Brain-Derived Neurotrophic Factor (BDNF) signaling pathway (Homo sapiens)

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VAV3MAPK9PCDK5R1SHC2MAPK8PMAPK3Y204T202ط®آ³-secretasecomplexCa2+ELMOEndocytosis-dependentOxidativeneuronalnecrosismembraneboundBrain-derived neurotrophic factor signaling pathwayIKKDegradationSelectivepostsynapticdevelopmentNeuriteoutgrowthReduction inphosphorylationLamellipodia formationand increasedneurite outgrowthSynaptic plasticityDissociationProteinsynthesisIKK1IKK2IkkGBCL2L11CYFIP1NCK1NCK2SHC1PPLCG1Y783PTPN11PCDH2TRAF6CTNNB1Y654SQSTM1FYNY420SHC3PNGFRNCAM1Y734TIAM1Y829LINGO1RANBP9DOK5PSHC4PGRB2SIRPAPKCNA3PFRS2PGRIN2BPFRS3PDOCK3PNTRK1PRAC1CDKL5PSORT1NGFBDNFGRIA2CREB1S133NSFGNB2L1GABRB3S432S433PPP2CACRTC1KSR1MAP2K2PMAPK1T185Y187MAP2K1PSH2B2PFOXO3T32S253MTORS2448KIDINS220PRPS6KB1T412S447T444EIF4EBP1T46T37AKT1S473T308BADS75S99SH2BPGSK3BS9GRIN1PIRS2PMAPK7T219Y221IRS1PTSC2T1462GRIA1PCAMK4PCAMK2PEEF2ACACBS78PRKAA2T172MAPTS202S198S195ELK1PIGF2BP1Y396PTK2BY402RAF1S338VAV2Y172CDK5Y15NFATC4NCF2NCF1NFATC4CYNUCYNUSTAT5BCDC42CNR1NTRK3PIK3R1NTF3BDNFPDPK1S241MAP3K1ADAM17MAPK10PHRASGTPRPS6S240S236S235S244EIF4EPPIK3R2IP3SRCFOXO3PIP2DAGSTAT5ANFKB1RELAS529NFKB1RELAS529NFKBIAS36S32JUNPCASP3ProteinReceptorProteinProteinmRNASmall moleculeLigandInduced activationEnzyme complexInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through multiple reactionsTranslocation UbiquitinationPTM stateProtein-protein interactionDephosphorylationLEGENDPhosphorylationNucleusCytoplasmPlasma membraneCYPMNUProteolytic cleavageMoleculeCalcificationNeuronal growth,differentiation,and protectionInhibition ofapoptosisNitric oxideproductionApoptosisInhibition ofapoptosisRPS6KA3S227S386YBX1S102RPS6KA1S380S221RPS6KA5S376CAMK1T177MAPK14T180Y182RASGRF1DPYSL2T514APCPTPRFDLG1GRIP1GRIA3RHOGPAKKCNN2PCFL1PBDNFBDNFPIP2PIP3PIK3CACalmodulinSOSCAMKKCalcineurinPRKAA1T196EnhancedfatoxidationReduction in FOXO3 shuttleto nucleus anddecrease in BIMMAP2K5MAP3K2MEF2CMEF2ACerebellargranuleneuronalsurvivalCYNURAP1AMAPK7Y221T219CYNURegulation of surface expression of AMPA receptorsPKCRegulation ofsynaptic plasticitySTAT5BSTAT5AGrowthconemotilityCYNURegulation of Pre-synapticplasticity CYNUCYNUHuman airwaysmooth muscle cellproliferationRelease of RNG105from RNA granulesJAK2PSTAT1STAT3PPMajor pelvicganglia neuriteoutgrowthCEBPBFOSEGR1EGR2Cortical dendrite differentiationMARCKSPPRKCDY311CDK5dependentregulation of CDC42activityRadial migrationof corticalneuronsNTRK2Y722S495NTRK2K811Y723In secretorygranulesROSGSK3BS9MicrotubuleassemblyCSNK2A1RAB3AGTPcAMPPKASPP1ALPLBMP2EIF2S1EIF2S2MAPK3Y204T202MAPK1T185Y187SYN1PNeurotransmitterreleasemembraneboundBDNFBDNFBDNFAutocrinesignalingExtracellularECRPS6KA5S376ECCYDendritic developmentAxonal growthand branchingp75 NTR