Limb and Fin Development (Mus musculus)

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13Pitx genesTbx genesEtv genesEpha genesRegulatory ElementsWnt genesTelomeric Gene DesertAnd genesFgf genesHox genesBmp genesHand genesosr genesSall genesNogginraldh2osr2hand2bmp2bhoxa11Tbx4etv5/etv5ahand1Grem1fgf10wnt2bwnt8choxc10fibinetv4Tbx5pdlim7ptc1/ptch1Tbx3retinoic acidbmp2afgf24osr1hoxa13Pitx1Pitx2fgf4fgf17pea3chordinfgf9Meis1wnt3ahoxd13a/ hoxd13and1shh/shhaermfgf8a/ fgf8gli3and2Epha4Epha3Sall1Sall3Island 2Island 4CsBCscCNS 65CNS 39Hoxd10Hoxd11Hoxd12


Description

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Bibliography

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  1. Mao J, McGlinn E, Huang P, Tabin CJ, McMahon AP; ''Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb.''; Dev Cell, 2009 PubMed Europe PMC Scholia
  2. Agarwal P, Wylie JN, Galceran J, Arkhitko O, Li C, Deng C, Grosschedl R, Bruneau BG; ''Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo.''; Development, 2003 PubMed Europe PMC Scholia
  3. Riddle RD, Johnson RL, Laufer E, Tabin C; ''Sonic hedgehog mediates the polarizing activity of the ZPA.''; Cell, 1993 PubMed Europe PMC Scholia
  4. Bouldin CM, Gritli-Linde A, Ahn S, Harfe BD; ''Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
  5. Schulte CJ, Allen C, England SJ, Juárez-Morales JL, Lewis KE; ''Evx1 is required for joint formation in zebrafish fin dermoskeleton.''; Dev Dyn, 2011 PubMed Europe PMC Scholia
  6. Nohno T, Noji S, Koyama E, Ohyama K, Myokai F, Kuroiwa A, Saito T, Taniguchi S; ''Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development.''; Cell, 1991 PubMed Europe PMC Scholia
  7. Izpisúa-Belmonte JC, Tickle C, Dollé P, Wolpert L, Duboule D; ''Expression of the homeobox Hox-4 genes and the specification of position in chick wing development.''; Nature, 1991 PubMed Europe PMC Scholia
  8. Galli A, Robay D, Osterwalder M, Bao X, Bénazet JD, Tariq M, Paro R, Mackem S, Zeller R; ''Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development.''; PLoS Genet, 2010 PubMed Europe PMC Scholia
  9. Duboc V, Logan MP; ''Regulation of limb bud initiation and limb-type morphology.''; Dev Dyn, 2011 PubMed Europe PMC Scholia
  10. Tarchini B, Duboule D, Kmita M; ''Regulatory constraints in the evolution of the tetrapod limb anterior-posterior polarity.''; Nature, 2006 PubMed Europe PMC Scholia
  11. Sims K Jr, Eble DM, Iovine MK; ''Connexin43 regulates joint location in zebrafish fins.''; Dev Biol, 2009 PubMed Europe PMC Scholia
  12. King M, Arnold JS, Shanske A, Morrow BE; ''T-genes and limb bud development.''; Am J Med Genet A, 2006 PubMed Europe PMC Scholia
  13. Tanaka M; ''Molecular and evolutionary basis of limb field specification and limb initiation.''; Dev Growth Differ, 2013 PubMed Europe PMC Scholia
  14. Sheth R, Grégoire D, Dumouchel A, Scotti M, Pham JM, Nemec S, Bastida MF, Ros MA, Kmita M; ''Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth.''; Development, 2013 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
97686view15:08, 1 June 2018Fehrhartcorrected ID
97589view08:28, 28 May 2018Fehrhartadded ID
88675view15:40, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
85552view07:45, 29 May 2016EgonwReplaced a mim-conversion with Arrow.
79792view16:03, 16 April 2015Mkutmonfixed unconnected line
78418view10:26, 7 January 2015MaintBotadded missing graphIds
73066view19:03, 22 December 2013LmjacksonModified title
73065view19:01, 22 December 2013LmjacksonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CNS 39GeneProductConserved Noncoding Sequence
CNS 65GeneProductConserved Noncoding Sequence
CsBGeneProduct
CscGeneProduct
Epha3GeneProductMGI:99612 (MGI)
Epha4GeneProductMGI:98277 (MGI)
Grem1GeneProduct
Hoxd10GeneProductMGI:96202 (MGI)
Hoxd11GeneProductMGI:96203 (MGI)
Hoxd12GeneProductMGI:96204 (MGI)
Island 2GeneProduct
Island 4GeneProduct
Meis1GeneProduct
NogginGeneProduct
Pitx1GeneProduct
Pitx2GeneProduct
Sall1GeneProductMGI:1889585 (MGI)
Sall3GeneProductMGI:109295 (MGI)
Tbx3GeneProduct
Tbx4GeneProduct
Tbx5GeneProduct
and1GeneProductZDB-GENE-030131-9105 (ZFIN)
and2GeneProductZDB-GENE-041105-2 (ZFIN)
bmp2aGeneProduct
bmp2bGeneProduct
chordinGeneProduct
ermGeneProduct
etv4GeneProduct
etv5/etv5aGeneProductZDB-GENE-030131-9572 (ZFIN)
fgf10GeneProduct
fgf17GeneProduct
fgf24GeneProduct
fgf4GeneProduct
fgf8a/ fgf8GeneProductZDB-GENE-990415-72 (ZFIN)
fgf9GeneProduct
fibinGeneProduct
gli3GeneProductZDB-GENE-041111-162 (ZFIN)
hand1GeneProduct
hand2GeneProductZDB-GENE-000511-1 (ZFIN)
hoxa11GeneProductENSMUSG00000038210 (Ensembl)
hoxa13GeneProduct
hoxc10GeneProduct
hoxd13a/ hoxd13GeneProductZDB-GENE-990415-119 (ZFIN)
osr1GeneProduct
osr2GeneProduct
pdlim7GeneProduct
pea3GeneProduct
ptc1/ptch1GeneProduct
raldh2GeneProductZebrafish mutants for retinaldehyde dehydrogenase 2 (raldh2) lack pectoral fin buds
retinoic acid
shh/shhaGeneProductZDB-GENE-980526-166 (ZFIN)
wnt2bGeneProduct
wnt3aGeneProduct
wnt8cGeneProduct

Annotated Interactions

No annotated interactions

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