Colchicine Metabolic Pathway (Homo sapiens)

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1, 2213DMCColchicine12DMCCYP3A4


Description

P450-mediated biotransformation pathway of colchicine with the CYP3A4, while colchicine inhibits the expression of this enzyme.

Quality Tags

Ontology Terms

 

Bibliography

  1. Tateishi T, Soucek P, Caraco Y, Guengerich FP, Wood AJ; ''Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation.''; Biochem Pharmacol, 1997 PubMed Europe PMC
  2. Dvorak Z, Modriansky M, Pichard-Garcia L, Balaguer P, Vilarem MJ, Ulrichov√° J, Maurel P, Pascussi JM; ''Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation.''; Mol Pharmacol, 2003 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
92288view12:39, 19 May 2017EgonwOntology Term : 'xenobiotic metabolic pathway' added !
74479view07:42, 25 April 2014EgonwFixed the Uniprot ID.
71707view19:59, 17 October 2013MaintBotUpdated data sources
70549view22:27, 10 August 2013EgonwModified description
70548view22:26, 10 August 2013EgonwCholchicine decreases the expression of the CYP that metabolises it.
70542view12:31, 10 August 2013EgonwIndicated the source of the two current conversions.
70518view13:08, 9 August 2013EgonwAdded a related paper, explaining a loop.
70517view13:07, 9 August 2013EgonwSimplified the diagram.
70513view12:41, 9 August 2013EgonwModified description
70512view12:40, 9 August 2013EgonwOntology Term : 'phase I biotransformation pathway via cytochrome P450' added !
70511view12:38, 9 August 2013EgonwAdded the ChemSpider IDs for 2DMC and 3DMC.
70510view12:35, 9 August 2013EgonwNew pathway

External references

DataNodes

NameTypeDatabase referenceComment
2DMCMetabolite22210 (Chemspider)
3DMCMetabolite264748 (Chemspider)
CYP3A4ProteinP08684 (Uniprot-TrEMBL)
ColchicineMetabolite5933 (Chemspider)

Annotated Interactions

No annotated interactions

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