Signal Transduction of S1P Receptor (Homo sapiens)

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Metabolism of sphingomyelin by the sphingomyelinase, ceramidase (Cer'ase) and the sphingosine kinase (SK) enzymes results in formation of S1P and receptor activation. Autocrine and paracrine modes of receptor activation have been implied but have yet to be rigorously proven. Critical signaling molecules, such as phospholipase C (PLC), ERK, PI3K, and Akt are activated. Active Akt binds to the receptor and phosphorylates the third intracellular loop, which is essential for Rac activation. Representation of Figure 2. from T. Hla, et al. 2001, Science, 294, pg. 1877. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Hla T, Lee MJ, Ancellin N, Paik JH, Kluk MJ; ''Lysophospholipids--receptor revelations.''; Science, 2001 PubMed Europe PMC Scholia


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106482view19:48, 3 September 2019KhanspersModified description
105814view22:56, 15 August 2019KhanspersModified description
102299view20:44, 17 December 2018KhanspersModified description
102298view20:44, 17 December 2018Khanspersremoved GenMAPP comment
79950view11:05, 28 April 2015Zaricorrected ID and symbol for LOC51190
78492view10:28, 7 January 2015MaintBotadded missing graphIds
69049view17:53, 8 July 2013MaintBotUpdated to 2013 gpml schema
67643view11:43, 26 June 2013DdiglesOntology Term : 'sphingosine 1-phosphate signaling pathway' added !
45223view17:32, 7 October 2011KhanspersOntology Term : 'G protein mediated signaling pathway' added !
41237view23:46, 1 March 2011MaintBotRemoved redundant pathway information and comments
38752view22:33, 23 September 2010AlexanderPico
38751view22:31, 23 September 2010AlexanderPicobeautification
37352view18:15, 28 May 2010KhanspersModified description
37351view18:13, 28 May 2010KhanspersLit ref
34506view00:35, 17 December 2009KhanspersAdded connector
32719view23:35, 2 September 2009MaintBotUpdated name
32016view13:22, 14 August 2009MaintBotFixed group labels
20731view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:S1P Signaling]] moved to [[Pathway:WP26]]: Moved to stable identifier
14939view15:32, 24 May 2008MartijnVanIerselcreated groups, linked up
12971view10:58, 17 May 2008MaintBotSticky edges patch by Sjoerd
10235view19:45, 17 January 2008Thomasgrouped genes and added linked lines
8372view13:46, 7 January 2008MaintBot[[Pathway:Human:S1P Signaling]] moved to [[Pathway:Homo sapiens:S1P Signaling]]: Renaming species
7804view16:19, 18 December 2007MaintBotfixed category names
7292view12:41, 4 November 2007MaintBotAdded categories to GPML
6368view22:18, 22 May 2007S.Donigergpml file for [[Human:S1P_Signaling]]

External references


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NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
AKT3GeneProduct10000 (Entrez Gene)
ASAH1GeneProduct427 (Entrez Gene)
EDG3GeneProduct1903 (Entrez Gene)
EDG5GeneProduct9294 (Entrez Gene)
EDG8GeneProduct53637 (Entrez Gene)
GNAI1GeneProduct2770 (Entrez Gene)
GNAI2GeneProduct2771 (Entrez Gene)
GNAI3GeneProduct2773 (Entrez Gene)
MAPK12GeneProduct6300 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK4GeneProduct5596 (Entrez Gene)
MAPK6GeneProduct5597 (Entrez Gene)
MAPK7GeneProduct5598 (Entrez Gene)
PIK3C2BGeneProduct5287 (Entrez Gene)
PLCB1GeneProduct23236 (Entrez Gene)
PLCB2GeneProduct5330 (Entrez Gene)
PLCB3GeneProduct5331 (Entrez Gene)
RACGAP1GeneProduct29127 (Entrez Gene)
S1PR1GeneProduct1901 (Entrez Gene)
SMPD2GeneProduct6610 (Entrez Gene)
SPHK1GeneProduct8877 (Entrez Gene)
SPHK2GeneProduct56848 (Entrez Gene)

Annotated Interactions

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