Spinal Cord Injury (Mus musculus)

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834Tnfsf13bNgfrPlxna2Cd47NOLtbPdynPtprz1LTB4Ltb4r1Cspg4Tnfsf1351732269Motor NeuronOligodendrocyteAstroctyeSpinal Cord InjuryTimePro-InflammatoryFactorsZfp36Fcgr2bPrb1PtpraIl1bZfp36Nos2TnfNr4a1Il4Btg2Btg2FBRCdk2Nos1Il2TnfIl6Tlr4FosIl1bTgfb1Tlr4TnfEgr1FosMmp12IfngGlial ScarAstrocyte GliosisSwelling/EdemaMbpAntigens ReleasedRtn4HcCxcl1Neutrophil ChemoattractantsCxcl129, 38NeurtrophilsMonocytesAqp441TTLegendTT:Therapeutic Target (increase)TTTTTT:Therapeutic Target (decrease)T-CellsB-CellsB Cell Stimulating33Activated Microglia/Macrophages(Transient)RepairIl1bNos2TnfArg1TOXIC FERROUSIRONFocal AdensionsEpha413, 20TTEfnb2TTTTTTTTCxcl10Neuro protectionAntibody ReleaseNeuronalInjuryResponseAstrocyteInjuryResponseG1-S Cell Cycle Re-entry (TT)3Ccng1MicrogliaMicrogliaActivationAxonal RetractionRecruitmentRecruitmentMmp911TTChondroitin Sulfate ProteoglycansNcan36Slit1Axon RetractionSlit236Slit3Ntn1RgmaTTTTTTTTTTMmp9Mmp911Mmp91111TTTTTTCcr2Il1r138TTECM BreakdownECM BreakdownIl1aCxcl1Monocyte Chemoattractants29, 38Cxcl2Ccl2OligodendrocyteInjury ResponsePla2g6Pla2g5Pla2g2amelittinInflammationDemyelinationAnxa114TTTTTTTTRed Blood CellsMyelinEndothelial LeukocyteAdehsion Factors2Icam1SelpTTTTPlasticityKlk8TT21MicrogliaActivated Microglia/MacrophagesActivated Microglia/MacrophagesGfapTT11IntermediateFillament27Cdk4Tacr1E2f5Rb1PrkcaE2f1Mapk1Ccnd1MycGadd45aMapk3TTTTTTAstroctyeNeuron & OligodendrocyteApoptosis/NecrosisMicrogliaProliferationCasp3Trp53CytotoxicCytotoxicChst11VcanCol4a1Xylt1Col2a1AcanBcanGlial Scar FromationSox9Axonal GrowthInhibition27IgG, IgMTrp537TTTTTTGrin135Vim42TTT Cell Stimulating33FK50640Ppp3caTTFK50618FK50618Gap43TTFK506Axonal Regeneration18Fkbp1aIl2C3 ToxinC1Q and Fc receptive cellsMagRtn4RhoaRhocRhobRock2OmgRtn4rLilrb31MyelinInjury ResponseArachidonic acidPGH2PTGS24TT22ROSNox4Mir23bOlomoucine25Cdk1Gdnf31TTSema6aTT9Axonal GrowthInhibitionGja1ATP-Release15TTBdnfTTImmediate Response Genes3


Description

This pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multi-step process that involves the regulation of gene expression and signaling in motor neurons, oligodentrocytes, microglia, and astrocytes that trigger immediate immune responses lasting several weeks. Within 24 hours, chemoattractants and cytokines released from the site of injury activate neutrophils which further recruit B and T cells or recruit monocytes that ultimately result in infiltration and activation by microglia and macrophages. These immune responses result in inflammation, excitotoxicity, cell death, formation of glial scar, and suppression of axonal regeneration. An increase in the expression of cell cycle genes further results in proliferation of astrocytes and microglia that leads to apoptosis and necrosis of oligodentrocytes and neurons.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
102465view05:52, 24 December 2018EgonwFixed a reference.
102464view05:51, 24 December 2018EgonwFixed a data source.
87679view08:55, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
79927view12:02, 27 April 2015EveloReplaced human C5 gene with mouse homologe Hc
79915view10:57, 27 April 2015EveloCorrected datasource for: ENSG00000106804 (was gene cards, should have been ensembl)
78436view10:26, 7 January 2015MaintBotadded missing graphIds
71041view01:36, 25 September 2013DMicaelModified description
69986view22:01, 11 July 2013MaintBotupdated to 2013 schema
59003view20:15, 21 February 2013MaintBotUpdated Ensembl data source
57151view12:39, 23 January 2013EgonwUsed "PubChem-compound"
55957view00:47, 29 December 2012NsalomonisSpecify description
55952view00:20, 29 December 2012Nsalomonisre-sized fonts and spacing for image export
55943view22:52, 28 December 2012NsalomonisOntology Term : 'traumatic neurosis' added !
55942view22:51, 28 December 2012NsalomonisOntology Term : 'spinal cord disease' added !
55941view22:51, 28 December 2012NsalomonisOntology Term : 'astrocyte of the spinal cord' added !
55940view22:49, 28 December 2012NsalomonisNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AcanGeneProductENSMUSG00000030607 (Ensembl)
Anxa1GeneProductENSMUSG00000024659 (Ensembl)
Aqp4GeneProductENSMUSG00000024411 (Ensembl)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
Arg1GeneProductENSMUSG00000019987 (Ensembl)
BcanGeneProductENSMUSG00000004892 (Ensembl)
BdnfGeneProductENSMUSG00000048482 (Ensembl)
Btg2GeneProductENSMUSG00000020423 (Ensembl)
Casp3GeneProductENSMUSG00000031628 (Ensembl)
Ccl2GeneProductENSMUSG00000035385 (Ensembl)
Ccnd1GeneProductENSMUSG00000070348 (Ensembl)
Ccng1GeneProductENSMUSG00000020326 (Ensembl)
Ccr2GeneProductENSMUSG00000049103 (Ensembl)
Cd47GeneProductENSMUSG00000055447 (Ensembl)
Cdk1GeneProductENSMUSG00000019942 (Ensembl)
Cdk2GeneProductENSMUSG00000025358 (Ensembl)
Cdk4GeneProductENSMUSG00000006728 (Ensembl)
Chst11GeneProductENSMUSG00000034612 (Ensembl)
Col2a1GeneProductENSMUSG00000022483 (Ensembl)
Col4a1GeneProductENSMUSG00000031502 (Ensembl)
Cspg4GeneProductENSMUSG00000032911 (Ensembl)
Cxcl10GeneProductENSMUSG00000034855 (Ensembl)
Cxcl1GeneProductENSMUSG00000029380 (Ensembl)
Cxcl2GeneProductENSMUSG00000058427 (Ensembl)
E2f1GeneProductENSMUSG00000027490 (Ensembl)
E2f5GeneProductENSMUSG00000027552 (Ensembl)
Efnb2GeneProductENSMUSG00000001300 (Ensembl)
Egr1GeneProductENSMUSG00000038418 (Ensembl)
Epha4GeneProductENSMUSG00000026235 (Ensembl)
FBRGeneProduct
FK506Metabolite104987-11-3 (CAS)
Fcgr2bGeneProductENSMUSG00000026656 (Ensembl)
Fkbp1aGeneProductENSMUSG00000032966 (Ensembl)
FosGeneProductENSMUSG00000021250 (Ensembl)
Gadd45aGeneProductENSMUSG00000036390 (Ensembl)
Gap43GeneProductENSMUSG00000047261 (Ensembl)
GdnfGeneProductENSMUSG00000022144 (Ensembl)
GfapGeneProductENSMUSG00000020932 (Ensembl)
Gja1GeneProductENSMUSG00000050953 (Ensembl)
Grin1GeneProductENSMUSG00000026959 (Ensembl)
HcGeneProductENSMUSG00000026874 (Ensembl)
Icam1GeneProductENSMUSG00000037405 (Ensembl)
IfngGeneProductENSMUSG00000055170 (Ensembl)
Il1aGeneProductENSMUSG00000027399 (Ensembl)
Il1bGeneProductENSMUSG00000027398 (Ensembl)
Il1r1GeneProductENSMUSG00000026072 (Ensembl)
Il2GeneProductENSMUSG00000027720 (Ensembl)
Il4GeneProductENSMUSG00000000869 (Ensembl)
Il6GeneProductENSMUSG00000025746 (Ensembl)
Klk8GeneProductENSMUSG00000064023 (Ensembl)
LTB4Metabolite169 (PubChem-compound)
Lilrb3GeneProductENSMUSG00000058818 (Ensembl)
Ltb4r1GeneProductENSMUSG00000046908 (Ensembl)
LtbGeneProductENSMUSG00000024399 (Ensembl)
MagGeneProductENSMUSG00000036634 (Ensembl)
Mapk1GeneProductENSMUSG00000063358 (Ensembl)
Mapk3GeneProductENSMUSG00000063065 (Ensembl)
MbpGeneProductENSMUSG00000041607 (Ensembl)
Mir23bGeneProductENSMUSG00000065599 (Ensembl)
Mmp12GeneProductENSMUSG00000049723 (Ensembl)
Mmp9GeneProductENSMUSG00000017737 (Ensembl)
MycGeneProductENSMUSG00000022346 (Ensembl)
NOMetabolite145068 (PubChem-compound)
NcanGeneProductENSMUSG00000002341 (Ensembl)
NgfrGeneProductENSMUSG00000000120 (Ensembl)
Nos1GeneProductENSMUSG00000029361 (Ensembl)
Nos2GeneProductENSMUSG00000020826 (Ensembl)
Nox4GeneProductENSMUSG00000030562 (Ensembl)
Nr4a1GeneProductENSMUSG00000023034 (Ensembl)
Ntn1GeneProductENSMUSG00000020902 (Ensembl)
OlomoucineMetaboliteHMDB35233 (HMDB)
OmgGeneProductENSMUSG00000049612 (Ensembl)
PGH2MetaboliteHMDB01381 (HMDB)
PTGS2GeneProduct469616 (Entrez Gene)
PdynGeneProductENSMUSG00000027400 (Ensembl)
Pla2g2aGeneProductENSMUSG00000058908 (Ensembl)
Pla2g5GeneProductENSMUSG00000041193 (Ensembl)
Pla2g6GeneProductENSMUSG00000042632 (Ensembl)
Plxna2GeneProductENSMUSG00000026640 (Ensembl)
Ppp3caGeneProductENSMUSG00000028161 (Ensembl)
Prb1GeneProductENSMUSG00000067543 (Ensembl)
PrkcaGeneProductENSMUSG00000050965 (Ensembl)
PtpraGeneProductENSMUSG00000027303 (Ensembl)
Ptprz1GeneProductENSMUSG00000068748 (Ensembl)
ROSGeneProduct
Rb1GeneProductENSMUSG00000022105 (Ensembl)
RgmaGeneProductENSMUSG00000070509 (Ensembl)
RhoaGeneProductENSMUSG00000007815 (Ensembl)
RhobGeneProductENSMUSG00000054364 (Ensembl)
RhocGeneProductENSMUSG00000002233 (Ensembl)
Rock2GeneProductENSMUSG00000020580 (Ensembl)
Rtn4GeneProductENSMUSG00000020458 (Ensembl)
Rtn4rGeneProductENSMUSG00000043811 (Ensembl)
SelpGeneProductENSMUSG00000026580 (Ensembl)
Sema6aGeneProductENSMUSG00000019647 (Ensembl)
Slit1GeneProductENSMUSG00000025020 (Ensembl)
Slit2GeneProductENSMUSG00000031558 (Ensembl)
Slit3GeneProductENSMUSG00000056427 (Ensembl)
Sox9GeneProductENSMUSG00000000567 (Ensembl)
Tacr1GeneProductENSMUSG00000030043 (Ensembl)
Tgfb1GeneProductENSMUSG00000002603 (Ensembl)
Tlr4GeneProductENSMUSG00000039005 (Ensembl)
TnfGeneProductENSMUSG00000024401 (Ensembl)
Tnfsf13GeneProductENSMUSG00000089669 (Ensembl)
Tnfsf13bGeneProductENSMUSG00000031497 (Ensembl)
Trp53GeneProductENSMUSG00000059552 (Ensembl)
VcanGeneProductENSMUSG00000021614 (Ensembl)
VimGeneProductENSMUSG00000026728 (Ensembl)
Xylt1GeneProductENSMUSG00000030657 (Ensembl)
Zfp36GeneProductENSMUSG00000044786 (Ensembl)
melittinMetabolite16133648 (PubChem-compound)

Annotated Interactions

No annotated interactions

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