Triglyceride Biosynthesis (Saccharomyces cerevisiae)

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1ACP-SHacyl-ACPACP-SHtriacylglycerolLecithinsphosphoryl-cholinephosphatidic acidH2O1,2-diacylglycerolCMPH2O1,2-diacylglycerol1-acylglycerol-3-phosphateacyl-ACPglycerol-3-phosphatephosphatidylcholineCPT1SLC1ISC1DGA1CDP-cholineacyl-CoAphosphateCoenzyme A


Description

Sphingolipids are essential components of the plasma membrane in all eukaryotic cells. S. cerevisiae cells make three complex sphingolipids: inositol-phosphoceramide (IPC), mannose-inositol-phosphoceramide (MIPC), and mannose-(inositol phosphate)2-ceramide (M(IP)2C)(CITS: [12069845]). In the yeast plasma membrane sphingolipids concentrate with ergosterol to form lipid rafts, specialized membrane microdomains implicated in a variety of cellular processes, including sorting of membrane proteins and lipids, as well as organizing and regulating signaling cascades (CITS: [12452424]). Intermediates in sphingolipid biosynthesis have been shown to play important roles as signaling molecules and growth regulators. Sphingolipid long chain bases (LCBs), dihydrosphingosine (DHS) and phytosphingosine (PHS), have been implicated as secondary messengers in signaling pathways that regulate heat stress response (CITS: [9405471])(CITS: [11967828]). Other intermediates, phytoceramide and long-chain base phosphates (LCBPs), have been shown to be components of the tightly-controlled ceramide/LCBP rheostat, which regulates cell growth (CITS: [12684378]). Since phosphoinositol-containing sphingolipids are unique to fungi, the sphingolipid biosynthesis pathway is considered a target for antifungal drugs (CITS: [9092515])(CITS: [15578972]). SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html

Comments

GenMAPP remarks 
Based on http://pathway.yeastgenome.org/biocyc/

Quality Tags

Ontology Terms

 

Bibliography

  1. Czabany T, Athenstaedt K, Daum G; ''Synthesis, storage and degradation of neutral lipids in yeast.''; Biochim Biophys Acta, 2007 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
69843view15:47, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69616view20:34, 8 July 2013MaintBotUpdated to 2013 gpml schema
67721view11:54, 26 June 2013DdiglesOntology Term : 'triacylglycerol biosynthetic pathway' added !
41850view04:51, 2 March 2011MaintBotRemoved redundant pathway information and comments
36649view22:38, 9 April 2010MaintBotDescription and bibliography added from SGD
21239view11:31, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Triglyceride Biosynthesis]] moved to [[Pathway:WP266]]: Moved to stable identifier
12879view08:06, 17 May 2008MaintBotautomated metabolite conversion
8978view14:13, 7 January 2008MaintBotAdded to category $category
8976view14:13, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CDP-cholineMetabolite987-78-0 (CAS)
CPT1GeneProductS000005074 (SGD)
Coenzyme AMetabolite64885-97-8 (CAS)
DGA1GeneProductS000005771 (SGD)
ISC1GeneProductS000000821 (SGD)
SLC1GeneProductS000002210 (SGD)
acyl-CoAMetabolite9029-97-4 (CAS)
phosphateMetabolite14265-44-2 (CAS)

Annotated Interactions

No annotated interactions
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