Mitotic Prophase (Homo sapiens)

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3, 17, 36, 38, 48...36, 59, 8223, 52, 751029, 456, 79576, 7933, 20, 41, 43, 54...9, 3442, 45, 71574, 20, 24, 37, 60...67, 8919, 30, 39, 74, 8562, 6914, 16, 26, 31, 44...3, 41, 43, 70101, 5, 28, 40, 45...10, 25, 398, 33, 45, 4967, 7639, 5740, 50, 9134, 587, 18, 2713, 402, 5132, 72, 922, 51, 586, 7957nucleoplasmcytosolGolgi membraneER to Golgi transport vesicle membraneNUP58-1 NUP54 H3K4me2 DAG:active PKC:Ca+2p-Y204-MAPK3-3 HIST1H2BA HIST1H2BO p-S37-GOLGA2 p-3S,2T-NEK9:NEK6/NEK7Fe2+ SMC2 p-S29,T210,T333,S750,S869-NEK9 p-T216,S274,S373-GORASP1 RB1 HIST1H2BB HIST1H2BA PHF8-3 SMC2 HIST2H2AC PHF8:Nucleosome withH3K4me2/3POM121C SEH1L-2 ADPH3K4me2 HIST1H2BB ATPHIST1H2BL HIST2H2BE p-4S,3T-NUP98-3 HIST2H2AA3 HIST1H2BD p-3S,2T-NEK9:p-S206-NEK6/p-S195-NEK7SMC4 p-S62-ARPP19H3K4me3 HIST1H2BK p-Y204-MAPK3-3/p-T185,Y187-MAPK1 homodimerHIST1H2BN NUP62 RB1p-S67-ENSA HIST1H2AJ NUP107 H3K4me3 p-4S,3T-NUP98-4 H3K4me2 ADPCH2ONUP205 NUP93 ATPH2AFZ NCAPG2 ATPATPHIST1H2AB HIST1H2AC HIST1H2AB p-S106-LPIN3 HIST1H2AD ATPADPTMPO-1 HIST1H2BB H2AFX HIST1H2BK NCAPH2 NUP88 NEK7 SEC13 HIST3H2BB HIST2H2BE Sister Centromere HIST1H2BC HIST1H2BB HIST1H2BD GTP HIST1H2BO LEMD3 H2AFB1 H3K4me2 2OGADPAdoMetBLZF1 SMC2 HIST1H2BB MeK-HIST1H4A HIST2H2BE SUCCAChromatinNUP58-1 GORASP1:GOLGA2:USO1:RAB1:GTPNUP160 HIST1H2AD H2OCCNB1:p-T161-CDK1HIST1H2BH HIST1H2BN NUP54 NUP43 TMPO-1 GTP H2AFZ PPP2R2D EMD ADPNCAPD3 EMD/ TMPO/ LEMD3/LEMD2GORASP1 HIST1H2BJ ATPp-S62-ARPP19/p-S67-ENSAHIST3H2BB H2AFX PPP2R2D HIST1H2BA HIST1H2AB H2AFJ H2AFJ Nuclear Pore Complex(p-2S,3T-NUP98)p-S67-ENSA HIST3H2BB USO1 p-PKCA, p-PKCBATPCondensin II:RB1NUP98-4 NCAPG2 HIST2H2BE H2AFV HIST3H2BB HIST1H2BB H3K4me3 p-S62-ARPP19/p-S67-ENSA:PP2A-PPP2R2DTMPO-1 ATPH3K4me3 LPIN2 Sister Chromosomal Arm p-T210-PLK1:Phosphorylated Condensin II:NucleosomeHIST1H2AC Ca2+NCAPG2 NUP214 RAB1A PPP2CB p-2S,3T-NUP98-4 ATPVRK1/VRK2SEC13 HIST1H2BJ H3K4me3 ADPp-T161-CDK1 NCAPH2 NUP50 SMC4 p-4S,3T-NUP98NUP160 ATPNUP210 HIST2H2AC RAB2A MeK-HIST1H4A NUPL2 ADPHIST1H2BJ NUP210 GOLGA2 H2BFS HIST1H2BJ H2AFV BANF1 MCPH1 HIST3H2BB H2BFS TPR HIST1H2BN NUPL2 H3K4me3 ATPp-S-NCAPH2 H2AFZ CondensinII:Nucleosome withH4K20me1HIST1H2BN p-T1415-NCAPD3 p-T161-CDK1 p-S106-LPIN1 GTP ADPUSO1 homodimerNEK6/NEK7NUP155 NUP85 MASTLp-T1415,S1419-NCAPD3 AAAS HIST1H2AJ CTDNEP1 p-S37-GOLGA2 NUP85 HIST1H2BO HIST1H2AD SMC2 HIST1H2BA HIST2H2AC EMD p-S23, S395, S405-LMNB1 p-S395, S405-LMNB1 HIST1H2BC CondensinII:MCPH1:SETNUP107 ATPHIST2H2BE NUP205 p-2S,3T-NUP98-3 PHF8:Nucleosome withH3K4me2/3:H4K20me1p-S206-NEK6 POM121C PPP2CA AAAS H2AFB1 EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:ChromatinHIST1H2BM HIST1H2BD NDC1 HIST1H2BO PhosphorylatedCondensinII:NucleosomeH2AFJ HIST1H2BH DAGHIST2H2BE NUP54 Stacked GolgicisternaeMeK-HIST1H4A p-T216,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTPNUP35 RAE1 NCAPH2 HIST2H2BE p-3S,T-NEK9HIST1H2BL SMC4 HIST2H2AC PPP2R1B HIST1H2BL p-T500,T642,S661-PRKCB Condensin IINCAPH2 LEMD3 Fe2+ ADPSETD8HIST1H2BH p-T216,S274,S373-GORASP1 p-T185,Y187-MAPK1 H2AFV SMC4 ADPp-T210-PLK1 HIST2H2AA3 NUP188 CCNB1 NUP93 NCAPG2 p-S106-LPIN2 NUP98-5 CNEP1R1 p-S67-ENSAp-3S,2T-NEK9HIST1H2BH SMC2 HIST1H2BN p-S62-ARPP19 HIST1H2AB p-T222,T225-GORASP2 HIST1H2BD p-S29,T210,T333,S750,S869-NEK9 NUP155 InterphasechromosomesPPP2CB NUP37 CCNB1 RAE1 HIST1H2BM NUP58-1 HIST1H2BM NUP43 RAB2A p-2S-PHF8:Fe2+HIST1H2AC NUP58-2 1,2-diacyl-glycerol3-phosphateSister Centromere NCAPD3 H2AFX HIST3H2BB p-T210-PLK1HIST1H2BL MeK-HIST1H4A EMD HIST1H2BB HIST1H2BK POM121 HIST1H2BC NUP43 HIST1H2AJ ENSASEH1L-2 CTDNEP1:CNEP1R1p-T2,T3,S4-BANF1H2AFB1 H2BFS AAAS HIST1H2BN NDC1 MeK-HIST1H4A p-T216,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP:p-T210-PLK1LEMD3 PPP2CA p-T191-RAB1B NUPL2 NEK7 RANBP2 NEK6 RAB1B HIST2H2AA3 p-S33,84-PHF8-2 GTP SMC4 NUMA1 homodimerADPHIST1H2BM SMC2 HIST1H2AC p-S395-LMNA-1 ADPp-S69,S120-PHF8-3 HIST1H2BJ p-T2,T3,S4-BANF1 HIST1H2BC LPINHIST2H2AC NCAPG2 HIST1H2AB NUP153 HIST1H2AC MCPH1CO2HIST2H2AA3 HIST1H2AJ p-T500,T642,S661-PRKCB EMD/TMPO/LEMD3/LEMD2:Lamin filamentsHIST1H2BJ NUP58-2 LPIN1 HIST1H2BD HIST1H2BK RANBP2 NUP188 SMC4 p-4S,3T-NUP98NUP37 p-T191-RAB1B HIST1H2BH NUP107 HIST1H2AC Sister Chromosomal Arm p-T333-NEK9 ADPSEC13 PHF8-2 p-T210-PLK1 HIST1H2BO HIST1H2BO NCAPD3 RAE1 HIST1H2AJ LPIN3 NUP88 NUP35 GTP p-S395-LMNA-2 p-S195-NEK7 LEMD2 GTP H2AFJ H2AFZ NUP133 p-T333-NEK9LEMD2 HIST1H2BC HIST1H2BO p-T1415-NCAPD3 p-T497,T638,S657-PRKCA H2AFB1 ATPNUP62 p-S395-Lamin dimersATPDAG HIST2H2AA3 NUP188 NUP85 H2AFV NUP133 HIST2H2AC HIST1H2BK PartiallyDisassembled NPCHIST1H2AD p-S22, S395-LMNA-2 p-S62-ARPP19 HIST1H2AJ PPP2R1B NUP50 AdoHcyADPNUP133 p-T191-RAB1B NUP93 HIST1H2BJ HIST1H2BN GORASP2 H2AFV H2BFS p-T210-PLK1NUP214 HIST1H2BM p-S37-GOLGA2 ATPSET CCNB1,CCNB2:p-T161-CDK1HIST1H2BK ER to Golgitransport vesicleHIST1H2BA SEH1L-2 NCAPG2 PHF8-1 p-S22, S395-LMNA-1 HIST1H2AD H2AFV p-T195-RAB1A TPR Mitotic G2-G2/MphasesHIST1H2BM NUP155 MeK-HIST1H4A p-4S,3T-NUP98-3 H2AFB1 Lamin filaments HIST1H2BD HIST1H2AB p-T497,T638,S657-PRKCA Nuclear Pore Complex(NPC)NUP62 H2AFJ ATPFe2+ HIST1H2AD HIST1H2BK NUP35 p-S22/23, S395-LamindimersNDC1 ADPp-T195-RAB1A HIST1H2AD p-S189,T216,S274,S373-GORASP1 ATPSMC2 SEH1L-1 p-T216,S189,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP:p-T210-PLK1PHF8-2 HIST1H2BC H3K4me3 HIST1H2BH PP2A-PPP2R2DNUMA1 H2AFB1 HIST1H2BL NUP153 NUP88 CCNB2 p-T210-PLK1 NUP98-5 POM121 PHF8-1 HIST1H2BH p-S106-LPINNUP210 ATPH2AFB1 H2BFS p-T2055-NUMA1 p-T195-RAB1A p-4S,3T-NUP98-4 HIST1H2BL HIST1H2BD USO1 H2AFZ H2AFJ Lamin filaments ADPNCAPH2 HIST1H2AC H2AFJ O2SMC4 HIST2H2AC H2AFZ NCAPH2 HIST1H2AB VRK2-2 p-S-NCAPG2 H2AFZ POM121 ADPGolgi cisternaeH2Op-S69,120-PHF8-1 p-S29,T210,T333,S750,S869-NEK9 p-S29,T333,S750,S869-NEK9 ADPPiNUP214 BLZF1 PHF8-3 H3K4me2 HIST2H2AA3 GORASP2:BLZF1:RAB2A:GTPSEH1L-1 VRK1 SEH1L-1 NUP153 PPP2R1A H3K4me2 NUP98-5 HIST3H2BB Nucleosome withH3K4me2/3:H4K20me1ADPH2AFX NUP58-2 NUP98-3 POM121C ARPP19HIST2H2AA3 Condensed prophasechromosomesH2BFS H2AFX ATPp-T194,T207,T741-MASTLPiNEK6 H2AFX NUP160 NCAPD3 TPR HIST1H2BC HIST1H2BA HyperphosphorylatedCondensinII:NucleosomeH2AFV SETER to Golgitransport vesiclefused withcis-GolgiRANBP2 PPP2R1A HIST1H4 p-T222,225-GORASP2:BLZF1:RAB2A:GTPNUP37 HIST1H2AJ p-T210-PLK1 NUP205 HIST1H2BM HIST1H2BL Mitotic PrometaphaseLEMD2 H2BFS H3K4me2 p-T2055-NUMA1homodimerHIST1H2BA NUP50 H2AFX Ca2+ 2, 51, 589412, 15, 22, 35, 53...46, 8622, 35, 9622, 586434, 5846, 869411, 21, 8422, 35, 96949434, 58