PIP3 activates AKT signaling (Homo sapiens)

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17, 50, 147111, 306250, 311341237, 258158250, 311184, 189100, 115, 254, 287, 3333, 14329033, 48, 59, 67, 68, 98...156, 3323, 143, 25043, 237, 25839, 140, 161, 31643, 237, 258237, 25885, 86, 91, 271, 3609072, 20041, 134, 308, 326, 3671514363, 142, 238, 37654, 2074336928, 48, 172, 187245, 253, 2769797, 12626927, 29897, 12680nucleoplasmcytosolTRIB3 ATPER alpha46 PPP2R5B 4xHC-INS(90-110) EGF-like ligands Extra-nuclearestrogen signalingp-Y,Y877-ERBB2 p-T23-CHUKSignaling by METp-12Y-PDGFRB PDPK1 ATPp-6Y-EGFR AKT1 p-T32,S253,S315-FOXO3 AKT PHLPP (Mn2+cofactor)p-S351-NR4A1PIK3R2 Neuregulins p-Y307-PP2ATRIB3 PPP2R1B IRAK1 p-T145-CDKN1A PRR5 PI3K inhibitorsAKT1 E17K p-T305,S472-AKT3 PI(4,5)P2 ATPIL1RL1 p-T,p-S-AKTPPP2CA PDPK1:PIP2ER alpha36 HS EREG(60-108) PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimersMYD88 PPP2R5C ADPPPP2R1B PIP5K1C ADPIL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6p-S-AKT:PDPK1:PIP3p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4,(p-T26,S184-FOXO6)KL-1 PPP2CA FGF6 PPP2R5A FOXO3 HBEGF(63-148) PPP2R1B AKT2 Signaling by ERBB4p-S474-AKT2 PDPK1 Autophosphorylated FLT3 ESR2 p-T305,S472-AKT3 p-S337-PPP2R5C Activator:PI3K RAC1 PI(3,4,5)P3 p-6Y,Y1112-ERBB2 p-Y394-LCK PDGFA-1 PHLPP2 AKT1 GSK3A CD86 AKT3 Signaling by PDGFMTOR signallingAKT2 PPP2R5E AKT1 E17KPPP2R5D THEM4 p-Y180-ICOS p-6Y-FGFR3b PPP2R5C PI3K Inhibitors:PI3Kp-Y307-PPP2CB KL-2 p-T-AKTSTRN PI(3,4,5)P3 Activator:PI3K Intrinsic Pathwayfor ApoptosisLCK CDKN1B PPP2R1A p-8Y-FGFR1c Activated FGFR2b homodimer bound to FGF p-T305-AKT3 p-8Y-FGFR1b PiEGF AKT1S1ATPp-Y419-SRC-1 PI(3,4,5)P3PI4PADPPI(3,4,5)P3 p-Y1234,Y1235,Y1349,Y1356-MET p-T,p-S-AKTTGFA(24-98) AKT3 RPS6KB2PPP2R1B PI(3,4,5)P3 p-Y-GAB2 PDPK1PI(4,5)P2 Metabolism of nitricoxide: NOS3activation andregulationMLST8 p-T308-AKT1 Signaling by EGFRSignaling by SCF-KITPPP2R5B p-5Y-FGFR4 PPP2R1B PPP2R1A AKT1 E17K PDPK1:p-S473-AKT1E17K mutant:PIP2PIP5K1B p-T202,Y204-MAPK3 ESR1 FOXO6 MyrG-p-Y419-SRC CASP9(1-416)PI3Kmutants,Activator:PI3Kp-T308,S473-AKT1E17KGTP GTP GAB1 p-Y1046,Y1178,Y1232-ERBB4 JM-B CYT-1 isoform EGF p-T185,Y187-MAPK1 PIK3R2 FYN ESTG AKT FGF18 PP2A-B56-beta,gammaPI3K alphap-S472-AKT3 FGF4 FOXO1,FOXO3,FOXO4,(FOXO6)ATPp-S-AKT:PIP3PPP2R5E PIP4K2C PI(4,5)P2FOXO1 H2OVAV1 p-Y-ERBB2 RAC1 IL33 PPP2R5A PDGFA-2 PIK3R1 RAC2 PPP2R5B Signaling by FGFRH2OATPH2OPTEN RegulationPIK3R1 TRAF6 FGF22 AKT1 E17K FOXO4 Costimulation by theCD28 familyp-6Y-FRS2 INSR(28-758) p-S196-CASP9(1-416)NRG2 PPP2CB TCR signalingFGF23(25-251) PI(4,5)P2 p-10Y-ERBB3-1 PHLPP1 PiPPP2R1A PDGFB (82-190) PPP2R1A RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alphaPI(3,4,5)P3 p-S474-AKT2 NR4A1p-T,Y MAPK dimersFGF5-1 p-S99-BADp-11Y-PDGFRA ADPPI(4,5)P2 p-T157-CDKN1B PPP2CB CDKN1A,CDKN1BAKT1IER3p-Y-IRS2 p-S472-AKT3 RHOG PIK3CD PIK3R3 p-Y63,Y79,Y110-TRAT1 PIP5K1A-CCD80 p-5Y-GAB1 RAF/MAP kinasecascadeRHOG FGF17-1 p-S939,T1462-TSC2CREB1p-S368-PPP2R5B,p-S337-PPP2R5CPIK3CA PIP4K2 dimersp-Y546,Y584-PTPN11 PPP2CB p-S473-AKT1 E17Kmutant:PIP2p-S473-AKT1 PP2A-A:PP2A-CKLB p-S15,S356-RPS6KB2Regulation of TP53Expression andDegradationATPEPGN(23-154) KITLG-1(26-190) GalNAc-T178-FGF23(25-251) p-T309,S474-AKT2 p-7Y-KIT p-T308,S473-AKT1 PPP2R5C GSK3B AKT:PIP3p-Y-IRS1 PIK3R3 ADPMKRN1AKT1 AREG(101-187) p-S109-MKRN1PTEN2xHC-INS(25-54) p-T308,S473-AKT1 FGF20 PP2APPP2CA IRAK4 p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform GRB2-1 PIK3CB PPP2CA PPP2CB RAC1 RICTOR Activated FGFR2c homodimer bound to FGF Signaling by the BCell Receptor (BCR)FGF1 BADp-S9-GSK3B HGF(32-494) PI(3,4,5)P3 p-S473-AKT1 E17K PiGRB2-1 TORC2 complexTHEM4/TRIB3ADPPDGFB(82-241) Signaling by NTRKsp-7Y-ERBB2 ADPTHEM4 p-T-CDKN1A/Bp-S473-AKT1 E17K p-T185,Y187-MAPK1 PIK3CA PIK3CA GSK3PIK3R1 PIP4K2A FGF10 p-T32,S197,S262-FOXO4 AKT3 ADPMn2+ PIK3R2 ATPCHUKp-S183,T246-AKT1S1PDPK1 p-S166,S188-MDM2TSC2p-6Y-ERBB2 p-Y307-PPP2CA FGF8-1 AKT inhibitorsFGF9 ATPActivator:PI3Kp-S21-GSK3A FGF16 p-6Y-EGFR p-S473-AKT1 PI3K mutants p-S133-CREB1MDM2AKT inhibitors:AKTSignaling by ERBB2AKT2 PPP2R5D FGF3 RAC2 p-4Y-PIK3AP1 RAC2 p-T308,S473-AKT1PDPK1:PIP3ATPActivatedSRC,LCK,EGFR,INSRFLT3LG ADPCDKN1A PIP5K1A RHOG MAPKAP1 NRG1 PI3K mutants MTOR AKT1 E17Kmutant:PIP2p-7Y,Y1112-ERBB2 p-T26,S184-FOXO6 p-6Y-FGFR3c IL1RAP-1 p-S9/21-GSK3PDPK1 AKT/AKT1 E17K mutantHGF(495-728) p-6Y-INSR(763-1382) p-T309-AKT2 p-Y191-CD28 GTP FGF2(10-155) p-T309,S474-AKT2 p-T202,Y204-MAPK3 PIK3R3 PI5PAKT:PIP3:THEM4/TRIB3ADPPPP2R1A FGF19 p-T24,S256,S319-FOXO1 PPP2R5C p-S368-PPP2R5B PIK3R1 AKTPIP4K2B BTC(32-111) p-6Y-CD19 RAC1:GTP,RAC2:GTP,RHOG:GTPMitotic G1 phase andG1/S transitionIER3 PPP2R5B 307, 330, 345324188, 221, 27523732, 152, 201, 2398, 9, 25, 30, 42...9018791213237250, 31148, 68, 106, 112, 162...1, 26, 35, 77, 79...5, 13, 20, 52, 84...32414, 38, 46, 87, 89...17029, 3226, 19, 23, 24, 60...23711, 69, 101, 131, 257...2372377, 10, 15, 16, 18...94, 144, 169, 183, 195...2, 155, 180211, 215, 31775, 96, 35715412, 34, 36, 45, 76...2374, 53, 55, 57, 66...31, 37, 49, 295, 301...237