Cardiac Progenitor Differentiation (Homo sapiens)

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1, 2ES/IPS cellsHypoxiaPOU5F1Retinoic acidINSNANOGSOX2LIN28ALIN28BZFP42THY1EctodermSOX1PAX6EndodermSOX17FOXA2MesodermMesodermProgenitorNCAM1TANPEPMIXL1ROR2WNT3ABMP4INHBAGSK3BFGF2Day 1Day 2CardiacMesodermMESP1MESP2KDRKITDay 3-4CXCR4PDGFRANOTCH1CardiacProgenitorISL1NKX2-5GATA4TBX5Day 5-6TBX20MEF2CMAPK14BMP1NOGNODALTGFB1WNTDKK1ImmatureCardiomyocyteMYH6TNNT2TNNI3MYLK3Day 7SIRPAMEF2CMatureCardiomyocyteTNNT2ACTC1MYL2SCN5ADay 30+IRX4IGF2IGF1WNT3ANRG1


Description

Factors involved in the induction of cardiac differentiation in vitro and in vivo. This model was based on the below two review articles. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

  1. Burridge PW, Keller G, Gold JD, Wu JC; ''Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming.''; Cell Stem Cell, 2012 PubMed Europe PMC Scholia
  2. Stillitano F, Karakikes I, Fish KD, Hajjar RJ, Hulot S; ''Preclinical animal models for testing iPSC/ESC-based heart therapy''; , 2012

History

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CompareRevisionActionTimeUserComment
106350view21:36, 21 August 2019KhanspersModified description
106164view12:06, 16 August 2019MaintBotHMDB identifier normalization
105551view06:11, 9 August 2019KhanspersModified description
89157view03:16, 23 August 2016AriuttaOntology Term : 'regulatory pathway' added !
73324view14:05, 20 January 2014MkutmonFixed unconnected lines
72105view22:00, 24 October 2013AlexanderPicoDKK1 inhibits WNT Signaling, rather than just a single WNT protein
71359view18:35, 17 October 2013MaintBotAutomated update of data sources
69893view19:16, 11 July 2013AlexanderPicoUpdated lines and interactions
63155view20:18, 8 May 2013MaintBotUpdating gpml version
59100view22:10, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
57668view20:12, 31 January 2013KhanspersModified categories
55502view04:02, 17 December 2012NsalomonisSpecify description
55181view09:04, 13 December 2012NsalomonisOntology Term : 'cardiac myocyte' added !
55180view09:03, 13 December 2012NsalomonisSpecify description
55179view08:55, 13 December 2012NsalomonisModified description
55178view08:53, 13 December 2012NsalomonisSpecify description
55177view08:52, 13 December 2012NsalomonisSpecify description
55176view08:51, 13 December 2012NsalomonisSpecify description
55175view08:34, 13 December 2012NsalomonisSpecify description
55174view08:27, 13 December 2012NsalomonisPeriodical save, work in progress
55173view08:16, 13 December 2012NsalomonisPeriodical save, work in progress
55172view08:06, 13 December 2012NsalomonisPeriodical save, work in progress
55171view08:01, 13 December 2012NsalomonisSpecify description
55170view07:56, 13 December 2012NsalomonisPeriodical save, work in progress
55169view07:44, 13 December 2012NsalomonisSpecify description
55168view07:39, 13 December 2012NsalomonisSpecify description
55163view07:06, 13 December 2012NsalomonisPeriodical save, work in progress
55162view06:54, 13 December 2012NsalomonisSpecify description
55161view06:46, 13 December 2012NsalomonisPeriodical save, work in progress
55160view06:41, 13 December 2012NsalomonisNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTC1GeneProductENSG00000159251 (Ensembl)
ANPEPGeneProductENSG00000166825 (Ensembl)
BMP1GeneProductENSG00000168487 (Ensembl)
BMP4GeneProductENSG00000125378 (Ensembl)
CXCR4GeneProductENSG00000121966 (Ensembl)
DKK1GeneProductENSG00000107984 (Ensembl)
FGF2GeneProductENSG00000138685 (Ensembl)
FOXA2GeneProductENSG00000125798 (Ensembl)
GATA4GeneProductENSG00000136574 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
IGF1GeneProductENSG00000017427 (Ensembl)
IGF2GeneProductENSG00000167244 (Ensembl)
INHBAGeneProductENSG00000122641 (Ensembl)
INSGeneProduct3630 (Entrez Gene)
IRX4GeneProductENSG00000113430 (Ensembl)
ISL1GeneProductENSG00000016082 (Ensembl)
KDRGeneProductENSG00000128052 (Ensembl)
KITGeneProductENSG00000157404 (Ensembl)
LIN28AGeneProductENSG00000131914 (Ensembl)
LIN28BGeneProductENSG00000187772 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MEF2CGeneProductENSG00000081189 (Ensembl)
MESP1GeneProductENSG00000166823 (Ensembl)
MESP2GeneProductENSG00000188095 (Ensembl)
MIXL1GeneProductENSG00000185155 (Ensembl)
MYH6GeneProductENSG00000197616 (Ensembl)
MYL2GeneProductENSG00000111245 (Ensembl)
MYLK3GeneProductENSG00000140795 (Ensembl)
NANOGGeneProductENSG00000111704 (Ensembl)
NCAM1GeneProductENSG00000149294 (Ensembl)
NKX2-5GeneProductENSG00000183072 (Ensembl)
NODALGeneProductENSG00000156574 (Ensembl)
NOGGeneProductENSG00000183691 (Ensembl)
NOTCH1GeneProductENSG00000148400 (Ensembl)
NRG1GeneProductENSG00000157168 (Ensembl)
PAX6GeneProductENSG00000007372 (Ensembl)
PDGFRAGeneProductENSG00000134853 (Ensembl)
POU5F1GeneProductENSG00000204531 (Ensembl)
ROR2GeneProductENSG00000169071 (Ensembl)
Retinoic acidMetaboliteHMDB0001852 (HMDB)
SCN5AGeneProductENSG00000183873 (Ensembl)
SIRPAGeneProductENSG00000198053 (Ensembl)
SOX17GeneProductENSG00000164736 (Ensembl)
SOX1GeneProductENSG00000182968 (Ensembl)
SOX2GeneProductENSG00000181449 (Ensembl)
TBX20GeneProductENSG00000164532 (Ensembl)
TBX5GeneProductENSG00000089225 (Ensembl)
TGeneProductENSG00000164458 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
THY1GeneProductENSG00000154096 (Ensembl)
TNNI3GeneProductENSG00000129991 (Ensembl)
TNNT2GeneProductENSG00000118194 (Ensembl)
WNT3AGeneProductENSG00000154342 (Ensembl)
WNTPathwayWP399 (WikiPathways)
ZFP42GeneProductENSG00000179059 (Ensembl)

Annotated Interactions

No annotated interactions

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