Blood Clotting Cascade (Rattus norvegicus)

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1Extrinsic PathwayFactor XIIIaFactor VIIIaPlasminTissue FactorFibrin MonomerFactor Xa Factor IXaFactor XIaFibrin Split ProductsTissue Injury Fibrin PolymerFactor VIIa+ThrombolysisIntrinsic PathwayThrombinFactor XIIaFactor VaPlatFgbFggFgaF8F7PlgPlauF10F2Serpinf2F8A1VwfF11Serpinb2FibrinSerpine1F5F9Prothrombinase ComplexF13bF12F10


Coagulation is a complex process by which blood forms clots. It is an important part of hemostasis (the cessation of blood loss from a damaged vessel), wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel. Disorders of coagulation can lead to an increased risk of bleeding (hemorrhage) or clotting (thrombosis). Source: Wikipedia


This pathway was inferred from Homo sapiens pathway WP272(r30179) with a 86% conversion rate.

Quality Tags

Ontology Terms



  1. Luchtman-Jones L, Broze GJ Jr; ''The current status of coagulation.''; Ann Med, 1995 PubMed Europe PMC Scholia


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71806view20:34, 17 October 2013MaintBotAutomated update of data sources
71309view17:00, 17 October 2013MaintBotAutomated update of data sources
69451view19:06, 8 July 2013MaintBotUpdated to 2013 gpml schema
67093view10:05, 26 June 2013Christine ChichesterOntology Term : 'coagulation cascade pathway' added !
62854view05:07, 3 May 2013MaintBotUpdated UniProt data source
41780view02:42, 2 March 2011MaintBotRemoved redundant pathway information and comments
35088view12:39, 11 February 2010Thomasfixed group positions, removed incorrect line
35081view12:23, 11 February 2010Thomasadded literature
35078view12:18, 11 February 2010Thomasremoved brace, added binding interaction with complex
35077view12:16, 11 February 2010Thomasfixed lines
35070view12:02, 11 February 2010ThomasModified description
34148view19:35, 9 December 2009MaintBotAutomatic update of empty xrefs
32015view13:21, 14 August 2009MaintBotFixed group labels
30951view00:43, 30 July 2009MaintBotConverted from Homo sapiens
21215view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Blood Clotting Cascade]] moved to [[Pathway:WP255]]: Moved to stable identifier
7930view13:46, 7 January 2008MaintBot[[Pathway:Rat:Blood Clotting Cascade]] moved to [[Pathway:Rattus norvegicus:Blood Clotting Cascade]]: Renaming species
7590view16:02, 18 December 2007MaintBotfixed category names
7457view12:42, 4 November 2007MaintBotAdded categories to GPML
19385view22:19, 22 May 2007M.Ramirezgpml file for [[Rat:Blood_Clotting_Cascade]]
6522view22:19, 22 May 2007A.Kwagpml file for [[Rat:Blood_Clotting_Cascade]]

External references


View all...
NameTypeDatabase referenceComment
F10GeneProduct29243 (Entrez Gene)
F11GeneProduct290757 (Entrez Gene)
F12GeneProduct306761 (Entrez Gene)
F13bGeneProduct289055 (Entrez Gene)
F2GeneProduct29251 (Entrez Gene)
F5GeneProduct304929 (Entrez Gene)
F7GeneProduct260320 (Entrez Gene)
F8GeneProduct302470 (Entrez Gene)
F8A1GeneProduct501661 (Entrez Gene)
F9GeneProduct24946 (Entrez Gene)
FgaGeneProduct361969 (Entrez Gene)
FgbGeneProduct24366 (Entrez Gene)
FggGeneProduct24367 (Entrez Gene)
PlatGeneProduct25692 (Entrez Gene)
PlauGeneProduct25619 (Entrez Gene)
PlgGeneProduct85253 (Entrez Gene)
Prothrombinase ComplexGeneProduct
Serpinb2GeneProduct60325 (Entrez Gene)
Serpine1GeneProduct24617 (Entrez Gene)
Serpinf2GeneProduct287527 (Entrez Gene)
VwfGeneProduct116669 (Entrez Gene)

Annotated Interactions

No annotated interactions
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