Secretion of Hydrochloric Acid in Parietal Cells (Homo sapiens)

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1Stomach lumenVenous bloodcarbonate dehydratase activityATP4ACHRM1GastrinBicarbonate ionPotassiumChloride ionHydrogenZincAcetylcholineHistamine Carbon dioxideWaterHRH2CCKBRBicarbonate ionHydrogenChloride ionPotassiumChloride ion


Description

Gastric parietal cells are stomach epithelial cells. They secrete gastric acid and intrinsic factor. This pathway is primarily based on https://en.wikipedia.org/wiki/Parietal_cell

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Ontology Terms

 

Bibliography

  1. Murakami H, Sly WS; ''Purification and characterization of human salivary carbonic anhydrase.''; J Biol Chem, 1987 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106721view13:16, 17 September 2019MaintBotHMDB identifier normalization
87647view08:54, 25 July 2016LindarieswijkOntology Term : 'acid-base homeostasis pathway' added !
78485view10:28, 7 January 2015MaintBotadded missing graphIds
77607view08:03, 30 September 2014Mkutmonconnected lines
76321view07:23, 2 July 2014Mkutmonchanged carbonate dehydratase activity from gene product to label.
73972view10:11, 13 March 2014MaintBotGuessing, but it is probably H+ and not H2.
72719view14:38, 3 December 2013AndraFixed curation issues
72718view14:38, 3 December 2013AndraFixed curation issues
72717view14:37, 3 December 2013AndraFixed curation issues
72660view12:55, 29 November 2013AndraModified description
72659view12:49, 29 November 2013AndraModified description
72658view12:38, 29 November 2013AndraOntology Term : 'parietal cell' added !
72657view12:36, 29 November 2013AndraFirst release
72656view12:26, 29 November 2013AndraPeriodical save, work in progress
72655view12:16, 29 November 2013AndraPeriodical save, work in progress
72654view12:06, 29 November 2013AndraPeriodical save, work in progress
72653view11:56, 29 November 2013AndraPeriodical save, work in progress
72652view11:46, 29 November 2013AndraPeriodical save, work in progress
72651view11:36, 29 November 2013AndraNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ATP4AGeneProduct495 (Entrez Gene)
AcetylcholineMetabolite182 (Chemspider)
Bicarbonate ionMetabolite749 (Chemspider)
CCKBRGeneProduct887 (Entrez Gene)
CHRM1GeneProduct1128 (Entrez Gene)
Carbon dioxideMetabolite274 (Chemspider)
Chloride ionMetaboliteHMDB0000492 (HMDB)
GastrinGeneProductP01350 (Uniprot-TrEMBL)
HRH2GeneProduct3274 (Entrez Gene)
Histamine Metabolite753 (Chemspider)
HydrogenMetaboliteHMDB0059597 (HMDB)
PotassiumMetaboliteHMDB0000586 (HMDB)
WaterMetabolite937 (Chemspider)
ZincMetabolite22430 (Chemspider)

Annotated Interactions

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