Ovarian Infertility Genes (Rattus norvegicus)

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NucleusOoplasmGranulosa CellNucleusCytoplasmOocytePrlrPtger2Ccnd2Nrip1Smpd1NCOR1Zp3Mlh1CebpbTF2DFig-alphaEgr1Nr5a1AtmMsh5Smad3Cyp19a1Cdkn1bFshrDmc1Esr2Gdf9DAZLZp3ZP2PgrGja4LhcgrSmpd1Gja4InhaVdrBMPR1BSyne2Cdk4


Ovarian bottleneck genes associated with infertility. A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility phenotypes. The individual gene pages in the OKdb (Ovarian Kaleidoscope Database: http://ovary.stanford.edu) contain information on associated fertility phenotypes sorted by ovarian and nonovarian defects and by subfertility or infertility. If one searches for null mutations (under mutation type) causing infertility (infertile - ovarian defect, under female fertility status) in mice (under species), 44 gene entries are found. The expression of these infertility genes in the oocyte and granulosa cells together with their cellular localization is presented in Ovarian Infertility gene map. The theca cell genes are not presented because most publications emphasize granulosa cell studies.


GenMAPP remarks 
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This pathway was inferred from Homo sapiens pathway WP34(r20749) with a 82% conversion rate.

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89873view12:40, 6 October 2016MkutmonModified description
88252view14:27, 1 August 2016FehrhartOntology Term : 'urogenital disease pathway' added !
88251view14:26, 1 August 2016FehrhartOntology Term : 'granulosa cell' added !
88250view14:25, 1 August 2016FehrhartOntology Term : 'oocyte' added !
88249view14:25, 1 August 2016FehrhartOntology Term : 'infertility' added !
71828view19:33, 18 October 2013MaintBotUpdated data sources
70128view20:12, 12 July 2013MaintBotupdated to 2013 schema
62855view05:11, 3 May 2013MaintBotupdated uniprot data source
41783view02:43, 2 March 2011MaintBotRemoved redundant pathway information and comments
35766view00:10, 13 February 2010KhanspersMoved from Comments to Description
35764view00:09, 13 February 2010KhanspersModified description
34151view19:36, 9 December 2009MaintBotAutomatic update of empty xrefs
32018view13:22, 14 August 2009MaintBotFixed group labels
30949view00:42, 30 July 2009MaintBotConverted from Homo sapiens
21233view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Ovarian Infertility Genes]] moved to [[Pathway:WP263]]: Moved to stable identifier
8316view13:46, 7 January 2008MaintBot[[Pathway:Rat:Ovarian Infertility Genes]] moved to [[Pathway:Rattus norvegicus:Ovarian Infertility Genes]]: Renaming species
7776view16:17, 18 December 2007MaintBotfixed category names
7285view12:41, 4 November 2007MaintBotAdded categories to GPML
19530view22:20, 22 May 2007A.Hsuehgpml file for [[Rat:Ovarian_Infertility_Genes]]
6583view22:20, 22 May 2007I.BenShlomogpml file for [[Rat:Ovarian_Infertility_Genes]]

External references


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NameTypeDatabase referenceComment
AtmGeneProduct300711 (Entrez Gene)
BMPR1BGeneProduct310914 (Entrez Gene)
Ccnd2GeneProduct64033 (Entrez Gene)
Cdk4GeneProduct94201 (Entrez Gene)
Cdkn1bGeneProduct83571 (Entrez Gene)
CebpbGeneProduct24253 (Entrez Gene)
Cyp19a1GeneProduct25147 (Entrez Gene)
DAZLGeneProduct680486 (Entrez Gene)
Dmc1GeneProduct362960 (Entrez Gene)
Egr1GeneProduct24330 (Entrez Gene)
Esr2GeneProduct25149 (Entrez Gene)
FshrGeneProduct25449 (Entrez Gene)
Gdf9GeneProduct59304 (Entrez Gene)
Gja4GeneProduct25655 (Entrez Gene)
InhaGeneProduct24504 (Entrez Gene)
LhcgrGeneProduct25477 (Entrez Gene)
Mlh1GeneProduct81685 (Entrez Gene)
Msh5GeneProduct294252 (Entrez Gene)
NCOR1GeneProduct54299 (Entrez Gene)
Nr5a1GeneProduct83826 (Entrez Gene)
Nrip1GeneProduct304157 (Entrez Gene)
PgrGeneProduct25154 (Entrez Gene)
PrlrGeneProduct24684 (Entrez Gene)
Ptger2GeneProduct81752 (Entrez Gene)
Smad3GeneProduct25631 (Entrez Gene)
Smpd1GeneProduct308909 (Entrez Gene)
Syne2GeneProduct299151 (Entrez Gene)
VdrGeneProduct24873 (Entrez Gene)
ZP2GeneProduct81828 (Entrez Gene)
Zp3GeneProduct114639 (Entrez Gene)

Annotated Interactions

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