Delta-Notch Signaling Pathway (Mus musculus)

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ICDPhosphorylationAcetylationENUbiquitinationReactioin through unknown mechanisms/moleculesNU->CYECCY->NUMolecular associationPM->NUCY->NUGO->PMCY->NUDemethylationGolgi apparatusICDPalmitoylationICDEndoplasmic reticulumTranslocationCY->NUMolecule in the pathwayAutophosphorylationGene SymbolGO->PMProteins in a complex interactionAccession Number: NetPath 3; cellmap:3Receptor(Protein-protein interaction)NU->CYMethylationSumoylationDMTEnzyme complexDeubiquitinationIntracellular DomainDephosphorylationCytoplasmCYPMICDGODControlNUNucleusGamma secretase complexDRecruitmentDDesumoylationICDPM->NUPlasma membraneInhibitionNU->CYDGlycosylationPM->NUPM->CYICDActivationMitochondrionPM->NUERDeacetylationDLigandExtracellularCY->NUProteolytic CleavageEndosome-- ICDNotch1Notch1Hey2MAGEA1Dll1SNW1Akt1Dll11700023B02RikMapk1Mapk3Dtx1FurinRbpjAscl1Ncor2Gm9840Zfpm1LckPsen2Gsk3bMef2cJag1Gm15429Yy1Maml3RelaHes5Dll1Notch3NumbHes1Jag2MfngAdam17Jag1Notch1CntfDll4Ring1Notch1Notch3Maml1Notch1Pik3r1Tle1Maml2Aph1bDtx1SpenNotch2Notch4AppHdac1Stat3Skp2Smad3NcstnNumblGsk3bWdr12Ep300Cdk2Hey1Pofut1Cntn1Fbxw7Ncor1Notch1NfkbiaJunNotch2Adam10SKP1APCAFJag1Pik3r2Notch2Hdac2NovLef1Trp53Fhl1Ncor2Smad1Notch2Jag2Hivep3Ep300Tcfe2aCul1Stat3Jag2Psen1EgfrSap30RelaSmad4Skp2Sin3aCntfrLfngDll4Notch3Notch4PSENENJak2Hes6SKP1AEgfItchNcor1


Description

There are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric proteins and their ligands are also membrane-bound. Signaling through the Notch receptors is triggered by ligand-binding that induces cleavage of the extracellular domain by an ADAM family metalloprotease followed by a cleavage within the transmembrane domain by gamma secretase complex. The second cleavage leads to translocation of the cytosolic domain of Notch receptors into the nucleus. Notch proteins are important in lineage specification and stem cell maintenance. Aberrant Notch signaling has been linked to a number of malignancies including leukemias, lymphomas and carcinomas of the breast, skin, lung, cervix and kidneys. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_3

Comments

GenMAPP notes 
NetPath 3; cellmap:3 - Delta-Notch Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org, http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP61(r20805) with a 94% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
69189view18:22, 8 July 2013MaintBotUpdated to 2013 gpml schema
67151view10:13, 26 June 2013Christine ChichesterOntology Term : 'Notch signaling pathway' added !
41380view00:28, 2 March 2011MaintBotRemoved redundant pathway information and comments
35709view23:19, 12 February 2010AlexanderPico
34421view23:17, 9 December 2009MaintBotAutomatic update of empty xrefs
31415view20:55, 13 August 2009MaintBotFixed text labels
30896view00:22, 30 July 2009MaintBotConverted from Homo sapiens
21237view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:Delta-Notch NetPath 3]] moved to [[Pathway:WP265]]: Moved to stable identifier
7986view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Delta-Notch NetPath 3]] moved to [[Pathway:Mus musculus:Delta-Notch NetPath 3]]: Renaming species
7617view16:04, 18 December 2007MaintBotfixed category names
7213view12:33, 4 November 2007MaintBotAdded categories to GPML
6431view22:18, 22 May 2007A.Pandeygpml file for [[Mouse:Delta-Notch_NetPath_3]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1700023B02RikGeneProduct66935 (Entrez Gene)
Adam10GeneProduct11487 (Entrez Gene)
Adam17GeneProduct11491 (Entrez Gene)
Akt1GeneProduct11651 (Entrez Gene)
Aph1bGeneProduct208117 (Entrez Gene)
AppGeneProduct11820 (Entrez Gene)
Ascl1GeneProduct17172 (Entrez Gene)
Cdk2GeneProduct12566 (Entrez Gene)
CntfGeneProduct12803 (Entrez Gene)
CntfrGeneProduct12804 (Entrez Gene)
Cntn1GeneProduct12805 (Entrez Gene)
Cul1GeneProduct26965 (Entrez Gene)
Dll1GeneProduct13388 (Entrez Gene)
Dll4GeneProduct54485 (Entrez Gene)
Dtx1GeneProduct14357 (Entrez Gene)
EgfGeneProduct13645 (Entrez Gene)
EgfrGeneProduct13649 (Entrez Gene)
Ep300GeneProduct328572 (Entrez Gene)
Fbxw7GeneProduct50754 (Entrez Gene)
Fhl1GeneProduct14199 (Entrez Gene)
FurinGeneProduct18550 (Entrez Gene)
Gm15429GeneProduct100039623 (Entrez Gene)
Gm9840GeneProduct100043674 (Entrez Gene)
Gsk3bGeneProduct56637 (Entrez Gene)
Hdac1GeneProduct433759 (Entrez Gene)
Hdac2GeneProduct15182 (Entrez Gene)
Hes1GeneProduct15205 (Entrez Gene)
Hes5GeneProduct15208 (Entrez Gene)
Hes6GeneProduct55927 (Entrez Gene)
Hey1GeneProduct15213 (Entrez Gene)
Hey2GeneProduct15214 (Entrez Gene)
Hivep3GeneProduct16656 (Entrez Gene)
ItchGeneProduct16396 (Entrez Gene)
Jag1GeneProduct16449 (Entrez Gene)
Jag2GeneProduct16450 (Entrez Gene)
Jak2GeneProduct16452 (Entrez Gene)
JunGeneProduct16476 (Entrez Gene)
LckGeneProduct16818 (Entrez Gene)
Lef1GeneProduct16842 (Entrez Gene)
LfngGeneProduct16848 (Entrez Gene)
MAGEA1GeneProduct17137 (Entrez Gene)
Maml1GeneProduct103806 (Entrez Gene)
Maml2GeneProduct270118 (Entrez Gene)
Maml3GeneProduct433586 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk3GeneProduct26417 (Entrez Gene)
Mef2cGeneProduct17260 (Entrez Gene)
MfngGeneProduct17305 (Entrez Gene)
Ncor1GeneProduct20185 (Entrez Gene)
Ncor2GeneProduct20602 (Entrez Gene)
NcstnGeneProduct59287 (Entrez Gene)
NfkbiaGeneProduct18035 (Entrez Gene)
Notch1GeneProduct18128 (Entrez Gene)
Notch2GeneProduct18129 (Entrez Gene)
Notch3GeneProduct18131 (Entrez Gene)
Notch4GeneProduct18132 (Entrez Gene)
NovGeneProduct18133 (Entrez Gene)
NumbGeneProduct18222 (Entrez Gene)
NumblGeneProduct18223 (Entrez Gene)
PCAFGeneProduct
PSENENGeneProduct66340 (Entrez Gene)
Pik3r1GeneProduct18708 (Entrez Gene)
Pik3r2GeneProduct18709 (Entrez Gene)
Pofut1GeneProduct140484 (Entrez Gene)
Psen1GeneProduct19164 (Entrez Gene)
Psen2GeneProduct19165 (Entrez Gene)
RbpjGeneProduct19664 (Entrez Gene)
RelaGeneProduct19697 (Entrez Gene)
Ring1GeneProduct19763 (Entrez Gene)
SKP1AGeneProduct21402 (Entrez Gene)
SNW1GeneProduct66354 (Entrez Gene)
Sap30GeneProduct60406 (Entrez Gene)
Sin3aGeneProduct20466 (Entrez Gene)
Skp2GeneProduct27401 (Entrez Gene)
Smad1GeneProduct17125 (Entrez Gene)
Smad3GeneProduct17127 (Entrez Gene)
Smad4GeneProduct17128 (Entrez Gene)
SpenGeneProduct56381 (Entrez Gene)
Stat3GeneProduct20848 (Entrez Gene)
Tcfe2aGeneProduct21423 (Entrez Gene)
Tle1GeneProduct21885 (Entrez Gene)
Trp53GeneProduct22059 (Entrez Gene)
Wdr12GeneProduct57750 (Entrez Gene)
Yy1GeneProduct22632 (Entrez Gene)
Zfpm1GeneProduct22761 (Entrez Gene)

Annotated Interactions

No annotated interactions
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