Interleukin-1 (IL-1) structural pathway (Homo sapiens)

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1-78IRAK2cyclinD1etc.IL1R1NIKB-defensin2 etcMAPKp38betaCellCycleMKK3MBPIKKalphaTPL2IL1AModificationMYD88IRAK4TAB1MEKK1NF-kappaB p105HSP27IFNalpha/betaERK1TOLLIPMAPKAPK2IL1,8,6, TNFa, IFNg, COX2, iNOSELK1TranslationNF-kappaB p50MEKK3NF-kappaB p65JNK1IkapaBalphaIRF7TRAF6IRAK1MSK1 TAK1IL1BIL1RAPTAB2TAB3MKK6MKK4MKK7MKK1MKK2IKKgammaIKKbetaMAPKp38alphaJNK2JNK3ERK2IkappaBbetaATF2Mnk1c-Junc-Fosc-MycMnk2CREB341Histone H3eIF-4E


IL-1 signaling pathway reconstructed by combining related pathways and information from the literature. This detailed map of IL-1 signaling presents the protein-protein interactions and the resulting cellular events. The colored nodes represent proteins having experimentally identified 3D structures and the white nodes are the proteins without 3D structures. The edges represent protein-protein interactions (straight/dashed arrows relate to available/unavailable 3D structures of proteins) or associations leading to cellular events such as cell cycle or gene expression (dashed arrows beginning with circular heads).


Pathway published in

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

Quality Tags

Ontology Terms



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  1. Sims JE, Nicklin MJ, Bazan JF, Barton JL, Busfield SJ, Ford JE, Kastelein RA, Kumar S, Lin H, Mulero JJ, Pan J, Pan Y, Smith DE, Young PR; ''A new nomenclature for IL-1-family genes.''; Trends Immunol, 2001 PubMed Europe PMC Scholia
  2. Dunn E, Sims JE, Nicklin MJ, O'Neill LA; ''Annotating genes with potential roles in the immune system: six new members of the IL-1 family.''; Trends Immunol, 2001 PubMed Europe PMC Scholia
  3. Lawson C, Al-Akoum M, Maheux R, Akoum A; ''Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions.''; Reproduction, 2007 PubMed Europe PMC Scholia
  4. Chang L, Karin M; ''Mammalian MAP kinase signalling cascades.''; Nature, 2001 PubMed Europe PMC Scholia
  5. Martinon F, Mayor A, Tschopp J; ''The inflammasomes: guardians of the body.''; Annu Rev Immunol, 2009 PubMed Europe PMC Scholia
  6. Pizarro TT, Cominelli F; ''Cloning IL-1 and the birth of a new era in cytokine biology.''; J Immunol, 2007 PubMed Europe PMC Scholia
  7. Acuner Ozbabacan SE, Gursoy A, Nussinov R, Keskin O; ''The Structural Pathway of Interleukin 1 (IL-1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer.''; PLoS Comput Biol, 2014 PubMed Europe PMC Scholia
  8. Pathak S, Borodkin VS, Albarbarawi O, Campbell DG, Ibrahim A, van Aalten DM; ''O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release.''; EMBO J, 2012 PubMed Europe PMC Scholia


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117962view10:54, 23 May 2021EweitzModified title
117961view10:53, 23 May 2021EweitzModified title
107551view23:33, 19 October 2019AlexanderPicoModified description
107550view23:33, 19 October 2019AlexanderPicoModified description
105827view23:04, 15 August 2019KhanspersModified description
87707view09:09, 25 July 2016MkutmonOntology Term : 'interleukin-1 signaling pathway' added !
87592view08:01, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
80029view12:23, 1 May 2015EgonwAdded the Ensembl ID for MKK3.
80007view12:30, 30 April 2015Zariannotated TPL2 ,kappaB p65 gene
79580view21:44, 25 March 2015Zari
76330view08:11, 2 July 2014MkutmonChanged database annotations from "Ensembl Human" to "Ensembl"
76319view06:59, 2 July 2014Mkutmonfixed datasource for IkappaBbeta datanode
73794view17:04, 24 February 2014AndraAdded the main reference
73793view17:02, 24 February 2014Andracorrected encoding errors of greek alphabet letters
73790view16:55, 24 February 2014Andra
73725view15:49, 19 February 2014AndraAdded references
73724view15:45, 19 February 2014AndraAdded identifiers
73723view15:11, 19 February 2014AndraModified description
73722view15:11, 19 February 2014AndraModified description
73721view14:49, 19 February 2014AndraNew pathway

External references


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NameTypeDatabase referenceComment
TAK1GeneProductENSG00000135341 (Ensembl)
ATF2GeneProductENSG00000115966 (Ensembl)
Cell CyclePathway
ELK1GeneProductENSG00000126767 (Ensembl)
ERK1GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
HSP27GeneProductENSG00000160633 (Ensembl)
Histone H3GeneProductQ66I33 (Uniprot-TrEMBL)
IKKalphaGeneProductENSG00000213341 (Ensembl)
IKKbetaGeneProductENSG00000104365 (Ensembl)
IKKgammaGeneProductENSG00000136560 (Ensembl)
IL1,8,6, TNFa, IFNg, COX2, iNOSPathway
IL1AGeneProductENSG00000115008 (Ensembl)
IL1BGeneProductENSG00000115008 (Ensembl)
IL1R1GeneProductENSG00000115594 (Ensembl)
IL1RAPGeneProductENSG00000196083 (Ensembl)
IRAK1GeneProductENSG00000184216 (Ensembl)
IRAK2GeneProductENSG00000134070 (Ensembl)
IRAK4GeneProductENSG00000198001 (Ensembl)
IRF7GeneProductENSG00000185507 (Ensembl)
IkapaBalphaGeneProductP25963 (Uniprot-TrEMBL)
IkappaBbetaGeneProductQ15653 (Uniprot-TrEMBL)
JNK1GeneProductP45983 (Uniprot-TrEMBL)
JNK2GeneProductP45984 (Uniprot-TrEMBL)
JNK3GeneProductP53779 (Uniprot-TrEMBL)
MAPKAPK2GeneProductENSG00000162889 (Ensembl)
MAPKp38alphaGeneProductENSG00000112062 (Ensembl)
MAPKp38betaGeneProductENSG00000185386 (Ensembl)
MBPGeneProductENSG00000197971 (Ensembl)
MEKK1GeneProductENSG00000095015 (Ensembl)
MEKK3GeneProductENSG00000198909 (Ensembl)
MKK1 GeneProductENSG00000169032 (Ensembl)
MKK2 GeneProductENSG00000126934 (Ensembl)
MKK3 GeneProductENSG00000034152 (Ensembl)
MKK4 GeneProductENSG00000065559 (Ensembl)
MKK6GeneProductENSG00000108984 (Ensembl)
MKK7 GeneProductENSG00000076984 (Ensembl)
MSK1GeneProductENSG00000100784 (Ensembl)
MYD88GeneProductENSG00000172936 (Ensembl)
Mnk1GeneProductENSG00000079277 (Ensembl)
Mnk2GeneProductENSG00000099875 (Ensembl)
NF-kappaB p105GeneProductP19838 (Uniprot-TrEMBL)
NF-kappaB p50GeneProduct
NF-kappaB p65GeneProductENSG00000173039 (Ensembl)
NIKGeneProductENSG00000006062 (Ensembl)
TAB1GeneProductENSG00000100324 (Ensembl)
TAB2GeneProductENSG00000055208 (Ensembl)
TAB3GeneProductENSG00000157625 (Ensembl)
TOLLIPGeneProductENSG00000078902 (Ensembl)
TPL2GeneProductENSG00000107968 (Ensembl)
TRAF6GeneProductENSG00000175104 (Ensembl)
c-FosGeneProductENSG00000170345 (Ensembl)
c-JunGeneProductENSG00000050748 (Ensembl)
c-MycGeneProductENSG00000136997 (Ensembl)
cyclinD1 etc.Pathway
eIF-4EGeneProductENSG00000151247 (Ensembl)

Annotated Interactions

No annotated interactions

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