Acetylcholine synthesis (Caenorhabditis elegans)

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1*Synaptic Cleft*Pyruvate from Glycolysis*Cytosol*ace-1PMT-1CKA-2PhosphatidylcholinesPhosphatidylethanolaminesPDHA2PDHA-1UNC-17PCYT-1PhosphorylcholineCytidine diphosphate cholineGlycerophosphocholineCholineAcetylcholineCholineAcetateAcetyl CoA


Acetylcholine is an important neurotransmitter. It can be rapidly released in the synaptic cleft upon activation of the neuron. In the synaptic cleft the compound is degraded rapidly into choline and acetate, this is essential for proper neuronal functioning. Choline and Acetate are taken up into the cytosol and recycled for the next activation.

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Ontology Terms



  1. Blusztajn JK, Wurtman RJ; ''Choline and cholinergic neurons.''; Science, 1983 PubMed Europe PMC Scholia


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117857view10:13, 23 May 2021EweitzModified title
104379view20:43, 22 May 2019MaintBotReplaced secondary ChEBI IDs with primary IDs.
104299view13:54, 15 May 2019Fehrhartconnected PDHA, UNC17 and ace1
104298view13:51, 15 May 2019Fehrhartadded metabolite Ids
104297view13:49, 15 May 2019Fehrhartadded IDs for metabolites
104296view13:43, 15 May 2019Fehrhartfixed connections
69946view20:24, 11 July 2013Mkutmonfixed unconnected lines
68465view20:26, 5 July 2013MaintBotUpdated to 2013 gpml schema
67026view09:55, 26 June 2013Christine ChichesterOntology Term : 'acetylcholine metabolic pathway' added !
51278view19:38, 4 September 2012CgroveUpdated PDHA-1
51277view19:36, 4 September 2012CgroveUpdating metabolites and genes
51276view19:32, 4 September 2012CgrovePeriodical save, work in progress
51275view19:21, 4 September 2012CgrovePeriodical save, work in progress
51274view19:11, 4 September 2012CgrovePeriodical save, work in progress
40620view19:57, 1 March 2011MaintBotRemoved redundant pathway information and comments
35064view11:15, 11 February 2010Thomasadded literature reference
35063view11:14, 11 February 2010ThomasModified description
21235view11:31, 14 November 2008MaintBot[[Pathway:Caenorhabditis elegans:Acetylcholine Synthesis]] moved to [[Pathway:WP264]]: Moved to stable identifier
8549view14:03, 7 January 2008MaintBotAdded to category $category
8547view14:03, 7 January 2008A.KwaUploaded new pathway

External references


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NameTypeDatabase referenceComment
AcetateMetaboliteCHEBI:30089 (ChEBI)
Acetyl CoAMetaboliteCHEBI:15351 (ChEBI)
AcetylcholineMetaboliteCHEBI:15355 (ChEBI)
CKA-2Protein180703 (Entrez Gene)
CholineMetaboliteCHEBI:15354 (ChEBI)
Cytidine diphosphate cholineMetaboliteCHEBI:16436 (ChEBI)
GlycerophosphocholineMetaboliteCHEBI:16870 (ChEBI)
PCYT-1GeneProductWBGene00017241 (WormBase)
PDHA-1GeneProduct3565996 (Entrez Gene)
PMT-1GeneProductWBGene00022781 (WormBase)
PhosphatidylcholinesMetaboliteCHEBI:49183 (ChEBI)
PhosphatidylethanolaminesMetaboliteCHEBI:16038 (ChEBI)
PhosphorylcholineMetaboliteCHEBI:49183 (ChEBI)
UNC-17GeneProduct177124 (Entrez Gene)
ace-1GeneProduct181706 (Entrez Gene)

Annotated Interactions

No annotated interactions

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