Glycolysis (Saccharomyces cerevisiae)

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2-phosphoglyceratefructose-1,6-bisphosphateH+pyruvate3-PhosphoglycerateH+dihydroxy-acetone-phosphateH2OH+NADfructose-6-phosphate (closed form)fructose degradationPYK2NADHTDH1phosphopyruvate hydrataseCDC19ADPADPENO1acetoin and butanediol biosynthesisTDH2GPM3ERR2amino acid biosynthesisTDH3PGK1PhosphateATPATPPFK2ATPFBA1mannose degradationGPM1phosphoenolpyruvateTPI13-phospho-D-glyceroyl-phosphateADPglyceraldehyde-3-phosphatePentose phosphate pathwayENO2TCA cyclePGI1ERR1PFK1chorismate biosynthesisglucose-6-phosphate (closed form)Glucose-6P (open)Fructose 6P (open)


Description

Many yeast and bacterial species ferment pyruvate to 2,3-butanediol via the intermediate, acetoin. Although acetoin is a flavorless compound, it is a precursor to some off-odor compounds, such as diacetyl, which can be unfavorable in beer and wine. Acetoin and 2,3-butanediol are both by-products of alcoholic fermentation by S. cerevisiae and other wine yeasts. Acetoin production during alcoholic fermentation depends on the yeast strain and other variables such as substrate and temperature (as reported in (CITS: [16535224])). Wine yeasts with high fermentation power generally produce low acetoin levels and large amounts of ethanol and higher alcohols (alcohols with more than 2 carbons) (as reported in (CITS: [16535224])). SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html

Comments

GenMAPP remarks 
Based on http://pathway.yeastgenome.org/biocyc/

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
107251view14:34, 17 September 2019MaintBotChEBI identifier normalization
107014view13:47, 17 September 2019MaintBotHMDB identifier normalization
96373view09:41, 10 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
94316view12:34, 1 September 2017Marvin M2Connected unconnected line
94177view13:32, 25 August 2017DeSlAdded identifiers for all metabolites, corrected some misconnected enzymes, gave all enzymes new IDs (previous ones did not link to anything)
94162view14:40, 24 August 2017DeSlChanged textlabels to metabolites, connected lines.
69832view14:54, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69648view20:38, 8 July 2013MaintBotUpdated to 2013 gpml schema
67311view10:35, 26 June 2013Christine ChichesterOntology Term : 'glycolysis pathway' added !
41887view04:53, 2 March 2011MaintBotRemoved redundant pathway information and comments
36613view22:30, 9 April 2010MaintBotDescription and bibliography added from SGD
21211view11:31, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Glycolysis]] moved to [[Pathway:WP253]]: Moved to stable identifier
12736view08:00, 17 May 2008MaintBotautomated metabolite conversion
8765view14:08, 7 January 2008MaintBotAdded to category $category
8763view14:08, 7 January 2008J.HeckmanUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-phosphoglycerateMetaboliteCHEBI:24344 (ChEBI)
3-PhosphoglycerateMetaboliteCHEBI:17050 (ChEBI)
3-phospho-D-glyceroyl-phosphateMetabolite38168-82-0 (CAS)
ADPMetabolite58-64-0 (CAS)
ATPMetabolite1927-31-7 (CAS)
CDC19GeneProductYAL038W (Ensembl) pyruvate kinase 1
ENO1GeneProductYGR254W (Ensembl)
ENO2GeneProductYHR174W (Ensembl)
ERR1GeneProductYOR393W (Ensembl) enolase: ERR1
ERR2GeneProductYPL281C (Ensembl) enolase: ERR2
FBA1GeneProductYKL060C (Ensembl)
Fructose 6P (open)MetaboliteCHEBI:57579 (ChEBI) fructose-6-phosphate (2-) open form
GPM1GeneProductYKL152C (Ensembl) phosphoglycerate mutase 1
GPM3GeneProductYOL056W (Ensembl)
Glucose-6P (open)MetaboliteCHEBI:57584 (ChEBI) D-Glucose-6-Phosphate (2-) open form
H+MetaboliteCHEBI:15378 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
NADMetaboliteCHEBI:13389 (ChEBI)
NADHMetabolite53-84-9 (CAS)
PFK1GeneProductYGR240C (Ensembl)
PFK2GeneProductYMR205C (Ensembl)
PGI1GeneProductYBR196C (Ensembl) glucose-6-phosphate isomerase
PGK1GeneProductYCR012W (Ensembl) 3-phophsoglycerate kinase
PYK2GeneProductYOR347C (Ensembl) pyruvate kinase 2
Pentose phosphate pathwayPathway
PhosphateMetabolite14265-44-2 (CAS)
TCA cyclePathway
TDH1GeneProductYJL052W (Ensembl) glyceraldehyde 3-phosphate dehydrogenase 1
TDH2GeneProductYJR009C (Ensembl) glyceraldehyde 3-phosphate dehydrogenase 2
TDH3GeneProductYGR192C (Ensembl) glyceraldehyde 3-phosphate dehydrogenase 3
TPI1GeneProductYDR050C (Ensembl)
acetoin and butanediol biosynthesisPathway
amino acid biosynthesisPathway
chorismate biosynthesisPathway
dihydroxy-acetone-phosphateMetaboliteHMDB0001473 (HMDB)
fructose degradationPathway
fructose-1,6-bisphosphateMetaboliteHMDB0001058 (HMDB)
fructose-6-phosphate (closed form)Metabolite26330295 (Chemspider)
glucose-6-phosphate (closed form)MetaboliteCHEBI:75150 (ChEBI)
glyceraldehyde-3-phosphateMetabolite591-57-1 (CAS)
mannose degradationPathway
phosphoenolpyruvateMetabolite138-08-9 (CAS)
phosphopyruvate hydrataseGeneProductS000004942 (SGD)
pyruvateMetaboliteCHEBI:15361 (ChEBI)

Annotated Interactions

No annotated interactions
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