Pto kinase mediated signaling pathway leading to the oxidative burst in tomato (Solanum lycopersicum)

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4phospholipase C?phospholipase APhysical pressure or Osmotic StressV. dahliaeOligogalacturonic Acids9, 11, 12NADP+FenthionP67p47AvrPtoSuperoxideFenReceptorPtoNADPHGp91Pti1Hydrogen peroxideKinasesp22(phox)OxygenG ProteinMechanosensor123, 112, 8, 106122725, 111211111


Hypothetical model showing the integration of the Pto kinase with other known signaling intermediates in the oxidative burst signal transduction pathways. See text for details and references. Plase A, phospholipase A; Plase C, phospholipase C; oxidase subunits include p47, p67, gp91, and p22.

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  1. Martin GB, Frary A, Wu T, Brommonschenkel S, Chunwongse J, Earle ED, Tanksley SD; ''A member of the tomato Pto gene family confers sensitivity to fenthion resulting in rapid cell death.''; Plant Cell, 1994 PubMed Europe PMC Scholia
  2. Martin GB, Brommonschenkel SH, Chunwongse J, Frary A, Ganal MW, Spivey R, Wu T, Earle ED, Tanksley SD; ''Map-based cloning of a protein kinase gene conferring disease resistance in tomato.''; Science, 1993 PubMed Europe PMC Scholia
  3. Yu L, Quinn MT, Cross AR, Dinauer MC; ''Gp91(phox) is the heme binding subunit of the superoxide-generating NADPH oxidase.''; Proc Natl Acad Sci U S A, 1998 PubMed Europe PMC Scholia
  4. Chandra S, Martin GB, Low PS; ''The Pto kinase mediates a signaling pathway leading to the oxidative burst in tomato.''; Proc Natl Acad Sci U S A, 1996 PubMed Europe PMC Scholia
  5. Manea A, Manea SA, Gafencu AV, Raicu M; ''Regulation of NADPH oxidase subunit p22(phox) by NF-kB in human aortic smooth muscle cells.''; Arch Physiol Biochem, 2007 PubMed Europe PMC Scholia
  6. Zhou J, Loh YT, Bressan RA, Martin GB; ''The tomato gene Pti1 encodes a serine/threonine kinase that is phosphorylated by Pto and is involved in the hypersensitive response.''; Cell, 1995 PubMed Europe PMC Scholia
  7. Legendre L, Heinstein PF, Low PS; ''Evidence for participation of GTP-binding proteins in elicitation of the rapid oxidative burst in cultured soybean cells.''; J Biol Chem, 1992 PubMed Europe PMC Scholia
  8. Lamb CJ; ''Plant disease resistance genes in signal perception and transduction.''; Cell, 1994 PubMed Europe PMC Scholia
  9. Blumenkrantz N, Asboe-Hansen G; ''New method for quantitative determination of uronic acids.''; Anal Biochem, 1973 PubMed Europe PMC Scholia
  10. Loh YT, Martin GB; ''The disease-resistance gene Pto and the fenthion-sensitivity gene fen encode closely related functional protein kinases.''; Proc Natl Acad Sci U S A, 1995 PubMed Europe PMC Scholia
  11. Dwyer SC, Legendre L, Low PS, Leto TL; ''Plant and human neutrophil oxidative burst complexes contain immunologically related proteins.''; Biochim Biophys Acta, 1996 PubMed Europe PMC Scholia
  12. Legendre L, Rueter S, Heinstein PF, Low PS; ''Characterization of the Oligogalacturonide-Induced Oxidative Burst in Cultured Soybean (Glycine max) Cells.''; Plant Physiol, 1993 PubMed Europe PMC Scholia


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87617view08:54, 25 July 2016LindarieswijkOntology Term : 'signaling pathway' added !
73748view15:27, 20 February 2014AndraModified description
73661view12:59, 13 February 2014Andraadded authors
73660view12:56, 13 February 2014Andraminor updates
73659view12:37, 13 February 2014AndraNew pathway

External references


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NameTypeDatabase referenceComment
AvrPto GeneProductQ08242 (Uniprot-TrEMBL)
FenGeneProductSolyc05g013290.1 (Ensembl)
FenthionMetabolite3229 (Chemspider)
G ProteinGeneProduct
Gp91GeneProductSolyc03g117980.2 (Ensembl)
Hydrogen peroxideMetabolite763 (Chemspider)
KinasesGeneProduct2.7.1.-. (Enzyme Nomenclature)
NADP+Metabolite5674 (Chemspider)
NADPHMetabolite5673 (Chemspider)
OxygenMetabolite952 (Chemspider)
Pti1GeneProductSolyc12g098980.1 (Ensembl)
PtoGeneProductSolyc05g013320.1 (Ensembl)
SuperoxideMetabolite4514331 (Chemspider)

Annotated Interactions

No annotated interactions

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