HIV Life Cycle (Homo sapiens)
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130, 151
12
40, 55
1, 67, 87, 99
35
15
72, 84, 94, 132
22, 38, 76, 89, 97...
111
160
12
54, 56
171
171
95
9, 51, 113
12
87
8, 18, 32, 34, 42...
12, 20
129
12
127
113
12
95, 167
12
12
10, 15, 152
169
22, 77, 108, 170
92, 133
93, 136, 161
169
40
29, 98, 112, 134
95
74
12
82, 169
26
21
12
60
101
15
19, 43, 138, 166
36
72, 169
64
15, 69
160
121, 172
113, 168
49, 53, 86, 114, 128...
6, 24, 47
105
12
4, 123
48, 66, 113
43, 71, 165, 166
12
26, 119
85, 98, 112
7, 33, 59, 90, 91, 104...
122
122
103, 129
2, 13
50
40, 55, 58, 109, 151...
95
40, 55
12
169
113
61, 153
154
52
40, 55, 58, 109, 151...
5, 22, 23, 27, 63...
79, 80, 162
95, 150
82, 169
45, 76, 88, 116, 143...
48, 113, 157
25, 102, 164
126
41
160
30, 82, 169
160
43, 166
40, 55
30, 82, 169
13
15, 117
64
110
40
135
171
26, 119
12
72, 115, 141, 169
113
161
13
3, 65, 158
74
113
3, 48, 65, 137, 157
Golgi membrane
cytosol
endoplasmic reticulum membrane
nucleoplasm
early endosome membrane
POLR2H
REV (P04618) protein
CCNT1
TAF4
POLR2L
p-S2,S5-POLR2A
POLR2A
TCEB3CL
SUPT16H
ERCC2
minus sssDNA
p6 (P04585) protein
GTF2A1(275-376)
POLR2F
POLR2H
GTF2H1
CCNH
CCNT1
p51 (RT)
CDK7
MA (P04591) protein
ERCC2
UBB(77-152)
NC (P04585) protein
p-S2,S5-POLR2A
REV (P04618) protein
POLR2A
VPR (P69726) protein
p6 (P04591) protein
VPR
VIF (P69723) protein
RTC with minus
strand DNA
synthesis initiated
from 3'-end
GTF2H1
POLR2F
p-SUPT5H
POLR2L
p51 (RT)
IN (Integrase) (P04585) protein
GDP
TCEB2
REV (P04618) protein
MNAT1
UBC(305-380)
TAF5
GTF2F1
Transmembrane protein gp41
CDK9
POLR2J
GTF2B
TCEB3
NELFCD
TAF3
POLR2D
XRCC5:XRCC6
POLR2K
GTF2H3
GTF2F1
CCNH
p-S5-POLR2A
POLR2A
POLR2B
POLR2K
tRNA-Lysine3
POLR2H
POLR2F
NELFE
POLR2C
POLR2B
POLR2B
TFIID
TAF13
POLR2G
TCEB3C
NC (P04585) protein
TCEB3
REV (P04618) protein
POLR2C
TAF11
POLR2A
Reverse transcriptase/ribonuclease H
p-S5-POLR2A
tRNA-Lysine3
REV (P04618) protein
POLR2L
MA (P04591) protein
GTF2H2
HIV-1 template DNA:30 nt transcript hybrid
GTP
POLR2I
POLR2D
P-TEFb(Cyclin
T1:Cdk9)-containing
elongation complex
with separated and
uncleaved
transcript
GTF2H2
POLR2H
HMGA1
TAF13
viral minus strand DNA with sticky 3' end
CDK9
GTF2H4
NELFA
POLR2H
NELFB
POLR2L
ERCC3
SEC13
TCEB2
CHMP6
CTDP1
Host genomic DNA
tRNA-Lysine3
GTF2F1
POLR2B
ATP
p-SUPT5H
p-SUPT5H
TAF9
ERCC3
VPS37C
NUP98-5
GTF2F1
CCNT1
POLR2D
TCEB3CL
TCEB3B
POLR2B
ATP
p6 (P04585) protein
NELFCD
SUPT16H
MA (P04591) protein
RAE1
RTC with duplex DNA
containing
discontinuous plus
strand flap
POLR2C
TAF11
SUPT4H1
NELFB
NELFB
TAF5
RTC with degraded
RNA template and
minus sssDNA
POLR2H
POLR2G
NUP88
GTF2E1
GTF2F2
P-TEFb(Cyclin
T1:Cdk9) complex
TCEB1
POLR2E
POLR2B
GTF2H2
POLR2J
capped HIV-1 pre-mRNA
ERCC2
NC (P04591) protein
XPO1
p6 (P04591) protein
UBB(153-228)
Reverse transcriptase/ribonuclease H
PPIA
CCR5
HIV-1 transcription
complex containing
3 nucleotide long
transcript
IN (Integrase) (P04585) protein
tRNA-Lysine3
SUPT16H
CHMP4C
NUPL2
POLR2B
POLR2G
POLR2F
TCEB2
GTF2H4
NUP188
POLR2C
NELFB
UBB(153-228)
CCNH
NUP93
VPU (P05919) protein
VPR
GTF2H2
TCEB3C
GTF2H4
POLR2H
NUP62
UBC(153-228)
TCEB3CL
TAF7
viral minus strand DNA (full-length)
POLR2D
GTP
UBC(533-608)
TFIID
p6 (P04591) protein
NTP
Pol II transcription
complex containing
extruded transcript
to +30
ATP
POLR2H
POLR2D
POLR2F
p6 (P04591) protein
NELFA
RAN
Multimeric capsid coat
VPR (P69726) protein
TAF5
UBC(609-684)
minus sssDNA
TCEB3C
POLR2K
CCNT1
GTF2H5
HIV-1 RNA
POLR2L
CCNH
SUPT4H1
p-S2,S5-POLR2A
dNTP
tRNA-Lysine3
GTF2A1(275-376)
viral plus strand DNA (full-length)
SUPT4H1
CCNH
TCEA1
Elongating HIV-1 transcript in processive Pol II mediated elongation
p51 (RT)
POLR2K
POLR2E
POLR2E
CCNT1
TAF9
NUP93
POLR2H
VPS37D
IN (Integrase) (P04585) protein
ERCC2
HIV-1 RNA template
TCEB1
Multimeric capsid coat
TAF12
POLR2J
GTP
GTF2F2
TAF5
viral plus strand DNA (full-length)
Reverse transcriptase/ribonuclease H
SSRP1
IN (Integrase) (P04585) protein
UBA52(1-76)
POLR2D
UBC(457-532)
Integrated provirus
minus sssDNA
BANF1
TAF1L
NUP35
p6 (P04591) protein
TCEB1
POLR2E
Reverse transcriptase/ribonuclease H
CCNT2
VPS28
POLR2K
PR (Protease) (P04585) protein
MNAT1
TAF5