Spinal Cord Injury (Rattus norvegicus)

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3326Plxna2Ltb4rNOLTB4Cspg4Tnfsf13Tnfsf13bPdynNgfrLtbCd47Ptprz1222436427Motor NeuronOligodendrocyteAstroctyeSpinal Cord InjuryTimePro-InflammatoryFactorsZfp36Fcgr2aPrb1PtpraIl1bZfp36Nos2TnfNr4a1Il4Btg2Btg2FBRCdk2Nos1Il2TnfIl6Tlr4FosIl1bTgfb1Tlr4TnfEgr1FosMmp12IfngGlial ScarAstrocyte GliosisSwelling/EdemaMbpAntigens ReleasedRtn4C5Cxcl1Neutrophil Chemoattractants29, 34IL8NeurtrophilsMonocytesAqp410TTLegendTT:Therapeutic Target (increase)TTTTTT:Therapeutic Target (decrease)T-CellsB-CellsB Cell Stimulating5Activated Microglia/Macrophages(Transient)RepairIl1bNos2TnfArg1TOXIC FERROUSIRONFocal AdensionsEpha41, 11TTEfnb2TTTTTTTTCxcl10Neuro protectionAntibody ReleaseNeuronalInjuryResponseAstrocyteInjuryResponseG1-S Cell Cycle Re-entry (TT)23Ccng1MicrogliaMicrogliaActivationAxonal RetractionRecruitmentRecruitmentMmp9TT30Chondroitin Sulfate Proteoglycans3NcanSlit1Axon Retraction3Slit2Slit3Ntn1RgmaTTTTTTTTTTMmp930Mmp9Mmp930TT30TTTTCcr2Il1r129TTECM BreakdownECM BreakdownIl1aCxcl1Monocyte Chemoattractants29, 34Cxcl2Ccl2OligodendrocyteInjury ResponsePla2g6Pla2g5Pla2g2amelittinInflammationDemyelinationAnxa1TT12TTTTTTRed Blood CellsMyelinEndothelial LeukocyteAdehsion Factors17Icam1SelpTTTTPlasticityKlk832TTMicrogliaActivated Microglia/MacrophagesActivated Microglia/MacrophagesGfapTT30IntermediateFillament40Cdk4Tacr1E2f5Rb1PrkcaE2f1Mapk1Ccnd1MycGadd45aMapk3TTTTTTAstroctyeNeuron & OligodendrocyteApoptosis/NecrosisMicrogliaProliferationCasp3Tp53CytotoxicCytotoxicChst11VcanCol4a1Xylt1Col2a1AcanBcanGlial Scar FromationSox9Axonal GrowthInhibition40IgG, IgMTp53TT6TTTTGrin1Vim1841TTT Cell Stimulating5FK50619Ppp3caTTFK506FK5063838Gap43TTFK506Axonal Regeneration38Fkbp1aIl2C3 ToxinC1Q and Fc receptive cellsMagRtn4RhoaRhocRhobRock2OmgRtn4rLilrb331MyelinInjury ResponseArachidonic acidPGH2PTGS225TT21ROSNox4Mir23bOlomoucine15Cdk1Gdnf2TTSema6aTT24Axonal GrowthInhibitionGja1ATP-Release7TTBdnfTTImmediate Response Genes23


Description

This pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multi-step process that involves the regulation of gene expression and signaling in motor neurons, oligodentrocytes, microglia, and astrocytes that trigger immediate immune responses lasting several weeks. Within 24 hours, chemoattractants and cytokines released from the site of injury activate neutrophils which further recruit B and T cells or recruit monocytes that ultimately result in infiltration and activation by microglia and macrophages. These immune responses result in inflammation, excitotoxicity, cell death, formation of glial scar, and suppression of axonal regeneration. An increase in the expression of cell cycle genes further results in proliferation of astrocytes and microglia that leads to apoptosis and necrosis of oligodentrocytes and neurons.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
106971view13:43, 17 September 2019MaintBotHMDB identifier normalization
87680view08:55, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
83002view05:04, 17 November 2015Mkutmonremoved redundant refrence
83001view05:01, 17 November 2015Mkutmonfixed errors in references
83000view04:40, 17 November 2015Mkutmonfix outdated identifiers
81936view00:13, 6 September 2015AlexanderPicoNo rat homolog for IL8; removed human xref
79923view11:26, 27 April 2015EveloFixed homolog issue for C5
79916view11:01, 27 April 2015EveloCorrected datasource for ENSG00000106804 (was gene cards should have been ENSEMBL), still needs replaced by rat homologe
78470view10:27, 7 January 2015MaintBotadded missing graphIds
71102view17:16, 4 October 2013DMicaelModified description
69987view22:02, 11 July 2013MaintBotupdated to 2013 schema
58948view18:14, 21 February 2013MaintBotUpdated Ensembl data source
57152view12:40, 23 January 2013EgonwUsed "PubChem-compound"
55949view23:18, 28 December 2012NsalomonisOntology Term : 'traumatic neurosis' added !
55948view23:17, 28 December 2012NsalomonisOntology Term : 'spinal cord disease' added !
55947view23:17, 28 December 2012NsalomonisOntology Term : 'astrocyte of the spinal cord' added !
55946view23:15, 28 December 2012NsalomonisNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AcanGeneProductENSRNOG00000028992 (Ensembl)
Anxa1GeneProductENSRNOG00000017469 (Ensembl)
Aqp4GeneProductENSRNOG00000016043 (Ensembl)
Arachidonic acidMetaboliteHMDB0001043 (HMDB)
Arg1GeneProductENSRNOG00000013304 (Ensembl)
BcanGeneProductENSRNOG00000018798 (Ensembl)
BdnfGeneProduct24225 (Entrez Gene)
Btg2GeneProductENSRNOG00000003300 (Ensembl)
C5GeneProductENSRNOG00000018899 (Ensembl)
Casp3GeneProductENSRNOG00000010475 (Ensembl)
Ccl2GeneProductENSRNOG00000007159 (Ensembl)
Ccnd1GeneProductENSRNOG00000020918 (Ensembl)
Ccng1GeneProductENSRNOG00000003256 (Ensembl)
Ccr2GeneProductENSRNOG00000006755 (Ensembl)
Cd47GeneProductENSRNOG00000001964 (Ensembl)
Cdk1GeneProductENSRNOG00000000632 (Ensembl)
Cdk2GeneProductENSRNOG00000006469 (Ensembl)
Cdk4GeneProductENSRNOG00000025602 (Ensembl)
Chst11GeneProductENSRNOG00000008885 (Ensembl)
Col2a1GeneProductENSRNOG00000058560 (Ensembl)
Col4a1GeneProductENSRNOG00000016281 (Ensembl)
Cspg4GeneProductENSRNOG00000017208 (Ensembl)
Cxcl10GeneProductENSRNOG00000022256 (Ensembl)
Cxcl1GeneProductENSRNOG00000002802 (Ensembl)
Cxcl2GeneProductENSRNOG00000002792 (Ensembl)
E2f1GeneProductENSRNOG00000016708 (Ensembl)
E2f5GeneProductENSRNOG00000010760 (Ensembl)
Efnb2GeneProductENSRNOG00000014648 (Ensembl)
Egr1GeneProductENSRNOG00000019422 (Ensembl)
Epha4GeneProductENSRNOG00000013213 (Ensembl)
FBRGeneProduct
FK506Metabolite104987-11-3 (CAS)
Fcgr2aGeneProductENSRNOG00000049422 (Ensembl)
Fkbp1aGeneProductENSRNOG00000008822 (Ensembl)
FosGeneProductENSRNOG00000008015 (Ensembl)
Gadd45aGeneProductENSRNOG00000005615 (Ensembl)
Gap43GeneProductENSRNOG00000001528 (Ensembl)
GdnfGeneProductENSRNOG00000012819 (Ensembl)
GfapGeneProductENSRNOG00000002919 (Ensembl)
Gja1GeneProductENSRNOG00000000805 (Ensembl)
Grin1GeneProductENSRNOG00000011726 (Ensembl)
IL8GeneProduct
Icam1GeneProductENSRNOG00000020679 (Ensembl)
IfngGeneProductENSRNOG00000007468 (Ensembl)
Il1aGeneProductENSRNOG00000004575 (Ensembl)
Il1bGeneProductENSRNOG00000004649 (Ensembl)
Il1r1GeneProductENSRNOG00000014504 (Ensembl)
Il2GeneProductENSRNOG00000017348 (Ensembl)
Il4GeneProductENSRNOG00000007624 (Ensembl)
Il6GeneProductENSRNOG00000010278 (Ensembl)
Klk8GeneProductENSRNOG00000018580 (Ensembl)
LTB4Metabolite169 (PubChem-compound)
Lilrb3GeneProductENSRNOG00000054954 (Ensembl)
Ltb4rGeneProductENSRNOG00000020399 (Ensembl)
LtbGeneProductENSRNOG00000000836 (Ensembl)
MagGeneProductENSRNOG00000021023 (Ensembl)
Mapk1GeneProductENSRNOG00000001849 (Ensembl)
Mapk3GeneProductENSRNOG00000053583 (Ensembl)
MbpGeneProductENSRNOG00000016516 (Ensembl)
Mir23bGeneProduct100314002 (Entrez Gene)
Mmp12GeneProductENSRNOG00000030187 (Ensembl)
Mmp9GeneProductENSRNOG00000017539 (Ensembl)
MycGeneProductENSRNOG00000004500 (Ensembl)
NOMetabolite145068 (PubChem-compound)
NcanGeneProductENSRNOG00000048036 (Ensembl)
NgfrGeneProductENSRNOG00000005392 (Ensembl)
Nos1GeneProductENSRNOG00000001130 (Ensembl)
Nos2GeneProductENSRNOG00000057443 (Ensembl)
Nox4GeneProductENSRNOG00000013925 (Ensembl)
Nr4a1GeneProductENSRNOG00000007607 (Ensembl)
Ntn1GeneProductENSRNOG00000003947 (Ensembl)
OlomoucineMetaboliteHMDB0035233 (HMDB)
OmgGeneProductENSRNOG00000014107 (Ensembl)
PGH2MetaboliteHMDB0001381 (HMDB)
PTGS2GeneProduct469616 (Entrez Gene)
PdynGeneProductENSRNOG00000026036 (Ensembl)
Pla2g2aGeneProductENSRNOG00000016945 (Ensembl)
Pla2g5GeneProductENSRNOG00000016838 (Ensembl)
Pla2g6GeneProductENSRNOG00000012295 (Ensembl)
Plxna2GeneProductENSRNOG00000007324 (Ensembl)
Ppp3caGeneProductENSRNOG00000009882 (Ensembl)
Prb1GeneProductENSRNOG00000010485 (Ensembl)
PrkcaGeneProductENSRNOG00000003491 (Ensembl)
PtpraGeneProductENSRNOG00000021223 (Ensembl)
Ptprz1GeneProductENSRNOG00000006030 (Ensembl)
ROSGeneProduct
Rb1GeneProductENSRNOG00000016029 (Ensembl)
RgmaGeneProductENSRNOG00000012874 (Ensembl)
RhoaGeneProductENSRNOG00000050519 (Ensembl)
RhobGeneProductENSRNOG00000021403 (Ensembl)
RhocGeneProductENSRNOG00000012630 (Ensembl)
Rock2GeneProductENSRNOG00000004496 (Ensembl)
Rtn4GeneProductENSRNOG00000004621 (Ensembl)
Rtn4rGeneProductENSRNOG00000030920 (Ensembl)
SelpGeneProductENSRNOG00000002794 (Ensembl)
Sema6aGeneProduct361324 (Entrez Gene)
Slit1GeneProductENSRNOG00000026065 (Ensembl)
Slit2GeneProductENSRNOG00000003840 (Ensembl)
Slit3GeneProductENSRNOG00000007377 (Ensembl)
Sox9GeneProduct140586 (Entrez Gene)
Tacr1GeneProductENSRNOG00000005853 (Ensembl)
Tgfb1GeneProductENSRNOG00000020652 (Ensembl)
Tlr4GeneProductENSRNOG00000010522 (Ensembl)
TnfGeneProductENSRNOG00000000837 (Ensembl)
Tnfsf13GeneProductENSRNOG00000014171 (Ensembl)
Tnfsf13bGeneProductENSRNOG00000014464 (Ensembl)
Tp53GeneProductENSRNOG00000010756 (Ensembl)
VcanGeneProductENSRNOG00000029212 (Ensembl)
VimGeneProductENSRNOG00000018087 (Ensembl)
Xylt1GeneProductENSRNOG00000056658 (Ensembl)
Zfp36GeneProductENSRNOG00000058388 (Ensembl)
melittinMetabolite16133648 (PubChem-compound)

Annotated Interactions

No annotated interactions

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