Sulindac Metabolic Pathway (Homo sapiens)

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1MsrB2CYP1B1MsrAFMOSulindac-SSulfindac sulfideSulindac-RSulindac sulfoneMsrB3CYP1A2CYP1A2


Metabolism of sulindac sulfide is catalyzed by MsrA, MsrB2, and MsrB3.

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  1. Brunell D, Sagher D, Kesaraju S, Brot N, Weissbach H; ''Studies on the metabolism and biological activity of the epimers of sulindac.''; Drug Metab Dispos, 2011 PubMed Europe PMC


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105115view13:43, 8 July 2019DeSlChanged ID for FMO from wikidata to interpro.
102205view14:56, 9 December 2018EgonwModified description
102204view14:55, 9 December 2018EgonwModified title
102203view14:54, 9 December 2018EgonwModified title
102202view14:54, 9 December 2018EgonwReplaced a Wikipedia with a Wikidata identifier.
97769view13:33, 7 June 2018MaxvansonModified description
92293view12:43, 19 May 2017EgonwOntology Term : 'xenobiotic metabolic pathway' added !
88583view19:21, 11 August 2016Mkutmonfix unconnected lines
87597view08:13, 25 July 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
70621view15:07, 16 August 2013EgonwHow did I manage to switch the R and S epimer??
70618view14:53, 16 August 2013EgonwHumanized the pathway: human Ensemble IDs.
70617view14:39, 16 August 2013EgonwNew pathway

External references


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NameTypeDatabase referenceComment
CYP1A2GeneProductENSG00000140505 (Ensembl)
CYP1B1GeneProductENSG00000138061 (Ensembl)
FMOGeneProductIPR000960 (InterPro)
MsrAGeneProductENSG00000175806 (Ensembl)
MsrB2GeneProductENSG00000148450 (Ensembl)
MsrB3GeneProductENSG00000174099 (Ensembl)
Sulfindac sulfideMetabolite4509492 (Chemspider)
Sulindac sulfoneMetabolite4582441 (Chemspider) The structure for the sulfone in the paper is inconsistent with the entries in ChemSpider and PubChem; I assume the paper made typographic errors.
Sulindac-RMetabolite16046677 (PubChem-compound)
Sulindac-SMetabolite11245227 (PubChem-compound)

Annotated Interactions

No annotated interactions

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