RTK/Ras/MAPK - LET-23, EGL-15 independent (Caenorhabditis elegans)

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1Positive and negative regulators and targets of various RTK/Ras/MAPK signaling pathways in C. elegans. LST-1LET-60/RasLET-92DPY-22LIN-3SUR-6SUR-5EGL-15DPY-23EGL-17LET-756SRA-13?SEM-5PTP-2KSR-1LST-3KSR-2ARK-1LIN-25ELT-6LIN-45/RafMEK-2/MekLET-23DAB-1LST-2GPA-5GTPCLR-1LIN-2LST-4CNK-1??SUR-7EGL-18ROM-1GAP-2EOR-1EFL-1GAP-1LIN-39MPK-1/ErkLRP-2?EOR-2UNC-101DAF-2LIN-10EGL-5SEM-4EGL-19VAB-1LIP-1SOS-1/GEFSUR-2SOC-1LIN-31LIN-7LRP-1PAR-1SOC-2LIN-12EGL-30LIN-35SLI-1CDF-1LIN-1??


Description

This pathway represents the core elements of Receptor Tyrosine Kinase (RTK)/Ras GTPase/MAP kinase (MAPK) pathways. Many developmental events in C. elegans require this signaling pathway with different RTK's providing activation of the pathway in specific cell-types and under different regulatory controls. Depending on the process, this signaling pathway may interact with the Wnt, Notch, or other pathways during development.

Quality Tags

Ontology Terms

 

Bibliography

  1. Sundaram MV; ''RTK/Ras/MAPK signaling.''; WormBook, 2006 PubMed

History

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CompareRevisionActionTimeUserComment
78457view10:27, 7 January 2015MaintBotadded missing graphIds
71868view08:32, 19 October 2013EgonwAdded a metabolite ID.
71440view19:06, 17 October 2013MaintBotAutomated update of data sources
70988view23:18, 19 September 2013KyookModified description
70987view23:08, 19 September 2013KyookOntology Term : 'the extracellular signal-regulated Raf/Mek/Erk signaling pathway' added !
70986view23:07, 19 September 2013KyookOntology Term : 'Ras mediated signaling pathway' added !
70985view23:05, 19 September 2013KyookNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
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??GeneProduct
ARK-1GeneProductWBGene00000186 (WormBase)
CDF-1GeneProductWBGene00000393 (WormBase)
CLR-1GeneProductWBGene00000548 (WormBase)
CNK-1GeneProductWBGene00000564 (WormBase)
DAB-1GeneProductWBGene00000894 (WormBase)
DAF-2GeneProductWBGene00000898 (WormBase)
DPY-22GeneProductWBGene00001081 (WormBase)
DPY-23GeneProductWBGene00001082 (WormBase)
EFL-1GeneProductWBGene00001161 (WormBase)
EGL-15GeneProductWBGene00001184 (WormBase)
EGL-17GeneProductWBGene00001185 (WormBase)
EGL-18GeneProductWBGene00001186 (WormBase)
EGL-19GeneProductWBGene00001187 (WormBase)
EGL-30GeneProductWBGene00001196 (WormBase)
EGL-5GeneProductWBGene00001174 (WormBase)
ELT-6GeneProductWBGene00001253 (WormBase)
EOR-1GeneProductWBGene00001324 (WormBase)
EOR-2GeneProductWBGene00001325 (WormBase)
GAP-1GeneProductWBGene00001515 (WormBase)
GAP-2GeneProductWBGene00001516 (WormBase)
GPA-5GeneProductWBGene00001667 (WormBase)
GTPMetaboliteCHEBI:15996 (ChEBI)
KSR-1GeneProductWBGene00002239 (WormBase)
KSR-2GeneProductWBGene00002240 (WormBase)
LET-23GeneProductWBGene00002299 (WormBase)
LET-60/RasGeneProductWBGene00002335 (WormBase)
LET-756GeneProductWBGene00002881 (WormBase)
LET-92GeneProductWBGene00002363 (WormBase)
LIN-10GeneProductWBGene00002999 (WormBase)
LIN-12GeneProductWBGene00003001 (WormBase)
LIN-1GeneProductWBGene00002990 (WormBase)
LIN-25GeneProductWBGene00003011 (WormBase)
LIN-2GeneProductWBGene00002991 (WormBase)
LIN-31GeneProductWBGene00003017 (WormBase)
LIN-35GeneProductWBGene00003020 (WormBase)
LIN-39GeneProductWBGene00003024 (WormBase)
LIN-3GeneProductWBGene00002992 (WormBase)
LIN-45/RafGeneProductWBGene00003030 (WormBase)
LIN-7GeneProductWBGene00002996 (WormBase)
LIP-1GeneProductWBGene00003043 (WormBase)
LRP-1GeneProductWBGene00003071 (WormBase)
LRP-2GeneProductWBGene00003072 (WormBase)
LST-1GeneProductWBGene00003083 (WormBase)
LST-2GeneProductWBGene00003084 (WormBase)
LST-3GeneProductWBGene00003085 (WormBase)
LST-4GeneProductWBGene00003086 (WormBase)
MEK-2/MekGeneProductWBGene00003186 (WormBase)
MPK-1/ErkGeneProductWBGene00003401 (WormBase)
PAR-1GeneProductWBGene00003916 (WormBase)
PTP-2GeneProductWBGene00004214 (WormBase)
ROM-1GeneProductWBGene00004400 (WormBase)
SEM-4GeneProductWBGene00004773 (WormBase)
SEM-5GeneProductWBGene00004774 (WormBase)
SLI-1GeneProductWBGene00004829 (WormBase)
SOC-1GeneProductWBGene00004928 (WormBase)
SOC-2GeneProductWBGene00004929 (WormBase)
SOS-1/GEFGeneProductT28F12.3 (WormBase)
SRA-13GeneProductWBGene00005039 (WormBase)
SUR-2GeneProductWBGene00006349 (WormBase)
SUR-5GeneProductWBGene00006351 (WormBase)
SUR-6GeneProductWBGene00006352 (WormBase)
SUR-7GeneProductWBGene00006353 (WormBase)
UNC-101GeneProductWBGene00006829 (WormBase)
VAB-1GeneProductWBGene00006868 (WormBase)

Annotated Interactions

No annotated interactions

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