Spinal Cord Injury (Mus musculus)

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2213LtbTnfsf13Ltb4r1LTB4Cd47Plxna2NgfrNOPtprz1PdynCspg4Tnfsf13b2410332823Motor NeuronOligodendrocyteAstroctyeSpinal Cord InjuryTimePro-InflammatoryFactorsZfp36Fcgr2bPrb1PtpraIl1bZfp36Nos2TnfNr4a1Il4Btg2Btg2FBRCdk2Nos1Il2TnfIl6Tlr4FosIl1bTgfb1Tlr4TnfEgr1FosMmp12IfngGlial ScarAstrocyte GliosisSwelling/EdemaMbpAntigens ReleasedRtn4HcCxcl1Neutrophil Chemoattractants17, 38Cxcl1NeurtrophilsMonocytesAqp4TT4LegendTT:Therapeutic Target (increase)TTTTTT:Therapeutic Target (decrease)T-CellsB-CellsB Cell Stimulating16Activated Microglia/Macrophages(Transient)RepairIl1bNos2TnfArg1TOXIC FERROUSIRONFocal Adensions1, 27Epha4TTEfnb2TTTTTTTTCxcl10Neuro protectionAntibody ReleaseNeuronalInjuryResponseAstrocyteInjuryResponseG1-S Cell Cycle Re-entry (TT)40Ccng1MicrogliaMicrogliaActivationAxonal RetractionRecruitmentRecruitmentMmp9TT30Chondroitin Sulfate ProteoglycansNcan7Slit1Axon Retraction7Slit2Slit3Ntn1RgmaTTTTTTTTTTMmp9Mmp930Mmp93030TTTTTTCcr2Il1r1TT17ECM BreakdownECM BreakdownIl1aCxcl1Monocyte ChemoattractantsCxcl217, 38Ccl2OligodendrocyteInjury ResponsePla2g6Pla2g5Pla2g2amelittinInflammationDemyelinationAnxa1TT25TTTTTTRed Blood CellsMyelinEndothelial LeukocyteAdehsion FactorsIcam121SelpTTTTPlasticityKlk829TTMicrogliaActivated Microglia/MacrophagesActivated Microglia/MacrophagesGfap30TTIntermediateFillament19Cdk4Tacr1E2f5Rb1PrkcaE2f1Mapk1Ccnd1MycGadd45aMapk3TTTTTTAstroctyeNeuron & OligodendrocyteApoptosis/NecrosisMicrogliaProliferationCasp3Trp53CytotoxicCytotoxicChst11VcanCol4a1Xylt1Col2a1AcanBcanGlial Scar FromationSox9Axonal GrowthInhibition19IgG, IgMTrp53TT5TTTTGrin1Vim3918TTT Cell StimulatingFK50616Ppp3ca3TTFK506FK5061414Gap43TTFK50614Axonal RegenerationFkbp1aIl2C3 ToxinC1Q and Fc receptive cellsMagRtn4RhoaRhocRhobRock2OmgRtn4rLilrb335MyelinInjury ResponseArachidonic acidPGH2PTGS220TT12ROSNox4Mir23bOlomoucine11Cdk1Gdnf34TTSema6aTT23Axonal GrowthInhibitionGja1ATP-Release32TTBdnfTTImmediate Response Genes40


Description

This pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multi-step process that involves the regulation of gene expression and signaling in motor neurons, oligodentrocytes, microglia, and astrocytes that trigger immediate immune responses lasting several weeks. Within 24 hours, chemoattractants and cytokines released from the site of injury activate neutrophils which further recruit B and T cells or recruit monocytes that ultimately result in infiltration and activation by microglia and macrophages. These immune responses result in inflammation, excitotoxicity, cell death, formation of glial scar, and suppression of axonal regeneration. An increase in the expression of cell cycle genes further results in proliferation of astrocytes and microglia that leads to apoptosis and necrosis of oligodentrocytes and neurons.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
106874view13:35, 17 September 2019MaintBotHMDB identifier normalization
102465view05:52, 24 December 2018EgonwFixed a reference.
102464view05:51, 24 December 2018EgonwFixed a data source.
87679view08:55, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
79927view12:02, 27 April 2015EveloReplaced human C5 gene with mouse homologe Hc
79915view10:57, 27 April 2015EveloCorrected datasource for: ENSG00000106804 (was gene cards, should have been ensembl)
78436view10:26, 7 January 2015MaintBotadded missing graphIds
71041view01:36, 25 September 2013DMicaelModified description
69986view22:01, 11 July 2013MaintBotupdated to 2013 schema
59003view20:15, 21 February 2013MaintBotUpdated Ensembl data source
57151view12:39, 23 January 2013EgonwUsed "PubChem-compound"
55957view00:47, 29 December 2012NsalomonisSpecify description
55952view00:20, 29 December 2012Nsalomonisre-sized fonts and spacing for image export
55943view22:52, 28 December 2012NsalomonisOntology Term : 'traumatic neurosis' added !
55942view22:51, 28 December 2012NsalomonisOntology Term : 'spinal cord disease' added !
55941view22:51, 28 December 2012NsalomonisOntology Term : 'astrocyte of the spinal cord' added !
55940view22:49, 28 December 2012NsalomonisNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AcanGeneProductENSMUSG00000030607 (Ensembl)
Anxa1GeneProductENSMUSG00000024659 (Ensembl)
Aqp4GeneProductENSMUSG00000024411 (Ensembl)
Arachidonic acidMetaboliteHMDB0001043 (HMDB)
Arg1GeneProductENSMUSG00000019987 (Ensembl)
BcanGeneProductENSMUSG00000004892 (Ensembl)
BdnfGeneProductENSMUSG00000048482 (Ensembl)
Btg2GeneProductENSMUSG00000020423 (Ensembl)
Casp3GeneProductENSMUSG00000031628 (Ensembl)
Ccl2GeneProductENSMUSG00000035385 (Ensembl)
Ccnd1GeneProductENSMUSG00000070348 (Ensembl)
Ccng1GeneProductENSMUSG00000020326 (Ensembl)
Ccr2GeneProductENSMUSG00000049103 (Ensembl)
Cd47GeneProductENSMUSG00000055447 (Ensembl)
Cdk1GeneProductENSMUSG00000019942 (Ensembl)
Cdk2GeneProductENSMUSG00000025358 (Ensembl)
Cdk4GeneProductENSMUSG00000006728 (Ensembl)
Chst11GeneProductENSMUSG00000034612 (Ensembl)
Col2a1GeneProductENSMUSG00000022483 (Ensembl)
Col4a1GeneProductENSMUSG00000031502 (Ensembl)
Cspg4GeneProductENSMUSG00000032911 (Ensembl)
Cxcl10GeneProductENSMUSG00000034855 (Ensembl)
Cxcl1GeneProductENSMUSG00000029380 (Ensembl)
Cxcl2GeneProductENSMUSG00000058427 (Ensembl)
E2f1GeneProductENSMUSG00000027490 (Ensembl)
E2f5GeneProductENSMUSG00000027552 (Ensembl)
Efnb2GeneProductENSMUSG00000001300 (Ensembl)
Egr1GeneProductENSMUSG00000038418 (Ensembl)
Epha4GeneProductENSMUSG00000026235 (Ensembl)
FBRGeneProduct
FK506Metabolite104987-11-3 (CAS)
Fcgr2bGeneProductENSMUSG00000026656 (Ensembl)
Fkbp1aGeneProductENSMUSG00000032966 (Ensembl)
FosGeneProductENSMUSG00000021250 (Ensembl)
Gadd45aGeneProductENSMUSG00000036390 (Ensembl)
Gap43GeneProductENSMUSG00000047261 (Ensembl)
GdnfGeneProductENSMUSG00000022144 (Ensembl)
GfapGeneProductENSMUSG00000020932 (Ensembl)
Gja1GeneProductENSMUSG00000050953 (Ensembl)
Grin1GeneProductENSMUSG00000026959 (Ensembl)
HcGeneProductENSMUSG00000026874 (Ensembl)
Icam1GeneProductENSMUSG00000037405 (Ensembl)
IfngGeneProductENSMUSG00000055170 (Ensembl)
Il1aGeneProductENSMUSG00000027399 (Ensembl)
Il1bGeneProductENSMUSG00000027398 (Ensembl)
Il1r1GeneProductENSMUSG00000026072 (Ensembl)
Il2GeneProductENSMUSG00000027720 (Ensembl)
Il4GeneProductENSMUSG00000000869 (Ensembl)
Il6GeneProductENSMUSG00000025746 (Ensembl)
Klk8GeneProductENSMUSG00000064023 (Ensembl)
LTB4Metabolite169 (PubChem-compound)
Lilrb3GeneProductENSMUSG00000058818 (Ensembl)
Ltb4r1GeneProductENSMUSG00000046908 (Ensembl)
LtbGeneProductENSMUSG00000024399 (Ensembl)
MagGeneProductENSMUSG00000036634 (Ensembl)
Mapk1GeneProductENSMUSG00000063358 (Ensembl)
Mapk3GeneProductENSMUSG00000063065 (Ensembl)
MbpGeneProductENSMUSG00000041607 (Ensembl)
Mir23bGeneProductENSMUSG00000065599 (Ensembl)
Mmp12GeneProductENSMUSG00000049723 (Ensembl)
Mmp9GeneProductENSMUSG00000017737 (Ensembl)
MycGeneProductENSMUSG00000022346 (Ensembl)
NOMetabolite145068 (PubChem-compound)
NcanGeneProductENSMUSG00000002341 (Ensembl)
NgfrGeneProductENSMUSG00000000120 (Ensembl)
Nos1GeneProductENSMUSG00000029361 (Ensembl)
Nos2GeneProductENSMUSG00000020826 (Ensembl)
Nox4GeneProductENSMUSG00000030562 (Ensembl)
Nr4a1GeneProductENSMUSG00000023034 (Ensembl)
Ntn1GeneProductENSMUSG00000020902 (Ensembl)
OlomoucineMetaboliteHMDB0035233 (HMDB)
OmgGeneProductENSMUSG00000049612 (Ensembl)
PGH2MetaboliteHMDB0001381 (HMDB)
PTGS2GeneProduct469616 (Entrez Gene)
PdynGeneProductENSMUSG00000027400 (Ensembl)
Pla2g2aGeneProductENSMUSG00000058908 (Ensembl)
Pla2g5GeneProductENSMUSG00000041193 (Ensembl)
Pla2g6GeneProductENSMUSG00000042632 (Ensembl)
Plxna2GeneProductENSMUSG00000026640 (Ensembl)
Ppp3caGeneProductENSMUSG00000028161 (Ensembl)
Prb1GeneProductENSMUSG00000067543 (Ensembl)
PrkcaGeneProductENSMUSG00000050965 (Ensembl)
PtpraGeneProductENSMUSG00000027303 (Ensembl)
Ptprz1GeneProductENSMUSG00000068748 (Ensembl)
ROSGeneProduct
Rb1GeneProductENSMUSG00000022105 (Ensembl)
RgmaGeneProductENSMUSG00000070509 (Ensembl)
RhoaGeneProductENSMUSG00000007815 (Ensembl)
RhobGeneProductENSMUSG00000054364 (Ensembl)
RhocGeneProductENSMUSG00000002233 (Ensembl)
Rock2GeneProductENSMUSG00000020580 (Ensembl)
Rtn4GeneProductENSMUSG00000020458 (Ensembl)
Rtn4rGeneProductENSMUSG00000043811 (Ensembl)
SelpGeneProductENSMUSG00000026580 (Ensembl)
Sema6aGeneProductENSMUSG00000019647 (Ensembl)
Slit1GeneProductENSMUSG00000025020 (Ensembl)
Slit2GeneProductENSMUSG00000031558 (Ensembl)
Slit3GeneProductENSMUSG00000056427 (Ensembl)
Sox9GeneProductENSMUSG00000000567 (Ensembl)
Tacr1GeneProductENSMUSG00000030043 (Ensembl)
Tgfb1GeneProductENSMUSG00000002603 (Ensembl)
Tlr4GeneProductENSMUSG00000039005 (Ensembl)
TnfGeneProductENSMUSG00000024401 (Ensembl)
Tnfsf13GeneProductENSMUSG00000089669 (Ensembl)
Tnfsf13bGeneProductENSMUSG00000031497 (Ensembl)
Trp53GeneProductENSMUSG00000059552 (Ensembl)
VcanGeneProductENSMUSG00000021614 (Ensembl)
VimGeneProductENSMUSG00000026728 (Ensembl)
Xylt1GeneProductENSMUSG00000030657 (Ensembl)
Zfp36GeneProductENSMUSG00000044786 (Ensembl)
melittinMetabolite16133648 (PubChem-compound)

Annotated Interactions

No annotated interactions

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