Glyoxylate cycle (Mycobacterium tuberculosis)

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21, 3, 4, 6, 7ICL2bOxaloacetateMQOSuccinateGlyoxylateMDHMLSMalateAcetyl-CoACitrateCITAIsocitrateICL1ACNICL2aFUMSDHAFumarateCITEAcetyl-CoA1, 4-6SDHBSDHCSDHDACN


The glyoxylate cycle transforms acetyl-CoA derived from the β-oxidation of fatty acids into oxaloacetate, an intermediate of the citric acid cycle

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  1. Bharadwaj VP, Katoch VM, Sharma VD, Kannan KB, Datta AK, Shivannavar CT; ''Metabolic studies on mycobacteria. IV. Assay of isocitrate lyase and malate synthase activity in M. leprae.''; Indian J Lepr, 1987 PubMed Europe PMC Scholia
  2. Muñoz-Elías EJ, Upton AM, Cherian J, McKinney JD; ''Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence.''; Mol Microbiol, 2006 PubMed Europe PMC Scholia
  3. Muñoz-Elías EJ, McKinney JD; ''Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence.''; Nat Med, 2005 PubMed Europe PMC Scholia
  4. Wheeler PR, Ratledge C; ''Use of carbon sources for lipid biosynthesis in Mycobacterium leprae: a comparison with other pathogenic mycobacteria.''; J Gen Microbiol, 1988 PubMed Europe PMC Scholia
  5. KORNBERG HL, KREBS HA; ''Synthesis of cell constituents from C2-units by a modified tricarboxylic acid cycle.''; Nature, 1957 PubMed Europe PMC Scholia
  6. Seshadri R, Murthy PS, Venkitasubramanian TA; ''Isociatrate lyase in mycobacteria.''; Indian J Biochem Biophys, 1976 PubMed Europe PMC Scholia
  7. McKinney JD, Höner zu Bentrup K, Muñoz-Elías EJ, Miczak A, Chen B, Chan WT, Swenson D, Sacchettini JC, Jacobs WR Jr, Russell DG; ''Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase.''; Nature, 2000 PubMed Europe PMC Scholia


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97588view08:24, 28 May 2018Fehrhartupdated outdated uniprot ID for MLS
89931view13:42, 6 October 2016MkutmonModified description
77539view19:52, 23 September 2014KhanspersOntology Term : 'glyoxylate and dicarboxylate metabolic pathway' added !
77538view19:47, 23 September 2014Khanspersconnected interactions
71840view19:46, 18 October 2013MaintBotUpdated UniProt/TrEMBL data source
70854view10:23, 12 September 2013AndraSpecify description
70849view08:59, 12 September 2013Mkutmoncircular structure
70841view17:29, 11 September 2013AndraModified description
70840view17:09, 11 September 2013AndraAdded MLS and ICL references
70839view17:06, 11 September 2013AndraPeriodical save, work in progress
70836view22:41, 10 September 2013AndraSpecify description
70834view17:24, 10 September 2013AndraMade it more circular
70831view16:30, 10 September 2013Andrafirst draft
70830view16:28, 10 September 2013AndraPeriodical save, work in progress
70829view16:18, 10 September 2013AndraPeriodical save, work in progress
70828view16:08, 10 September 2013AndraPeriodical save, work in progress
70827view15:57, 10 September 2013AndraPeriodical save, work in progress
70826view15:25, 10 September 2013Andrawork in progress
70825view15:14, 10 September 2013AndraPeriodical save, work in progress
70821view12:49, 10 September 2013AndraAdded source reference
70820view12:48, 10 September 2013AndraFirst Draft
70819view12:47, 10 September 2013AndraNew pathway

External references


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NameTypeDatabase referenceComment
ACNGeneProductL7N4I7 (Uniprot-TrEMBL)
Acetyl-CoAMetabolite392413 (Chemspider)
CITAGeneProductP63777 (Uniprot-TrEMBL)
CITEGeneProductO06162 (Uniprot-TrEMBL)
CitrateMetabolite29081 (Chemspider)
FUMGeneProductO53446 (Uniprot-TrEMBL)
FumarateMetabolite4573886 (Chemspider)
GlyoxylateMetabolite2849615 (Chemspider)
ICL1GeneProductP0A5H3 (Uniprot-TrEMBL)
ICL2aGeneProductL0T829 (Uniprot-TrEMBL)
ICL2bGeneProductL0T891 (Uniprot-TrEMBL)
IsocitrateMetabolite4573809 (Chemspider)
MDHGeneProductP0A5J6 (Uniprot-TrEMBL)
MLSGeneProductP9WK16 (Uniprot-TrEMBL)
MQOGeneProductP65419 (Uniprot-TrEMBL)
MalateMetabolite140981 (Chemspider)
OxaloacetateMetabolite2509917 (Chemspider)
SDHAGeneProductL7N501 (Uniprot-TrEMBL)
SDHBGeneProductL7N605 (Uniprot-TrEMBL)
SDHCGeneProductL7N510 (Uniprot-TrEMBL)
SDHDGeneProductL0TC66 (Uniprot-TrEMBL)
SuccinateMetabolite140973 (Chemspider)

Annotated Interactions

No annotated interactions

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