MAPK Cascade (Mus musculus)

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1, 2GqGiGrowth and MitogenesisActivatedRap1GAPNucleusComplexStress Activated Pathwaysp38 MAPK PathwayGb and GgGTPRrasMap2k7Mapk3Mapk1MbpRasa3Map2BrafMap3k2Mapk14JunHrasMap3k12Map3k1Elk1NrasMap2k3Map2k2Plcb3GDPMap2k4Map2k4Sipa1Raf1Map2k1ApoptosisArafMap2k6Mapk12KrasRapGAPIIMapk10Map3k3


Description

The MAPK cascades are central signaling pathways that regulate a wide variety of stimulated cellular processes, including proliferation, differentiation, apoptosis and stress response. Therefore, dysregulation, or improper functioning of these cascades, is involved in the induction and progression of diseases such as cancer, diabetes, autoimmune diseases, and developmental abnormalities.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP422 (r95146) with a 96.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Plotnikov A, Zehorai E, Procaccia S, Seger R; ''The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation.''; Biochim Biophys Acta, 2011 PubMed Europe PMC
  2. Orton RJ, Sturm OE, Gormand A, Wolch W, Gilbert DR; ''Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway.''; IET Syst Biol, 2008 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
95771view14:24, 19 January 2018MkutmonHomology conversion update
71729view20:17, 17 October 2013MaintBotAutomated update of data sources
71318view17:16, 17 October 2013MaintBotAutomated update of data sources
69104view18:12, 8 July 2013MaintBotUpdated to 2013 gpml schema
67957view15:03, 28 June 2013DdiglesOntology Term : 'mitogen activated protein kinase signaling pathway' added !
62830view04:45, 3 May 2013MaintBotUpdated UniProt data source
41289view00:22, 2 March 2011MaintBotRemoved redundant pathway information and comments
35459view11:53, 12 February 2010MichielAdded ref
35431view11:13, 12 February 2010MichielModified description
35430view11:12, 12 February 2010MichielModified description
35429view11:10, 12 February 2010MichielAdded literature reference
34388view22:50, 9 December 2009MaintBotAutomatic update of empty xrefs
32979view23:26, 29 September 2009MaintBotadded xrefs
32377view16:52, 15 August 2009MaintBotFixed text labels
32013view13:21, 14 August 2009MaintBotFixed group labels
31413view20:54, 13 August 2009MaintBotFixed text labels
30851view00:07, 30 July 2009MaintBotConverted from Homo sapiens
21207view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:MAPK Cascade]] moved to [[Pathway:WP251]]: Moved to stable identifier
8244view13:46, 7 January 2008MaintBot[[Pathway:Mouse:MAPK Cascade]] moved to [[Pathway:Mus musculus:MAPK Cascade]]: Renaming species
7742view16:14, 18 December 2007MaintBotfixed category names
7275view12:41, 4 November 2007MaintBotAdded categories to GPML
19506view22:19, 22 May 2007I.Reyesgpml file for [[Mouse:MAPK_Cascade]]
6473view22:19, 22 May 2007Nsalomonisgpml file for [[Mouse:MAPK_Cascade]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ApoptosisPathwayWP254 (WikiPathways)
ArafGeneProductENSMUSG00000001127 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:369
BrafGeneProductENSMUSG00000002413 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:673
Elk1GeneProductENSMUSG00000009406 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2002
GDPMetabolite146-91-8 (CAS)
GTPMetabolite2564-35-4 (CAS)
HrasGeneProductENSMUSG00000025499 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3265
JunGeneProductENSMUSG00000052684 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3725
KrasGeneProductENSMUSG00000030265 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3845
Map2GeneProductENSMUSG00000015222 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4133
Map2k1GeneProductENSMUSG00000004936 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5604
Map2k2GeneProductENSMUSG00000035027 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5605
Map2k3GeneProductENSMUSG00000018932 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5606
Map2k4GeneProductENSMUSG00000033352 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6416
Map2k6GeneProductENSMUSG00000020623 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5608
Map2k7GeneProductENSMUSG00000109061 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5609
Map3k12GeneProductENSMUSG00000023050 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7786
Map3k1GeneProductENSMUSG00000021754 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4214
Map3k2GeneProductENSMUSG00000024383 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10746
Map3k3GeneProductENSMUSG00000020700 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4215
Mapk10GeneProductENSMUSG00000046709 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5602
Mapk12GeneProductENSMUSG00000022610 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6300
Mapk14GeneProductENSMUSG00000053436 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1432
Mapk1GeneProductENSMUSG00000063358 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5594
Mapk3GeneProductENSMUSG00000063065 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5595
MbpGeneProductENSMUSG00000041607 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4155
NrasGeneProductENSMUSG00000027852 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4893
Plcb3GeneProductENSMUSG00000024960 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5331
Raf1GeneProductENSMUSG00000000441 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5894
RapGAPIIGeneProduct
Rasa3GeneProductENSMUSG00000031453 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:22821
RrasGeneProductENSMUSG00000038387 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6237
Sipa1GeneProductENSMUSG00000056917 (Ensembl)
  • not confirmed SwissProt ID - mu: SPA1 MOUSE
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6494

Annotated Interactions

No annotated interactions
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