Ebstein-Barr virus LMP1 signaling (Homo sapiens)

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2, 3PPS32-PTES1PS36-PUPTES2UUPS36-PS32-Pp52IKK-alphaIKK-alphap50/p52LMP1IKK-betap65MAP3K3TNFTRAF6p100IKK-gammaCCL5IRAK1I-Kappa-BTAB1p65MAP3K7CCL20HSP90SFC complexp50NIKp65JNKIFNBIL8p65TRADDp38TRAF1p50p50p65I-Kappa-Bp651, 4


Latent membrane protein 1 (LMP1) of the Ebstein-Barr Virus (EBV) elicits its oncogenice effects through the activation of several downstream pathways suchs as Pi3K/akt, IRF4, and NFkB pathways. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC; ''Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.''; J Leukoc Biol, 2008 PubMed Europe PMC Scholia
  2. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J; ''TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  3. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E; ''IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
  4. Lee JS, Lee JY, Son JW, Oh JH, Shin DM, Yuk JM, Song CH, Paik TH, Jo EK; ''Expression and regulation of the CC-chemokine ligand 20 during human tuberculosis.''; Scand J Immunol, 2008 PubMed Europe PMC Scholia


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116630view11:18, 9 May 2021EweitzModified title
106391view21:27, 28 August 2019KhanspersModified description
105573view06:29, 9 August 2019KhanspersModified description
97758view13:25, 7 June 2018RoelodModified description
86888view07:51, 14 July 2016MkutmonOntology Term : 'oxidative phosphorylation pathway' added !
86887view07:51, 14 July 2016MkutmonOntology Term : 'PW:0000034' removed !
84487view23:10, 25 February 2016KhanspersQuick edit to datanode annotation or property
84486view23:08, 25 February 2016KhanspersQuick edit to datanode annotation or property
84485view23:07, 25 February 2016KhanspersQuick edit to datanode annotation or property
79554view12:35, 25 March 2015Zariadded ID for I-Kappa-B
70166view00:29, 13 July 2013AlexanderPicoModified description
67172view10:16, 26 June 2013Christine ChichesterOntology Term : 'Epstein-Barr virus infection pathway' added !
63175view20:29, 8 May 2013MaintBotUpdating gpml version
59185view18:51, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
41154view23:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
34653view00:36, 8 January 2010Khanspersupdate xrefs
32017view13:22, 14 August 2009MaintBotFixed group labels
29609view12:06, 23 May 2009MartijnVanIerselUpdated ensembl references
24885view11:31, 17 November 2008Thomasremoved nested groups and reconnected lines
21231view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:EBV LMP1 signaling]] moved to [[Pathway:WP262]]: Moved to stable identifier
20591view13:32, 10 November 2008Thomasadded references for CCL20
11816view12:36, 5 May 2008MartijnVanIerselModified description
11634view11:57, 17 April 2008ThomasModified categories
11632view11:56, 17 April 2008ThomasNew pathway

External references


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NameTypeDatabase referenceComment
CCL20GeneProductENSG00000115009 (Ensembl)
CCL5GeneProductENSG00000271503 (Ensembl)
HSP90GeneProduct3320 (Entrez Gene)
I-Kappa-BGeneProductENSG00000100906 (Ensembl)
IFNBGeneProductENSG00000171855 (Ensembl)
IKK-alphaGeneProduct1147 (Entrez Gene)
IKK-alphaGeneProductENSG00000213341 (Ensembl)
IKK-betaGeneProductENSG00000104365 (Ensembl)
IKK-gammaGeneProductENSG00000269335 (Ensembl)
IL8GeneProductENSG00000169429 (Ensembl)
IRAK1GeneProductENSG00000184216 (Ensembl)
JNKGeneProductENSG00000107643 (Ensembl)
LMP1GeneProductENSG00000196923 (Ensembl)
MAP3K3GeneProductENSG00000198909 (Ensembl)
MAP3K7GeneProductENSG00000135341 (Ensembl)
NIKGeneProductENSG00000006062 (Ensembl)
SFC complexGeneProduct
TAB1GeneProductENSG00000135341 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
TRADDGeneProductENSG00000102871 (Ensembl)
TRAF1GeneProductENSG00000056558 (Ensembl)
TRAF6GeneProductENSG00000175104 (Ensembl)
p100GeneProductENSG00000077150 (Ensembl)
p38GeneProductENSG00000100030 (Ensembl)
p50/p52GeneProductENSG00000109320 (Ensembl)
p50GeneProductENSG00000109320 (Ensembl)
p52GeneProductENSG00000077150 (Ensembl)
p65GeneProductENSG00000173039 (Ensembl)

Annotated Interactions

No annotated interactions

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