Aripiprazole Metabolic Pathway (Homo sapiens)

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1-5CYP3A43dehydroaripiprazoleCYP2D6aripiprazoleProduct4


Description

The CYP P450 metabolism of aripiprazole has been studied and described in several papers (like the one in the bibliography), except for the original primary literature describing the experiments and the exact metabolite structures. The two CYPs are said to be involved in N-dealkylation and dehydrogenation.

Quality Tags

Ontology Terms

 

Bibliography

  1. Molden E, Lunde H, Lunder N, Refsum H; ''Pharmacokinetic variability of aripiprazole and the active metabolite dehydroaripiprazole in psychiatric patients.''; Ther Drug Monit, 2006 PubMed Europe PMC
  2. Swainston Harrison T, Perry CM; ''Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder.''; Drugs, 2004 PubMed Europe PMC
  3. Spina E, de Leon J; ''Metabolic drug interactions with newer antipsychotics: a comparative review.''; Basic Clin Pharmacol Toxicol, 2007 PubMed Europe PMC
  4. Kubo M, Koue T, Inaba A, Takeda H, Maune H, Fukuda T, Azuma J; ''Influence of itraconazole co-administration and CYP2D6 genotype on the pharmacokinetics of the new antipsychotic ARIPIPRAZOLE.''; Drug Metab Pharmacokinet, 2005 PubMed Europe PMC
  5. Argo TR, Carnahan RM, Perry PJ; ''Aripiprazole, a novel atypical antipsychotic drug.''; Pharmacotherapy, 2004 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
92286view12:34, 19 May 2017EgonwOntology Term : 'xenobiotic metabolic pathway' added !
79129view12:52, 3 March 2015EgonwAnnotated the Product as a (ChEBI) metabolite (removing a warning about a missing ID).
77339view15:10, 22 August 2014EgonwAdded a XMetDB identifier for one of the conversions.
77338view15:09, 22 August 2014EgonwUse a mim type.
73981view13:28, 13 March 2014MaintBotAdded two more papers.
73971view07:25, 13 March 2014MaintBotAdded a reference.
73897view11:22, 2 March 2014EgonwFigured out the identity of one of the metabolites.
73896view10:53, 2 March 2014EgonwMoved the title closer to the entities, effectively zooming in.
73895view10:52, 2 March 2014EgonwModified description
73894view10:49, 2 March 2014EgonwOntology Term : 'phase I biotransformation pathway via cytochrome P450' added !
73892view10:44, 2 March 2014EgonwNew pathway

External references

DataNodes

NameTypeDatabase referenceComment
CYP2D6GeneProductENSG00000100197 (Ensembl)
CYP3A43GeneProductENSG00000021461 (Ensembl)
ProductMetaboliteCHEBI:25212 (ChEBI)
aripiprazoleMetaboliteHMDB05042 (HMDB)
dehydroaripiprazoleMetabolite10114519 (PubChem-compound) Also known as OPC14857.

Annotated Interactions

SourceTargetTypeDatabase referenceComment
aripiprazoledehydroaripiprazolemim-conversionXMETDB172 (XMetDB)
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