Transcription initiation by sigma factors (Mycobacterium tuberculosis)

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4777771, 3, 7lrpGImmune pathology pathway in hostGlyoxylate cycle (icl1)methylcitrate cycle (gltA1)Rv1823Rv2884PhoY1lrpI77774involved in the virulence of the tubercle bacilli42, 8Stress responseRsfB4, 5UsfXRsfA4, 54, 5SigASigB6, 9, 109, 10SigG9, 10SigH9, 10SigI9, 10SigJSigK9, 109, 10SigL9, 10SigMSigC9-14SigD9, 109, 10SigESigF8-109, 10


Sigma factors are components of the RNA polymerase complex that are responsible for binding to the RNA polymerase complex, promoter recognition and separating DNA strands. The number of sigma factors is extremely diverse between bacteria, ranging from three in Helicobacter pylori to 63 in Streptomyces coelicolor. M. tuberculosis possesses 13 sigma factors, 10 of which are from the ECF sub-family, enabling this bacterium to cope with various environmental conditions

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  1. Song T, Song SE, Raman S, Anaya M, Husson RN; ''Critical role of a single position in the -35 element for promoter recognition by Mycobacterium tuberculosis SigE and SigH.''; J Bacteriol, 2008 PubMed Europe PMC Scholia
  2. Calamita H, Ko C, Tyagi S, Yoshimatsu T, Morrison NE, Bishai WR; ''The Mycobacterium tuberculosis SigD sigma factor controls the expression of ribosome-associated gene products in stationary phase and is required for full virulence.''; Cell Microbiol, 2005 PubMed Europe PMC Scholia
  3. Manganelli R, Voskuil MI, Schoolnik GK, Smith I; ''The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages.''; Mol Microbiol, 2001 PubMed Europe PMC Scholia
  4. Williams EP, Lee JH, Bishai WR, Colantuoni C, Karakousis PC; ''Mycobacterium tuberculosis SigF regulates genes encoding cell wall-associated proteins and directly regulates the transcriptional regulatory gene phoY1.''; J Bacteriol, 2007 PubMed Europe PMC Scholia
  5. Beaucher J, Rodrigue S, Jacques PE, Smith I, Brzezinski R, Gaudreau L; ''Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms.''; Mol Microbiol, 2002 PubMed Europe PMC Scholia
  6. Collins DM, Kawakami RP, de Lisle GW, Pascopella L, Bloom BR, Jacobs WR Jr; ''Mutation of the principal sigma factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complex.''; Proc Natl Acad Sci U S A, 1995 PubMed Europe PMC Scholia
  7. Datta P, Shi L, Bibi N, Balázsi G, Gennaro ML; ''Regulation of central metabolism genes of Mycobacterium tuberculosis by parallel feed-forward loops controlled by sigma factor E (σ(E)).''; J Bacteriol, 2011 PubMed Europe PMC Scholia
  8. Manganelli R, Fattorini L, Tan D, Iona E, Orefici G, Altavilla G, Cusatelli P, Smith I; ''The extra cytoplasmic function sigma factor sigma(E) is essential for Mycobacterium tuberculosis virulence in mice.''; Infect Immun, 2004 PubMed Europe PMC Scholia
  9. Waagmeester A, Thompson J, Reyrat JM; ''Identifying sigma factors in Mycobacterium smegmatis by comparative genomic analysis.''; Trends Microbiol, 2005 PubMed Europe PMC Scholia
  10. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG; ''Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.''; Nature, 1998 PubMed Europe PMC Scholia
  11. Manganelli R, Dubnau E, Tyagi S, Kramer FR, Smith I; ''Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis.''; Mol Microbiol, 1999 PubMed Europe PMC Scholia
  12. Sassetti CM, Boyd DH, Rubin EJ; ''Genes required for mycobacterial growth defined by high density mutagenesis.''; Mol Microbiol, 2003 PubMed Europe PMC Scholia
  13. Lamichhane G, Zignol M, Blades NJ, Geiman DE, Dougherty A, Grosset J, Broman KW, Bishai WR; ''A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: application to Mycobacterium tuberculosis.''; Proc Natl Acad Sci U S A, 2003 PubMed Europe PMC Scholia
  14. Griffin JE, Gawronski JD, Dejesus MA, Ioerger TR, Akerley BJ, Sassetti CM; ''High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism.''; PLoS Pathog, 2011 PubMed Europe PMC Scholia


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117428view10:46, 21 May 2021EweitzModified title
87808view11:28, 25 July 2016MirellaKalafatiOntology Term : 'transcription pathway' added !
87804view11:25, 25 July 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
71842view19:49, 18 October 2013MaintBotUpdated UniProt/TrEMBL data source
71807view14:14, 18 October 2013EgonwAdded a missing data source.
70855view10:35, 12 September 2013AndraAdded references
70822view12:57, 10 September 2013AndraAdded id to Glyoxylate cycle pathway
70815view16:53, 9 September 2013AndraAdded link to methylcitrate cycle in WikiPathways
70810view16:00, 9 September 2013AndraRegulation of central metabolism genes
70809view15:51, 9 September 2013AndraPeriodical save, work in progress
70808view15:30, 9 September 2013AndraPeriodical save, work in progress
70807view14:13, 9 September 2013AndraSpecify description
70806view14:11, 9 September 2013AndraSpecify description
70805view14:05, 9 September 2013AndraAdded reference
70804view14:04, 9 September 2013AndraAdded sigf interacts
70803view13:38, 9 September 2013Andraanti and anti anti SigF and references added
70786view15:30, 6 September 2013AndraAdded references and clustered according to functional properties
70785view15:19, 6 September 2013AndraRemoved double references
70784view15:14, 6 September 2013AndraModified description
70783view15:09, 6 September 2013AndraAdded references
70782view15:06, 6 September 2013AndraFirst draft
70781view13:37, 6 September 2013AndraNew pathway

External references


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NameTypeDatabase referenceComment
Glyoxylate cycle (icl1)PathwayWP2566 (WikiPathways)
Immune pathology pathway in hostPathway
PhoY1GeneProductP65718 (Uniprot-TrEMBL)
RsfAGeneProductQ11035 (Uniprot-TrEMBL)
RsfBGeneProductO69655 (Uniprot-TrEMBL)
Rv1823GeneProductP64891 (Uniprot-TrEMBL)
Rv2884GeneProductQ10808 (Uniprot-TrEMBL)
SigAGeneProductP0A602 (Uniprot-TrEMBL)
SigBGeneProductQ59563 (Uniprot-TrEMBL)
SigC GeneProductP66809 (Uniprot-TrEMBL)
SigDGeneProductP66811 (Uniprot-TrEMBL)
SigEGeneProductO06289 (Uniprot-TrEMBL)
SigFGeneProductQ7D5S2 (Uniprot-TrEMBL)
SigGGeneProductL7N5U5 (Uniprot-TrEMBL)
SigHGeneProductP66807 (Uniprot-TrEMBL)
SigIGeneProductL7N4U5 (Uniprot-TrEMBL)
SigJGeneProductL0TCG5 (Uniprot-TrEMBL)
SigKGeneProductO53730 (Uniprot-TrEMBL)
SigLGeneProductQ7D9D4 (Uniprot-TrEMBL)
SigMGeneProductO53590 (Uniprot-TrEMBL)
Stress responsePathway
UsfXGeneProductP96892 (Uniprot-TrEMBL)
lrpGGeneProductL7N534 (Uniprot-TrEMBL)
lrpIGeneProductO53750 (Uniprot-TrEMBL)
methylcitrate cycle (gltA1)PathwayWP2565 (WikiPathways)

Annotated Interactions

No annotated interactions

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