Sulindac Metabolic Pathway (Rattus norvegicus)

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1MsrB2Sulindac-SSulindac sulfideCYP1A1FMOMsrASulindac-RSulindac sulfoneMsrB3CYP1A2


Metabolism of sulindac involves various enzymes.

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Ontology Terms



  1. Brunell D, Sagher D, Kesaraju S, Brot N, Weissbach H; ''Studies on the metabolism and biological activity of the epimers of sulindac.''; Drug Metab Dispos, 2011 PubMed Europe PMC


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105114view13:42, 8 July 2019DeSlupdate typo (InterPro)
105113view13:41, 8 July 2019DeSlConverted FMO ID from Wikidata to Interpro
102139view09:51, 2 December 2018EgonwFixed a typo.
102138view09:50, 2 December 2018EgonwReplaced a Wikipedia with a Wikidata identifier.
102137view09:36, 2 December 2018EgonwFixed an interaction that was not properly connected.
102136view09:35, 2 December 2018EgonwModified description
92291view12:41, 19 May 2017EgonwOntology Term : 'xenobiotic metabolic pathway' added !
87596view08:13, 25 July 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
70622view15:52, 16 August 2013EgonwThe significant oxidation of Sulindac-S is actually not reported for rat CYPs.
70620view15:06, 16 August 2013EgonwHow did I manage to switch the R and S epimer??
70616view14:30, 16 August 2013EgonwRemoved another human gene.
70615view13:39, 16 August 2013EgonwRemoved a human CYP protein.
70614view12:13, 16 August 2013EgonwAdded the CYP enzymes.
70613view12:07, 16 August 2013EgonwAdded the literature reference.
70612view12:06, 16 August 2013EgonwThe text specifies more specific genes.
70610view11:51, 16 August 2013EgonwA -like enzyme is not a GeneProduct (don't complain about a missing identifier), and set the data source for the WP identifier.
70609view11:50, 16 August 2013EgonwNew pathway

External references


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NameTypeDatabase referenceComment
CYP1A1GeneProductENSRNOG00000019500 (Ensembl)
CYP1A2GeneProductENSRNOG00000016173 (Ensembl)
FMOGeneProductIPR000960 (InterPro)
MsrAGeneProductENSRNOG00000012440 (Ensembl)
MsrB2GeneProductENSRNOG00000016873 (Ensembl)
MsrB3GeneProductENSRNOG00000042668 (Ensembl)
Sulindac sulfideMetabolite4509492 (Chemspider)
Sulindac sulfoneMetabolite4582441 (Chemspider) The structure for the sulfone in the paper is inconsistent with the entries in ChemSpider and PubChem; I assume the paper made typographic errors.
Sulindac-RMetabolite16046677 (PubChem-compound)
Sulindac-SMetabolite11245227 (PubChem-compound)

Annotated Interactions

No annotated interactions

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