Methapyrilene Metabolic Pathway (Rattus norvegicus)

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1314, 52Metabolitesmethapyrilene-S-oxideGSHCYPsmethapyrilene-S-oxideglutathion conjugateMethapyrileneMP-NoxidePeriportal LiverNecrosisHepatotoxicitydemethylated methapyrilene


No description

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Ontology Terms



  1. Graham EE, Walsh RJ, Hirst CM, Maggs JL, Martin S, Wild MJ, Wilson ID, Harding JR, Kenna JG, Peter RM, Williams DP, Park BK; ''Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore.''; J Pharmacol Exp Ther, 2008 PubMed Europe PMC
  2. Ratra GS, Cottrell S, Powell CJ; ''Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene.''; Toxicol Sci, 1998 PubMed Europe PMC
  3. Craig A, Sidaway J, Holmes E, Orton T, Jackson D, Rowlinson R, Nickson J, Tonge R, Wilson I, Nicholson J; ''Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat.''; J Proteome Res, 2006 PubMed Europe PMC
  4. Uehara T, Kiyosawa N, Hirode M, Omura K, Shimizu T, Ono A, Mizukawa Y, Miyagishima T, Nagao T, Urushidani T; ''Gene expression profiling of methapyrilene-induced hepatotoxicity in rat.''; J Toxicol Sci, 2008 PubMed Europe PMC
  5. Mercer AE, Regan SL, Hirst CM, Graham EE, Antoine DJ, Benson CA, Williams DP, Foster J, Kenna JG, Park BK; ''Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis.''; Toxicol Appl Pharmacol, 2009 PubMed Europe PMC


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92292view12:42, 19 May 2017EgonwOntology Term : 'xenobiotic metabolic pathway' added !
77786view08:49, 18 October 2014EgonwA few more pointers.
77785view08:25, 18 October 2014EgonwExtended the pathway. Haven't found specific CYP reactions yet.
70608view11:11, 16 August 2013EgonwWidened the box.
70606view09:53, 16 August 2013Egonw
70605view09:47, 16 August 2013Egonw
70600view09:26, 16 August 2013EgonwAdded two more metabolite structures.
70595view20:08, 15 August 2013Egonw
70587view15:19, 15 August 2013EgonwOntology Term : 'cellular detoxification pathway' added !
70586view15:17, 15 August 2013EgonwAdded a first conversion and a paper discussing the metabolism.
70585view15:08, 15 August 2013EgonwNew pathway

External references


View all...
NameTypeDatabase referenceComment
MP-NoxideMetabolite138399 (Chemspider)
MethapyrileneMetabolite3956 (Chemspider)
Periportal Liver NecrosisPathway
demethylated methapyrileneMetabolite157251 (PubChem-compound)
methapyrilene-S-oxide glutathion conjugateMetabolite
methapyrilene-S-oxideMetabolite29303354 (Chemspider) Structure has been submitted to PubChem.

Annotated Interactions

No annotated interactions

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