Methapyrilene Metabolic Pathway (Rattus norvegicus)

From WikiPathways

Jump to: navigation, search
1314, 52Metabolitesmethapyrilene-S-oxideGSHCYPsmethapyrilene-S-oxideglutathion conjugateMethapyrileneMP-NoxidePeriportal LiverNecrosisHepatotoxicitydemethylated methapyrilene


Description

No description

Quality Tags

Ontology Terms

 

Bibliography

  1. Graham EE, Walsh RJ, Hirst CM, Maggs JL, Martin S, Wild MJ, Wilson ID, Harding JR, Kenna JG, Peter RM, Williams DP, Park BK; ''Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore.''; J Pharmacol Exp Ther, 2008 PubMed Europe PMC
  2. Ratra GS, Cottrell S, Powell CJ; ''Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene.''; Toxicol Sci, 1998 PubMed Europe PMC
  3. Craig A, Sidaway J, Holmes E, Orton T, Jackson D, Rowlinson R, Nickson J, Tonge R, Wilson I, Nicholson J; ''Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat.''; J Proteome Res, 2006 PubMed Europe PMC
  4. Uehara T, Kiyosawa N, Hirode M, Omura K, Shimizu T, Ono A, Mizukawa Y, Miyagishima T, Nagao T, Urushidani T; ''Gene expression profiling of methapyrilene-induced hepatotoxicity in rat.''; J Toxicol Sci, 2008 PubMed Europe PMC
  5. Mercer AE, Regan SL, Hirst CM, Graham EE, Antoine DJ, Benson CA, Williams DP, Foster J, Kenna JG, Park BK; ''Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis.''; Toxicol Appl Pharmacol, 2009 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
92292view12:42, 19 May 2017EgonwOntology Term : 'xenobiotic metabolic pathway' added !
77786view08:49, 18 October 2014EgonwA few more pointers.
77785view08:25, 18 October 2014EgonwExtended the pathway. Haven't found specific CYP reactions yet.
70608view11:11, 16 August 2013EgonwWidened the box.
70606view09:53, 16 August 2013Egonw
70605view09:47, 16 August 2013Egonw
70600view09:26, 16 August 2013EgonwAdded two more metabolite structures.
70595view20:08, 15 August 2013Egonw
70587view15:19, 15 August 2013EgonwOntology Term : 'cellular detoxification pathway' added !
70586view15:17, 15 August 2013EgonwAdded a first conversion and a paper discussing the metabolism.
70585view15:08, 15 August 2013EgonwNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CYPsProtein
GSHProtein
HepatotoxicityPathway
MP-NoxideMetabolite138399 (Chemspider)
MethapyrileneMetabolite3956 (Chemspider)
Periportal Liver NecrosisPathway
demethylated methapyrileneMetabolite157251 (PubChem-compound)
methapyrilene-S-oxide glutathion conjugateMetabolite
methapyrilene-S-oxideMetabolite29303354 (Chemspider) Structure has been submitted to PubChem.

Annotated Interactions

No annotated interactions

Personal tools