Gastric acid production (Homo sapiens)

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14, 51Parietal cellG cellGastric Chief CellsECL CellFoveolar cellSodium ChlorideGastric pepsin releaseAcetylcholineSecretinPepsin BGastric Intrinsic Factorpotassium chloridehydrochloric acidGRPVIPGastric Histamine releaseMucus and bicarbonate secretionHistamineBicarbonate ionsParietal Cell productionGastric Gastrin ReleaseGastrinMUC6CCKpepsinogen64Pepsin C


Gastric acid forms a protective buffer against pathogenic agents. It is also essential in the digestion of the food. The stomach wall is protected to the high acidity by a mucus layer and bicarbonate ions.

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Ontology Terms



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  1. Sandvik AK, Waldum HL; ''CCK-B (gastrin) receptor regulates gastric histamine release and acid secretion.''; Am J Physiol, 1991 PubMed Europe PMC Scholia
  2. Dekker J, Rossen JW, Büller HA, Einerhand AW; ''The MUC family: an obituary.''; Trends Biochem Sci, 2002 PubMed Europe PMC Scholia
  3. Sigurdsson HH, Kirch J, Lehr CM; ''Mucus as a barrier to lipophilic drugs.''; Int J Pharm, 2013 PubMed Europe PMC Scholia
  4. Allen A, Garner A; ''Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection.''; Gut, 1980 PubMed Europe PMC Scholia
  5. Williams SE, Turnberg LA; ''Demonstration of a pH gradient across mucus adherent to rabbit gastric mucosa: evidence for a 'mucus-bicarbonate' barrier.''; Gut, 1981 PubMed Europe PMC Scholia
  6. Toribara NW, Roberton AM, Ho SB, Kuo WL, Gum E, Hicks JW, Gum JR Jr, Byrd JC, Siddiki B, Kim YS; ''Human gastric mucin. Identification of a unique species by expression cloning.''; J Biol Chem, 1993 PubMed Europe PMC Scholia


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115458view08:06, 21 February 2021EgonwMade five pathways clickable
87520view01:54, 25 July 2016AlexanderPicoOntology Term : 'regulatory pathway' added !
72724view15:09, 3 December 2013AndraAdded reference and MUC6
72692view11:52, 2 December 2013AndraSpecify description
72691view11:50, 2 December 2013AndraSpecify description
72689view11:43, 2 December 2013AndraAdded pathway identifier for external pathway
72687view11:34, 2 December 2013AndraAdded literature reference
72686view11:32, 2 December 2013AndraProvided identifier gor teh Gastric Gastrin release pathway
72684view11:25, 2 December 2013Andrasmall improvement
72683view11:24, 2 December 2013AndraImproved layout
72682view11:22, 2 December 2013AndraSpecify description
72679view10:59, 2 December 2013AndraUpdated pathway
72678view10:50, 2 December 2013AndraConnected unconnected line
72662view12:58, 29 November 2013AndraOntology Term : 'stomach enteroendocrine cell' added !
72661view12:56, 29 November 2013AndraOntology Term : 'parietal cell' added !
72650view11:22, 29 November 2013AndraModified description
72649view11:14, 29 November 2013AndraSpecify description
72648view11:10, 29 November 2013AndraPeriodical save, work in progress
72647view11:00, 29 November 2013AndraPeriodical save, work in progress
72646view10:50, 29 November 2013AndraPeriodical save, work in progress
72645view10:40, 29 November 2013AndraPeriodical save, work in progress
72644view10:30, 29 November 2013AndraPeriodical save, work in progress
72643view10:11, 29 November 2013AndraFirst draft
72642view10:02, 29 November 2013AndraPeriodical save, work in progress
72641view09:32, 29 November 2013AndraPeriodical save, work in progress
72640view09:21, 29 November 2013AndraPeriodical save, work in progress
72639view09:11, 29 November 2013AndraPeriodical save, work in progress
72638view09:01, 29 November 2013AndraWork in progress
72637view08:31, 29 November 2013AndraNew pathway

External references


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NameTypeDatabase referenceComment
AcetylcholineMetabolite182 (Chemspider)
Bicarbonate ionsMetabolite749 (Chemspider)
CCKGeneProduct885 (Entrez Gene)
GRPGeneProduct2922 (Entrez Gene)
Gastric Gastrin ReleasePathwayWP2599 (WikiPathways)
Gastric Histamine releasePathwayWP2598 (WikiPathways)
Gastric Intrinsic FactorGeneProductP27352 (Uniprot-TrEMBL)
Gastric pepsin releasePathwayWP2601 (WikiPathways)
GastrinGeneProductP01350 (Uniprot-TrEMBL)
Histamine Metabolite753 (Chemspider)
MUC6GeneProduct4588 (Entrez Gene)
Mucus and bicarbonate secretionPathwayWP2600 (WikiPathways)
Parietal Cell production PathwayWP2597 (WikiPathways)
Pepsin BGeneProduct3.4.23.2 (Enzyme Nomenclature)
Pepsin CGeneProduct3.4.23.3 (Enzyme Nomenclature)
SecretinGeneProduct6343 (Entrez Gene)
Sodium ChlorideMetabolite5044 (Chemspider)
VIPGeneProduct7432 (Entrez Gene)
hydrochloric acidMetabolite307 (Chemspider)
pepsinogenGeneProductO95576 (Uniprot-TrEMBL)
potassium chlorideMetabolite4707 (Chemspider)

Annotated Interactions

No annotated interactions

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