J, Addison D, Lewis LM, Meiler J, Denton JS.; ''The Kir channel immunoglobulin domain is essential for Kir1.1 (ROMK) thermodynamic stability, trafficking and gating.''; PubMed Europe PMC Scholia
  15. Baruscotti M, Bottelli G, Milanesi R, DiFrancesco JC, DiFrancesco D.; ''HCN-related channelopathies.''; PubMed Europe PMC Scholia
  16. Sheng JZ, Ella S, Davis MJ, Hill MA, Braun AP.; ''Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilation.''; PubMed Europe PMC Scholia
  17. Lafrenière RG, Cader MZ, Poulin JF, Andres-Enguix I, Simoneau M, Gupta N, Boisvert K, Lafrenière F, McLaughlan S, Dubé MP, Marcinkiewicz MM, Ramagopalan S, Ansorge O, Brais B, Sequeiros J, Pereira-Monteiro JM, Griffiths LR, Tucker SJ, Ebers G, Rouleau GA.; ''A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura.''; PubMed Europe PMC Scholia
  18. Hibino H, Inanobe A, Furutani K, Murakami S, Findlay I, Kurachi Y.; ''Inwardly rectifying potassium channels: their structure, function, and physiological roles.''; PubMed Europe PMC Scholia
  19. Dallas ML, Scragg JL, Wyatt CN, Ross F, Hardie DG, Evans AM, Peers C.; ''Modulation of O(2) sensitive K (+) channels by AMP-activated protein kinase.''; PubMed Europe PMC Scholia
  20. Shorter K, Farjo NP, Picksley SM, Randall VA.; ''Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil.''; PubMed Europe PMC Scholia
  21. Shin HG, Lu Z.; ''Mechanism of the voltage sensitivity of IRK1 inward-rectifier K+ channel block by the polyamine spermine.''; PubMed Europe PMC Scholia
  22. Feliciangeli S, Tardy MP, Sandoz G, Chatelain FC, Warth R, Barhanin J, Bendahhou S, Lesage F.; ''Potassium channel silencing by constitutive endocytosis and intracellular sequestration.''; PubMed Europe PMC Scholia
  23. Gestreau C, Heitzmann D, Thomas J, Dubreuil V, Bandulik S, Reichold M, Bendahhou S, Pierson P, Sterner C, Peyronnet-Roux J, Benfriha C, Tegtmeier I, Ehnes H, Georgieff M, Lesage F, Brunet JF, Goridis C, Warth R, Barhanin J.; ''Task2 potassium channels set central respiratory CO2 and O2 sensitivity.''; PubMed Europe PMC Scholia
  24. McKeown L, Swanton L, Robinson P, Jones OT.; ''Surface expression and distribution of voltage-gated potassium channels in neurons (Review).''; PubMed Europe PMC Scholia
  25. Pongs O, Schwarz JR.; ''Ancillary subunits associated with voltage-dependent K+ channels.''; PubMed Europe PMC Scholia
  26. Moroni A, Gorza L, Beltrame M, Gravante B, Vaccari T, Bianchi ME, Altomare C, Longhi R, Heurteaux C, Vitadello M, Malgaroli A, DiFrancesco D.; ''Hyperpolarization-activated cyclic nucleotide-gated channel 1 is a molecular determinant of the cardiac pacemaker current I(f).''; PubMed Europe PMC Scholia
  27. Toyoda H, Saito M, Okazawa M, Hirao K, Sato H, Abe H, Takada K, Funabiki K, Takada M, Kaneko T, Kang Y.; ''Protein kinase G dynamically modulates TASK1-mediated leak K+ currents in cholinergic neurons of the basal forebrain.''; PubMed Europe PMC Scholia
  28. Krenz M, Oldenburg O, Wimpee H, Cohen MV, Garlid KD, Critz SD, Downey JM, Benoit JN.; ''Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells.''; PubMed Europe PMC Scholia
  29. Xie K, Allen KL, Kourrich S, Colón-Saez J, Thomas MJ, Wickman K, Martemyanov KA.; ''Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling.''; PubMed Europe PMC Scholia


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114844view16:34, 25 January 2021ReactomeTeamReactome version 75
113290view11:36, 2 November 2020ReactomeTeamReactome version 74
112502view15:46, 9 October 2020ReactomeTeamReactome version 73
101414view11:29, 1 November 2018ReactomeTeamreactome version 66
100952view21:06, 31 October 2018ReactomeTeamreactome version 65
100489view19:40, 31 October 2018ReactomeTeamreactome version 64
100034view16:23, 31 October 2018ReactomeTeamreactome version 63
99587view14:57, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93800view13:37, 16 August 2017ReactomeTeamreactome version 61
93337view11:20, 9 August 2017ReactomeTeamreactome version 61
88104view09:34, 26 July 2016RyanmillerOntology Term : 'ion transport pathway' added !
88103view09:33, 26 July 2016RyanmillerOntology Term : 'regulatory pathway' added !
86424view09:17, 11 July 2016ReactomeTeamreactome version 56
83272view10:37, 18 November 2015ReactomeTeamVersion54
81384view12:54, 21 August 2015ReactomeTeamVersion53
76853view08:12, 17 July 2014ReactomeTeamFixed remaining interactions
76558view11:54, 16 July 2014ReactomeTeamFixed remaining interactions
75891view09:54, 11 June 2014ReactomeTeamRe-fixing comment source
75591view10:43, 10 June 2014ReactomeTeamReactome 48 Update
74946view13:47, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74590view08:38, 30 April 2014ReactomeTeamNew pathway

External references


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NameTypeDatabase referenceComment
ABCC8 ProteinQ09428 (Uniprot-TrEMBL)
ABCC9 ProteinO60706 (Uniprot-TrEMBL)
ATP sensitive K+ channels (SUR1)ComplexR-HSA-1297378 (Reactome)
ATP sensitive K+


rectifying (SUR2)
ComplexR-HSA-1369001 (Reactome)
ATPMetaboliteCHEBI:30616 (ChEBI)
BK channelComplexR-HSA-418473 (Reactome) BK channels (also called Maxi-K or slo1) are potassium ion channels. They are activated by changes in membrane electrical potential and increases in intracellular [Ca2+]. Opening of BK channels results in cell membrane hyperpolarization. BK channels are tetramers of dimer subunits formed by the association of a pore-forming alpha subunit, always derived from the same gene KCNMA1, and a modulatory beta subunit, dervied from one of 4 human genes KCNMB11-4. Intracellular calcium regulates the physical association between the alpha and beta subunits.
G-protein beta-gamma complexComplexR-HSA-167434 (Reactome)
GABA B receptor

G-protein beta-gamma and Kir3

channel complex
ComplexR-HSA-1013011 (Reactome)
GABA B receptor


beta-gamma complex
ComplexR-HSA-1013017 (Reactome)
GABA MetaboliteCHEBI:59888 (ChEBI)
GABBR1 ProteinQ9UBS5 (Uniprot-TrEMBL)
GABBR1:GABBR2:GABAComplexR-HSA-420698 (Reactome)
GABBR2 ProteinO75899 (Uniprot-TrEMBL)
GNB1 ProteinP62873 (Uniprot-TrEMBL)
GNB2 ProteinP62879 (Uniprot-TrEMBL)
GNB3 ProteinP16520 (Uniprot-TrEMBL)
GNB4 ProteinQ9HAV0 (Uniprot-TrEMBL)
GNB5 ProteinO14775 (Uniprot-TrEMBL)
GNG10 ProteinP50151 (Uniprot-TrEMBL)
GNG11 ProteinP61952 (Uniprot-TrEMBL)
GNG12 ProteinQ9UBI6 (Uniprot-TrEMBL)
GNG13 ProteinQ9P2W3 (Uniprot-TrEMBL)
GNG2 ProteinP59768 (Uniprot-TrEMBL)
GNG3 ProteinP63215 (Uniprot-TrEMBL)
GNG4 ProteinP50150 (Uniprot-TrEMBL)
GNG5 ProteinP63218 (Uniprot-TrEMBL)
GNG7 ProteinO60262 (Uniprot-TrEMBL)
GNG8 ProteinQ9UK08 (Uniprot-TrEMBL)
GNGT1 ProteinP63211 (Uniprot-TrEMBL)
GNGT2 ProteinO14610 (Uniprot-TrEMBL)
HCN channel bound to cAMPComplexR-HSA-1297435 (Reactome)
HCN channelsComplexR-HSA-1297434 (Reactome)
HCN1 ProteinO60741 (Uniprot-TrEMBL)
HCN2 ProteinQ9UL51 (Uniprot-TrEMBL)
HCN3 ProteinQ9P1Z3 (Uniprot-TrEMBL)
HCN4 ProteinQ9Y3Q4 (Uniprot-TrEMBL)
K+MetaboliteCHEBI:29103 (ChEBI)
KCNAB1 ProteinQ14722 (Uniprot-TrEMBL)
KCNAB2 ProteinQ13303 (Uniprot-TrEMBL)
KCNAB3 ProteinO43448 (Uniprot-TrEMBL)
KCND1,2,3 R-HSA-1296101 (Reactome)
KCNF1 ProteinQ9H3M0 (Uniprot-TrEMBL)
KCNJ tetramerComplexR-HSA-1299200 (Reactome) Kir 2 channels form heterotetramers of any two of the four subunits.
KCNJ1 ProteinP48048 (Uniprot-TrEMBL)
KCNJ10 ProteinP78508 (Uniprot-TrEMBL)
KCNJ11 ProteinQ14654 (Uniprot-TrEMBL)
KCNJ12 ProteinQ14500 (Uniprot-TrEMBL)
KCNJ14 ProteinQ9UNX9 (Uniprot-TrEMBL)
KCNJ15 ProteinQ99712 (Uniprot-TrEMBL)
KCNJ16 ProteinQ9NPI9 (Uniprot-TrEMBL)
KCNJ2 ProteinP63252 (Uniprot-TrEMBL)
KCNJ3 ProteinP48549 (Uniprot-TrEMBL)
KCNJ4 ProteinP48050 (Uniprot-TrEMBL)
KCNJ5 ProteinP48544 (Uniprot-TrEMBL)
KCNJ6 ProteinP48051 (Uniprot-TrEMBL)
KCNJ8 ProteinQ15842 (Uniprot-TrEMBL)
KCNJ9 ProteinQ92806 (Uniprot-TrEMBL)
KCNK1 ProteinO00180 (Uniprot-TrEMBL)
KCNK10 ProteinP57789 (Uniprot-TrEMBL)
KCNK13 ProteinQ9HB14 (Uniprot-TrEMBL)
KCNK16 ProteinQ96T55 (Uniprot-TrEMBL)
KCNK17 ProteinQ96T54 (Uniprot-TrEMBL)
KCNK18 ProteinQ7Z418 (Uniprot-TrEMBL)
KCNK2 ProteinO95069 (Uniprot-TrEMBL)
KCNK3 ProteinO14649 (Uniprot-TrEMBL)
KCNK4 ProteinQ9NYG8 (Uniprot-TrEMBL)
KCNK6 ProteinQ9Y257 (Uniprot-TrEMBL)
KCNK7 ProteinQ9Y2U2 (Uniprot-TrEMBL)
KCNK9 ProteinQ9NPC2 (Uniprot-TrEMBL)
KCNMA1 ProteinQ12791 (Uniprot-TrEMBL)
KCNMB1 ProteinQ16558 (Uniprot-TrEMBL)
KCNMB2 ProteinQ9Y691 (Uniprot-TrEMBL)
KCNMB3 ProteinQ9NPA1 (Uniprot-TrEMBL)
KCNMB4 ProteinQ86W47 (Uniprot-TrEMBL)
KCNN1 ProteinQ92952 (Uniprot-TrEMBL)
KCNN2 ProteinQ9H2S1 (Uniprot-TrEMBL)
KCNN3 ProteinQ9UGI6 (Uniprot-TrEMBL)
KCNN4ProteinO15554 (Uniprot-TrEMBL)
Kir heterotetramersComplexR-HSA-975294 (Reactome)
Kv1 subunits of voltage gated potassium channels R-HSA-1296109 (Reactome)
Kv10 subunits of voltage gated potassium channels R-HSA-1296110 (Reactome)
Kv11 subunits of voltage gated potassium channels R-HSA-1296103 (Reactome)
Kv12 subunit of voltage gated potassium channels R-HSA-1296097 (Reactome)
Kv2 subunits of voltage gated potassium channels R-HSA-1296096 (Reactome)
Kv3 subunits of voltage gated potassium channels R-HSA-1296107 (Reactome)
Kv6 subunits of voltage gated potassium channels R-HSA-1296106 (Reactome)
Kv7 subunits of voltage gated potassium channels R-HSA-1296100 (Reactome)
Kv8 subunits of voltage gated potassium channels R-HSA-1296108 (Reactome)
Kv9 subunits of voltage gated potassium channels R-HSA-1296105 (Reactome)
Octamer of Voltage gated K+ channelsComplexR-HSA-1297370 (Reactome)
Potassium transport

channels (Kir 1.1

and Kir 4.1/5.1)
ComplexR-HSA-1299206 (Reactome)
Small conductance

Ca2+ activated

potassium channel
ComplexR-HSA-1297362 (Reactome)
TALK 1and 2ComplexR-HSA-1299271 (Reactome)
TASKComplexR-HSA-1299270 (Reactome)
THIK1 homodimersComplexR-HSA-1299264 (Reactome)
TREK homodimersComplexR-HSA-1299260 (Reactome)
TRESK homodimerComplexR-HSA-1299256 (Reactome)
TWIK channelsComplexR-HSA-1299255 (Reactome)
cAMP MetaboliteCHEBI:17489 (ChEBI)
cAMPMetaboliteCHEBI:17489 (ChEBI)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
ATP sensitive K+ channels (SUR1)mim-catalysisR-HSA-1296024 (Reactome)
ATP sensitive K+


rectifying (SUR2)
mim-catalysisR-HSA-1369017 (Reactome)
ATPTBarR-HSA-1296024 (Reactome)
BK channelmim-catalysisR-HSA-1296037 (Reactome)
G-protein beta-gamma complexR-HSA-1013013 (Reactome)
GABA B receptor

G-protein beta-gamma and Kir3

channel complex
ArrowR-HSA-1013012 (Reactome)
GABA B receptor

G-protein beta-gamma and Kir3

channel complex
mim-catalysisR-HSA-1013020 (Reactome)
GABA B receptor


beta-gamma complex
ArrowR-HSA-1013013 (Reactome)
GABA B receptor


beta-gamma complex
R-HSA-1013012 (Reactome)
GABBR1:GABBR2:GABAR-HSA-1013013 (Reactome)
GABBR1:GABBR2:GABAmim-catalysisR-HSA-1013012 (Reactome)
GABBR1:GABBR2:GABAmim-catalysisR-HSA-1013013 (Reactome)
HCN channel bound to cAMPArrowR-HSA-1297444 (Reactome)
HCN channel bound to cAMPmim-catalysisR-HSA-1296043 (Reactome)
HCN channelsR-HSA-1297444 (Reactome)
K+ArrowR-HSA-1013020 (Reactome)
K+ArrowR-HSA-1296024 (Reactome)
K+ArrowR-HSA-1296035 (Reactome)
K+ArrowR-HSA-1296037 (Reactome)
K+ArrowR-HSA-1296039 (Reactome)
K+ArrowR-HSA-1296043 (Reactome)
K+ArrowR-HSA-1296045 (Reactome)
K+ArrowR-HSA-1296046 (Reactome)
K+ArrowR-HSA-1296127 (Reactome)
K+ArrowR-HSA-1296348 (Reactome)
K+ArrowR-HSA-1299297 (Reactome)
K+ArrowR-HSA-1299304 (Reactome)
K+ArrowR-HSA-1299318 (Reactome)
K+ArrowR-HSA-1299338 (Reactome)
K+ArrowR-HSA-1299359 (Reactome)
K+ArrowR-HSA-1369017 (Reactome)
K+R-HSA-1013020 (Reactome)
K+R-HSA-1296024 (Reactome)
K+R-HSA-1296035 (Reactome)
K+R-HSA-1296037 (Reactome)
K+R-HSA-1296039 (Reactome)
K+R-HSA-1296043 (Reactome)
K+R-HSA-1296045 (Reactome)
K+R-HSA-1296046 (Reactome)
K+R-HSA-1296127 (Reactome)
K+R-HSA-1296348 (Reactome)
K+R-HSA-1299297 (Reactome)
K+R-HSA-1299304 (Reactome)
K+R-HSA-1299318 (Reactome)
K+R-HSA-1299338 (Reactome)
K+R-HSA-1299359 (Reactome)
K+R-HSA-1369017 (Reactome)
KCNJ tetramermim-catalysisR-HSA-1296046 (Reactome)
KCNN4mim-catalysisR-HSA-1296035 (Reactome)
Kir heterotetramersR-HSA-1013012 (Reactome)
Octamer of Voltage gated K+ channelsmim-catalysisR-HSA-1296127 (Reactome)
Potassium transport

channels (Kir 1.1

and Kir 4.1/5.1)
mim-catalysisR-HSA-1296045 (Reactome)
R-HSA-1013012 (Reactome) The release of G beta gamma from Gi/o enables binding of G beta gamma to GIRK/Kir3 K+ channels.
R-HSA-1013013 (Reactome) Activation of GABA B receptors by GABA stimulates Gi/o proteins releasing the G beta gamma subunit that binds to voltage dependent Ca2+ channels.
R-HSA-1013020 (Reactome) Binding of G beta gamma activates the GIRK/Kir3 channels that allow the efflux of K+ out of the cell resulting in a hyperpolarized membrane potential. This negative membrane potential prevents the activation of voltage dependent Ca2+ channels.
R-HSA-1296024 (Reactome) In neuroendocrine cells such as pancreatic alpha-, beta-, and delta-cells and in the brain, ATP sensitive K+ channels assemble as octamers of four Kir 6.1, 6.2 subunits and four high-affinity sulfonyl urea receptor 1 subunits (SUR1). These channels are blocked by excess intracellular levels of ATP. When the ATP is low, ATP dissociates and the channel opens to allow K+ efflux.
R-HSA-1296035 (Reactome) Intermediate conductance K+ channels are restricted to non neuronal tissues like epithelia, blood cells and are activated by intracellular Ca2+ ion concentration. Activation of Ca2+ activated K+ channels with intermediate conductance leads to K+ efflux in to the extracellular space.
R-HSA-1296037 (Reactome) Increase in intracellular concentration of Ca2+ ions and membrane depolarization cooperatively activates BKca, which exhibit large unitary conductance. Ca2+ activated potassium channels. Activation leads to K+ efflux which changes the membrane potential, which leads to inactivation voltage activated Ca2+ channels. BKca are involved in regulation of smooth muscle tone, microbial killing in leukocytes and modulation of neurotransmitter release. Activation of BKca channel with increase in intracellular concentration of Ca2+ leads to efflux of K+ into the extracellular space, which contributes to hyperpolarization of the membrane potential.
R-HSA-1296039 (Reactome) Small conductance Ca2+ activated potassium channels (SKca) are solely activated by intracellular Ca2+ concentration. SKca channels form functional tetramers. SKca channels control the contractility of uterus, maintian vascular tone, modulate hormone secretion, control cell volume in red blood cells and activation of microglia and lymphocytes. Actiavtion of SKca channels is triggered by increase in the intracellular Ca2+ ion concentration. Activation of Skca channels leads to relatively small K+ ion effluxes.
R-HSA-1296043 (Reactome) HCN channels are activated upon hyperpolarization of membrane potential and cAMP binding leading to K+ efflux.
R-HSA-1296045 (Reactome) Homotetramers of Kir 1.1 function as inwardly rectifying potassium transport channels. Ki 1.1 are found on the apical side of the cells in the ascending limp of loop of henle and upon activation transport K+ into the extracellular space. Heterotetramers of Kir 4.1 and Ki 5.1 are found on the basolateral side of cells in the distal convoluted tube. Activation of kir 4.1 and 5.1 heterotetramers leads to efflux of K+ into the extracellular space.
R-HSA-1296046 (Reactome) Activation of classical Kir (K+ inwardly rectifying) channels (KCNJ2, 4, 12 and 14) results in K+ influx which contributes to the maintenance of the membrane potential (Phase 4 of the action potential). The current created by this flow of K+ is called the inward rectifying current (IK1). A channel that is inwardly-rectifying is one that passes current more easily into the cell than out of the cell. At membrane potentials negative to potassium's reversal potential, KCNJs support the flow of K+ ions into the cell, pushing the membrane potential back to the resting potential. Two factors regulate K+ permeability - cell permeability to K+ is increased at more negative membrane potentials and increasing extracellular K+ concentrations.

When the membrane potential is positive to the channel's resting potential (such as in Phase 3 of the action potential), these channels pass very little charge out of the cell. This may be due to the channel's pores being blocked by internal Mg2+ and endogenous polyamines such as spermine (Shin & Lu 2005).

Inwardly rectifying (Kir) channels contribute to potassium leak, stabilizing cells near the equilibrium reversal potential of potassium (EK). Kir channels pass small outward currents because of pore blockade by internal magnesium and polyamines; at potentials negative to EK, large inward currents are passed upon relief from blockade.
R-HSA-1296127 (Reactome) Activation of voltage gated potassium channel is triggered by membrane potential changes that is sensed by the channel assembly. Activation of voltage-gated potassium channel leads to selective outward current of K+ ions.
R-HSA-1296348 (Reactome) TREK channels are activated by mechanical stretch, pH temperature and arachidonic acid which leads to efflux of K+ into the extracellular space resulting in membrane hyperpolarization.
R-HSA-1297444 (Reactome) HCN channels require cAMP binding and hyperpolarization of membrane potential for channel opening.
R-HSA-1299297 (Reactome) THIK subfamily has 2 members, THIK1 and THIK 2. THIK 1 forms functional homodimers whereas THIK2 function has not been demonstrated. THIK1 channels are inhibited by halothane. THICK1 channels form K+ leak channels and are not regulated by acidity or alkalanity changes.
R-HSA-1299304 (Reactome) Activation of TWIK channels results in low outward K+ currents.
R-HSA-1299318 (Reactome) TASK are tandem repeat K+ channels that are sensitive to extracellular pH. Activation of TASK results in efflux of K+ into the extracellular space.
R-HSA-1299338 (Reactome) TRESK is expressed in spinal cord and brain and is involved in K+ efflux. TRESK activation may be mediated by calcineurin.
R-HSA-1299359 (Reactome) TALK is activated by increase in pH alkalinity in the extracellular fluid. Potassium is pumped out into the extracellular fluid.
R-HSA-1369017 (Reactome) In muscle cells such as cardiac, skeletal, vascular and nonvascular smooth muscle, ATP sensitive K+ channels assemble as octamers of four Kir 6.x subunits and four low-affinity sulfonyl urea receptor 2 subunits (SUR2). The human gene encoding SUR2 gives rise to two splice variants, SUR2A and SUR2B. These channels are blocked by excess intracellular levels of ATP. When the ATP is low, ATP dissociates and the channel opens to allow K+ efflux (Krenz et al. 2002).
Small conductance

Ca2+ activated

potassium channel
mim-catalysisR-HSA-1296039 (Reactome)
TALK 1and 2mim-catalysisR-HSA-1299359 (Reactome)
TASKmim-catalysisR-HSA-1299318 (Reactome)
THIK1 homodimersmim-catalysisR-HSA-1299297 (Reactome)
TREK homodimersmim-catalysisR-HSA-1296348 (Reactome)
TRESK homodimermim-catalysisR-HSA-1299338 (Reactome)
TWIK channelsmim-catalysisR-HSA-1299304 (Reactome)
cAMPR-HSA-1297444 (Reactome)
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