Nifedipine Activity (Homo sapiens)

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79VasodilatationRapid degration by daylight8179, 82, 8477Antioxidative867779phosphorylation86Delay G0/G1 --> S-phaseNa balance797979Nitrosonifedipinephosphorylationcell growth inhibition8381, 88in vivo8381Angiogenesis81AntithromboticLactam derivate8877Serum induced DNA synthesisFe uptakeZn uptake77CholesterolROSphosphorylationNifedipine8681AntiartherosclerosisCa uptake8183AntiprolerativeMETABOLISM liver and small intestine777988PKCNADPH oxidaseMAP2K1SODCYP2C11Cholesterol esteraseVEGFKDR/FLK1PTK2BNOBDKRB2Ca-channelPCNAMAPK1CYP3A4Cholesterol hydrolase1


Nifedipine (brand names Adalat, Nifediac, Cordipin, Nifedical, and Procardia) is a dihydropyridine calcium channel blocker. Its main uses are as an antianginal (especially in Prinzmetal's angina) and antihypertensive, although a large number of other indications have recently been found for this agent, such as Raynaud's phenomenon, premature labor, and painful spasms of the esophagus in cancer and tetanus patients. It is also commonly used for the small subset of pulmonary hypertension patients whose symptoms respond to calcium channel blockers. Source: Wikipedia (wikipedia:Nifedipine)

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Ontology Terms



  1. Hirata A, Igarashi M, Yamaguchi H, Suwabe A, Daimon M, Kato T, Tominaga M; ''Nifedipine suppresses neointimal thickening by its inhibitory effect on vascular smooth muscle cell growth via a MEK-ERK pathway coupling with Pyk2.''; Br J Pharmacol, 2000 PubMed Europe PMC Scholia


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106191view12:08, 16 August 2019MaintBotHMDB identifier normalization
88585view19:25, 11 August 2016Mkutmonfix unconnected lines
75227view19:24, 12 May 2014Khansperslayout, xrefs, connections
74419view12:42, 18 April 2014EgonwConverted two labels into metabolite DataNodes with an identifier.
71991view11:18, 24 October 2013MkutmonChanged Unknown -> GeneProduct for all annotated data nodes
68905view17:30, 8 July 2013MaintBotUpdated to 2013 gpml schema
67508view11:18, 26 June 2013DdiglesOntology Term : 'nifedipine drug pathway' added !
45358view20:43, 7 October 2011KhanspersModified description
45357view20:42, 7 October 2011KhanspersModified description
45356view20:41, 7 October 2011KhanspersOntology Term : 'heart disease' added !
45355view20:40, 7 October 2011KhanspersOntology Term : 'hypertension' added !
41054view23:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
39776view21:35, 17 January 2011AlexanderPicomore complete title
38868view18:23, 24 September 2010KhanspersChanged line types
34583view22:23, 21 December 2009KhanspersModified categories
34447view18:20, 10 December 2009MaintBotAutomatic update of empty xrefs
26597view19:11, 10 December 2008AlexanderPicoupdate
26595view19:10, 10 December 2008AlexanderPicoadded connectors, database refs and literature ref
26593view19:05, 10 December 2008AlexanderPicoPeriodical save, work in progress
21223view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:test1234]] moved to [[Pathway:WP259]]: Moved to stable identifier
20471view10:39, 7 November 2008RobatwikiNew pathway

External references


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NameTypeDatabase referenceComment
BDKRB2GeneProduct624 (Entrez Gene)
CYP3A4GeneProduct1576 (Entrez Gene)
Cholesterol esterase
Cholesterol hydrolase
CholesterolMetaboliteCHEBI:16113 (ChEBI)
KDR/FLK1GeneProduct3791 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
NADPH oxidaseGeneProduct
NOMetaboliteHMDB0003378 (HMDB)
NifedipineMetaboliteCHEBI:7565 (ChEBI)
PCNAGeneProduct5111 (Entrez Gene)
PKCGeneProduct50818 (Entrez Gene)
PTK2BGeneProduct2185 (Entrez Gene)
SODGeneProduct6647 (Entrez Gene)
VEGFProteinVEGF (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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