Dopamine metabolism (Homo sapiens)

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1P:STYRiron(2+)FADDopamineDopamine semiquinoneSOD1Dopamine quinoneGlutathione5-glutathionyl dopamineL-DopaCO2DDCDDCLeukoaminochromeDopaminochromeNQO1L-Dopa quinoneLeucodopachromeL-Dopachrome5,6-DihydroxyindoleDHICAICQANeuromelaninPolymerizationL-TyrosineTetrahydrobiopterin4a-HydroxytetrahydrobiopterinTHPRKACAPRKACBPRKACGPPP2CAPPP2CBDOPAL3-MethoxytyramineROSS-Adenosylhomocysteine1-chloro-2,4-dinitrobenzeneS-AdenosylmethionineN-MethylserotoninH2OO2H2O2AmmoniaMAOACOMTFADMAOBHomovanillinDOPETDOPACHomovanillic acid


Description

Dopamine is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body. It is an amine synthesized by removing a carboxyl group from a molecule of its precursor chemical L-DOPA, which is synthesized in the brain and kidneys. Dopamine is also synthesized in plants and most animals.

The dopamine system plays a central role in several significant medical conditions, including Parkinson's disease. Parkinson's disease is an age-related disorder characterized by movement disorders such as stiffness of the body, slowing of movement, and trembling of limbs when they are not in use. The main symptoms are caused by the loss of dopamine-secreting cells in the substantia nigra. These dopamine cells are especially vulnerable to damage, and a variety of insults, including encephalitis (as depicted in the book and movie "Awakenings"), repeated sports-related concussions, and some forms of chemical poisoning such as MPTP, can lead to substantial cell loss, producing a parkinsonian syndrome that is similar in its main features to Parkinson's disease. The most widely used treatment for parkinsonism is administration of L-DOPA, the metabolic precursor for dopamine. L-DOPA is converted to dopamine in the brain and various parts of the body by the enzyme DOPA decarboxylase. L-DOPA is used rather than dopamine itself because, unlike dopamine, it is capable of crossing the blood-brain barrier. Description source: Wikipedia

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

  1. Jones DR, Moussaud S, McLean P; ''Targeting heat shock proteins to modulate α-synuclein toxicity.''; Ther Adv Neurol Disord, 2014 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
107129view14:21, 17 September 2019MaintBotChEBI identifier normalization
106713view13:15, 17 September 2019MaintBotHMDB identifier normalization
106389view21:26, 28 August 2019KhanspersModified description
105571view06:27, 9 August 2019KhanspersModified description
98240view14:02, 14 August 2018EgonwReplace a PubChem SID with a Wikidata ID (which has more links out).
97673view11:17, 1 June 2018AMTanOntology Term : 'dopaminergic neuron' added !
96040view16:00, 15 February 2018Mkutmonremove old pathway attributes
96039view15:59, 15 February 2018Mkutmonadd literature reference
96037view15:52, 15 February 2018MkutmonModified description
96036view15:52, 15 February 2018MkutmonModified description
94675view13:47, 4 October 2017Marvin M2Connected unconnected lines
93092view13:44, 28 July 2017DeSlChanged 4 pubchem substance IDs to other with more stereospecificity (except for Neuromelanin)
93090view13:38, 28 July 2017DeSlOntology Term : 'dopamine metabolic pathway' added !
93089view13:38, 28 July 2017DeSlOntology Term : 'dopamine degradation pathway' added !
93088view13:38, 28 July 2017DeSlOntology Term : 'dopamine biosynthetic pathway' added !
90505view14:00, 19 November 2016EgonwOntology Term : 'classic metabolic pathway' added !
71387view18:41, 17 October 2013MaintBotAutomated update of data sources
68759view14:50, 7 July 2013EgonwTypo :(
68758view14:45, 7 July 2013EgonwFixed PubChem identifier structure, and one PubChem data source name.
68757view14:42, 7 July 2013EgonwFixed ChEBI identifier structure.
68756view14:41, 7 July 2013EgonwFixed the data source to HMDB.
67956view14:38, 28 June 2013MaintBotOntology Term : 'dopaminergic pathway' added !
67955view14:36, 28 June 2013MaintBotOntology Term : 'PW:0000394' removed !
61605view07:05, 15 April 2013Mostaszewskihomovanilic acid and dopaminochrome added
57740view22:19, 1 February 2013MaintBotModified categories
56800view13:41, 14 January 2013Mostaszewskiminor layout correction
56797view13:31, 14 January 2013MostaszewskiOntology Term : 'Parkinson disease pathway' added !
56796view13:31, 14 January 2013MostaszewskiOntology Term : 'dopaminergic pathway' added !
56795view13:26, 14 January 2013MostaszewskiNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1-chloro-2,4-dinitrobenzeneMetaboliteCHEBI:34718 (ChEBI)
3-MethoxytyramineMetaboliteHMDB0000022 (HMDB)
4a-HydroxytetrahydrobiopterinMetaboliteHMDB0002281 (HMDB)
5,6-DihydroxyindoleMetaboliteHMDB0004058 (HMDB)
5-glutathionyl dopamineMetabolite
AmmoniaMetaboliteHMDB0000051 (HMDB)
CO2MetaboliteHMDB0001967 (HMDB)
COMTGeneProduct1312 (Entrez Gene)
DDCGeneProduct1644 (Entrez Gene)
DHICAMetaboliteHMDB0001253 (HMDB)
DOPACMetaboliteCHEBI:41941 (ChEBI)
DOPALMetaboliteHMDB0003791 (HMDB)
DOPETMetaboliteHMDB0005784 (HMDB)
Dopamine quinoneMetaboliteHMDB0012219 (HMDB)
Dopamine semiquinoneMetabolite
DopamineMetaboliteHMDB0000073 (HMDB)
DopaminochromeMetabolite170262 (PubChem-compound)
FADMetaboliteHMDB0001248 (HMDB)
GlutathioneMetaboliteHMDB0000125 (HMDB)
H2O2MetaboliteHMDB0003125 (HMDB)
H2OMetaboliteHMDB0002111 (HMDB)
Homovanillic acidMetaboliteHMDB0000118 (HMDB)
HomovanillinMetaboliteHMDB0005175 (HMDB)
ICQA Metabolite46173450 (PubChem-compound)
L-Dopa quinone MetaboliteCHEBI:16852 (ChEBI)
L-DopaMetaboliteHMDB0000181 (HMDB)
L-DopachromeMetaboliteHMDB0001430 (HMDB)
L-TyrosineMetaboliteHMDB0000158 (HMDB)
LeucodopachromeMetaboliteHMDB0004067 (HMDB)
LeukoaminochromeMetaboliteHMDB0012992 (HMDB)
MAOAGeneProduct4128 (Entrez Gene)
MAOBGeneProduct4129 (Entrez Gene)
N-MethylserotoninMetaboliteHMDB0004369 (HMDB)
NQO1GeneProduct1728 (Entrez Gene)
NeuromelaninMetaboliteQ1981297 (Wikidata)
O2MetaboliteHMDB0001377 (HMDB)
PPP2CAGeneProduct5515 (Entrez Gene)
PPP2CBGeneProduct5516 (Entrez Gene)
PRKACAGeneProduct5566 (Entrez Gene)
PRKACBGeneProduct5567 (Entrez Gene)
PRKACGGeneProduct5568 (Entrez Gene)
ROSMetaboliteCHEBI:26523 (ChEBI)
S-AdenosylhomocysteineMetaboliteHMDB0000939 (HMDB)
S-AdenosylmethionineMetaboliteHMDB0001185 (HMDB)
SOD1GeneProduct6647 (Entrez Gene)
THGeneProduct7054 (Entrez Gene)
TYRGeneProduct7299 (Entrez Gene)
TetrahydrobiopterinMetaboliteHMDB0000027 (HMDB)
iron(2+)MetaboliteCHEBI:29033 (ChEBI)

Annotated Interactions

No annotated interactions

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