Lidocaine metabolism (Homo sapiens)

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1-31, 24-hydroxy-2,6-dimethylanilineglycinexylidide3-hydroxymonoethylglycinexylidideLidocaine2-amino-3-methylbenzoate3-hydroxylidocaine2,6-xylidineCYP3A4CYP1A2monoethylglycinexylidideCYP1A2CYP3A4


Lidocaine is primarily metabolized by CYP1A2 but minor involvement of CYP3A4 is observed too. Based on KEGG

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Ontology Terms



  1. Wang JS, Backman JT, Wen X, Taavitsainen P, Neuvonen PJ, Kivistö KT; ''Fluvoxamine is a more potent inhibitor of lidocaine metabolism than ketoconazole and erythromycin in vitro.''; Pharmacol Toxicol, 1999 PubMed Europe PMC
  2. Isohanni MH, Neuvonen PJ, Olkkola KT; ''Effect of fluvoxamine and erythromycin on the pharmacokinetics of oral lidocaine.''; Basic Clin Pharmacol Toxicol, 2006 PubMed Europe PMC
  3. Orlando R, Piccoli P, De Martin S, Padrini R, Floreani M, Palatini P; ''Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function.''; Clin Pharmacol Ther, 2004 PubMed Europe PMC


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94915view00:13, 13 October 2017Khanspersmoved link to KEGG
94737view15:03, 5 October 2017EgonwAdded a missing mim-type.
92384view18:19, 31 May 2017EgonwOntology Term : 'xenobiotic metabolic pathway' added !
74430view15:48, 18 April 2014EgonwAdded a third reference.
74429view15:47, 18 April 2014EgonwModified description
74428view15:43, 18 April 2014EgonwAdded two literature references.
74427view15:36, 18 April 2014EgonwOntology Term : 'phase I biotransformation pathway via cytochrome P450' added !
74424view15:33, 18 April 2014EgonwRemoved a redundant (empty) comment.
74423view15:32, 18 April 2014EgonwNew pathway

External references


View all...
NameTypeDatabase referenceComment
2,6-xylidineMetaboliteCHEBI:28738 (ChEBI)
2-amino-3-methylbenzoateMetabolite4161142 (PubChem-compound)
3-hydroxylidocaineMetabolite161824 (PubChem-compound)
3-hydroxymonoethyl glycinexylidideMetaboliteC16572 (KEGG Compound)
4-hydroxy- 2,6-dimethylanilineMetaboliteCHEBI:55545 (ChEBI)
CYP1A2GeneProductENSG00000140505 (Ensembl)
CYP3A4GeneProductENSG00000160868 (Ensembl)
LidocaineMetaboliteHMDB14426 (HMDB)
glycinexylidideMetaboliteCHEBI:357241 (ChEBI)
monoethyl glycinexylidideMetabolite24415 (PubChem-compound)

Annotated Interactions

No annotated interactions

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